Alpha-blocker

Alpha-blocker inikeza iqembu elikhulu futhi heterogeneous izidakamizwa. Esikhathini yoma, inzalo kulezi izidakamizwa yehlile kakhulu ngenxa yokuthi, ukwelapha umfutho ophakeme wegazi Ochwepheshe baqala ukusebenzisa isisu thiazide, ACE inhibitor. By nineties zakuqala kwatholakala ukuthi alpha 1-blocker kukhona abakhethayo ephuza (ikakhulukazi ukulungiselela "Doxazosin") tolerability efanayo, ukuphepha, agntigipertenzivnoy umsebenzi nezinye izidakamizwa, okuyinto isenzo siqondiswe ukwehlisa wegazi. Ngaphezu kwalokho, nemithi Kwatholakala futhi izakhiwo ezengeziwe ubavumele ukuba linqume ukuba iziguli sikashukela, Benign Prostatic Hyperplasia nemvelo, dyslipidemia, endaweni zangasese zamadoda endarteritis nya.

Alpha-blocker. ngezigaba

Izidakamizwa zihlukaniswe ngezigaba ezimbili eziyinhloko: sokukhohlwa nonselective.

Iqembu liqukethe ejenti nonselective-alpha 1- kanye blocker 2-adrenergic (isb, "Fetolamin" ukulungiselela).

Ngu ngokukhetha zihlanganisa izidakamizwa ezifana "terazosin", "Doxazosin", "Prazosin". Izidakamizwa kulesi sigaba ikakhulu ezithinta receptor, okuyinto zitholakala kule imisipha abushelelezi wendlala yabesilisa, isinye entanyeni Prostatic urethra ingxenye.

Ezinye izidakamizwa antihypertensive angawelinye nabanye amaqembu amafa abonise ezifanayo kodwa ngesikhathi esifanayo njenge-alpha-blocker. Le mithi, ngokukhethekile, faka izidakamizwa "Carvedilol".

Kukhona futhi izidakamizwa, izakhiwo zazo zifana nalezo abonise futhi beta- futhi alpha-adrenergic blocker. Lezi imithi, ngaphezu, futhi babe izakhiwo antioxidant. Mshini nomphumela kwabo ukuncintisana catecholamines. Umzabalazo Kwenziwa ngaso neuropathy-alpha adrenergic receptor ne-beta-receptor 1-adrenergic. Ngekusetjentiswa kwesikhathi eside umthelela mithi uqala fade, futhi ezinyangeni ezimbalwa kamuva iphele.

Alpha-blocker kunezimo eziningi. Ikakhulu, amathuluzi asetshenziswayo nomphumela ozuzisayo ezingeni triglyceride futhi cholesterol oketshezini olungenambala lwegazi. Lokhu kwehlisa ingozi isifo sokuqina kwemithambo yegazi. Umuthi akunamthelela lokuhlushwa ushukela egazini, ephansi blood pressure ngaphandle okwandisa ukuvama ukusikwa inhliziyo. Ngaphezu kwalokho, le mithi musa kuthinte isimo potency.

imiphumela emibi ye-alpha-blocker lincane ngokwanele. "Umthamo umphumela Okokuqala" njengokunesidingo kakhulu.

Kumele ukuthi alpha-blocker unekhono ukwandisa nezitsha ezincane, futhi kahle esikhulu igazi. Kule ndaba, ukunciphisa ingcindezi ibonakala kahle kakhulu kule sikhundla uqotho esiguli, futhi kancane liphinyiselwe - e ovundlile. Lapho indoda (evamile) avuke embhedeni, isimiso sezinzwa ithuthukisa ithoni ekhipha igazi enhliziyweni. Kuyadingeka ukuba yenza umzimba ukuze ime mpo. Ukuthola alpha 1-blocker ukuvimbela kule divayisi. Lapho senza indoda isikhundla uqotho kukhona ukwehla elibukhali ingcindezi. Ngenxa yalokho, ubuchopho uthola oksijini eliningi enganele. Umuntu uqala mnyama emehlweni, isiyezi, singenzeka ubuthakathaka ezinzima, kwezinye izimo, isiguli singase iwela swoon. Ngemva aquleke (ukuthatha evundlile) kwenzeka kuthuthukise ukugeleza palsy. Ngenxa yalokho, unembeza ngokushesha libuyiselwa esigulini. Lokhu eyethile, eqinisweni, ngokwako akusona ithwala kubafake engozini enkulu. Nokho, ngesikhathi kuwa kungenzeka ukuthi isiguli bangathola ingozi yokulimala.