"Mirapex": yokusetshenziswa, incazelo, ukubuyekezwa

Kulesi sihloko uzofunda konke mayelana nokulungiselela "mirapex": indlela esikhundleni lokhu izidakamizwa, yini imiphumela yako, Izimo, side effects, iziyalezo eziqondile ngesandla sakhe. Lezi amaphilisi angabangela ukuziphatha okungafanele kanye nomthelela impendulo lesiguli. Ngakho-ke, ngaphambi kokuthatha lesi imithi "mirapex" yokusetshenziswa okufanele uzifunde ngokucophelela. Siphinde ngikuxoxele ukuhambisana lawo amaphilisi nezinye izidakamizwa.

Isikhathi eside "mirapex": ulwazi olujwayelekile mayelana izidakamizwa futhi izinkomba ukusetshenziswa

Ingqikithi asebenzayo ekulungisweni "mirapex" kuyinto pramipexole. Asizayo izingxenye Tablets: povidone, mannitol, isitashi, aerosil, magnesium stearate.

Nale ukwelashwa wenziwa idiopathic (ezimele nezinye izilonda) syndrome ka "imilenze ukubuyisa" futhi Parkinson kanye nezinye motor elicwengiweyo neziyaluyalu extrapyramidal.

Umkhiqizo: amaphilisi "mirapex PD" 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0,375 mg. Agcwele e amabhamuza yizicucu 10, bese ku amakhadibhodi amabhokisi.

amaphilisi emhlophe. Banezinhliziyo onqenqemeni beveled nomumo flat nhlangothi zombili, omunye ephethe ingozi iba mikhulu.

Tablets okufanele zithathwe ngomlomo, kungakhathaliseki ukudla. Yidla izidakamizwa uvunyelwe nganoma yisiphi isikhathi. Kulokhu, kufanele wageza phansi ngamanzi. Kunconywe umthamo wansuku zonke ihlukaniswe izigaba ezintathu.

Lo mshini wezenzo (pharmacodynamics) "mirapex" Tablets

Ngempumelelo izidakamizwa pramipexole elibandakanya ukulungiselela "mirapex" ngokuqondile futhi selectivity eliphezulu sithuthukisa Ukusabela elincane Dopamine receptor D2. Siyabonga kuye, kwavuzwa zingenzi lutho olunyakazisa umzimba esimweni Parkinson. Lokhu kungenxa ukusebenza Dopamine zemizwa striatum. Ngakho pramipexole kuvimbela ukonakala izinzwa ukuthi kwenzeka ngenxa neurotoxicity noma ischemia. It kuvimbela noma kunciphisa izinga zamagama, umzimba, kanye nokukhipha Dopamine. Ngenxa izinzwa pramipexole bavikelekile imiphumela anobuthi anti-Parkinson ejenti "Levodopa". Futhi ngenxa umphumela wawo incipha prolactin (umthamo-kuncike).

Endabeni ukusetshenziswa isikhathi eside amaphilisi "mirapex" ekwelapheni isifo i-Parkinson (iminyaka engaphezu kwemithathu) futhi lesi sifo of "imilenze ukubuyisa" (ngaphezu konyaka) akalushongo kahle ukuncipha pramipexole.

izinqubo kwamakhemikhali ezihilela ukulungiselela "mirapex 'emzimbeni wesiguli (pharmacokinetics)

Active izidakamizwa "mirapex" izidakamizwa is ngokuphelele futhi ngokushesha matasa ngemva kokuphathwa ngomlomo. Ukwazi nokwenziwa (bioavailability) cishe ngokuphelele - ezingaphezu kuka-90%. Ubuningi esiphezulu izidakamizwa e-plasma waphawula ngemva kwamahora angu-1-3 emva kokudla. Ekudleni pramipexole ukumuncwa rate incipha. Kulokhu, inani ukudla siyagwinyeka aliguquki.

C amaprotheni sibopha pramipexole kancane (ngaphansi kuka-20%). It has a ukusatshalaliswa yenqwaba - 400 amalitha, okusho ukuthi lokuhlushwa igazi uphansi. Ngokwezinga elithileko encane obala inqubo izidakamizwa umzimba. Cishe u-90% umthamo "mirapex" zithutha excreted ngu izinso, nge 80% - zinjalo. Indle pramipexole itholakala isamba engaphansi kuka 2% semali kudliwe izidakamizwa. Izicubu kanye lomzimba bahlanzwe kusukela "mirapex" amaphilisi ngesilinganiso esingaba 500 ml / imiz.

Ukusebenzisa "mirapex" izidakamizwa ngesikhathi sokukhulelwa

Ngingakwazi ukusebenzisa ngesikhathi sokukhulelwa "mirapex" ithebhulethi? Yokusetshenziswa zomuthi likwenza kucace ukuthi umthelela isidakamizwa ukuthuthukiswa umbungu esibelethweni kanye lactation engakaze uphenyo.

Umthelela okungenzeka pramipexole ku izinhlelo kanye igunya leziphathimandla ezibangela inqubo kokukhulelwa abangu wafunda e ukulinga izilwane. Akukona sibonakalise ukwephulwa wokukhula kwengane esiswini ngesikhathi sokukhulelwa onogwaja kanye namagundane.

Excretion of pramipexole ku ubisi lwebele engakaze wafunda. Omunye nje ukuthi nokwami ketshezi singavimbela lactation, kusukela ukukhiqizwa kuvimbela i-hormone luteotrophic. Ngakho-ke, musa ukuthatha "mirapex" iphilisi phakathi ibele.

Phakathi nenkathi yokukhulelwa, le izidakamizwa kufanele kuthathwe kuphela uma inzuzo ezingase zisetshenziselwe ukuba umama bulingana ingozi esizayo ezingenzeka embungwini.

Izimo ukusetshenziswa mirapex amaphilisi ' "

Izidakamizwa "mirapex" ngeke kuthathwe uma hypersensitivity kuya pramipexole, kanye nabantu azifinyelelanga engu-18 ubudala.

Nge ukuqapha okukhethekile Kunconywa ukusebenzisa amaphilisi ngaphansi encishisiwe blood pressure kanye nokwehluleka ukusebenza kwezinso.

Imiphumela emibi "mirapex" izidakamizwa nesimiso sezinzwa

Ukulungiselela "mirapex" - amaphilisi okungabangela isimiso sezinzwa elandelayo ukusabela:

• ukudideka;
• ukunxanela ngokweqile sokulala noma itlhogeko;
• ukusangana;
• ukulahlekelwa amandla okukhumbula;
• asthenia;
• isiyezi;
• syndrome extrapyramidal;
• hypoesthesia;
• eliqhaqhazelayo;
• myoclonus;
• dystonia;
• nokucindezeleka;
• delirium;
• kokuzibulala;
• hypokinesia;
• ataxia;
• ukukhathazeka;
• neuroleptic syndrome ebulalayo.

Ugcine ukubonwa ngesimo komzimba okukhulu, ukuphazamiseka ukwazi futhi ukucabanga, imisipha rigidity, lability autonomic, akathisia.

Imiphumela engemihle amaphilisi "mirapex" ngakolunye izinhlelo zomzimba womuntu

uhlelo zemisipha angaphendula ukusetshenziswa kwemithi "mirapex" ezinjalo:

• imisipha hypertonic, Ukudlikizela zabo, ukudikiza;
• nesenzakalo arthritis, myasthenia gravis noma bursitis;
• ubuhlungu esifubeni, entanyeni noma emgogodleni (ku lumbosacral).

Bangaphinde zenzeka ukuhlukahluka isimiso sokugaya ukudla bungene. Uma lokhu kwenzeka:

• ukungakuthandi ukudla;
• ukuqunjelwa;
• isicanucanu;
• dyspepsia;
• ukubuyisa;
• isifo sohudo,
• ukuhlanza;
• nomlomo owomile;
• ukusika umuzwa esiswini.

Zokuphefumula reception "mirapex" zomuthi kungaholela ukuthuthukiswa sinusitis, pharyngitis, rhinitis, zomkhuhlane syndrome. Libuye nesenzakalo kungenzeka iphika, ukukhwehlela anda futhi ushintsho izwi.

Uyini umphumela senhliziyo uhlelo "mirapex" ithebhulethi? Yokusetshenziswa zomuthi yazisa nge kungenzeka ukuthuthukiswa tachycardia, arrhythmia, angina pectoris, hypotension orthostatic.

Okunye imiphumela emibi

Lapho ethola izidakamizwa "mirapex" yezinkinga ezifana kungenzeka ohlelweni urogenital, njengoba kaningi wamathumbu ukunyakaza, ukutheleleka. Ngakho ngisho engabe ukulahlekelwa libido futhi potency.

Ngaphezu kwalokho, ungase ube nombono double, cataract, conjunctivitis, ukukhubazeka yokuhlala, komzimba, futhi ukungezwa kahle ingcindezi intraocular.

Okunye ukusabela ezingezinhle zomzimba:

• cystic retroperitoneal;
• effusion pleural;
• kokuziphatha yamaphaphu;
• kwesisindo;
• edema neuropathy.

Isikali nokuPhatha "mirapex" Tablets

Ukusebenzisa izidakamizwa udinga ngaphakathi, nsuku zonke izikhathi 3. Kokuqala umthamo "mirapex PD" amaphilisi - 0,375 mg ngosuku. Kancane kancane ukwandisa inani izidakamizwa ezidingekayo (zonke izinsuku ezingu-7) ukuthola oyifunayo nomphumela oqabulayo. Esikhathini Ngesonto ukwelashwa kwesibili nsuku zonke kumele babuswe 0.75 mg ngowesithathu - ukuze 1,5 mg for yesine - by 2.25 mg e isidingo yesihlanu ukuphuza imithi "mirapex" 3 mg nsuku zonke, ku lesithupha - 3,75 mg, lwesikhombisa - 4.5 mg.

Ngo ezingamahlalakhona ukwehluleka kwezinso, umthamo is silungiswe ngokususelwe ezingeni ukusebenza creatinine imvume. Inani esiqondile izidakamizwa kufanele aqokwe udokotela.

Imiphumela yokweqisa iphilisi "mirapex"

Uma usebenzisa lwaphuka "mirapex" Isikali izidakamizwa, lezi zimpawu kungenzeka mhlawumbe ukuhhema, hyperkinesia, isicanucanu, ukuhlanza, kunciphisa umfutho wegazi futhi ukuqhanyelwa.

Ngenxa yalesi simo, alikaziwa ikhambi lobuthi bama ayifakiwe. Amacala izidakamizwa ukweqisa izidakamizwa "mirapex" azifani. Kunconywe yokwelapha lingaze, lavage esiswini nokuqaphelisisa ashukumisayo. Uma kukhona izimpawu ngokweqile of excitation we isimiso sezinzwa esiyinhloko, kubalulekile ukuba sisebenzise amalungiselelo, neuroleptics.

Ukusebenzisana amaphilisi "mirapex" nezinye izidakamizwa

Pramipexole ezihambisana plasma amaprotheni kancane futhi biotransformation. Ngakho-ke, ukuxhumana yayo nezinye izidakamizwa ezithinta la izinqubo cishe.

Izidakamizwa okuyinto zivimbela noma ukucindezela ukukhiqizwa izinto ezisebenzayo noma samovyvodyaschiesya cationic ngokusebenzisa tubules kwezinso, kungaba asabela nge amaphilisi "mirapex". Yokusetshenziswa uchaza ukuthi kuleli cala nokwehla isivinini manifest ukuhlanzwa kwezicubu nasoketshezini yemvelo noma kokubili imithi noma omunye wabo.

Uma kanyekanye ne mirapex amaphilisi ' "wasebenzisa lezi izidakamizwa, kufanele sinake ukusangana kungenzeka, dyskinesia, ukuyaluza. Uma lezi zimpawu zenzeka, umthamo we izidakamizwa kumele kungancipha.

amaphilisi Oluvumelana "mirapex" nezidakamizwa "Amantadine" futhi "L-dopa"

Kwenzekani lapho kuhlanganiswe reception "Levodopa" izidakamizwa "selegiline" amaphilisi "mirapex PD"? Ukufundiswa uthi pharmacokinetics ye-ejenti asebenzayo akuphazamisi futhi yokuqala noma yesibili. Ngesikhathi esifanayo kwi nokwenziwa okugcwele excretion zomuthi ngendlela yemvelo "Levodopa" ithebhulethi "mirapex" ababhekwa.

Pramipexole awuzange watadisha nokuxhumana zomuthi "Amantadine". Kodwa kwedivayisi kungenzeka therapy, ngoba izindlela ezifanayo excretion.

Lapho umthamo "mirapex" ukulungiselela yanda, lemali isicelo "Levodopa" Kunconywa ukuze wehlise. Isibalo nezinye izidakamizwa antiparkinsonian kufanele kugcinwe njalo ezingeni elifanayo.

Izici Oluvumelana ukulungiselela "mirapex" nezinye izidakamizwa

Ngenxa kungenzeka yokwanda okuqhubekayo ngokucophelela okukhulu Kunconywa ukuba asebenzise amaphilisi "mirapex" lihambisana sedatives, utshwala, nezidakamizwa ezisiza ukwandisa pramipexole lokuhlushwa igazi (isib umuthi "Cimetidine").

isiqondiso Ahlala Kuyo ukusetshenziswa "mirapex" amaphilisi

Thina echaza izidakamizwa is hhayi Kunconywa ukuthatha ngokuhlanganyela antipsychotics.

Ekwelapheni Dopamine agonist eyaziwa side effects kukhona ukudideka futhi babone izinto ezingekho. Ezimweni "mirapex" amaphilisi lihambisana izidakamizwa "Levodopa" kwezinso abanjalo babehamba njalo emabangeni kamuva lesi sifo edlula monotherapy ekuseni.

Udokotela kufanele azise ngesineke okuvela okungenzeka ukusangana ezibukwayo. Lokhu side effect kuthinta ikhono ukushayela izimoto futhi ukwenza izinqumo ezivuthiwe.

Ngo ukuqedwa abukhali amaphilisi esimweni Parkinson zitholiwe ukubonakala izimpawu ukuthi sifana neuroleptic syndrome ebulalayo.

ukuziphatha ezingasadingeki e ukusetshenziswa "mirapex" izidakamizwa

Iziguli nalabo ukubanakekela, kubalulekile ukwazi ukuthi yokwamukela dopaminergic kwezidakamizwa, kuhlanganise "mirapex" amaphilisi (izibuyekezo uqinisekise lesi), ngokuvamile kubangela ukuziphatha okungafanele isiguli. Ungezwa hyperphagia (ukuluthwa ukudla), ukuyothenga sokugembula (yisifiso esilawulayo ukwenza okuningi ukuthenga), ukugembula kuphoqeleke, futhi hypersexuality. Ezimweni ezinjalo kubalulekile ukunciphisa umthamo zomuthi noma kancane kancane ayeke balithathe.

Isexwayiso e ukusetshenziswa "mirapex" amaphilisi

Medicine "mirapex" ziphele ngokuqapha iziguli khona izifo okunzima yisimiso senhliziyo nemithambo yegazi. Ekuqhubeni yokwelapha nge dopaminergic izidakamizwa kukhona ingozi hypotension orthostatic. Ngakho-ke, ukulawula umfutho wegazi, ikakhulukazi esigabeni sokuqala ukwelashwa.

Lapho ongaboni kuyadingeka ukuthi ihlole ngokushesha emva aphoyintimenti amaphilisi "mirapex" futhi ngezikhawu okwengeziwe echaziwe.

Iziguli kufanele inikwe iqiniso lokuthi izidakamizwa kungaba nomphumela okulalisayo. Sekube amacala ubuthongo kungazelelwe futhi ukozela ngokweqile emini ukuze imisebenzi suku. Kubandakanya lokhu kungenzeka nganoma isiphi isikhathi ekuphathweni owamukela noma izimoto ukushayela.

Kungenzeka ube ne-melanoma ekuthuthukiseni

Ngenxa yalokho izifundo epidemiological luye lwabonisa ukuthi iziguli ene-Parkinson basengozini melanoma. Ingabe imbangela yalesi sifo, noma ezinye izici, ezifana nokusetshenziswa "mirapex" isidakamizwa engakaze isungulwe.

Ukuqinisa yalesi sifo of "imilenze ukubuyisa"

kanjani lesi sifo of "imilenze ukubuyisa" isidakamizwa "mirapex"? Nobufakazi abonisa ukuthi dopaminergic izidakamizwa ingase ithuthukise ke. Lokhu kubonakala ngendlela ukuqala ekuqaleni izimpawu kule syndrome kusihlwa futhi ngezinye izikhathi ntambama. Kulokhu, izimpawu basakazekela kwezinye izitho zomzimba. I labetibambile amasonto 26 isifundo emitholampilo elawulwa futhi esasiklanyelwe ukufunda lo mphumela, umehluko okukhulu phakathi pramipexole kanye nomkhiqizo ongenamuthi kufana amaqembu ekusimamiseni izici yalesi sifo aye atholakala.

izimo Isitoreji eshalofini yokuphila

"Mirapex" ithebhulethi libhekisela wokulungiselela ohlwini B. Isitolo kufanele endaweni emnyama. Kulokhu lokushisa ekamelweni kumele singeqi 30 ° C.

Shelf-ukuphila izidakamizwa - izinyanga 36 (iminyaka engu-3) kusukela ngosuku ukukhiqizwa.

Ukusetshenziswa "mirapex" amaphilisi ebuntwaneni nemibandela zokuthenga

Umuthi is contraindicated ukusetshenziswa ezinganeni. Livu pha abantu abathola amaphilisi, okuyinto Usufike engu-18 ubudala. Medicine "mirapex" eyakhishwa ngo Pharmacy ekwetfuleni kadokotela.

Izidakamizwa analogue "mirapex"

Awukwazi, nganoma isiphi isizathu, ukuze bathole thebhulethi "mirapex"? Yini esikhundleni izidakamizwa, kufanele batshele usokhemisi noma udokotela. Futhi sinikeza analogue elandelayo.

1. "Motopram" amaphilisi-mbumbulu. Izinkomba ukusetshenziswa: Parkinson. Kungaba kwenziwe wedwa noma kuhlangene 'levodopa' imithi imithi. Iphinde isetshenziselwe yefomu ezinzima noma okusesilinganisweni idiopathic yalesi sifo of "imilenze ukubuyisa".
2. "Oprimeya" amaphilisi-mbumbulu. Injongo: antiparkinsonian ikhambi ivuselela dopaminergic yokudlulisela in isimiso sezinzwa esiyinhloko.
3. "Pramipexole" amaphilisi-mbumbulu. I-ejenti zokwelapha elisetshenziswa Parkinson. Kukholakala ukuthi lo mshini wezenzo is ngqo exhumene ikhono a pramipexole izidakamizwa zishukumisa Dopamine zemizwa striatum.

Tablets "mirapex" - analogue noma loqobo? Ayikho self!

Ngo le mikhiqizo engenhla, okuyizinto analogue of 'mirapex "amaphilisi. Sinenkosi esiyingqayizivele, international igama elifanayo non-nokuphathelene (noma ATC-ikhodi), okuyinto Kunconywa-WHO (World Health Organization).

Uma udinga ukwelashwa besebenzisa amaphilisi "mirapex" analogs nakho kungaba okunye okukhulu. Kodwa ngaphambi kokuba esikhundleni izindlela ezimisiwe yokwelapha, qiniseka ubonane onguchwepheshe. Ngisho ngaphansi kwaziphi izimo ukwenza akazibekanga! Lokhu kungadala nemiphumela awushintsheki omubi empilweni yakho.

Isexwayiso! Lesi sihloko incazelo "mirapex" ukulungiselela kulekelelwa futhi lula version of imiyalelo olusemthethweni ukuze zisetshenziswe. Imininingwane Izidakamizwa uvezwa ngenhloso isibuyekezo. Akunakusetshenziswa ungayisebenzisi njengesiqondiso zokuzelapha.