Calcium abamelene - izidakamizwa ezibanzi-spectrum

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Emphilweni umzimba alawule calcium ion ukudlala indima kunalokho ezibalulekile. Iqiniso lokuthi kwaba calcium, engena phakathi amaseli uyakwazi isebenze zonke zhiznenovazhnye izinqubo intracellular e i umzimba, isib, ukuguquka ATP ekamu noma amaprotheni phosphorylation izinqubo.

Regulation of calcium ion emzimbeni

Calcium lingena amaseli ngemigudu ekhethekile, okuyizinto amaprotheni molecule esikhulu okuyinto igcwale ngokusebenzisa ulwelwesi multilayer amaseli. Lezi "iziteshi", phakathi kokunye, kufanele receptor ethize, okuyinto eyenziwa ukuhlonza-calcium ion, ngaphandle ukweqa nezinye izinhlayiya.

Ukugeleza calcium ion e i umzimba kulawulwa izici ezithile endogenous ukuthi kungase kudingeke njengoba imvelaphi neurogenic futhi ukuba balamuli endocrine ezifana acetylcholine noma le-serotonin.

Izidakamizwa ukuthi uvimbele Ukungena kwe-calcium ion ku amaseli

Izifundo izidakamizwa ukuthi singavimbela iziteshi calcium le ndima lwaluqala 60s futhi usaqhubeka. Ekuqaleni lolu cwaningo avuleka izidakamizwa fenilakilamina okunye, lolo ngesikhathi sokuhlwanyelwa Kuye kwahlongozwa ukuba lisetshenziswe njengesifanekiselo amalungiselelo koronorasshiryayuschih. Namuhla wavula ngempela inqwaba izinto ezinjalo, elihlanganiswa ku neqembu elilodwa, okuyinto wethiwa igama elithi - calcium abantu abamelene nani.

Ukusebenzisa i-calcium abamelene

Calcium abamelene manje kabanzi emikhakheni ehlukahlukene imithi, lokhu kungenxa yokuthi abe impela ezahlukene isinyathelo. Ngakho, ngokwesibonelo, i-calcium abamelene kungathinta contractility esivimba amanzi, conduction atrioventricular nomsebenzi itheku engeyokuqala.

A nomphumela ofanayo kuyinto aldosterone abamelene ukuthi uvimbele isenzo ngenxa conductivity aldosterone yayo yokwamukela, ngaleyo ndlela kwande inani calcium amaseli.

Kwezinye izinhlobo izimo zokucabanga okubangelwa isifo, ezifana hypoxia noma ischemia, ngokweqile-calcium ion kungayandisa izinqubo intracellular, bese kukhula izicubu-mpilo ngokufunwa, okungaholela imiphumela ehlukahlukene sokugembula. Kulokhu, lo abamelene calcium abe nomphumela oqabulayo, okulinganisela isinyathelo-calcium ion ku izinqubo cell.

Calcium abamelene for ekwelapheni izifo ezihambisana ne-CAS

Ukusetshenziswa Its eyinhloko-calcium channel blocker ezitholakala namuhla ekwelapheni izifo zenhliziyo nemithambo yegazi. Izidakamizwa kungathinta conductivity futhi excitability kwenhliziyo, kunemiphumela antianginal, ngcono yenhliziyo ukugeleza kwegazi futhi kuncishiswe blood pressure.

Izidakamizwa ezithinta conduction zenhliziyo excitability wanamuhla wayebizwa ngokuthi izidakamizwa antiarrhythmic, okwaphumela ukukhethwa ehlukile iqembu kwemithi (angianginalnye izindlela).

Abamelene kakhulu ezithinta wokuhlanganisa platelet, ekunciphiseni coalescence yabo futhi enza kube lula bonyana disaggregation ka-platelet. Le mithi asetshenziselwa ukunciphisa igazi viscosity futhi ukwandisa kuyaqina of nama-platelet. Ukuze kwandiswe umthamo we anticoagulant igazi angasebenza futhi vitamin K abamelene ukuthi ukuphazamisa ukusebenza prothrombin, ivimbela kumiswa fibrin amahlule.

Nomkhakha we isinyathelo izidakamizwa

Nomkhakha we isinyathelo-calcium abamelene wehlukile ngempela, ngoba manje bajwayele hhayi kuphela ekwelapheni izinhlobo ezinkulu isifo senhliziyo, kodwa futhi ngoba impatho migraine, isifuba somoya, izifo kwegazi cerebral palsy. Calcium abamelene zidlala indima ebalulekile ekwelapheni zengqondo esetshenziswa ekwelashweni kwe-isithuthwane futhi dyskinesia in iziguli bayasangana.