Umuthi 'Lamikon ": imfundo, ukubuyekezwa kwesicelo, analogue, Ukwakheka

Ingakanani le izidakamizwa ngokuthi "Lamikon"? Intengo yaleli izidakamizwa izokwethulwa kulesi sihloko. Futhi lapho uzothola iziyalezo eziningiliziwe ukusetshenziswa kwezidakamizwa, Izimo yayo, analogs, izinkomba, ukusabela ezingezinhle, ifomu ukukhululwa, isakhiwo nokunye.

Ukwakheka, ukuma isembozo imithi

Zuza kubhekwe isidakamizwa kungaba amafomu alandelayo:

• "Lamikon" aerosol. Ikani iqukethe ketshezi asebenzayo ezifana terbinafine. Njengoba izingxenye ezengeziwe yefomu kukhona propylene glycol, macrogol cetostearyl ether 20, benzoic acid, disodium edetate, namanzi umjovo Poloxamer 407. izidakamizwa epicutaneous ikhishwe egabheni nge futha metering at 25 g.
• Cream "Lamikon" (wamafutha). Umhlahlandlela ibika ukuthi element asebenzayo yaleli fomu ikhonza terbinafine. izithako ephakeme zaleli fomu yilezi: uwoyela amaminerali, sodium hydroxide, emhlophe upharafini elithambile, cetostearyl utshwala phenylethyl, macrogol cetostearyl ether 20, propylene glycol, poloxamer 407 namanzi ahlanzekile. Ngo ukudayiswa lamafutha iza amashubhu 15 g
• "Lamikon" ukulungiselela ngomlomo. Tablets, ukulaya okuyinto ebiyelwe ebhokisini elenziwe amakhadibhodi, futhi aqukethe into enjalo esebenzayo kuyinto terbinafine. Ngokuphathelene izingxenye ezengeziwe, zihlanganisa: corn isitashi, sodium isitashi glycolate, microcrystalline cellulose, colloidal Silica anhydrous, hydroxypropylmethylcellulose kanye magnesium stearate. Izibhebhe eziqukethwe emangqamuzaneni nentaba 7 izingcezu.

pharmacodynamics

iqembu kwemithi kubhekwe izidakamizwa - antifungal. Ngokusho imiyalelo, isakhi esiyinhloko sale ejenti kuyinto alilamin okuyinto ubukisa umphumela asebenzayo zokwelapha ku inqwaba ezahlukene isikhunta amagciwane.

I izakhiwo fungicidal ka terbinafine (okuhlushwa evamile) futhi basakaza dermatophyte isikhunta, kanye ezinye izinhlobo isikhunta dimorphic.

Kuye ngohlobo, ngokumelene nembiliso lo muthi ungase abonise kokubili umsebenzi fungicidal futhi fungistatic.

Umgomo we operation

Kanjani lesi sidakamizwa "Lamikon"? Umhlahlandlela ibika ukuthi lokhu ejenti kuvimbela ngokuqondile zisandakuqala sterol biosynthesis e fungal cell ulwelwesi. Umphumela kuzichaya esivuna ekuqongeleleni intracellular ka squalene, nokuntuleka ergosterol. Lokhu kuholela ekubhujisweni lamaseli fungal.

Lo mshini wezenzo izimali ihlobene ngokuqondile inqubo okusithiyayo we epoxidase enzyme squalene efana, lapho sibhekisela cytochrome P-450.

Ochwepheshe bezifo, izidakamizwa "Lamikon" ayinalo ithonya endleleni imiphumela kwezinye izidakamizwa, futhi umzimba hormone.

Pharmacokinetics

Njengoba izidakamizwa amuncwa umzimba, "Lamikon"? Umhlahlandlela lithi uma isicelo sendawo noma baqonde izinto ezenzekayo ukumuncwa ketshezi esebenzayo ngaphansi kwama-5% umthamo esetshenziswa. Ngakho-ke, ukuchayeka yayo letindzala uphansi.

Lapho iqondiswa ihlelwe ngokulandelana kwezihloko zomuthi ngokushesha uqala ukusebenza futhi zisebenze kahle kakhulu isikhathi esifushane (cishe 8-13 izinsuku).

Ngokugcina emakamu oyifunayo zomuthi ku corneum stratum we epidermis, okuyinto etholwe ngesikhathi yokwelapha, isenzo fungicidal we nomuthi iyaqhubeka iviki elilodwa ngemuva yokukhansela yayo.

Lapho ezithathwe ngomlomo, "Lamikona 'wesimo asebenzayo aqoqana isikhumba, izinzipho kanye izinwele. I lokuhlushwa izidakamizwa e nezicubu inikeza ngokuphelele ngezici zawo fungicidal.

Absorption amaphilisi kuyinto 70%, kanye bioavailability zabo ngokuphelele - 50%.

Le mfundiso eyasungulwa ethi etholwe isamba 250 mg iyona okuhlushwa eliphakeme egazini ngemva ingxenye yehora. Indlela ephumelela isikhathi isigamu-ukuphila amahora angaba ngu-30.

I ukudla kancane kuphela kuthinte bioavailability zomuthi. Nge amaprotheni oketshezi olungenambala olusegazini sibopha ukuthi ketshezi asebenzayo of 99,5%. Imithi kunalokho ngokushesha lingena dermis kanye aqoqana corneum stratum.

Ukuba kude kwendawo "Lamikona" eyenziwa nezindlala sebaceous. Futhi, butholakala izinwele, isikhumba nezinwele follicle. Emavikini ekucala yokwelapha, umuthi lingena ipuleti nail.

Terbinafine is akheka ngokushesha cytochrome P 450. Ngemva biotransformation umkhiqizo etholakala metabolites ngasebenzi ngu nezinso.

Lapho okuthile okungavamile esibindini nezinso imvume isivinini terbinafine siyehla kakhulu, okwenza kube lokuhlushwa ephakeme e-plasma.

izinkomba

Kusukela ngaleso sikhathi ukhethe amafomu Isikali wendawo "Lamikon" izidakamizwa? Wamafutha, yokusetshenziswa elichazwa ngezansi, kanye spray ine izinkomba ezilandelayo:

• Izilonda fungal, okuyinto zazibangelwa isikhunta bohlobo lwe-Trichophyton, Microsporum futhi Epidermophyton (dermotofitiya izinyawo, imbilapho, esifubeni, njll);
• multicolor (noma pityriasis) versicolor, nesuka umthelela Malassezia isikhunta;
• candidiasis kwesikhumba, okuyinto kwaba senziwa isikhunta bohlobo lwe-Candida.

Lokhu kwakwenziwa ngayiphi injongo wasebenzisa izinhlobo ngomlomo "Lamikon" (amaphilisi) zomuthi? Umhlahlandlela ibika izimpawu ezilandelayo:

• izifo fungal kwesikhumba, lapho amazinga okutheleleka zabo, emakamu noma inkulumo enjengokuthi ukuthi kufanele baphathwe kahle umzila setemlomo (inquma udokotela kuphela);
• mycosis ikhanda futhi onychomycosis (nail izifo amapuleti).

Kumele kuqashelwe ukuthi "Lamikon" amaphilisi engasetshenziselwa ukwelapha ezinemibala (noma zibe maholoholo) zoster.

Izimo

Hlobo luni Izimo kufanele bazazi eminingi ngaphambi kokuba usebenzise izidakamizwa "Lamikon"? Umhlahlandlela wathi ukuthi ukwenqatshelwa kuphela ngokuphelele kuwo wonke amafomu imithi ibhekwa hypersensitivity ekusebenziseni yayo.

Ngokuqondene inkathi yokukhulelwa, ebuntwaneni kanye nokuncelisa ibele, zingabantu Izimo isihlobo.

Wamafutha "Lamikon": yokusetshenziswa

amafomu Lezo izidakamizwa eziyingozi, njengezinto isifutho, futhi amafutha, ukuphakamisa isicelo sabo zangaphandle. Ngaphambi kokusebenzisa kubo for ekwelapheni izifo fungal, kumele kuqala ehlanzekile ome ezindaweni ezithintekile zesikhumba.

Kuye kobukhulu isifo futhi uhlobo lwegciwane izidakamizwa "Lamikon" (wamafutha) kusetshenzisiwe kabili ngosuku. Aerosol isetshenziswa nge imvamisa efanayo.

Ukhilimu okumele asetshenziswe hhayi kuphela abathintekayo isikhumba ukhunta, kodwa futhi ezindaweni angomakhelwane. Ukuze afeze le nqubo kuyinto efiselekayo ungqimba elincanyana kancane kancane bezihlikihla nesembozo wamafutha.

Uma isifo esithathelwanayo kuhambisana inabukeni amawala (isib ngaphansi amabele, imbilapho, izibunu noma phakathi iminwe), ezindaweni iphathwa kufanele amboze gauze (ubusuku).

Ukusetshenziswa aerosol

kufanele ngisebenzisa kanjani fafaza "Lamikon"? Izibuyekezo ochwepheshe ukubika ukuthi isetshenziswa eliningi eyanele imanzise by sishaye ezindaweni ukuba ngimangaliswe nge isikhunta, kanye isikhumba enempilo eseduze nale ndlela.

Isikhathi yokwelapha kuncike yabezindaba isifo kobukhulu (amasonto amabili).

Relief isiguli waphawula kwezinsuku ezimbalwa. Ukuze ukwelashwa ngendlela ephumelela kakhudlwana liyadingeka abanamathela imiyalelo esiqinile ungalahlekelwa kolunye uhlelo lokusebenza hhayi umutsi kwesikhathi. Kungenjalo kunobungozi eliphezulu kokushelela.

Indlela ukuthatha amaphilisi?

iqembu kwemithi ukuthi ungumnikazi imithi phambi kwethu, kukhonjisiwe imiyalelo. Uxoxa indlela yokwenza ukuthi ithuluzi.

Njengomthetho, "Lamikon" namaphilisi izingane ezineminyaka engu-6 ubudala, kanye neziguli omdala. Ukuthola ukulungiselela temlomo iyaqhubeka kuze ukunyamalala oluphelele lwazo zonke izimpawu yesifo fungal (kuye ngokuthi isimo nobukhali).

Imfucuza umthamo nomuthi abadala kuyinto 250 mg, futhi izingane enesisindo 20-40 kg - 125 mg. Nge isisindo enkulu ingane njengoba kushiwo 250 mg zomuthi.

Isikhathi yokwelapha nge trichophytosis futhi isikhumba candidosis singemaviki lange 2-4, futhi ngezinye Tinea pedis - amasonto 2-6.

izifo fungal ikhanda kuvamile ezinganeni. Njengomthetho, zingabantu amenable ekwelashweni uma izidakamizwa isetshenziswa imithamo batusa nodokotela inyanga.

ukuphathwa Onychomycosis kuthatha amasonto 6 izinzipho kanye 12 - I-uzwane nail. Ngaphansi ukukhula encishisiwe nail amapuleti yokwelapha ingase isikhathi eside.

ukusabela ezingezinhle

izidakamizwa Local "Lamikon", analogue zazo ezibalwe ngezansi, kungabangela izimpawu ezifana isikhumba uyaxebuka, evutha, ukulunywa, ubuhlungu, ukucasuka, lesikhumba kahle, erythema futhi uqweqwe kumiswa. Bangase komzimba.

Lapho ethola amaphilisi, miphumela elandelayo engathandeki:

• neutropenia, agranulocytosis, Lyell syndrome, pancytopenia, Stevens-Johnson syndrome;
• thrombocytopenia, ukusabela anaphylactoid, ukunambitheka thuthuva, izimpawu lupus, ikhanda;
• photosensitivity, paresthesia, hypoesthesia, neuralgia;
• isiyezi, umuzwa ukuphelela esiswini, uhudo, ukungakuthandi ukudla;
• exacerbation psoriasis, isicanucanu, psoriasiform ukuqubuka, ubuhlungu besisu, myalgia;
• urticaria, arthralgia, amawala, pustulosis generalized, ukuqothuka kwezinwele, ukwanda enzyme isibindi;
• ukukhathala, ukungasebenzi hepatobiliary, jaundice, i-hepatitis.

Analogs futhi izindleko zomuthi

Kungakanani buyisidakamizwa "Lamikon"? Intengo yaleli izidakamizwa incike ezakheke ngayo. Amafutha spray angathengwa ruble 180-220, kanye amaphilisi - I-ruble 370-400.

Kepha kumakhophi, phakathi ngempumelelo ngaphezulu ungakwazi ukwaba lezo zimali njengoba "Amorolak" salicylic acid. "Mikoseptin", "Nitrofungin", "Mikolak", "Exoderil".

Uphenyo nomuthi

Impendulo kulabo abaye basebenzisa izidakamizwa "Lamikon" akhayo kakhulu. Iziguli ukubika ukuthi kusebenta zokwelapha zalesi izidakamizwa Kuye kwaphawulwa izinsuku ezimbalwa emva ukusetshenziswa akhe asebenzayo. Ngokuvamile, isifo fungal futhi iphele ekupheleni inkambo yokwelapha.

Ezimweni ezimbi kakhulu, odokotela basikisela elihlangene ngomthamo ifomu (isb, amaphilisi kanye wamafutha, spray kanye amaphilisi).

Ngaphezu imiyalezo emihle "Lamikon" ukulungiselela meet futhi impendulo engeyinhle. Avame exhumene ukwehluleka yayo. Nokho, ochwepheshe bathi lokhu kungenzeka kuphela ekwelapheni non-nozwelo isikhunta nomuthi noma kabi. Ngakho-ke, ngaphambi kokufaka isicelo okugcoba, amaphilisi noma isifutho Kunconywa ukuba aye kudokotela futhi ngimise isihlalo ejenti causative izifo fungal.