Acinene fafaza "Dezrinit": ukubuyekezwa odokotela, yokusetshenziswa kanye nokusungulwa

"Dezrinit" - zokwenziwa glucocorticosteroid (GCS) isicelo nezokusigcoba. I-ejenti esebenzayo mometasone isinyathelo antiallergic futhi antiinflammatory. Lapho ebonisa indlela lo izidakamizwa ngemithamo ukuthi musa abangele imiphumela letindzala sibonakalise umsebenzi wayo eqeda ukuvuvukala nezokusigcoba. Cabangela lesi sihloko mayelana "Dezrinit" ukulungiselela impendulo evela kodokotela abathengi.

Umuthi engasenamahloni ukukhululwa kwe balamuli ukuvuvukala, lenyuka production lipomodulin, kuyinto inhibitor ka phospholipase A, futhi lokhu kungenxa wokwehla ezikhishwe arachidonic acid prostaglandin zamagama okusithiyayo futhi endoperoxides eyindilinga. Umuthi ukuvimbela ukunqwabelana neutrophil nama ukunciphisa ukukhiqizwa exudate ukuvuvukala futhi lymphokine, okusithiyayo of kufuduka macrophage, ekunciphiseni granulation izinqubo kanye kokuziphatha, ukunciphisa ukwakheka chemotaxis, okusho nomthelela indlela asabela kamuva iguliswa kwenzeka ayeke ukuthuthukiswa okusheshayo ukuphendula nomzimba.

Lokhu kuqinisekiswa phezu nomuthi "Izibuyekezo Dezrinit 'odokotela - Ochwepheshe emkhakheni wabo. Izindlela isakhiwo kuhlanganisa mometasone furoate nezinsizasenzo.

Pharmacokinetics

isicelo Intranasal kunciphisa bioavailability letindzala ka mometasone furoate ukuba ngaphansi kuka-1%. izidakamizwa Active bakwazi ukungena igazi, izinto eziningi ezincane wakwamukela futhi ngenkuthalo biotransformed emva pass lokuqala ngokusebenzisa isibindi. On the ukulungiselela "Dezrinit" Odokotela Izibuyekezo lingama omuhle.

Ingabe wabonisa for:

• ekwelapheni zisetshenziswa futhi zonyaka iguliswa rhinitis izingane ezineminyaka engu-2 nangaphezulu kanye nabantu abadala;
• sinusitis acute, exacerbation of ezingamahlalakhona sinusitis izingane iminyaka eyishumi nambili ubudala nangaphezulu, futhi abantu abadala (kuhlanganise nasebekhulile) njengenhlangano ukwelashwa adjuvant ngemithi elwa namagciwane,
• ekwelapheni adenoids ezinganeni noma abadala polyposis acinene;
• zokuvimbela zonyaka rhinitis iguliswa ezimweni nokulinganisela ezinzima izingane kusukela eminyakeni eyishumi nambili ubudala nangaphezulu kanye nabantu abadala. Ukuziphatha Kunconywa amasonto amane ngaphambi kokuqala dusting isizini.

ukukhululwa Ifomu

Alinganisiwe acinene spray. Omunye isitsha iqukethe ngemithamo 140. Ifomu inkomba zomuthi ngesimo amaconsi akekho phakathi sokushicilela nokulungiselela. Ifanele "Dezrinit" izingane. Uphenyo odokotela siliqinisekise.

Indlela yokusebenzisa futhi yokusetshenziswa

Umuthi iqondiswa intranasally. Ikani eziqukethwe isitsha is injected ekhaleni usebenzisa idivayisi ekhethekile nokushintsha kokudla nokufakwa.

Ngaphambi kokuqala isicelo spray ukwenza 10 test ompompi kudivayisi nokushintsha kokudla nokufakwa. Ngemva Samandla, imithi ukulethwa izinga isethiwe, cindezela ngamunye Rolls ukumiswa 100 mg eyayinekheli 50 mcg ka mometasone. Ngaphambi kokusebenzisa umkhiqizo ngemva kweminyaka engaphezu ikhefu sezinsuku ezingu-14, i-Samandla kufanele okuphindaphindiwe. Isicelo ngasinye kumele sihambisane kwesikhashana shaking isitsha.

side effects

Mayelana "Dezrinit» Amalungiselelo Izibuyekezo yezokwelapha ukuphakamisa lokhu okulandelayo imiphumela engemihle engase ibe:

• ukufiphala;
• hypersensitivity ukusabela kuhlanganise dyspnea, futhi bronchospasm;
• anaphylaxis;
• ikhanda ezinganeni nakubantu abadala;
• angioedema;
• umongozima;
• evuthayo ngalo ingaphakathi acinene;
• izingane zingase zibhekane ukungakhuli kahle, lengqondo hyperactivity, izinkinga zokulala, ukukhathazeka, ngokuziphatha okunonya, ukucindezeleka;
• umphimbo obuhlungu;
• perforation we septum acinene ;
• umuzwa yokucasuka we lwamafinyila e ngalo ingaphakathi acinene;
• ukuzwa mucosa pharyngeal ukucasuka;
• engenhla zokuphefumula ipheshana izifo;
• sneezing;
• ukunambitha ukuhlupheka;
• kokunikezwa kwe-lokuhogela;
• ngwengwezi;
• waqinisa intraocular;
• ulceration we mucosa e ngalo ingaphakathi acinene.

Izimo

Izidakamizwa "Dezrinit" (ukubuyekezwa odokotela siliqinisekise) is contraindicated ku:

• hypersensitivity kuya mometasone noma wengxenye ekwakhiweni;
• .. A kokungenela yamuva kuhlinzwa noma acinene ukuhlukumezeka esilondeni sokuphulukiswa, osithathayo isinyathelo ukuze GCS ngendlela inhibitory ngesikhathi ephilisa izinqubo;
• ezinganeni (uma polyposis acinene 18; exacerbations acute sinusitis okungamahlalakhona, oyingozi noma iminyaka engu-12; oneminyaka engu-2 rhinitis nge iguliswa zisetshenziswa futhi zonyaka).

Ukusetshenziswa kwezidakamizwa ngenkathi bekhulelwe nangenkathi bencelisa

Ikakhulukazi akukho izifundo ukusetshenziswa ephephile "Dezrinita" phakathi nokukhulelwa kanye lactation lwenziwe. Lesi sidakamizwa kufanele sinikezwe ukuba ibele kanye nabesifazane abakhulelwe kuphela uma izinzuzo impilo kamama idlule izingozi ezingase zisetshenziselwe ukuba ingane noma ingane. Izinsana zomama esetshenziswa corticosteroids ngesikhathi sokukhulelwa, kudingeka kudlule ukuhlolisisa ekhethekile ukuhlonza kungenzeka hypoadrenalism. Lokhu kuqinisekiswa phezu nomuthi "Dezrinit" izibuyekezo kwezokugoma wezokwelapha.

Ukusebenzisa izidakamizwa izingane

Ukusetshenziswa "Dezrinita" is contraindicated nezingane acinene polyposis ingaphakathi 18; i exacerbation sinusitis esingamahlalakhona noma ifomu acute babengagwetshwa iminyaka engaze ibe 12; nge zisetshenziswa futhi zonyaka rhinitis iguliswa engu-2. Ngokuvamile wasebenzisa "Dezrinit" e adenoids ezinganeni. Uphenyo odokotela kulesi sici akhayo.

yokusetshenziswa

Izimpawu yoma we mucosa acinene emva kokwelashwa unyaka owodwa (izinyanga eziyi-12) awazange uyalandelwa. Ukutadisha biopsies ka mucosa acinene yabonisa umphumela mometasone ukuze isimo ukuzinza of Histology. ukusetshenziswa isikhathi eside zomuthi, kanye nanoma yikuphi ukwelashwa eside, kufaka kokuhlolwa ngezikhathi acinene mucosa udokotela otorhinolaryngology.

Ngo sofuba umgudu (elele noma esebenzayo); igciwane, letindzala viral (kuhlanganise herpes kuthinta amehlo, noma-Herpes simplex) noma izifo fungal; ukwelashwa isikhathi eside ngu corticosteroids; khona ingelashwa ukutheleleka ehunyushelwe we mucosa acinene, kanye ibele nokukhulelwa, umuthi kufanele ubeke ngokuqapha.

Ukwelashwa kusho "Dezrinit" ukuncoma ukumisa bese uqale ukuqhuba yokwelapha ekhethekile ukuthuthukiswa ukutheleleka wendawo fungal we pharynx noma ekhaleni.

Ukucasuka we pharynx futhi acinene ingaphakathi, okuyinto iqhubeka isikhathi eside kakhulu isikhathi, kungaba kubhekwe inkomba ngokwehluleka zomuthi. Ungase futhi uqaphele ukuthi kwakungasebenzeki ukucindezelwa kohlelo hypothalamic-pituitary-adrenal phendla ukusetshenziswa isikhathi eside zomuthi. Lokhu kufakazelwa Izibuyekezo sokulungiselela "Dezrinit".

ukunakekela okukhethekile uqobo zidinga seziguli ezithola ukwelashwa isikhathi eside nge corticosteroids, odlulayo ukuba imishanguzo mometasone. Uma ukhansela GCS uhlelo isinyathelo ke ithuba singasho ukuthi kuzobangela ukuntula umsebenzi adrenal, ekwelapheni lapho kuyodinga ukuba kuthathwe izinyathelo ezifanele.

Kwezinye iziguli, kwathatha ukuphathwa mometasone ngemva corticosteroids kungenzeka nokuqaleka ukusetshenziswa letindzala ka glucocorticosteroids. Zihlanganisa ukucindezeleka, ukukhathala, ubuhlungu bemisipha kanye / noma amalunga omzimba. Iziguli zidinga ekhethekile sikholelwe ukuthi ukwelashwa nge "Dezrinit" kuyafaneleka, naphezu nokuncipha kobukhulu izimpawu acinene mucosa izilonda. Kufihlwe (kodwa sikhona kakade isiguli) ekwelapheni glucocorticoid izifo letindzala iguliswa ezifana eczema futhi conjunctivitis, bungabonakala nge kwathatha corticosteroids wendawo.

Ekwelapheni polyp sohlangothi olulodwa; polyp, okuyizinto ezihlobene cystic fibrosis futhi polyp, esehlanganise ngokuphelele ngalo ingaphakathi acinene, ukuphepha kanye kusebenta "Dezrinita" engakaze wafunda. Ukopha futhi polyp sohlangothi olulodwa kokuba i ijamo okungajwayelekile, kubalulekile ukuba iphenye kabanzi.

Iziguli yokwelapha by corticosteroids, uthole encishisiwe reactivity mzimba futhi ngenxa yalokho kufanele ubaxwayise ukuthi kwandisa ingozi yokutheleleka ngokuxhumana isimungumungwane ogulayo, inkukhu Pox namanye imvelo ezithathelwanayo lesi sifo, futhi kufanele ubuze onguchwepheshe, uma ukuxhumana nesineke namanje ngathatha indawo.

ukusetshenziswa isikhathi eside corticosteroids acinene ngemithamo ezinkulu kungaba kulethe ukuthuthukiswa amathuba okuba nemiphumela engemihle. Nokho, le miphumela ingaba kakhulu amathuba kuka uma zisetshenziswa corticosteroids letindzala, futhi ziyahlukahluka iziguli ngabanye. imithelela engaba letindzala ingase ihlanganise Cushing Syndrome, esibonakala by ukucindezelwa adrenal, ukufiphala kwamehlo ale nkinga, ukukhula retardation ezinganeni kanye intsha, futhi ngezinye izikhathi eziningana imiphumela yokuziphatha nezingokwengqondo, ehlanganisa nokukhathazeka, ukuphazamiseka kokulala, ukucindezeleka noma ukucasuka, lengqondo hyperactivity.

Ngokuqondene nokuxhumana izidakamizwa phakathi izidakamizwa ezahlukene mometasone, ngalokhu ucwaningo lwenziwe.

Acinene spray «Teva Dezrinit": ukubuyekeza amakhasimende futhi odokotela

Izibuyekezo sokulungiselela ikakhulukazi omuhle. Usizo Good kanye rhinitis iguliswa. Ngokuvamile ibekezelelwe alivamile engemihle. Bantwana kusiza adenoids, kunciphisa ukuvuvukala. Into esemqoka ukuhlonipha imiyalelo ukusetshenziswa.