Umuthi 'Fluorouracil ": yokusetshenziswa, incazelo, ukwakheka, analogs kanye nokubuyekeza

Umdlavuza, ngeshwa, kukhona manje kaningi impela. Ngokwemvelo, asikwazi give up, kumelwe silwe nalesi sifo. Kunoma yikuphi akufanele aphathwe ngokuzimela. Ngaphandle usizo lochwepheshe lubaluleke. Iqiniso lokuthi ezinye izidakamizwa kungenziwa kuphela ebekwe kadokotela futhi isetshenziswa kuphela lwemithi ekhethekile. Ezimweni eziningi, odokotela linqume lokhu izidakamizwa ngokuthi "Fluorouracil". Yokusetshenziswa zomuthi azosethwa naphambili ngemuva kwalokhu.

izici Jikelele

Ngakho, wethule izidakamizwa isetshenziswa Oncology, njengoba nomphumela anti-isimila. It bungabalwa phakathi antimetabolite. Okungukuthi, ketshezi eziqukethwe ketshezi, kungaba ngokuphawulekayo ukubambezela exchange of izinto phakathi amaseli.

"Fluorouracil" (yokusetshenziswa njalo zahlanganiswa ne izidakamizwa) likwazi isakhiwo esilula. Kubandakanya amanzi oyinyumba kanye sodium hydroxide. Kodwa ingxenye esebenzayo eyinhloko esikhathazeka ngayo fluorouracil.

amafomu Dedela futhi izici izidakamizwa

Kumele kuqashelwe ukuthi le imithi has izinhlobo eziningana. Uma udinga ke, "Fluorouracil" imfundo manual elikushoyo ezifana izinhlobo:

1. Isixazululo liquid ekuphathweni emthanjeni noma intracavitary. Ngokuvamile kwenzeka th aqueous 5% ingxube 5 ml ampoules. Kukhona isixazululo kanzulu okuyinto ibekwe egabheni 10 ml.

2. Wamafutha. Libuye ngokuvamile 5% of th. Isetshenziselwa ukwelapha isikhumba esibi, isib Basile.

Uma Aye amiswa njengesigaba "Fluorouracil" imfundo manual iqukethe ulwazi olulandelayo mayelana izifunda reception:

- Nsuku zonke uthola 0.5 g / m. noma 12 mg / kg. yokwelapha akusiyo izinsuku ezingaphezu kwezingu-5. Ngemva kwalokho kudingeka inyanga eyodwa ikhefu.

- izinsuku kanye 7 0.6 g / m. Yiqiniso yokwelapha imayelana 6-10 amasonto.

- Lihambisana nezinye izidakamizwa anticancer - 1st nemini 8 inkambo 0.6 g / m.

Nokho, kuzo zonke izimo, umthamo kanye indlela yokuphathwa zomuthi ezinqunyiwe ngamunye. Konke kuncike kobukhulu kanye nesigaba lesi sifo, isimo jikelele isiguli, impilo yakhe kanye nepulani lokuqalisa i-imiphumela emibi yokwelashwa ngamakhemikhali.

Liquid ingasatshenziswa bolus noma ukumnika. Khumbula ukuthi ezinye izidakamizwa enikezwa isiguli owawuhlangene nalokhu, ukunikeza fluorouracil umthamo ukunciphisa by 20-30%.

imiphumela kwemithi kanye ekuxhumaneni nezinye izidakamizwa

Ngakho, "Fluorouracil" (yokusetshenziswa, incazelo ukulungiselela kumele ufunde yisiguli) inikeza umphumela anti-inflammatory futhi kakhulu kubamba yokusabela chemical walabo ekhuthaza nokuhlukana kwamangqamuzana ebulalayo. Okungukuthi, abangabantwana amabhlogo izidakamizwa kumiswa DNA.

Ukuncela kusho ngokushesha, ukwakha ftoruridinmonofosfat. It is wajinge wanamatsela esibindini amahora angu-20. I Ukuhoxiswa zokuphefumula abathintekayo (60-80%) nezinso (7-10%, akushintshiwe).

Uma udinga ukuthatha "Fluorouracil" imfundo manual (ingxenye imithi, sixoxisane kakade) uthi kukhona abanye izinto ezingeke kuhlangene nabo. Ngokwesibonelo, sulfa izidakamizwa, futhi Phenylbutazone azihambelani wathi izindlela. Kodwa-alpha-interferon futhi cytotoxic ejenti, kunalokho, ukwandisa umphumela "Fluorouracil". Kufanele kucatshangelwe ekumisweni umthamo.

Phawula ukuthi lo wokugoma esiguli, ngenxa isimiso sakhe somzimba sokuzivikela saba buthaka kumele kwenziwe ngaphambili kuka izinyanga 3 - ngonyaka.

Izinkomba ukusetshenziswa

Uma udinga "Fluorouracil", yokusetshenziswa (izidakamizwa intengo ngokwesilinganiso 3000-3990 ruble) iyalandisa lezi izimo zezokwelapha:

• Umdlavuza wamaphaphu mncane noma ingemuva, emphinjeni nasesiswini. Ngakho ngisho noma ngabe izidakamizwa kunikezwa esiteji noma metastases unresectable.
• nomdlavuza wesibindi Primary.
• izifo ebulalayo kwesinye inyongo esibelethweni, webele, wesibeletho.
• Umdlavuza nezindlala adrenal.
• Umdlavuza wamaphaphu lesion wendlala.
• Kartsinoz noma umdlavuza penile.
• Izimila entanyeni ekhanda.
• Isimo precancerous, futhi izimila ezincane.

Zilethwa izidakamizwa lungasetshenziswa lapho fungal Izilonda.

Lokho Izimo kuthiwa zikhona?

Ngokwemvelo, azikho ukulungiselela chemical kungaba ngokulinganayo ewusizo okwazo zonke iziguli. Kulokhu, indaba anezinye Izimo.

• Inkulu kakhulu uzwela ezinye izingxenye ithuluzi.
• Nokukhulelwa kanye lactation. Lesi sidakamizwa kuyalithinta enobuthi kakhulu embungwini. Uma ukwamukela umiselwa ngesikhathi ibele, ingane ebeleni-ukudliwa.
• Peptic isilonda isifo 12 isilonda duodenal noma esiswini, elisetendeni esigabeni oyingozi.
• igazi kakhulu ukopha njalo ukuthi kunzima noma kungenakwenzeka ayeke (hemophilia).
• Leukopenia.
• Ukuphazamiseka umsebenzi kwezinso noma isibindi.
• Impilo isiguli ngaphambi kokufa begazi.
• degree kakhulu eqinile yokukhathala.

Ngaphezu kwalokho, kukhona ezinye ukulinganiselwa. Ngokwesibonelo, ukunakekelwa linqume izidakamizwa kubantu abaphethwe ezimise okwama-tile noma upokisi. Kuyadingeka ukuba unake okukhethekile ukuqokwa izidakamizwa uma isiguli sekuqalile cytostatics.

Imiphumela engemihle

Uma ekunike Yiqiniso zomuthi ngokuthi "imiyalelo Fluorouracil-Lance 'ukusetshenziswa zomuthi akahlukile kusukela ebhaliwe ngaphambili. Umbuzo oyithandayo iziguli eziningi, emibi. Iqiniso ukuthi ngezinye izikhathi kungaba nzima okungaphezu nje kwesifo ngokwaso. Ngakho, ngemva kokuthola ukuthi uketshezi lolu waphawula side effects:

• Ukunciphisa inani leukocyte nama-platelet egazini.
• Umongozima, okuyinto kunzima ukukuyeka.
• angaboni kahle, iso okusheshayo.
• Ukucanuzela kwenhliziyo, okungase enamathiselwe ukuhlanza, ukukhishwa yisisu. Kulokhu, ukwelashwa kufanele okwesikhashana noma ukushintshwa.
• isilonda peptic.
• Stomatitis.
• Alopecia kwengxenye noma Imininingwane (impandla).
• ukuhluleka Ischemic inhliziyo, arrhythmia, angina, senhliziyo, isilethikusebenza, zenhliziyo, thrombophlebitis.
• Ubuhlungu yelangabi ekhanda, lenyuka production izinyembezi, nokwesaba ukukhanya, disorientation, nokulahlekelwa ukwazi ukucaciseleka.
• Dysarthria.
• Ukunambitheka, ukopha kakhulu esiswini, isilungulela, ukudla noma ukusebenza hepatic.
• Iphika, ukukhwehlela, bronchospasm.
• Ukukhubazeka ohlelweni zokuzala: abesifazane - ukungabi khona owesifazane esesikhathini, amadoda - azoospermia.
• hyperpigmentation kwesikhumba, ukoma kwemifantu.
• Urticaria, amawala, dermatitis.
• imisipha ebuthaka kanye nezifo ngokujoyina yemihlobo ehlukeneko.

Njengoba ubona, inqobo ketshezi noma "Fluorouracil" amafutha, imfundo manual ukuthi une kucace, yizidakamizwa ngempela yingozi. Ngaphezu kwalokho, abanye ucwaningo lubonisa cishe yemiphumela toxigenic futhi umdlavuza zomuthi.

Imibandela imikhiqizo isitoreji

Ngakho, usuvele wathola eziningi ulwazi isifanekiso okufakiwe. Manje kudingeka ucabangele izici isitoreji yayo. Ukuba "Fluorouracil" kumelwe endaweni emnyama kakhulu. lokushisa isitoreji kufanele kube 15-25 degrees. Yiqiniso, lesi sidakamizwa kufanele igcinwe kude kude nezingane. liquid oluyiqhwa hhayi Kunconywa.

Shelf-ukuphila umuthi engu-2. Ngemva kokuphela kwalo mkhiqizo awukwazi ukuthatha isikhathi.

Kunezikhathi lapho inzika livela phansi izitsha eziyisikhombisa. Lokhu kwenzeka ngesikhathi isitoreji yesikhathi eside. Zama ukufudumeza uketshezi 60 ° ne banikine ngamandla. Okulandelayo izidakamizwa cool degrees 35. Uma kwenze kakhulu ziyoncibilika, futhi uketshezi baba esobala futhi, ngakho-ke, ukulungiselela ilungele ukusetshenziswa.

analogue imithi

Into eyinhloko ukuthi yini wena okudingeka ukwazi ngaphambi kokuthatha "Fluorouracil" izidakamizwa - yokusetshenziswa. Izibuyekezo beyoba engadingekile. You enza thola cishile kamuva.

Uma isiguli cha ngakhokhela it ukuthenga imithi, udokotela angase akunikeze analogue kuye. Sinenkosi main isithako efanayo esebenzayo - fluorouracil. Manje kukhona analogue yalesi izidakamizwa:

1. "Fluor-uracil."

2. "Efundeks".

3. "EPF-Ricks."

4. "Fluoropleks".

5. "Fluratsil".

6. "ufulawa".

7. "Kveropleks".

8. "Timazin".

Izibuyekezo

Kufanele kuqashelwe ukuthi imithi isetshenziswa kaningi. Iziguli eziningi kubika kusebenta okusezingeni eliphezulu ekulweni izimila.

Nokho, bathi, futhi inani elikhulu labantu side effects: isicanucanu, ukuhlanza, ikhanda elibuhlungu, disorientation emkhathini. Lokhu akusona isimanga, ngoba umuthi enobuthi kakhulu.

Ngakho, sinikeze ulwazi mayelana nemithi "Fluorouracil": yokusetshenziswa, intengo, ukubuyekezwa. Khumbula ukuthi umuntu ethatha lo muthi, akufanele. Qiniseka kudokotela. Kungenjalo wena engozini ukuba uzilimaze nakakhulu. Lapho ukuthi okuyikona kungenziwa kuphela setha onguchwepheshe ewumngcingo, ngemva ukucwaninga okufanele. Hlala uphilile!