"Neofilin" (amaphilisi): yokusetshenziswa. "Neofilin 100 mg": incazelo ukulungiselela

Ukuze ekwelapheni isifo samaphaphu okubangwa spasm yaleli pheshana yokuphefumula, isetshenziswa bronchodilators ka Methylxanthine iqembu. umumele esemqoka ye theophylline izidakamizwa.

Kusekelwe izidakamizwa dambisa ukuhlaselwa kwakhe isifuba somoya somoya bronchial, ukucinana kwemigudu yokuphefumula obstructive futhi elele singathatha.

incazelo imithi

I nomuthi "Neofilin" (amaphilisi) yokusetshenziswa njengoba nomuthi libhekene kukhishelwa ezithaka imithi Ukrainian ngokuqinile "Darnitsya" ngemithamo ezimbili: mg 100 300. Umuthi kunomphumela isikhathi eside.

Kuthinta emzimbeni

Isithako asebenzayo zomuthi (theophylline) kunomphumela bronchodilatory ku umzimba lapho ivinjiwe adenosine receptor engasenamahloni phosphodiesterase kwandisa okuqukethwe ekamu intracellular, kunciphe lokuhlushwa calcium ion. It ephumula imisipha bushelelezi ku bronchi, pheshana emathunjini, ipheshana biliary, kwesibeletho, i-coronary, samaphaphu, izitsha palsy, Ukuvuleka komlomo nemithambo yegazi yenhliziyo, ukwehla neuropathy ukumelana semithambo.

Ngaphansi kwethonya izidakamizwa waphawula ukwanda ithoni imisipha zokuphefumula, ezifaka hlangana ukuhlahluba imisipha intercostal kanye diaphragm. Ngaphezu kwalokho, encishisiwe yamaphaphu ukumelana semithambo, kuthuthukisa oxygenation kokusakaza igazi, ukusebenza enkabeni zokuphefumula ku oblongata medulla, kwandisa ezifweni yayo carbon dioxide, ngcono ukupholisa alveolar.

Lokhu kunciphisa kobukhulu kanye nokuvama izitobhi incipha zokuphefumula ukunyakaza. Theophylline ekwakhiweni "Neofilin" (amaphilisi) imfundo manual uchaza njengoba kusho zokususa vasoconstriction, ukwandisa eseduze ukugeleza kwegazi ne-oksijini saturation igazi, Ukwehla perifocal futhi jikelele ingqondo edema, ukunciphisa utshwala kanye ingcindezi intracranial.

I nomuthi kuhloswe ukuba ngcono izici rheological wegazi, ekuvimbeleni ukwakheka amahlule, ukunciphisa platelet clumping amaseli kujwayeleke microcirculation. Theophylline abonise isinyathelo antiallergic, lapho degranulate insika amaseli bese incipha lokuhlushwa balamuli nomzimba, ezifana histamine, serotonin, leukotriene.

Ngokwandisa kwezinso ukugeleza kwegazi waphawula umphumela isisu lapho amanzi okukhipha, chloride ion kanye sodium.

Lokho ephatha izidakamizwa

Izidakamizwa "Neofilin 100" imfundo (amaphilisi) mathupha uncoma ekwelapheni ufuba bronchial, isimo somoya, ukucinana kwemigudu yokuphefumula, obstructive ifomu okungamahlalakhona, iphaphu bronchial, umfutho ophakeme wegazi yamaphaphu, ebusuku ukuboshwa zokuphefumula.

Lezi zincomo zisebenza kwabahamba emikhulu Isikali izidakamizwa - 300 mg.

Indlela

I nomuthi imfundo 'Neofilin "(amaphilisi) mathupha incoma ukuthatha umthamo obekwe eceleni isifo ngasinye futhi sincike isivinini izinqubo umzimba, yobudala kanye nesisindo isigaba izici nesineke.

Umuthi baphuze 1 isikhathi ngelanga ngesikhathi sasekuseni noma dinner. Nomuthi imfundo 'Neofilin "(amaphilisi) kubonisa ukuthatha kumodi eqinile. Akunakwenzeka ngosuku olulodwa ukuthi uphuze imithi ngesikhathi sokudla, kwathi ngakusasa - sokudla nangemva kwaso.

Ukubalwa umthamo esijwayelekile imvume kwezinso

Ukuze kokuqala okwengeziwe ukulungisa inani izidakamizwa okudingekile ukunquma umfutho uyakwazisa ukuthi uhlanzekile of plasma kusukela ezintweni ezahlukene ngu nezinso.

Ukulungiselela "Neofilin" (amaphilisi) yokusetshenziswa izingane ezivela engu-12 kuya ku-15 ubudala nge esisindo esingaphansi 45 kg Kunconywa ukuba asebenzise izinsuku zokuqala ezintathu yokwelapha umthamo zonke izinsuku we-12 kuya ku-14 g ngalinye esisindo 1 kg. Kodwa awukwazi ukuthatha ezingaphezu kuka-300 mg zomuthi.

Ngemva kwezinsuku ezintathu zale ndlela yokwelapha ngaphansi ibekezelelwe evamile umthamo wansuku zonke anda 16 mg ngayinye isisindo 1 kg. Kodwa-ke kumele singeqi 400 mg ngosuku.

Ngemva okwengeziwe izinsuku ezintathu ngaphansi evamile ibekezelelwe umthamo ukukhuphuka 20 mg ngayinye isisindo 1 kg. Kodwa manje-ke akufanele bube ngaphezu kuka-600 mg.

Ukulungiselela "Neofilin" (amaphilisi) yokusetshenziswa izingane zeminyaka futhi abadala 16 futhi eminyakeni engu-60 ubudala kanye isisindo emzimbeni ezingaphezu kuka-45 kg ezinsukwini zokuqala ezintathu zokwelashwa elikuyalayo isetshenziswa inani 300 kuya 400 mg ngelanga ngomlomo.

Ngemva kwezinsuku ezintathu ngaphansi evamile ibekezelelwe umthamo ukukhuphuka 400-600 mg.

Ngemva kwezinsuku ezintathu, ngaphansi kwezimo ezifanayo umthamo nsuku zonke lingadlula 600 mg, kodwa-ke, kuyadingeka ukusungula ukulawula emakamu theophylline e umthamo wegazi lesiguli.

Ukubalwa umthamo nge kahle imvume kwezinso futhi asebekhulile

kanjani ukwamukela ezinye izigaba iziguli lesi sidakamizwa "Neofilin" (amaphilisi)? Imiyalelo izingane Kunconywa ukuyithola ku umthamo, okuyinto akumele kube ngaphezulu kuka-16 mg ngayinye 1 kg esisindo ngosuku, kodwa akukho mg ezingaphezu kuka-400 isiyonke. Lezi zincomo zisebenza intsha esikhulakhulile engu-12 kuya ku-15 nge kahle kwezinso imvume amazinga, noma ngokungabi bikho ikhono ukulandelela lokuhlushwa plasma theophylline.

Ukuze ukulungiselela "Neofilin 300" (amaphilisi) yokusetshenziswa kuhlanganisa idatha elandelayo. Bona okukhathazayo ukusetshenziswa kwezidakamizwa yintsha emva kweminyaka 16, kanye neziguli kwasebekhulile nge kahle kwezinso imvume amazinga, kanye nabantu singenakulinganiswa plasma lokuhlushwa theophylline. Ngokuvamile i-lezo zigaba iziguli inani isithako zomuthi akufanele idlule 400 mg.

Isikali Ukubalwa plasma lokuhlushwa theophylline

Kuye okuqukethwe isithako esisebenzayo plasma Kwenziwa umthamo ukulungiswa "Neofilin 100" (amaphilisi). Imiyalelo isenzo esinjalo kudinga ukukhiqiza futhi uma nithatha ebulilini imithi. Yehlisa izinga isithako esisebenzayo kanye ukulawula inani serum kuyadingeka uma kwenzeka ukusabela ezingezinhle, disorder bokuphila, okuyinto kuvimbela excretion zomuthi.

Uma emakamu bafinyelela inani eliphakeme labangu theophylline egazini esingaphansi 9.9 g ngalinye 1 ml, ukuntuleka Umthelela nomuthi e ukubekezelelana evamile kudinga banda ngamaphesenti angu-25 ngo-umthamo. Ngemva kwezinsuku ezintathu, ngokuba ozayo ushintsho inani izidakamizwa eyenziwa emakamu plasma theophylline by.

Uma umphumela ukwelashwa kanye tolerability ukuza ubudala umthamo ukwelashwa okuhle eminye kungenzeka kuphela ngemuva ukuzimisela plasma lokuhlala isithako esebenzayo. Kulesi sibalo kufanele kube ku ezahlukene kusukela micrograms ngamunye 1 ml 10 kuya 14.9. Uma kungekho ukusebenza, kodwa ukuphatheka muhle, ukungezwa neminye imithi.

Lapho umthamo kumele kungancipha

Lapho emakamu plasma theophylline ku ezahlukene micrograms ml ngayinye 15 kuya 19,9, zidinga umthamo nokwehlisa 10%.

Lapho Inkomba izidakamizwa 20 kuya 24,9 micrograms ml labanti ladzingekako kute kuncishiswe inani umuthi 25%, ngisho noma kungekho ukusabela sobala ezingezinhle. Ngemva kwezinsuku ezintathu emva ukuncipha umthamo Kwenziwa ukuqapha plasma theophylline inkomba kungenzeka ukusetshenziswa ngokwengeziwe izidakamizwa.

Uma izinga liphansi izinga esebenzayo kusuka 25 kuya ku-30 g ngalinye 1 ml, ethola nokushintsha kokudla nokufakwa okwalandela sidlulile, futhi eminye ukunciphisa lemali edingekile of nomuthi 25%.

Ngemva kwezinsuku ezintathu emva ukuncipha umthamo Kwenziwa ukuqapha plasma theophylline inkomba ukunquma ukusetshenziswa esizayo zomuthi. Uma izimpawu kungenzeka nemiphumela engemihle, izinyathelo ezifanele.

Lapho lokuhlushwa theophylline egazini okukhulu kuka-30 micrograms ngamunye 1 ml kungenzeka overdosing. Ukuze isicelo okwengeziwe umthamo kuyehla ngesigamu. Ngemva kwezinsuku ezintathu, kwenziwe kabusha yokukala umthamo izidakamizwa e-plasma umthamo efanele.

Izici isicelo

Lapho ethola "100 Neofilin" ababhemayo ezibhebheni isicelo Umsebenzisi esixwayisa ukunciphisa okungenzeka umphumela ukwelashwa.

Ukuze abantu abanezifo okunzima inhliziyo, imithambo yegazi, isibindi, igciwane lohlobo, esegugile umthamo is kushintshwe ngamunye bese uthatha imithi kulezi zimo ngokucophelela okukhulu.

izidakamizwa ngokweqile

In iziguli omdala, imithi ukweqisa izidakamizwa "Neofilin 300" (amaphilisi) ibhukwana elichaza amajaqamba, imfiva, semfene inhliziyo, kuhlanganise tachycardia, arrhythmia ventricular, hypotension.

Izimpawu sici ebuntwaneni, zihlanganisa ukucasuka yanda, iziyaluyalu ubuntu, imfiva, isicanucanu, isimo convulsive, tachycardia, hypotension, inhliziyo ukusabela zokuphefumula.

Ukwelapha kufanele uqale uyeka ukuphuza amaphilisi, bese iphume ingaphakathi lesisu, amathumbu nisela usawoti lihambisana polyethylene glycol, ukuthatha namalahle. Uncoma imvume theophylline ukushukuma wegazi esebenzisa diuresis ophoqelelwe, hemosorption, plasma sorption, hemodialysis, isebenzisa umshini wezinso peritoneal.

Endabeni ka isicanucanu nokuhlanza nesineke iqondiswa ejenti lingaze, isibonelo, reception "Ondansetron" noma "i-MCP". Ukuqeda nokuquleka bangathola "Diazepam".

Ubani akufanele bathathe

Lapho belungela ukuya khona "Neofilin 100" imfundo (amaphilisi) sibandakanya uhla Izimo, okuyinto akunakwenzeka lapho imithi. Lezi zihlanganisa ezwela lenyuka zonke izingxenye kusho emithini uchungechunge xanthine, okuhlanganisa i-caffeine, theobromine, pentoxifylline.

Ayikwazi amukelwe acute imisipha esivimba amanzi esivimba amanzi zinkulu, tachyarrhythmias, hypertrophic zenhliziyo obstructive, wegazi vele ophakeme kakhulu, isifo sokuwa, i-hyperthyroidism, isilonda peptic esiswini noma duodenum zokukhukhumala, iziyaluyalu ezinzima kwesibindi, porphyrin isifo.

Kusho contraindicated izingane ezingaphansi kweminyaka engu-12 ubudala.

ukusabela ezingezinhle

Inombolo yemiphumela emibi angagcina reception "Neofilin" ukulungiselela (amaphilisi). Yokusetshenziswa lidlulisela iziguli ulwazi kungenzeka iziyaluyalu e pheshana emathunjini. Basuke izimpawu ubuhlungu esiswini, isicanucanu, reflex Gag, Reflux gastroesophageal, isilungulela, okubi kakhulu izilonda, uhudo, kwehle iphango.

ukusabela ezingezinhle kubonakala esimiso senhliziyo nemithambo yegazi ngesimo palpitations, tachycardia, arrhythmias inhliziyo, ukwehlisa umfutho wegazi, angina zamanga, pectoris angina.

Theophylline kungase kube nomthelela isimiso sezinzwa esiyinhloko. Kungaba lungase lubonakale isiyezi, ubuhlungu bekhanda, isimo ukubuyisa noma ujabule, unenkinga, liqhaqhazela, delirium, Ukudlikizela kanye nokuquleka.

Ngaphambi izidakamizwa komzimba ne okuvela ukuqubuka kwesikhumba, i-erythema, dermatitis exfoliative, urticaria, imfiva.

Okunye imiphumela engathandeki zokwelapha zihlanganisa nezinwele ekhanda, ubuhlungu besifuba, engajulile ukuphefumula okusheshayo, siwasebenzise, excretion albumin wamaprotheni emchamweni, khona igazi umchamo, kukhuphuke umchamo okukhipha, ukujuluka anda futhi isikhumba lokushisa.

Theophylline kuthinta ku imingcele laboratory. Ekwelapheni izidakamizwa "Neofilin" zingashintsha okuqukethwe potassium ion e serum phansi ekuthuthukiseni hypokalemia. Ngesikhathi esifanayo ezingeni creatinine, ion, calcium oxalate, okuyizinto nosawoti ka uric acid kanye ushukela luyanda, okuholela hypercalcemia, Hyperglycemia futhi hyperuricemia.

Ngemva kokudla nokufakwa of nomuthi ukunciphisa izinga amathuba okuba nemiphumela engemihle kuyehla.

Nokukhulelwa kanye lactation

Tablets ingxenye Active odlula umgoqo esinomhlapho futhi iyangena ubisi lwebele.

reception nokubeletha engavumelekile itholakala kuphela uma umphumela ekwelapheni unina ingozi bebakhulu umntwana ongakazalwa. Endabeni yokwelapha anjalo kufanele kube ingxenye ethile plasma lokuhlala theophylline, kanye ukulungiswa okuhambisanayo kusho nokushintsha kokudla nokufakwa. Engathandeki ukuthatha izidakamizwa ezinyangeni okugcina enkathi yokukhulelwa ngenxa nokucindezela imisipha lesizalo.

Abantu besifazane abane-webele udla futhi ziphathwe theophylline kufanele ziqashwe ukubukeka ingane hypersensitivity. ukuthuthukiswa olungenzeka excitation noma ukulala izinkinga, okudinga ukuqedwa zomuthi.