ImpiloAmalungiselelo

"Kardosal": imfundo manual, ukubuyekezwa, izincazelo, analogs

"Kardosal" (igama international - "olmesartan medoxomil") kuyinto omelene ka angiotensin II yokwamukela (uhlobo AT1) - eyinhloko vasoactive-hormone okuthiwa i-RAAS eziphathelene nentuthuko nomfutho wegazi ophezulu ebalulekile.

Yakha ukukhulula izidakamizwa, izingxenye zalo

Umuthi itholakala izibhebhe imbozwe emgodleni. izidakamizwa Basic, okwenza nomuthi we olmesartan medoxomil elisetshenziswa izibhebhe zihlanganisa kusuka 10 kuya 40 mg ( "Kardosal 10", "20 Kardosal", "Kardosal 40").

Ngaphezu kwalokho, izidakamizwa ingezwe magnesium stearate, microcrystalline cellulose, monohydrate-lactose. Futhi, ongumsizi koponentov esetshenziswa giproloza futhi ongaphakeme giproloza ukufaka endaweni. Igobolondo kudalwa kusukela titanium dioxide ne talc kungezwa hypromellose.

imiphumela kwemithi

Kusolwa ukuthi lesi sidakamizwa "Kardosal" kusho lowo oyibamba ku umzimba, kunomthelela ekuvimbeni imithelela angiotensin II, AT1 yokwamukela umlamuleli. Ngo nomfutho wegazi ophezulu nomuthi kwehlisa lwemithambo ingcindezi, lo mphumela ihlala isikhathi eside. Azikho idatha eqinisekisa okuvela hypotension emva kokusetshenziswa kokuqala kwe-umthamo kokuqala umuthi futhi tachycardia ngenxa yokwelapha eside ( "Kardosal 20", "Kardosal 40"), ukubukeka ukuhoxiswa ephelezelwa waba ukwanda okukhulu kwezincwadi blood pressure.

Ukusetshenziswa kwezidakamizwa kanye Imiphumela usuku ukwehla omnene wegazi izinkomba. Umthelela oyifunayo eba phezu amahora 24. Ngokuvamile, umphumela hypotensive kufinyelelwa ngosuku lweshumi nane ukwelashwa, imiphumela emihle kakhulu waphawula ngemva ekwelapheni cishe izinyanga ezimbili.

Pharmacokinetics

Ukunciphisa zomuthi, ukusatshalaliswa yayo

ithebhulethi Drunk kuthatha ngokushesha ngendlela metabolite pharmacologically asebenzayo emathunjini (ngenxa isenzo ezilethwa enzyme) negazi portal (ngesikhathi ukumuncwa kusukela ipheshana emathunjini).

Phakathi zokwelapha yokwakheka oketshezini olungenambala lwegazi is ayitholiwe izidakamizwa esebenzayo zinjalo. bioavailability Isilinganiso imayelana 26%. Izinga esiphezulu zomuthi ezitholakala isilinganiso samahora amabili ngemuva kokuthatha ke, nge umthamo okwandisa (umthamo owodwa - 80 mg) ka ukhula.

"Kardosal 40", kanye imikhiqizo Isikali ezahlukene isithako esebenzayo, ingase ikhishwe ngaphandle ukugxila ukusetshenziswa ukudla. Ukudla cishe akunamthelela bioavailability.

Uxhumano amaprotheni oketshezi olungenambala olusegazini ucishe uphelele, futhi uhambelana 99,7%. Nokho, ukusetshenziswa ngesikhathi esisodwa "Kardosala" vysokosvyazyvayuschimisya nezinye izidakamizwa it is kakhulu ziyancipha.

Izidakamizwa umzimba futhi kukhuthaza yayo kusukela umzimba

isibindi Ngokuyinhloko izidakamizwa etholakala (60%), okunye (40%) - nezinso. ukuzungeza Intrahepatic we ketshezi esebenzayo kubantu aphila nabo. Njengoba excretion ikhiqizwa ngokuyinhloko kwesibindi, ukwelashwa nge-ejenti "Kardosal plus" ke akuvunyelwe uma isiguli biliary ipheshana isimiso. ukusetshenziswa Ngemva okuphindiwe imithi kancane ukuboniswa isilinganiso amahora 12. umphumela Okuhle is baphawula lapho ethola Isikali zomuthi, okuhambelana ngemithamo eziningana "Kardosala". A nomphumela enkulu ukhona futhi emva kwezinsuku eziyishumi nane ukwelashwa, ngemuva kwalokhu ekuqongeleleni ingekho. Kulesi sibalo, njengoba imvume kwezinso ayitsintseki Isikali izidakamizwa ezahlukene, kuba uhla kusuka 0.5 kuya 0.7 L / h (cishe).

amacala zokwelapha Special

Labo iziguli ababetholakala ukwephulwa umsebenzi so-renal (imnene, ngokulinganisela, ezinzima), AUC kukhuphuke ngo-62, 82 no 179%, uma isimo sizinzile.

Lapho izinkinga isibindi, kancane futhi ngokulinganisela uzwakalise, olulodwa umthamo AUC okwandisa izindlela kuyasiza 6 futhi 65%.

ubufakazi

Ukuqokwa kusho "Kardosal" imfundo on isicelo usenza ukuthola umfutho ophakeme wegazi kubalulekile.

Waphatha "Kardosalom" ngesikhathi sokukhulelwa akwamukeleki. Uma ekhulelwe enqubeni ukwelashwa, kubalulekile ukwenza ukuqedwa zomuthi.

Ngenxa yokushoda idatha ukusekela ukuphepha ekwelapheni ibele ngesikhathi sokwelashwa yekani ibele.

Ukuze ukwazi ukuthenga "Kardosal 'futhi baqale baphathwe ke, udokotela kufanele ubhale kadokotela.

Izimo

Izimo zihlanganisa hypersensitivity kulabo izinto okuyinto afakiwe ekwakhiweni, ingane (eneminyaka engaphansi kwengu-18), ukukhulelwa, ibele. Ngaphezu kwalokho, iphilisi akukashicilelwa kulezi zimo ezilandelayo:

  • isimiso ipheshana biliary;
  • khona malabsorption syndrome, galactosemia;
  • yokuntuleka lactase;
  • isikhathi emva ukufakelwa izinso;
  • ukwehluleka kwezinso ngesikhathi QC ongaphakeme (ngaphansi kuka-20 ml / iminithi).

"Kardosal" - umuthi iqondiswa ngokucophelela okukhulu iziguli izimo:

  • yenhliziyo isifo Umthambo;
  • hyperaldosteronism (primary);
  • iziyaluyalu kwesibindi;
  • ukwehluleka kwezinso, lapho KK mkhulu kuka-20 ml / iminithi;
  • stenosis, lesion ephelezelwa mitral noma valve yomthambo i-aorta;
  • ezingamahlalakhona senhliziyo ukugeleza;
  • isifo cerebrovascular;
  • Ukudla ephelezelwa elinganiselwe sodium eyanele;
  • hyponatremia, hyperkalemia (kukhona ingozi esingamahlalakhona kwezinso, hypotension noma ukuphelelwa amanzi emzimbeni);
  • isimo lapho bcc incipha avele ukuhlanza, ukukhishwa isisu;
  • stenosis, ukushaya i Umthambo kuphela izinso, stenosis zamazwe amabili, lapho abathintekayo Umthambo kwezinso;
  • hypertrophic zenhliziyo obstructive;
  • yobudala engaphezu kwengu-65;
  • isidingo isisu.

Ukusebenzisa "Kardosala"

"Kardosal" imfundo manual uncoma ukusebenzisa 10 mg, okuhambelana umthamo kokuqala. Lapho ukuzinza enganele wegazi ziphele ngosuku mg izidakamizwa 20. umthamo ngokweqile 40 mg izidakamizwa ngelanga akwamukeleki. imithi Daily kufanele baphuze esisodwa, ngesinye futhi ngesikhathi esifanayo. Ukuze iziguli ezinezinkinga zezinso wembula okuncane kanzima lapho imvume ku ezahlukene kusukela 20 kuya ku-60 ml / imiz, umthamo esiphezulu "Kardosala" ayikwazi ukuba abangaphezu kuka-20 mg. Ezimweni lapho kukhona isidingo sokuqinisa umphumela okuholela ikhiqizwa ukwelashwa eziyinkimbinkimbi (ngaphandle "Kardosala" isicelo "Hydrochlorothiazide").

side effects

Ekwelapheni izidakamizwa "Kardosal" imfundo manual sikuvumela side effects:

  • ukusabela okungekuhle ezimisweni zokuphefumula futhi wokugaya ukudla, ukubukeka yokuphazamiseka uhlelo zemisipha, ngomgudu womchamo abese izinso, ishintsha ezinye nemingcele laboratory, ukuthuthukiswa kohlelo iziyaluyalu uhlamvu ejwayelekile (efana side effects zenzeka kaningi);
  • ukuthuthukiswa angina, ukubukeka iziyaluyalu ezithinta isimiso sezinzwa (ngezinye izikhathi avele);
  • izinguquko esimiso senhliziyo nemithambo yegazi, ukuthuthukiswa hyperkalemia (asivamile ukubonwa).

Imiphumela engemihle ezingavela kakhulu kuyaqabukela ngemuva kokuthola nomuthi "Kardosal" yokusetshenziswa zihlanganisa:

  • yokuphazamiseka uhlelo hematopoietic;
  • ukukhwehlela;
  • ifomu okukhulu ukwehluleka kwezinso;
  • izinkinga zesikhumba;
  • syndrome asthenic;
  • ikhanda, ukubukeka isiyezi;
  • myalgia;
  • isimo convulsive;
  • isicanucanu ephelezelwa ukuhlanza, ubuhlungu besisu,
  • ukwanda urea, creatinine egazini;
  • izinguquko isibindi - ukwanda umsebenzi enzyme yayo.

ukweqisa izidakamizwa

Overdose kungenzeka, sinezimfanelo ukuncipha wawubona wegazi izinkomba. Endabeni yalokho ezifana ukwelashwa kudinga ukuqapha njalo iziguli. Ukuqeda izimpawu ezihambisana ukweqisa izidakamizwa kusho "Kardosal", odokotela batusa ukuthi enze Izibuyekezo ukwelashwa lingaze futhi ukwelashwa bangisekela kulesetayelekile blood pressure. Endabeni ka ukweqisa izidakamizwa isiguli walala emhlane wakhe futhi uphakamise imilenze yakhe. Ngaphezu kwalokho, uma usebenzisa umthamo enkulu izidakamizwa Kunconywa ukwenza lavage esiswini, ngimuphe carbon isebenze. Kukhona isidingo ivolumu esikhundleni, ukuqedwa amanzi emzimbeni kanye nokubuyiselwa amanzi-usawoti ibhalansi. Ulwazi mayelana nokwenzeka excretion izidakamizwa olmesartan medoxomil ngu zelashwe khona.

Izixwayiso

Ezigulini phambi yokwelapha uye wakwenza ziphathwe isisu futhi banamathela ukudla akufaki ukusetshenziswa kasawoti, kungadala hypotension ngenxa umthamo ukusetshenziswa lokuqala izidakamizwa. Umphumela efanayo kungabonakala nasemkhakheni ezigulini eziye zenzeka ukuhlanza noma isifo sohudo. Isizathu salokhu ukusabela komzimba - Ukwehliswa BCC. umcimbi Esibi leminyenti yaloluhlobo kufanele kungavinjelwa. Ingozi ivela khona kufanele kubhekwe ngaphambi kokuqala ukwelashwa.

Uma umuntu ongene ngobugebengu izinso, kubalulekile ukuba ngezinye izikhathi hlola lezi zibalo serum njengoba creatinine, i-potassium. Ukusetshenziswa ACE inhibitor iziguli ziye kwatholakala hyperaldosteronism (primary), akusho lutho, ngakho musa linqume izindlela "Kardosal" (izilinganiso khombisa ukungaqapheli ephendula ACE inhibitor).

Khumbula ukuthi ukwehla eqinile wegazi in iziguli isifo sokuqina kwemithambo yegazi, esithinta imithambo ubuchopho, noma nge yenhliziyo Umthambo isifo kungabangela ukuthuthukiswa izimo eziyingozi ezifana unhlangothi ischemic futhi isilethikusebenza.

Uma umuntu enze nokugcinwa kwemishini uyinkimbinkimbi noma ukushayela imoto, kubalulekile ukwazi ukuthi ukuthatha "Kardosala" kungabangela Ukuwohloka impilo (ukukhathala, ubuthakathaka, isiyezi), nakuba lokhu kuyaqabukela kwenzeka.

Ngenxa okuqukethwe lactose izidakamizwa ukuthatha Kwenqatshelwe iziguli lezinceku galactose ukungabekezelelani uhlamvu. Kuyefana nasendleleni iziguli malabsorption syndrome galactose kanye glucose, lactase ukuntula emzimbeni.

Ukuxhumana nezinye izidakamizwa

Udokotela kumele abhale kadokotela futhi uthole ukuthi uma isiguli iphathwa ngezinye izindlela ukuvimbela ukusabela engadingeki. It is hhayi Kunconywa ukusebenzisa kokubili "Kardosalom" futhi lezi zinhlobo ezilandelayo izidakamizwa:

  • kusho equkethe potassium;
  • usawoti esikhundleni, okuhlanganisa labo potassium likhona;
  • Potassium-engashiyi isisu;
  • imithi yokwelapha engiyisebenzisayo ethonya amazinga potassium serum igazi (okwandisa lesi sibalo).

Isibonelo zindlela iyona "Heparin". It uyakwazi ukuthonya okuqukethwe potassium igazi. Ngezinye nakwenzeka ukwelashwa "Kardosal" analogue ukunikeza ithuba lokwenza esikhundleni salo.

Ukuqiniswa inciphise umfutho wegazi ophakeme siyenzeka lapho ukwelashwa weminye imilaliso antihypertensive futhi ama-NSAID, ie ukuqaliswa ukwelashwa olunzulu. Ukwelashwa nge indlela eqotho kuhilela ukusetshenziswa Cox-2 inhibitor, acetylsalicylic acid (umthamo wansuku - ezingaphezu kuka-3 g). Isenzo angiotensin II yokwamukela abantu abamelene nani kungaba synergistically ezinomthelela filtration glomerular by ukunciphisa yayo.

Ngekusetjentiswa ngesikhathi esisodwa ukuthaka imithi efana angiotensin II yokwamukela abantu abamelene nani, futhi ama-NSAID, kukhona amathuba acute kwezinso ukwehluleka ukuma lesiguli. Ngenxa yalesi sizathu, ukuqapha isimo kwezinso lapho besanda kuqala ukwelashwa kufanele kwenziwe njalo. Impatho enjalo kufanele nakanjani baphuze uketshezi ngokwanele. Nokho, ukunciphisa kungenzeka e kobukhulu isinyathelo antihypertensive, lapho ukuwohloka siyenzeka njalo ukusebenza yokwelapha.

Uma "Kardosal" lisetshenziswa esikhathini ukwelashwa antacids, okungukuthi aluminium hydroxide kanye magnesium, kukhona ukwehliswa engozini bioavailability we ketshezi esebenzayo (esiphakathi nendawo).

Kuthiwa esethola inyuka lithium amazinga serum igazi ukubonisa izakhiwo anobuthi okubangelwa ukwabelana ACE inhibitor, angiotensin II yokwamukela abamelene nezidakamizwa equkethe lithium. Mayelana inhlanganisela enjalo yokwelapha imiyalezo "Kardosalom" nezidakamizwa, omunye lapho izingxenye - Lithium, hhayi Kunconywa. Nokho, uma kunesidingo enjalo, ukulawula igazi kufanele kube njalo.

Izindleko izidakamizwa, analogs, ukubuyekezwa

Lapho ukwabela "Kardosal" amaphilisi afana intengo akuyona zonke iziguli, ngakho banesithakazelo kungenzeka ukwelashwa nokusetshenziswa kwezinye, izindlela eziphumelelayo kakhudlwana. "Kardosal" ngokuqukethwe 10 mg isithako esebenzayo angathengwa RUB 610, umuthi lapho Ukwakheka has mg isithako esisebenzayo 20 -. Kuka 756 deda. "Kardosal", ogama intengo ruble mayelana 860., Iqukethe 40 mg ingxenye eyinhloko.

Njengoba isifaniso, lapho kufanele ukhethe enye indlela yekusetjentiswa yokwelapha, esikhundleni "Kardosala" ungakwazi ukusebenzisa imithi "Olimestra" noma ukukhiqiza ukwelashwa okusekelwe ukusetshenziswa "hydrochlorothiazide", "olmesartan medoxomil". Ungakwazi ukusizakala ontanga ezifana "Lozarel 'noma' Cozaar '. Ngaphezu kwalokho, i-esikhundleni izidakamizwa ofanele "Nortivan" "Valsartan Zentiva".

Ekuqaphela ukwakhiwa ezifana "Olmesar", "Plaunak". Ngokuvamile esikhundleni zehluke izimali zokuqala, omunye umehluko kuyinto ngemali ephansi futhi yehlise bioavailability imingcele, ngakho mancane ngempumelelo, nakuba kungaba lapho zibhekene nomsebenzi.

Analogs njalo wasebenzisa ngaphansi ebhekiwe of onguchwepheshe, kubalulekile ukuthi ihlole blood pressure. Uma udinga eyolanda Analogue kuya luhlobo "Kardosal" kuka esikhundleni lokhu izidakamizwa, udokotela enquma, ecabangela izikhathi ezahlukene. Phezu ukuthola izigigaba ezingezinhle ngesikhathi impatho Analogue kufanele kube ukwenza izenzo ezidingekayo ngendlela esifike ngesikhathi okuhloswe ngaso ukuqedwa kwabo. Phakathi ukwelashwa kubalulekile ukuhlola umphumela emzimbeni.

Lapho yokuqala ngaphandle amathuluzi ekushintsheni Awukwazi ukwenza, kufanele makudle izidakamizwa oluqanjwe izinkampani European ihlolwe. Lapho uhlela esikhundleni "Kardosal" amaphilisi analogue wena nje kufanele akhethe eliphezulu kakhulu.

Amazwana kwesokunxele phezu izinkundla kukadokotela nesiguli, abonisa ukuthi lesi sidakamizwa "Kardosal" ngesikhatsi ukwelashwa ngokuvamile kubangela ukusabela ezingezinhle, ezivame kakhulu zazo - ubuhlungu esifubeni ukutubeka. Kodwa naphezu kwalezi zikhathi ezingemnandi, umphumela hypotensive uhlale kakhulu. Ukubukeka nemiphumela engemihle kudinga yokudluliselwa kuchwepheshe ukuze iseluleko, futhi ingase ishintshe eziyalezweni ukwelashwa.

Esikhathini nokwelashwa kweziguli umfutho wegazi ophakeme emithanjeni eziye zembulwa, kubalulekile ukuthi ukulawula lesiguli unomphela. Ukuqala kokusetshenziswa kokwelashwa, ngaleyo ndlela ngeke ukunikeza umphumela oyifunayo, bese ulandela isimo umzimba, futhi uma kwenzeka ukwephulwa - ukuze uziqede ngesikhathi. Okubalulekile indlela ihlanganiswe, kodwa imithi akwanele, kumelwe futhi ukhethe isidlo esikhethekile. Phakathi kwezimfuneko ukwelashwa okudingekayo - ukuhambisana imodi mnene yomsebenzi, ukususa imikhuba emibi, nomkhawulo imisebenzi ngokomzimba nokulandela abanye Imikhandlu okuphakanyiswe udokotela okungcono ekwelashweni imiphumela.

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