Lozap Plus - Iziyalezo yokusetshenziswa

Medicine "Lozap plus" ihlinzekwa amaphilisi ifilimu-camera, ukukhanya yellow noma ogodweni ngombala. Izibhebhe unayo i shape oblong futhi sokuhlukanisa ingozi ngakolunye uhlangothi.

isakhiwo

ezisebenzayo:

• hydrochlorothiazide - 12.5 mg; (1 ithebhu.)
• losartan - 50 mg (Table 1).

Excipients:

• macrogol 6000;
• microcrystalline cellulose;
• mannitol;
• krosparmelloza sodium;
• magnesium stearate;
• povidone;
• Valium;
• talc;
• ukudaya;
• simethicone emulsion.

imiphumela kwemithi

Losartan - kuyinto angiotensin 2 yokwamukela omelene okungahambisani zivimbela kinase 2. Ukulungiselela kunciphisa OPSS, umfutho wegazi, amazinga igazi aldosterone futhi epinephrine. Ngaphezu kwalokho, izidakamizwa has umphumela yimpumelelo isisu futhi kunciphisa afterload.

Losartan kungathiya intuthuko zokugula ezifana hypertrophy esivimba amanzi, kanye ngcono ukuzinza iziguli abathatha lesi kwezidakamizwa yokumelwa yinhliziyo.

Hydrochlorothiazide kungokwalabo isisu thiazide. Kunciphisa reabsorption sodium futhi kukhulisa okukhipha potassium, ne-phosphate ne-hydrogen umchamo.

Effect Its esiphezulu antihypertensive bengase bazikhandlele amaviki 3.

ubufakazi

• nomfutho wegazi ophakeme isiguli;
• ukunciphisa ingozi CVD in iziguli eziphambili kwesokunxele hypertrophy ventricular kanye nomfutho wegazi ophezulu

side effects

Imiphumela engemihle plus Lozap ezichazwe imiyalelo ngesisekelo imiphumela emibi ye izithako zako asebenzayo main - losartan futhi hydrochlorothiazide.

Imiphumela engemihle ethinta isimiso sezinzwa esiyinhloko

• isiyezi (ivela kaningi ngokwanele).

imiphumela engemihle ezenza abantu basabele ngendlela iguliswa zomzimba:

• angioedema;
• laryngeal edema (kanye nezinye izingxenye elingenhla ipheshana zokuphefumula);
• isifuba;
• vasculitis;
• isifo Henoch sika.

Imiphumela engemihle ezithinta zenhliziyo (esimiso senhliziyo nemithambo yegazi):

• nomfutho wegazi ophezulu.

Imiphumela engemihle ethinta ipheshana wokugaya ukudla (ubungozi engaphansi kuka-1%):

• ukusha kwesibindi kohlobo;
• isifo sohudo,
• anda transaminases isibindi.

Imiphumela engemihle ethinta umgudu wokuphefumula:

• ukukhwehlela.

Imiphumela engemihle ethinta ibhalansi amanzi-electrolyte (ubungozi engaphansi kuka-1%):

• hyperkalemia.

Izimo

• nomfutho wegazi ophezulu;
• anuria;
• hypovolemia;
• ukungasebenzi kwekhono izinso futhi isibindi;
• kweminyaka eyi-18;
• kuvelana izingxenye;
• ukhulelwe;
• lactation.

Uma ukukhulelwa lesiguli iphutha ngokumelene isizinda izidakamizwa ukusetshenziswa, kufanele ngokushesha yesulwe. Iqiniso lokuthi Lozap plus kungithinte uhlelo renin-angiotensin, okungase kubangele ukufa fetus ezimbili zokugcina trimesters sokukhulelwa.

Tablets "Lozap plus" ukuthatha nesineke abakhulelwe Namanje hhayi Kunconywa ngoba izidakamizwa kungabangela jaundice kule osanda kuzalwa, futhi thrombocytopenia nakomama. Ukwelashwa ukuqhutshwa ngeBhayibheli isisu, kulesi simo kungasizi ukugwema ubuthi.

ukweqisa izidakamizwa

Izimpawu ukweqisa izidakamizwa:

• ukwehlisa umfutho wegazi;
• bradycardia;
• tachycardia;
• amanzi emzimbeni (ngenxa lenyuka umchamo okukhipha).

ukwelashwa izidakamizwa ukweqisa izidakamizwa kumele kuqale nge lavage esiswini uma kwenzeka ukuthi isiguli uthethe Lozap plus muva. Khona-ke isiguli ekwelashweni kudingekile lingaze, futhi kwezinye izimo - ukulungiswa uketshezi electrolyte thuthuva. Hemodialysis ngeke bakwazi ukususa njengoba losartan futhi metabolites yayo.

izidakamizwa ekuhlanganyeleni

plus Losap potentiates isenzo nezinye izidakamizwa antihypertensive endabeni ukusetshenziswa kwabo elihlangene. Umuthi kungase kubangele a potentiation ka hypotension orthostatic, esimweni lapho isicelo kanye barbiturates.