ImpiloImithi

Gamma-interferon: indima kanye nokubaluleka emzimbeni womuntu

Ukuvikela umzimba womuntu emiphumeleni elimazayo kwamagciwane - amagciwane, kukhona indlela kwesimiso somzimba sokuzivikela, ukuhlinzeka ukulawula izifo ezithathelwanayo. Kuyinto amaseli ukukhiqiza, ezifana T-lymphocyte izinto ezithile, enye yazo-gamma-interferon. Owenza kwesimiso somzimba sokuzivikela, uxhumano uba ukuzivikela yeselula. Kungani kubaluleke kangaka njengoba isithombe, futhi kungasiphi isisekelo kufanele ubuqotho umzimba wethu - mibuzo izophendulwa lesi sihloko.

Isakhiwo amakhemikhali nokwamukela

Ngesisekelo izidakamizwa - a glycoprotein - ezihlobene peptide carbohydrate. Biochemists labelwe amafomu amabili angafani acid acid Ukwakheka 139 kanye monomer kuqala uchungechunge polypeptide. Zibizwa ngokuthi ama-gamma-interferon 1a futhi 2a. Isilinganiso isisindo yamangqamuzana komyalelo wokungabi 20 - 25 kDa. Amiswa ngenxa kwema- ezicutshini futhi amaseli ejenti pathogenic emelelwa izinhlayiya ezibangelwa amagciwane. Ngoqobo kwesibeletho etholwe yesayensi yokushintshwa kwezakhi zofuzo usebenzisa zamagciwane webhaktheriya ka Escherichia coli, a plasmid equkethe isakhi sofuzo i-interferon womuntu. Lokhu-gamma-interferon ngokuthi isakhi sokuzakhela iyingxenye amalungiselelo: "Immuneron" "Ingaron" "Immunnomaks".

Mshini kwezimpendulo mzimba

Ukubukeka umzimba alien Amagciwane ekuphikisweni ngokunamandla ngaso sonke isikhathi sihambisana uhlelo izinqubo zokuzivikela, enye yazo ukuvuvukala. It ukhonza njengelungu umaka, okuphawula ukuqala kokubili isifo futhi impendulo iseli ekuphenduleni antigen we lwegciwane. Kukhona ekuhlobaneni okuyinkimbinkimbi emkhatsini wetincenye teluhlaka we nezicubu ezibolile noma sitho. Kusekelwe izinto ezivezwa amaseli lymphoid: cytokines (lymphokines). Ngokwesibonelo, amangqamuzana omuntu interferon-gamma, i-interleukin 2 ngokuncenga ekusebenzisaneni ulwelwesi ungazange itheleleke uqale zamagama omzimba, futhi ngokuyisisekelo okuwuphawu amaprotheni. Ake sihlole kubo ngokuningiliziwe.

izakhiwo lymphokines

Isimiso somuntu chromosome 6 pair Locus elise ehlanganisa iqoqo ufuzo, bephethe ulwazi izakhiwo antigenic we ulwelwesi plasma nezinye organelles yeselula: nucleus, mitochondria, njll Lymphokines ngokwabo abakwazi ngqo nomthelela antigen amagciwane, kodwa ngokushesha ukudlulisela ukwaziswa khona kwamagciwane kusukela kwesinye isitokisi bazifake kwesinye. Ngokwesibonelo, yokwamukela kwamaseli antigen-umsizi ne-T-lymphocyte Tor eheha isignali intracellular, ezimbili eziqondile Kuvuselela amaprotheni. Enabileko nezicubu ze-lymph luphakanyiswa mitotic division inqubo - ayanda, nokuvikeleka iseli aqashwe luyanda kakhulu. Njengezinye lymphokines, interferon-gamma kuvimbela izinqubo of umbhalo ka-viral nucleic acid, futhi kuvimbela inhlangano yabantwana bakwa-mshini amaprotheni molecule lwegciwane. Singasho ukuthi amaprotheni compounds, kubhekwe yithi, ziyisisekelo amasosha omzimba humoral.

Kanjani izivikeli mzimba

Thymus, izindlala zamanzi, amalaka, i-appendix - ukwakheka indawo lymphocyte. amaseli Avikelayo akhiqiza amasosha omzimba zivimbela ukukhula komzimba umsuka ezithathelwanayo. Ngo kusaqalwa ukuthuthukiswa omzimba abizwa ngokuthi ukuzikhohlisa, awukwazi lokhozi antigen angaphandle, lamagciwane. Badinga ukuvuthwa futhi babe immunocompetent - ke kwenzeka e-thymus. Uhlelo umzimba ukhiqiza kokubili siqu amaseli ukuzivikela: macrophage, ama-T cell, killer cells, kanye izinhlobo ezahlukene gamma-interferon ngaphansi kokulawulwa izikhungo ephakeme cortical zobuchopho.

umsebenzi Its futhi kulawulwa nezindlala adrenal, pituitary indlala futhi le ngxenye. iziyaluyalu Psycho-ngokomzwelo, ukungondleki kahle ne-imikhuba emibi ukunciphisa omzimba yomzimba, avame lokhu okwenzekayo ngokumelene isizinda nokucindezeleka okungapheli. Njengoba impendulo umzimba kuwumphumela izenzo zonke izinhlelo zalo, yikuphi ukwephula homeostasis mzimba kubabangele ukwehluleka kwakhe nempilo engeyinhle.

Amasosha omzimba womuntu interferon gamma

Zokwelapha njengendlela agent prophylactic nokwelapha wasebenzisa izinto equkethe amaprotheni zokuzivikela ezivezwa yokugoma izilwane nge interferon isakhi sokuzakhela. molecule omzimba ukugqashuka egazini serum, ukuhlanzwa kanye sisetshenziswe njengesigungu sokufaka izidakamizwa elwa namagciwane. It uyakwazi ukuthuthukisa umsebenzi uqobo compounds zokuzivikela umzimba, isib, gamma-globulin, futhi banciphise izimpawu eziwumphumela wokugula of izifo zokuphefumula: rhinitis futhi acinene ukuminyana, ukukhwehlela.

Umthelela oqabulayo interferon

glycoprotein Avikelayo kuvimbela ukuphindwaphindwa amagciwane kudaleke cell enzyme, ezifana amaprotheni kinase adenilatsintetazu nokunikeza nokucindezela synthesis acid nucleic namaprotheni of the imvilophi ezibangelwa amagciwane. Ingqikithi unekhono ukuthonya nozwela ulwelwesi amaprotheni kuya lymphokines cell, t. E. Ingabe immunomodulators. Gamma-interferon izingane kanye nabantu abadala osetshenziselwa nokwelashwa kwezinkinga Umkhuhlane futhi zokuphefumula izifo, kanye amasampula emihle khona imbewu eletha Koch sika emzimbeni. I-ejenti zokwelapha ikhishwe ngendlela amaphilisi yokugcoba, suppositories kanye imijovo.

Ukusetshenziswa umuthi udokotela, izingane zingaqala kusuka izinyanga 6 Njengoba kungekho ukusabela kwengane iguliswa futhi pathologies ezibucayi yisimiso senhliziyo nemithambo yegazi. Contraindication ekwelapheni kwabesifazane sokukhulelwa kanye yokungezwani komzimba. izidakamizwa yamanje ikakhulukazi elisetshenziswa wezifo zezingane, aqukethe zokuzivikela amaprotheni isakhi sokuzakhela ukuzihlambulula okuyisiko okusezingeni eliphezulu futhi ukungabi oluphelele polypeptide izinsalela.

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