"Indapamide": nozakwabo. "Indapamide": izibuyekezo odokotela

Kuyini umuthi "Indapamide"? Analogs ithuluzi, umhlahlandlela walo, imiphumela emibi futhi izinkomba ukusetshenziswa izokwethulwa ngezansi. Ngaphezu kwalokho, kulesi sihloko uzofunda yini noma cha lesi Izimo izidakamizwa, yini okufanele uyenze uma ukweqisa izidakamizwa njengoba kufanele kube, ukuthi kungenzeka ukuba zihlangana kanjani nezinye izidakamizwa, futhi lokho abakucabangayo ochwepheshe ke.

Ukwakheka izidakamizwa futhi injalo ukukhululwa

Yini ifomu le izidakamizwa itholakale ukudayiselwa? Ekhemisi kungatholakala kuphela ngesimo amaphilisi biconvex camera ne ezimhlophe ifilimu enamathela.

Siyini isithako esebenzayo kufaka nomuthi "Indapamide"? Analogs lokhu ejenti (iningi labo) nokulungiselelwa ngokwayo aqukethe izingxenye asebenzayo ezifana indapamide. Mayelana izinto elisizayo, izibhebhe zihlanganisa izingxenye ezilandelayo: monohydrate lactose, crospovidone, povidone K-30, i-magnesium stearate, talc futhi sodium lauryl sulfate.

Isenzo kwemithi zomuthi

Yini izakhiwo izidakamizwa "Indapamide", intengo olubonakaliswa ekupheleni kwalesi sihloko? Lo muthi kungokwalabo ejenti antihypertensive. Ngamanye amazwi, kuba isisu futhi vasodilator.

Ngokusho impahla yabo kwemithi, umuthi esondelene kakhulu isisu thiazide wathola ukwephulwa reabsorption sodium nosawoti, okuyinto zitholakala kule ingxenye cortical loop of Henle. It uyakwazi ukwandisa kwemvelo chlorine, magnesium ion, i-sodium ne-potassium umchamo.

Kungani akunikeze imithi "Indapamide"? Analogs ithuluzi ngokwayo yathi nomuthi uyakwazi ivimbela "bese wehlisa" calcium channel ngendlela abakhethayo, ukwandisa kuyaqina isitsha izindonga ukwehlisa ukumelana Imininingwane semithambo (neuropathy).

Ukwamukelwa izidakamizwa kunciphisa hypertrophy kwenhliziyo, noma kunalokho ventricle sako sobunxele. It akunamthelela inani lipids egazini, kanye umzimba carbohydrate, okubandakanya abantu abanezifo ezinjengesifo sikashukela.

Wathi nomuthi kunciphisa uzwela odongeni semithambo angiotensin II futhi norepinephrine, nisekeliwe kunciphisa ukukhiqizwa-mpilo free radicals, kuvusa synthesis prostaglandin E2.

Ngemuva kokufaka isicelo izidakamizwa isinyathelo hypotensive eba ekupheleni kwesonto 1st yokwelapha. Kulokhu lilondolozwe amahora 25 (emva temlomo olulodwa)

Pharmacokinetics zomuthi

Lapho ugxile izidakamizwa "Indapamide"? Imiyalelo, amazwana kusukela ochwepheshe bathi emva ngokuthatha izidakamizwa ngaphakathi ke cishe ngokuphelele futhi ngokushesha matasa kusukela ipheshana emathunjini. Njengoba kunodokotela silondoloze bioavailability salo 93%. reception ngesikhathi esisodwa ukudla siyehla izinga ukumuncwa kancane, kodwa akuphazamisi ivolumu umthamo ugxile iyona element lamanje.

Ubuningi esiphezulu isithako esisebenzayo plasma kufinyelelwa ngemva kwamahora angaba ngu-2 emva nokuphathwa iphilisi elilodwa. Impilo kwesigamu umuthi amahora 14-25. Ukuxhumana Amaprotheni egazi - mayelana 79%.

Lokhu ukulungiselela kahle sidlula kusivimbeli gazi izicubu (kuhlanganise esinomhlapho). Wabuye ingena obisini lwebele.

Umzimba izidakamizwa esibindini. It is esephetha izinso (njengoba metabolites) e isamba 60-80%, futhi 20% - by amathumbu.

Izinkomba ngoba ukusetshenziswa nomuthi

Kwezinye izimo, iziguli ezinqunyiwe isidakamizwa "Indapamide"? Izinkomba ukusetshenziswa kwaleli thuluzi zihlanganisa isimo esisodwa kuphela sokugembula isiguli. It nomfutho wegazi ophezulu. Ngaphezu kwalokho, imithombo yezokuzijabulisa ingadlulisela nomuthi eyabelwe ne sodium ne egcina amanzi emzimbeni. Ngokuvamile, lesi sifo ngokuvamile kubonakala iziguli nesifo senhliziyo.

Izimo ukusetshenziswa kwezidakamizwa

Manje ngoba sewuyazi ukuthi lokho okushiwo izidakamizwa "Indapamide" (izinkomba ukusetshenziswa kwezimali ziye ethulwa ngenhla nje). Nokho, kufanele kuphawulwe ukuthi lokhu izidakamizwa kukhona Izimo. Lezi zihlanganisa lezi zinto ezilandelayo:

• nesineke ne-lactose;
• ngesikhathi sokukhulelwa;
• galactosemia;
• hypokalemia;
• syndrome iziyaluyalu ukuncela galactose noma glucose;
• lactation;
• isicelo kanyekanye kwemithi, ekwazi ukuba zinde QT isikhawu;
• ezinzima ukwehluleka kwezinso (noma anuria isinyathelo);
• yobudala umuntu ongaphansi kweminyaka engu-18 ubudala (ukuphepha nokusebenza ngempumelelo ekwelapheni izingane ungazange sezisunguliwe);
• hepatic obukhulu, obuhlanganisa encephalopathy, ukwehluleka;
• hypersensitivity kuya izidakamizwa nezinye nemikhiqizo sulfonamide.

Ukusetshenziswa kwesivuno ngokuqikelela nomuthi

Abantu abaningi bayazibuza ukuthi ukuthenga "Indapamide" kudingeka kadokotela? Eqinisweni, ngaphambi kokuba usebenzise yanoma yimuphi izidakamizwa Kunconywa kudokotela - onguchwepheshe kuphela emva kuhlolwa futhi ngesisekelo imiphumela yokuhlolwa ungazakhela abanekhono ukwelashwa lwemithi. Ngokuphathelene indaba yethu, siphawula ukuthi ithuluzi kubhekwe ngokucophelela okukhulu elibekelwe abantu abanesifo sikashukela, sifo, kanye nalabo iziguli okukuyo yokungezwani komzimba ukuze sulfonamide nemikhiqizo.

Ngaphezu kwalokho, izidakamizwa okufanele zithathwe ngokucophelela in iziyaluyalu kwesibindi, izinso namanzi-electrolyte ukungalingani.

Phakathi ukwelashwa udokotela kumele sihlale njalo siqaphele izinga le electrolyte egazini isiguli (potassium, i-sodium, i-calcium).

Izidakamizwa "Indapamide": yokusetshenziswa, ochwepheshe zangempela

Ngokusho imiyalelo enamathiselwe, umuthi kumele kuthathwe ngomlomo, kungakhathaliseki ukudla. Ithebhulethi kumele zithathwe nge isamba elanele ngamanzi acwebileyo.

Indlela "Indapamide"? Ochwepheshe bezifo, lokhu izidakamizwa kungcono ugxile kusukela ipheshana emathunjini kuphela ekuseni. Ngakho-ke, kutuswa ukuba aphuze nje ngalesi sikhathi sosuku.

Isikali kuyinto 2.5 mg (isb, esinye isibhebhe sibonisa) nsuku zonke. Uma ngemva kwamasonto 4-8 okwelashwa, nomphumela ofiselekayo engakaze ufinyelelwe, ivolumu imithi akudingekile ukwandisa (nakuba ngokuvamile odokotela ukwenza lokho). Leli qiniso kungenxa yokuthi ngezinye ebulilini kwandisa ingozi nemiphumela engathandeki yalawo maphilisi. Kunalokho, ukwelashwa kuyadingeka ukuze sifake nabanye ejenti antihypertensive ukuthi akuyona isisu.

Indlela "Indapamide" kuleli cala? Lapho ukuphatha concomitant imithi emibili kubhekwe yithi umthamo izidakamizwa uhlala ingashintshiwe, isb 2.5 mg ngelanga (ekuseni).

Amacala ukweqisa izidakamizwa: Izimpawu, Ukwelashwa

Kwenzekani uma uthatha inombolo enkulu "Indapamide" izidakamizwa? Uphenyo odokotela bathi ezimweni ezinjalo isiguli isicanucanu, ubuthakathaka kanye nokuhlanza. Ngaphezu kwalokho, isiguli amanzi okhathazekile futhi electrolyte ukulinganisela umsebenzi ipheshana wokugaya ukudla. Kwezinye izimo, isiguli ukuncipha okukhulu wegazi nokucindezeleka zokuphefumula. In iziguli isifo sokusha kwesibindi kungaba ikhoma hepatic.

Indlela esiphatha ngayo? Endabeni ka ukweqisa izidakamizwa, iziguli kufanele ahlanze esiswini, ukulungisa amanzi electrolyte ibhalansi, futhi zisebenza ukwelashwa lingaze.

imiphumela emibi ngemva kokwamukela nomuthi

ukusabela ezingezinhle ngemva kokuthatha kuni okungaba khona uma "Indapamide" izidakamizwa? Imiphumela engemihle yalesi izidakamizwa. Lapha abayikho manje.

• wokugaya ukudla: gastralgia, isicanucanu, ubuhlungu besisu, ukuhlanza, sokuzincisha ukudla, ukuqunjelwa, nomlomo owomile, pancreatitis, uhudo, encephalopathy hepatic.
• uhlelo zokuphefumula: sinusitis, ukukhwehlela, rhinitis kanye pharyngitis.
• isimiso sezinzwa: ukuqwasha, ukukhathala, imisipha amajaqamba, uvalo, ubuthakathaka, ukukhathazeka, ubuhlungu bekhanda, ukukhathala, inzululwane, isiyezi, ukucindezeleka, ukozela, ukucasuka, ukucobeka nezingxabano.
• System urinary: nocturia, yizifo njalo, futhi polyuria.
• Inhliziyo negazi izitsha: arrhythmia, hypotension orthostatic, kwenhliziyo izinguquko ECG (ie, hypokalemia).
• Yokungezwani komzimba: isifuba amawala, ukulunywa futhi oluhambisana vasculitis.
• uhlelo hemopoietic: thrombocytopenia, anaemia hemolytic, leukopenia, umnkantsha aplasia, futhi agranulocytosis.
• Laboratory okutholakele: glycosuria, hyperuricemia, kukhuphuke urea nitrogen plasma, Hyperglycemia, hypercreatininemia, hypokalemia, hypercalcemia, hyponatremia futhi hyposalemia.
• Okunye: exacerbation of omzimba izicubu erythematosus.

Ukuxhumana nezinye izidakamizwa

Izidakamizwa "Indapamide", ogama senzo ihlose ukwehlisa ingcindezi, it is hhayi Kunconywa ukuthatha ngokuhlanganyela glycosides inhliziyo, njengoba kwandisa amathuba digitalis ukudakwa. Uma usebenzisa leli thuluzi calcium amalungiselelo futhi metformin, isiguli singase ukuthuthukisa hypercalcemia futhi esebenzisa lactic acidosis.

ekuphathweni Kanyekanye we nomuthi nge corticosteroids, ama-NSAID, sympathomimetics futhi tetrakozaktidom encishisiwe umphumela hypotensive ayengaphansi. Ngokuphathelene esebenzisa "baclofen", yena, kunalokho, zayiqinisa.

Ingxube izidakamizwa isisu potassium-engashiyi ngempumelelo inamba encane iziguli. Nokho, alikwenqabeli ukuphuza kungenzeka hyper- noma hypokalemia, ikakhulukazi in iziguli esingamahlalakhona kwezinso kanye nesifo sikashukela.

ACE inhibitor kungandisa ingozi hypotension futhi ukwehluleka oyingozi so-renal.

Zingaphazamisa izinso ngenkathi usebenzisa ejenti iodinated ebulilini.

Neuroleptics kanye nemithi yokunciphisa ukucindezeleka imipraminovye neqhaza lenyuka isinyathelo hypotensive futhi kwengozi hypotension orthostatic.

imiyalelo Special ukusetshenziswa "Indapamide" izidakamizwa

Ngaphansi kwaziphi izimo kufanele ukuqapha igazi isithombe sesiguli emva ukuqokwa kwe "Indapamide" izidakamizwa? Uphenyo odokotela bathi lokhu izidakamizwa zingashintsha inani creatinine kanye potassium ion kulezo ziguli ukuthatha laxatives, glycosides inhliziyo, kanye nabantu abaneminyaka engama-60.

Uma usebenzisa lokhu ejenti Kunconywa onekhono ehlelekile ukuqapha lokuhlushwa sodium ion, i-potassium ne-magnesium e oketshezini olungenambala lwegazi, kwazise iziguli ingaqala electrolyte thuthuva. Kuyadingeka ukuqapha i-pH, lo lokuhlushwa uric acid, i-glucose, kanye nitrogen asalile.

isilawuli Special kumele babhekane iziguli nge isibindi sibe sesomile (nge edema eqinile noma ascites), kanye senhliziyo futhi ischemic isifo senhliziyo.

iqembu ephezulu kufaka iziguli nge anda qt isikhawu ku-electrocardiogram (kungenzeka azalwa naso noma ukuthuthukisa ku ngemuva kwanoma yiluphi zokugula).

Isilinganiso lokuqala potassium ion lokuhlushwa igazi nesineke Kunconywa ukuthi ngesonto lokuqala ukwelashwa.

ngokukhethekile Kunconywa ukuba kunikwe iziguli sikashukela. Ikakhulukazi, kubalulekile ukuqapha ezingeni glucose egazini, ikakhulukazi uma umuntu ethola ukuthi unesifo hypokalemia.

Iziguli kokuthatha lesi imithi, kufanele isinxephezelo nokulahlekelwa amanzi ngokudla nangokuphuza uketshezi oluningi ngosuku. Ngaphezu kwalokho, ekuqaleni ukwelashwa, kubalulekile ukuqapha umsebenzi izinso.

Asinakusho ukuthi izidakamizwa "Indapamide", analogue zazo kukhonjisiwe ngezansi, ungakwazi ukunikeza umphumela omuhle phakathi isilawuli doping.

Iziguli hyponatremia, kanye nomfutho wegazi ophezulu, izinsuku 3 ngaphambi ukusetshenziswa angiotensin ukuguqulela enzyme inhibitor, isisu kufanele ayisekho. Ukwelashwa ingaqhutshezwa kamuva.

Ngo kuqokwa izidakamizwa "Indapamide" ochwepheshe kufanele uqaphele ukuthi esuselwe sulfonamide kalula babhebhethekise izifo ezifana omzimba izicubu erythematosus.

Kuze kube yimanje, ukuphepha nokusebenza ngempumelelo zomuthi ekwelapheni izingane ezincane kanye intsha engakaze isungulwe.

Kwezinye izimo, kungenzeka ukusabela ngabanye ukuthi ahlobene nezinguquko wegazi. Ngokuvamile, lokhu kwenzeka ekuqaleni ukwelashwa, kanye usebenzisa ezinye izidakamizwa antihypertensive. Ngenxa yalokho, lokhu kungase wehlise ikhono lokulawula umshini futhi izosebenzisana namanye izindlela ukuthi adinga ukunakekelwa okukhethekile.

Izibuyekezo ochwepheshe kanye neziguli ku imithi

Manje uyazi ukuthi kuyinto izidakamizwa "Indapamide". Ukubuyekeza, intengo izidakamizwa izokwethulwa manje.

Ochwepheshe bathi imithi ubhekana kahle umsebenzi. Lokhu ngempumelelo kwehlisa umfutho wegazi, futhi uba isisu.

Izibuyekezo sokulungiselela "Indapamide" asikisela ukuthi ngemva isicelo kwesokunxele ventricular hypertrophy kuyehla, futhi umphumela wawo antihypertensive abonakala kulezo ziguli abaku- hemodialysis.

Ngokuqondene imibono engakhi wathi izindlela, ezikhathini eziningi zihlotshaniswa ukubukeka inqwaba ukusabela ezingezinhle. Nokho, kufanele kuphawulwe ukuthi imiphumela enjalo kuyagcinwa kuphela labo Udlule Isikali ayabelwe imithi noma akususe, naphezu Izimo ezikhona.

Inani kanye analogue zomuthi

Kungakanani buyisidakamizwa "Indapamide"? Intengo zomuthi zingahluka (kuye ngokuthi umenzi kanye eziseceleni ekhemisi chain). Nokho, ngokwesilinganiso leli thuluzi angathengwa 95-100 ruble Russian (amaphilisi 30).

Kodwa yini okufanele uyenze uma isiguli sifuna abakwazi ukuthola izidakamizwa "Indapamide"? Analogue, intengo okuyilona elisebenzayo futhi hhayi eliphezulu kakhulu, edayiswa cishe njalo ikhemisi. Le mishanguzo zihlanganisa lezi ezilandelayo: "kuthiye indapamide," "Akripamid", "indapamide-Teva", "CP Indamed", "Akripamid kuthiye ukukhula", "Ravel CP", "Akuter-Sanovel", "Retapres", "Arindap "" Lorvas "," Arifon "," Pamid "," Arifon kuthiye ukukhula "," Tenzar "," Ipres Long "," Vero indapamide, "" Indipam "," Indap "," Indiur "," indapamide-Verte "" ionic "," indapamide kuthiye-Teva "," Indapres "," indapamide Sandoz, "" ionic kuthiye ukukhula "," indapamide-OBL "," indapamide Stada "nokunye.

Thatha imali ngokubona kwayo futhi esikhundleni imithi yabo "Indapamide" akuvunyelwe nakancane. Kufanele ukhethe udokotela kuphela, futhi kuphela ngemva kokuba lapho ngihlolwa. Futhi, ngaphambi kokuthatha lezi imithi kumele ayejwayele imiyalelo enamathiselwe.

izimo Isitoreji ekulungisweni kanye usuku lokuphelelwa isikhathi

Izidakamizwa esitolo endaweni eyomile futhi omnyama, okuyinto zingakwazi ukufunda izingane ezincane. lokushisa isitoreji ukulungiselela kumele singeqi degrees 25. Impilo eshalofini zeminyaka 3. Emva kwalesi sikhathi, ukuthatha nomuthi is nhlobo.