Inkomba Prothrombin, isilinganiso kanye nenani

Prothrombin Inkomba, ngesilinganiso okuyinto ilingana 95-105%, - ingenye izinkomba esibonisa igazi ekunqandeni. Igazi ekunqandeni - inqubo eyinkimbinkimbi kakhulu owenziwa iqhaza kubangela amaprotheni ekhethekile okuthiwa ezijiyisa igazi. Ukusebenza kwawo le nqubo kungenzeka ngezindlela ezimbili - zangaphakathi nezangaphandle.

It Inkomba prothrombin ephawula ukusebenza coagulation nge indlela extrinsic. Kuyinto kanje: ephula ubuqotho kwezicubu (isilonda) lwabelwe okuthiwa izicubu thromboplastin, iprotheni ekhethekile kuzo zonke ezicutshini zomzimba. It icuphe yokusabela wendlale okuyinto faka nezinye izakhi ezijiyisayo (V, VII, futhi X, II, mina), zilandelana isebenze nomunye. Ekugcineni, kwakhiwa ihlule legazi is ukopha sithule.

Yini index prothrombin

izakhi ezijiyisayo akhiwa esibindini. Kulawa, II, V, X vitamin K nasekuthengeni. Nge ukuntuleka vitamin zamagama abo iphazamisekile. Ngakho, kukhona ukwephulwa hemostasis. Ukwazi Inkomba prothrombin, okuyinto isilinganiso aziwayo, udokotela wakho kungase:

1. Umsebenzi Ukukala tentatively II, V, VII futhi X izici ekunqandeni
2. Yimbi kangakanani le inkomba ukuze nahlulele umsebenzi kwesibindi
3. On ukugcwaliswa vitamin K
4. Isimo jikelele kohlelo igazi coagulation
5. Ngokusho le nkomba, ungakwazi ukusebenza yokwelapha anticoagulant.

Njengoba kunqunywa index prothrombin

Prothrombin Inkomba kunqunywa capillary noma igazi emithambo yegazi. Esimeni sesibili igazi kokuzila esithathwayo ibe tube test nge anticoagulant e isilinganiso 9: 1. Njengoba lisetshenziswe anticoagulant sodium citrate. Ngo-laboratory, igazi centrifuged. I-plasma okuholela isetshenziselwa ukuzimisela prothrombin isikhathi (PT). Norm MF ungaphakathi ibanga kusuka 12 amasekhondi kuya ku-20, kuye ngokuthi umsebenzi thromboplastin elisetshenziswa inkambo ukusabela egunjini lokucwaninga esibhedlela.

Ukwazi PT lesiguli, ungakwazi ukubala PI, ie prothrombin Inkomba, okuyinto kuyinto evamile laboratories ezahlukene kungaba futhi ihlukile. Unamandla okuxazulula noma isilinganiso px umuntu enempilo ukuze isiguli PV, iphindwe 100:

PI = PV enempilo. / SA ogulayo. X 100 (evamile 95-105%)

Ukubaluleka basemtholampilo PI

Ngezinye ephakeme PT coagulation noma prothrombin kabani kuyinsakavukela imizuzwana 12 kuya ku-20 mfushane, futhi PI iyakhula. Lokhu kungaba ngesikhathi sokukhulelwa, kulandela ukulimala okukhulu lapho igazi kuza eziningi izicubu thromboplastin.

Ngakolunye uhlangothi, MF uyanda futhi uya ngokuya incipha nokungawuvivinyi ngokwanele PI ekunqandeni, ezifana esimweni ukuntula azalwa naso we izakhi ezijiyisayo, kanye ezinzima isibindi isifo, kanye nokuntuleka vitamin K (okungase kwenzeke e cholestasis, dysbacteriosis, zikhala ngezinye umsebenzi esiswini). PI incipha nge fibrinogen ongaphakeme noma ukukhubazeka ukusebenza, ne syndrome DIC, ebukhoneni izinto zivimbela ekunqandeni.

Kuyini INR

Ukwelashwa nokuvikelwa anticoagulants engaqondile ngokwemvelo kunciphisa prothrombin Inkomba. kuyinsakavukela wayo ungaba siqu yayo yonke laboratory. Ngakho-ke, ukuze bakwazi ukuqhathanisa imiphumela yokuhlolwa etholwe laboratories ezahlukene, kwathiwa wasungula test zifane ezifana INR. Kulolu hlu ukubala. Okunqumayo esekelwe ratio isikhathi prothrombin esiguli, ukubaluleka evamile MF futhi degree thromboplastin ukuzwela Inkomba (ISI).

INR = (PT b th / MF izinga) e-degree of ISI

Kumuntu ophile kahle le INR ku uhla 0, 8-1,2.

Le nkomba isetshenziswa ukuqapha ukusebenza kwe anticoagulants senzo. Ekwelapheni anticoagulant lapho coagulation kuyehla (isibonelo ngemva kokuhlinzwa inhliziyo) INR kufanele senyukela 2-3. Njengoba kwanda INR ekunqandeni sinciphile. Lihlela isilinganiso phakathi kwama PI kanye INR kangangokuthi ukwehla ohlwini lwezikhombo PI anda INR.