"Glibenclamide": yokusetshenziswa, ifomu ukukhululwa, isithombe, analogs

Uyini elaphe "glibenclamide"? Yokusetshenziswa, ifomu ukukhululwa, analogue nokubonakaliswa ekuphathweni zomuthi tibalwe lapha ngentasi.

Ukwakheka, emabhokisini ifomu ukukhululwa ejenti

Ngayiphi ifomu senziwa imithi "glibenclamide"? Umhlahlandlela ibika ukuthi ithuluzi ikhiqizwa ngesimo amaphilisi okuyinto ezibekwe nezipakupaku (uhlaka yeseli) kanye ibhokisi eyenziwe amakhadibhodi, ngokulandelana.

Ukwakheka izidakamizwa ngaphansi ukucatshangelwa zihlanganisa 5 mg glibenclamide kanye izithako asizayo ezifana amazambane isitashi, monohydrate lactose, magnesium stearate, sodium croscarmellose, indigo carmine E 132 colloidal Silicon dioxide 25, futhi povidone.

isenzo izidakamizwa

Uyini izidakamizwa "glibenclamide"? Iziyalezo yokusetshenziswa uthi lokhu kusho bembonisa umphumela hypoglycemic kubantu enempilo futhi iziguli sikashukela ohlobo II.

Ukuphumelela kule izidakamizwa ngenxa yekhono layo ukuze wandise insulini uketshezi of pancreatic beta amaseli ngenxa ukushukuma yabo. Ngokusho ochwepheshe, lo mphumela zomuthi luphakanyiswa bedle glucose.

Kinetic ekulesi ekwakhiweni ngomlomo

Yiziphi izinto ezinganembile nobuntu pharmacokinetic izidakamizwa "glibenclamide"? Yokusetshenziswa ugomela ngokuthi ngemva kokudla nokufakwa ngemlomo ngaloko lokusandza kwenteka izibhebhe ketshezi asebenzayo ngokushesha futhi cishe ngokuphelele ugxile kusukela ipheshana wokugaya ukudla.

ukudla ngesikhathi esisodwa eyanele kuholela Ukwehliswa emakamu glibenclamide e-plasma (uma kuqhathaniswa ne esiswini esingenalutho). Uxhumano lokhu ingxenye ne-albumin idlula 98%.

isibindi glibenclamide wesiguli iguqulwe ibe le metabolites ezilandelayo: 3-cis-hydroxy-glibenclamide kanye 4-trans-hydroxy-glyburide. Ziyakwazi okukhipha ngokwezinga ofanayo nezinso, kanye indle.

Incazelo ukuqedwa isigamu-ukuphila umuthi amahora 2-3.5. Ngo nabantu kahle isibindi umsebenzi, leli nani liphindeke ziyancipha.

Izinkomba ukusetshenziswa zomuthi

Kwezinye izimo, amaphilisi nesineke "glibenclamide" angabelwa? Lokhu kusho ukuncoma ukuthatha iziguli sikashukela ohlobo II, lapho kungekho kungenzeka olungaba isinxephezelo Hyperglycemia Ukudla okuqinile futhi umsebenzi ngokomzimba noma kwesisindo.

Uvala ukusetshenziswa

Ingabe kukhona Izimo kule izidakamizwa "glibenclamide"? Iziyalezo yokusetshenziswa uthi lesi sakhiwo akufanele iqondiswa iziguli:

• ukusha ebanzi;
• Hypersensitivity ukuba ingxenye iyasebenza, futhi isisu thiazide noma sulfonamides;
• ketoacidosis;
• ikhoma sikashukela kanye uthi prekomatosnoe;
• ukuthuthukiswa kahle kungakhuphula izinga likashukela,
• ukuhlinzwa nezinye ukuhlukumezeka;
• gastroparesis futhi isimiso emathunjini;
• ukhulelwe;
• sikashukela Uhlobo lokuqala;
• ibele.

Nomuthi "glibenclamide": yokusetshenziswa

Kubhekwe ukuthi lo muthi kufanele sinikezwe kuphela udokotela abanolwazi. Lesi sidakamizwa ngaso sonke isikhathi kufanele kuhlanganiswe ukudla okuqinile. Kuphela kulesi simo-ke zizosebenza. Isikali kwawo kuxhomeke kulokho Imiphumela nesineke test (amazinga kashukela egazini, izinkomba ethathwe umchamo, njll).

Ngakho indlela ukuthatha izidakamizwa "glibenclamide"? Ukwelashwa lokho kusho ukuqala nge amazinga okukhishwa omncane. Lokhu kuyiqiniso ikakhulukazi ngokuphathelene nabantu ukuthambekela kahle kungakhuphula izinga likashukela nesisindo umzimba ngaphansi kuka-50 kg.

Ngokuvamile, umthamo lokuqala nomuthi kuyinto 0,5-1 ithebhulethi ngosuku. Lokhu kuhambelana 2.5-5 mg isithako esebenzayo. Lapho izidakamizwa isinyathelo inombolo iyasilela ecacisiwe kungenziwa kancane kancane amaphilisi amathathu ngosuku, elihambisana 15 mg isithako esisebenzayo. Lokhu kumele kwenziwe ngezikhathi kwezinsuku ezimbalwa kuze kube iviki elilodwa, kuze elamukelekile abayifunayo.

Kanjani ukuze uthumele isiguli kwesinye izidakamizwa e umuthi "glibenclamide"? Ukusetshenziswa imithi kuleli cala kumele kwenziwe ngokucophelela okukhulu. Okokuqala, isiguli ezinqunyiwe izibhebhe amahora 0.5, bese kancane kancane ukwandisa umthamo ukuze sibe abafundisi abaphumelela kakhulu.

ezigulini esezikhulile futhi buthakathaka noma iziguli ezine ukungondleki kahle isibindi noma izinso umsebenzi izisekelo noma umthamo kokuqala imithi efiselekayo ukunciphisa amathuba ukuthuthukiswa kahle kungakhuphula izinga likashukela. Futhi anqume ku umthamo efanele kwezidakamizwa kufanele kube ne ngincipha esisindo noma lapho beshintsha isendleleni yokuphila evamile.

Indlela yokuthola ithebhulethi hypoglycemic

Indlela yokusebenzisa lesi sidakamizwa "glibenclamide"? Yokusetshenziswa (isithombe se-isidakamizwa okwethulwa kulesi sihloko) ithi Okubukwe ithebhulethi okufanele zithathwe ngaphambi kokudla ne ingilazi yamanzi elicwengekileyo futhi ngaphandle ukuhlafuna.

Ngezinye izilinganiso nsuku zonke amaphilisi 2, kutuswa ukuba kwahlukaniswe nomuthi e 2 ngemithamo ahlukaniswe (ekuseni nakusihlwa) endaweni isilinganiso 2: 1.

Kubalulekile kakhulu ukusebenzisa lolu imithi ngesikhathi esifanayo. Yeqa ekwakhiweni reception ithebhulethi sinqatshiwe kuthathwe kanye okulandelayo.

Isikhathi yokwelapha nale ejenti kuncike isifo. Kuyo yonke imithi oyinikiwe liyadingeka ukuze afeze ukuqapha okuqhubekayo zombuso lesiguli zezinto exchange.

side effects

I nomuthi "Glibenclamide" analogs abalwe ngezansi, kungabangela ukuthuthukiswa ukusabela engadingeki ezithinta, endocrine, izinhlelo sezinzwa neuropathy wokugaya ukudla bese hematopoietic. Kule ndaba, isiguli bangase balwisane izimpawu enqabayo ezinjengesicanucanu, kahle kungakhuphula izinga likashukela of kobukhulu obuhlukahlukene, ukungasebenzi hepatic, uhudo, ikhanda elibuhlungu, cholestasis, ubuthakathaka, isiyezi kanye nokukhathala.

Kufanele kuphawulwe ukuthi ukuthathwa ithuluzi akusho ukubeka eceleni ukubukeka ukusabela dermatological kanye iguliswa njengoba photosensitivity izinhlungu, ukulunywa, ukuqubuka kwesikhumba kanye nezinye izimpawu ezingezinhle.

Ezimweni Overdose ejenti hypoglycemic

Yiziphi izimpawu zenzeka lapho ephakeme esenikwe imithi "glibenclamide"? Manual ithi ukweqisa izidakamizwa, isiguli singase ukuthuthukisa kahle kungakhuphula izinga likashukela, mhlawumbe ephelezelwa ubuthakathaka, umuzwa indlala, ikhanda, ukukhathazeka, ukujuluka ngokweqile, isiyezi, imisipha liqhaqhazela, palpitations, ukuvuvukala kobuchopho, umbono kanye inkulumo iziyaluyalu.

Ukwelashwa nokuvikelwa izimo ezinjalo kudinga esiphuthumayo yokuvuma ukudla glucose-digestible. Ngokwesibonelo, ijusi yezithelo, ushukela, corn isiraphu, amnandi itiye hot noma uju.

Ezimweni ezimbi kakhulu, isiguli iqondiswa isixazululo glucose 50%, "Dextrose" "Glucagon" noma "Diazoxide". Iphinde kudinga ukuzithiba olukhethekile glycemia, creatinine, urea nitrogen, electrolyte futhi ekunqumeni pH.

Ukuxhumana nezinye izindlela zokwelapha

Ingxube izidakamizwa kubhekwa nge elwa ne-letindzala, tetracyclines, fluoroquinolones, chloramphenicol, mao inhibitor, futhi ACE, H2-blocker, "clofibrate" beta-blocker, probenecid, bezafibrate, "paracetamol", Ama-anabolic steroid, ethionamide, allopurinol, pentoxifylline, cyclophosphamide "reserpine", insulini kanye sulfonamides uyakwazi potentiate kahle kungakhuphula izinga likashukela.

isicelo ngesikhathi esisodwa imithi nge phenothiazines, yegilo kanye glucocorticoid hormone, barbiturates, estrogens, diazoxide, progestins, glucagon, lithium nosawoti, Adrenomimeticalkie kusho saluretikami nicotinic acid nemikhiqizo ingalimaza umphumela wawo hypoglycemic.

ukwakhiwa okunjalo acidified umchamo (ye ammonium chloride, i-calcium chloride, ascorbic acid), kungaba ngcono isenzo nomuthi kubhekwe.

Ukusetshenziswa "glibenclamide" nge "rifamycins" ngesivinini inactivation nokwehlisa ukusebenza ayengaphansi.

ulwazi oluthile

ejenti hypoglycemic kufanele kubhekwe ngokuqapha ukuze iziguli ukungasebenzi kwezinso nesibindi, kanye sokugembula ndlala nezindlala adrenal, izimo febrile nokuluthwa utshwala ezingamahlalakhona.

Ukuze afeze ukuphathwa evamile kudinga ukuqapha njalo amazinga igazi glucose isiguli, kanye excretion yayo.

Uma edonsa imithi isiguli eba kahle kungakhuphula izinga likashukela, ushukela esimisiwe ingaphakathi (endabeni uma umuntu ezazi). Uma ungazi lutho, i-glucose iqondiswa ngemithambo yegazi, futhi glucagon - phansi kwesikhumba, intramuscularly noma ngemithambo yegazi. Emva isiguli evuka, ngeke ngokushesha anikeze ukudla, ecebile carbohydrate, ukuze ugweme yokuphindela kahle kungakhuphula izinga likashukela.

Izindleko kanye analogue (omqondofana) izindlela

Khetha analogs yalesi izidakamizwa kufanele kuphela kube abanolwazi lochwepheshe. Ukuze odokotela like izidakamizwa zihlanganisa lezi ezilandelayo: "Manin", "Manin", "Maniglid", "Betanaz" futhi "Antibet".

Kufanele kuphawulwe ukuthi Pharmacy ngokuvamile ukudayisa omqondofana kwaleli thuluzi. Ukusetshenziswa ezivame kakhulu kubo, "Glidanil", "Glibeks", "Glibamid", "Gilemal", "Glibomet", "glibenclamide". Umthamo lezi zimali ikhethwa ngamunye.

Njengoba ngentengo "glibenclamide" umuthi, luyehluka in the ububanzi 280-360 ruble.

Uphenyo imithi

Manje uyazi ukuthi kuyinto izidakamizwa "glibenclamide". Yokusetshenziswa, futhi ngendlela analogue izindlela ezichazwe ngenhla.

Abakushoyo ngalokhu abasebenzisa izidakamizwa? Njengomthetho, yonke imilayezo ngakho ziyancipha ukuba zixoxe nalabo noma ezinye izinhlobo zemithi zokwelapha Kunconywa kubantu abanesifo sikashukela.

Abathengi bathi avame "glibenclamide" lisetshenziswa njengedivaysi monotherapy. Nakuba kukhona labo iziguli ezinqunyiwe izidakamizwa lihambisana namanye izidakamizwa hypoglycemic.

Ngokusho odokotela, ukuqokwa izidakamizwa ngaphansi ukucatshangelwa kudinga indlela ngamunye. Kulokhu, uchwepheshe kumele ayejwayele zonke imiphumela cwaningo, kanye nezinye izifundo. Thatha "glibenclamide" iziguli uma bebona kunesidingo kuyingozi kakhulu impilo nokuphila.