Interferon inducers, izidakamizwa izingane: uhlu isenzo. Fast-oyibamba inducer ka interferon endogenous

Ngenjongo nokwelashwa kwezifo ezibangelwa amagciwane interferon inducers esetshenziswa. indlela izenzo zaso lihlotshaniswa ukuthuthukiswa wamaprotheni izinto ukuvimbela ukubuyabuyelela kwamagciwane. inductors based izidakamizwa bangalwa nezifo zokuphefumula, herpes kanye nezifo hepatic nge Umkhuhlane.

Ukunqunywa interferon

Ngakho iqembu compounds kokuba amaprotheni imvelaphi. Bakha amaseli ungenwa Amagciwane ezibangelwa amagciwane.

Interferon izinto yizici non-ethize indlela ukuzivikela emzimbeni ngokumelene webhaktheriya, chlamydial, izifo ezingosomathuba fungal, isimila iseli izakhiwo. Futhi ukudlala indima yokuba nabalawuli kokusebenzisana intercellular amasosha omzimba letindzala. Zibizwa ngokuthi immunomodulators nobunjalo endogenous.

Kukhona izinhlobo eziningana womuntu interferon izinto leukocyte noma-interferon, fibroblast, noma b-interferon, futhi mzimba noma g-interferon.

Ukushayela indlela wokusebenza iqala namaprotheni ngibopha futhi zemizwa amaseli bemvelo ethile. Lapho ukuxhumana enjalo kwemiqondo amaprotheni molecule zingakapheli izinsuku ezingamashumi amathathu. Nge ukukhuthazwa peptides zokulawula kwenziwe umsebenzi T-lymphocyte futhi macrophage-uhlobo izakhiwo kwenzeka ukuvimbela ingress amagciwane ngokusebenzisa ulwelwesi cell futhi ukwanda kwabo. Kuyinto ba abaphethe izakhiwo zokuzivikela.

interferon Yemvelo inducers - amaseli viral ukuthi kwangena emzimbeni eziphilayo. Ziyakwazi stimulators abanamandla nababuthaka ukukhiqizwa amaprotheni zokuzivikela. Iningi ejenti izifo ngempela inducers abampofu. Lezi zihlanganisa cytomegalovirus kanye negciwane lesandulela ngculaza, i-herpes, i-hepatitis C no ifomu B Kodwa eziningi kwamagciwane abangela zokuphefumula izifo ezibangelwa amagciwane, ezibhekwa stimulators anamandla ukukhiqizwa amaprotheni zokuzivikela.

Interferon inducers (izidakamizwa): ukuthi kuyini

Ngokuvamile libhekisela isigaba zokwenziwa izidakamizwa immunomodulators. Lakhicitwe ngokuzimisela yizinkampani ezithaka imithi. Interferon inducers (izidakamizwa) zibekwa njengoba ikilasi enkulu ezahlukene amakhemikhali isakhiwo zezakhi. izingxenye ezisebenzayo kungenzeka izidakamizwa ephansi futhi ephezulu yamangqamuzana, umsuka zokwenziwa noma ezingokwemvelo. Bahlanganyela esivamile, okuvumela umzimba ntombazane kumaseli eyakho, noma interferon endogenous. amalungiselelo anjalo kungakwenza abonise nethonya namagciwane futhi immunomodulating.

Indlela yokufaka isicelo

Inducers ka interferon endogenous - amalungiselelo okuhloswe, ezimweni eziningi, ukuze alwe namagciwane ahlukahlukene. Mshini nomphumela yabo kusekelwe ukuxhumana esebenzayo izidakamizwa izidakamizwa yeselula nezicubu okuqukethwe olungaholela ukukhiqizwa iprotheni zokuzivikela.

Interferon inducers - Okwemithi imvelo ezithuthukisa kwemihlambi amaprotheni eyayenziwe. umphumela yabo liyafana evuselela zemvelo, ezihlanganisa viral, amaseli amagciwane izinto ezihlukahlukene.

Ukusetshenziswa interferon inducers kungabangela hyporesponsiveness. Kuleli zinga, phezu ekuphathweni okuphindiwe izidakamizwa akahambi ukuthuthukisa zokuzivikela impendulo amaprotheni, waphawula ukucindezelwa yayo. Kulesi sigaba kuyinto engenakwenzeka ukuba libhekele izidakamizwa. Isikhathi salesi isimo kunqunywa inductor. Guqula isithako esebenzayo, kanye nokuphazamiseka yokwelashwa nge okufanayo ejenti usizo ukuze aqede hyporesponsiveness.

Ukuqokwa izidakamizwa ukuthi kukhuthaza ukukhiqizwa kwamangqamuzana amaprotheni zokuzivikela akakubangeli imiphumela ezinzima enqabayo ezidinga ukususwa kwabo.

Buhle inducers wamaprotheni endogenous

Kunezindlela ezimbili ukuthuthukisa amasosha omzimba interferon. Le ngxube ingasatshenziswa ngokuqondile noma exogenously e i umzimba. Enye indlela kuhilela interferonizatsiyu endogenous lapho umuntu eba izinto kukhuthaza ukukhiqizwa kwe interferon lalo. Lokhu amaprotheni akabonisi antigenicity, okuyinto akulona interferon isakhi sokuzakhela. Ukuphatha isikhathi eside kwe-siphelile amaprotheni izidakamizwa kuholela ukuthuthukiswa ukusabela ezingezinhle.

Inducers ka interferon endogenous ekuhloleni ukusebenza kwabo wabonisa umsebenzi kwemithi e spectrum ezibanzi izifo. Kwatholakala isakhiwo sabo bifunctional, libhekene umphumela namagciwane evelele, futhi immunomodulating umphumela.

Isenzo interferon inducers kuholela zamagama amaprotheni, okuyinto emisebenzini yabo efana amaprotheni ukulungele e-ultraviolet. inqubo okunjalo ukulinganisela, ukulawula yayo izindlela ukuthi ukuvikela ngempumelelo umzimba kusuka kumiswa ngokweqile lezi zakhi.

Ukuze isicelo esisodwa amalungiselelo ngokuyenga interferon kuyinto kwegazi sasivumela isikhathi eside amaprotheni zokuzivikela kuyadingeka umthamo zokwelapha. Ukuze uthole umthamo anjalo esikhathini ukuqokwa amaprotheni exogenous kufanele ngokuphindaphindiwe yaphathwa omningi. Lokhu kwelashwa ubhekwa ezibizayo.

Uhlu izidakamizwa

Okwamanje, odokotela ziya ziba mandla ekusebenziseni interferon inducers - izidakamizwa okuyinto uhlu unyaka ngamunye ngokungeza imithi emisha. Inani elikhulu ejenti immunomodulating ikuvumela ukuba ukulwa nezifo eziningi.

Njengengxenye izivikeli mzimba yizici samanje ezisebenza oxhumene ngazo afeze ukuqedwa okungavamile umzimba imvelaphi compounds antigenic. element ngayinye has a ejenti ethize mzimba. Lokhu kuchaza ukuhlukahluka imikhiqizo neqhaza ekuthuthukiseni yamaprotheni zokuzivikela.

Kukhona inducers ahlukahlukene interferon (izidakamizwa), uhlu okuyinto iholwa izidakamizwa "Poludan". Leli thuluzi kubhekwa stimulator amaprotheni lokuqala zokuzivikela, okuyinto beqale ingasetshenziswa ngisho 70s. Kuhlanganisa poliuridinovaya futhi polyadenylic acid. ukusebenza yalo iwukuba ukuthuthukisa interferon encane. Eye amaconsi futhi imijovo zomuthi "Poludan" aphathe keratitis herpetic futhi keratokonyunktivity. Isixazululo izidakamizwa kwenza izicelo ekwelapheni herpes lezinkinobho futhi vulvovaginitis.

Interferon inducers - izidakamizwa "Aktaviron", "Lavomax", "Tilaksin" "dihydrochloride tilorona", "Amiksin", "Tiloram" - e isakhiwo babe esebenzayo isithako tilorona.

Izidakamizwa "Ridostin" futhi "sodium usawoti kabili balahleke ribonucleic acid" ekhiqizwa ne-sodium ribonukleat wenza izidakamizwa.

izidakamizwa umifenovir kufakwe "Arbidol" Imithi, "Arbivir", "Immustat" futhi "Arpeflyu".

Kukhona inducers futhi interferon, izidakamizwa elibizwa igama izinto asebenzayo. Lezi zihlanganisa "Kagocel" amaphilisi kanye "tilorona".

Isekelwe akridonatsetata meglumine ekhiqizwa imithi "Meglumine akridonatsetat" futhi "TSikloferon" kanye sodium oksodigidroakridinilatsetat elikhona izidakamizwa "Neovir".

Ukwakheka kusho "Jodantipyrin" kuhlanganisa 1-phenyl-2,3-dimethyl-4-yodpirazolon, futhi "Alpizarin" amaphilisi equkethwe magniferrina usawoti.

Inductors interferon izingane, incazelo yabo

Kukhona imithi eminingi omdala ukuthi kumele inikwe ingane, kodwa kuphela ube neminyaka ethile ubudala. Ngokwesibonelo, lesi sidakamizwa "TSikloferon 'aye aqale aphathe ngonyaka abaneminyaka ezine, futhi lisho" Ridostin "aqokwe yobudala eyisikhombisa. Bobabili izidakamizwa ezahlukene yemiphumela. Ziyakwazi efanelekayo ekwelapheni izifo zemigudu yokuphefumula nesifo bemvelo viral, umkhuhlane isimo, i-hepatitis okungamahlalakhona, isifo i-herpes. kusimo wabo okunokwenzeka engathandeki ohlangothini ukusabela.

Interferon inducers - ngamalungiselelo elakhelwe izingane ifomu wengane ethile. "Arbidol" Phakathi kwabo kukhona indlela. Isetshenziselwa nge umntwana eseneminyaka emibili. Izingane ifomu nomuthi enziwa ngendlela amaphilisi ngoba nokuphathwa kweBhange ngaphakathi. Ukulungiswa possesses imiphumela namagciwane futhi immunomodulatory.

Lihlobene ejenti elwa namagciwane ukuthi zivimbela igciwane cell B no-hlobo. With iqhaza lakhe yabangela ka interferon yangaphakathi, okuyinto evimbela contact kanye Ukungena ku ukutheleleka cell. Ngaphansi isenzo zokuzivikela lipid viral imvilophi amaprotheni akakwazi baxhumane ulwelwesi cell.

Interferon inducers izingane nomthelela okwandisa ukungatheleleki we humoral uhlobo nganoma isinyathelo umzimba wabo kuba livikela kakhulu izinto ezithwala izifo, inciphise inani ukuxakeka.

Izidakamizwa "Kagocel" kunomphumela ofanayo emzimbeni wengane. It ikhiqizwa ngesimo amaphilisi ukusebenza kwangaphakathi. Ubudala umkhawulo ukusetshenziswa kwezidakamizwa - ne eminyakeni emithathu.

Ukwelashwa nokuvikelwa nezifo zokuphefumula

Interferon inducers - izidakamizwa ukuze aphathe SARS, okuholela ekwakhekeni kumaseli umzimba iprotheni zokuzivikela. Babuye esimisiwe nokugula Umkhuhlane.

Izindlela ephumelela kunazo ezibhekwa nemithi tilorona based, ezihlanganisa amaphilisi "tilorona" futhi "Amiksin". Ukuze ukwelashwa Umkhuhlane ne-acute nezifo zokuphefumula viral kunconywa ukusebenzisa omdala ngaphakathi 125 mg ngesikhathi. Lokhu umthamo kwasakazwa ku ngezinsuku zokuqala ezimbili, bese 125 mg kuthathwe ngosuku olulodwa. Course inani nomuthi kuyinto 750mg.

Sokufeza izinyathelo zokuvimbela esetshenziswa 125 mg ngesikhathi ke izinsuku 6 off. Inkambo enjalo iyaphindwa mayelana emavikini ayisithupha.

based tilorona imithi contraindicated kokungabekezelelani ekhona umuntu, ngesikhathi sokukhulelwa futhi ngenkathi ukuncelisa ingane yakho.

Ukuthola imithi enjalo kungabangela ukucanuzelelwa inhliziyo, imfiva, ukusabela nomzimba.

Ukulungiselela "umifenovir" Umsebenzi interferon-ukuyenga, ukukhuthazwa yeselula uhlobo amasosha omzimba, ngcono ukuzinza wonke umzimba ukuze izinto ezithwala izifo.

Ukuze izinyathelo uma nabo abagulayo ebekiwe umthamo zonke izinsuku we mg 200 ngeviki elilodwa. Isikhathi sesizini Umkhuhlane nezifo zokuphefumula usebenzisa umthamo zonke izinsuku we mg 100 ngesikhathi, bese wenza ikhefu izinsuku ezimbili. Le course ihlala amasonto amathathu. Ukuze ekwelapheni imikhuhlane babelwe 200 mg kane ngosuku, izinsuku ezintathu.

Izidakamizwa nge umifenovir ayisetshenziswa kokungabekezelelani ekhona umuntu phakathi ezinzima zokugula ukuphathwa kwabathintwayo. Ukwamukelwa kwemithi enjalo kungaba baxabane nomzimba.

Ukwelashwa kwezifo sokuhlasela kwamasosha omzimba

Izifo ezihlala zihlanganisa uthi sokugembula lapho namasosha noma wande autoaggressive killer cell ukufaniswa ekuphenduleni inyama ephilile. Lokhu kuholela kulimaze nokubhujiswa izicubu onempilo, umphumela lapho yisishiso sokuhlasela kwamasosha omzimba.

Ngokuvamile esetshenziswa ekwelashweni kwe-interferon inducers. Ukwakhiwa yaphathwa izifo sokuhlasela kwamasosha omzimba, labo isenzo immunosuppressive.

Ukuze ekwelapheni amaningi sclerosis ukusetshenziswa kwezidakamizwa zihlakazeke 'Amiksin ". Ngesikhathi izimpawu kancane sibi zokuphefumula ukutheleleka semvelo, lokuyindlela eshubisa isimo umthamo ayabelwe 125 mg noma 250 mg zomuthi ngemva ukungenisa. Tablets baphuze ngosuku, isikhathi reception - 6 kuya 12 izinsuku.

Ngokuba nokuvimbela ehlakazekile sclerosis exacerbation inikezwa 125 mg zomuthi, izikhathi 2 per izinsuku ezingu-7.

Lapho eziyinkimbinkimbi yesigaba asebenzayo lesi sifo ukwelapha izimpawu ekhona imithi acute ezithathwe 10 kuya 125 mg zonke izinsuku ezingu-30 izinyanga ezingu-6. Ukulungiselela "Amiksin" inikezwa ne peptide bioregulators umphumela jikelele esehlisa ukuzwela omzimba anda myelin amaprotheni.

Kuhlanganiswe yokwelapha izidakamizwa "TSikloferon" ikuvumela ukuba ulwe jet abanesifo sokuqaqamba kwamalunga kanye samathambo izifo letindzala ezithinta ezicutshini. Umsebenzi wakhe kuhloswe ukucindezelwa izinqubo sokuhlasela kwamasosha omzimba, enikeza nomphumela eqeda ukuvuvukala kanye analgesic bemvelo. Ukusebenzisa izindlela ezilungisiwe isimo somzimba sokuzivikela ezifweni ngeziphambeko ahlukahlukene immunodeficient. "TSikloferon" Umuthi ikhiqizwa ifomu ithebhulethi, ngesimo isixazululo komjovo futhi liniment.

Ukuze nokwelashwa arthritis izidakamizwa iqondiswa ngemithambo yegazi noma intramuscularly 1 isikhathi ngosuku. Umthamo 250 mg usebenzisa lokuqala ngokusebenzisa Ngosuku lweshumi nambili ku ngisho izinsuku. In izifo sibi siyasebenza anda umthamo kokuqala mg 500.

Ukwelashwa of okunobuthi Izifo

Izidakamizwa "Amiksin" libhekisela interferonovym inductors fluoreonovogo ongaphakeme yamangqamuzana ekilasini isisindo. With iqhaza lakhe kwakhiwa zonke izinhlobo amaprotheni zokuzivikela, okuyinto ezingeni olulodwa ngemva kwesicelo se-nomuthi ifinyelela inani layo eliphezulu ukuwedlula wonke e-plasma.

Umuthi inebanga elikhulu isenzo elwa namagciwane. Ngaphezu nezifo zokuphefumula, isetshenziswa hepatitis C futhi oyingozi futhi ezingalapheki, yansukuzonke samabhamuza ezithweni zangasese, cytomegalovirus ukutheleleka chlamydial hlobo.

izidakamizwa abaningi namagciwane - inducers interferon, ayikho into okuthiwa ihlukile kuyindlela yokuthola "Neovir". With iqhaza lakhe, uveza semali amaprotheni zokuzivikela, ikakhulukazi fibroblast-hlobo, echaza le immunomodulatory, umphumela anti-viral anti-isimila yalesi izidakamizwa. Izidakamizwa "Neovir" uswidi encephalitis, isifo sokusha kwesibindi kohlobo C no-B, urethritis, cervicitis, salpingitis kubangelwa chlamydia.

Enye inducer efanayo wamaprotheni zokuzivikela kuyinto ongaphakeme yamangqamuzana isisindo izidakamizwa "TSikloferon", ezisetshenziswa for usawoti le karboksimetilenakridona zamagama methylglucamine. With iqhaza kwakhiwa yakhe-alpha interferon, okuqukethwe okuyinto lilondolozwe lymphoid izinsuku ezintathu.

B lymphocyte T ne-B-hlobo macrophage Ukwakheka kwezitho ngesikhwama esivikelayo amaprotheni kusebenze ebuchosheni stem izakhiwo ithambo, ukukhuthazwa ukukhiqizwa granulocyte amayunithi. Umuthi asetshenziswe ezithwalwa encephalitis, i-herpes, i-hepatitis, cytomegalovirus, human immunodeficiency virus futhi papillomas.

Ngaphezu kwalokho namagciwane ukuchayeka izindlela has umsebenzi e oyingozi futhi ezingalapheki chlamydia webhaktheriya, ukuvuvukala imvelo erysipilatous, ukucinana kwemigudu yokuphefumula, ukuxakeka nasezinkingeni ezilandela ngemva kokuhlinzwa, izifo genitourinary, izilonda emathunjini.

Kwakubonakala emakethe a ikhambi elenziwa "Lavomax" ezikhiqizwa "Nizhpharm" manje. It has umphumela immunomodulatory, uyakwazi ukuyenga interferon, umphumela namagciwane uhla enkulu.

Njengengxenye 'Lavomax "amaphilisi equkethwe 125 tilorona mg njengoba kwakwakhe esebenzayo. Umuthi kuyinto analogue zomuthi "Amiksin". umsebenzi wayo siqondiswe isizukulwane ukukhuthazwa ezintathu izinhlobo interferon-T lymphocyte, hepatocytes, amaseli EPITHELIAL odongeni emathunjini.

Ithonya immunomodulating imiphumela kungenxa ukubuyisela ibhalansi phakathi ukubulawa amasosha omzimba futhi ukuzinza zokukhiqiza omzimba. Ngesisekelo mshini umsebenzi elwa namagciwane iyona okusithiyayo wamaprotheni zamagama, amagciwane ikakhulukazi ezindaweni elinegciwane emzimbeni. Lokhu kwephula ukwanda kwabo okwengeziwe.

Zomkhuhlane izidakamizwa ngempumelelo aphathe isimo, isifo, nemvelo zokuphefumula, isifo sokusha kwesibindi kohlobo ezibangelwa amagciwane kanye herpes ngamawala.

Inductors isinyathelo esisheshayo

Ngokuvamile, ukwethulwa kwemithi enjalo kuholela ekuthuthukiseni okusheshayo kwiprotheni evikelayo.
Ama-inducers aphezulu kakhulu e-interferon engapheli amahora ambalwa okuhlala emzimbeni angabangela ukwakheka kwamaprotheni, okufakazela ukusebenza kwawo.

Isidakamizwa sikaTyloron ngemuva kwesicelo sangaphakathi sikhulisa ukuhlushwa kwamaprotheni kuze kube yizinga eliphakeme emva kwamahora angu-4. Kukhona ukwakheka okwesikhashana kwe-interferon kuqala emathunjini, bese kuba sesibindi, futhi ngosuku - egazini.

Isidakamizwa "I-Cycloferon" sidonsa amaprotheni emva kwamahora angu-4, kanti ukuphakama kuyabonakala emva kwamahora angu-8, emva kwalokho ukuhlushwa kwehlisa kancane kancane.