Isidakamizwa esithi "Revmoxicam": imiyalelo yokusetshenziswa (imijovo, amaphilisi namakhandlela). Ama-analogues nezibuyekezo mayelana nomuthi

Ukwelashwa kwezifo zesimiso se-musculoskeletal, ukususwa kobuhlungu nokuvuvukala kwamalunga nama-muscle kungenzeka ngenxa yezidakamizwa ezingezona ukuvuvukala, okungenazo izidakamizwa "I-Revmoxicam." Imfundo yalo mmele ihlanganisa incazelo yokwakheka kwazo zonke izinhlobo zama-dosage, izici ze-pharmacodynamic, izinkomba kanye nolwazi mayelana nezici zokusetshenziswa.

Incazelo yokulungiselela

Isithako esikhulu esisebenzayo salesi sidakamizwa singumuthi we-meloxicam eqenjini le-oxicam, isisekelo salo i-enol acid. Lesi sidakamizwa sinomphumela wokukhetha ngokumelene nabaxhumanisi ngenqubo yokuvuvukala, ebalulekile ekuvikeleni izitho zokugaya ezivela ezinkambweni ezingafuneki.

Esifundisweni semithi ethi "Revmoxicam" yokusetshenziswa sichaza amafomu amaningana wokulinganisa okuvumela ukuba ukhethe indlela efanele yokwelapha, ucabangela izici zomzimba nezifo ezihlobene.

Ukuze kusetshenziswe ngomlomo, ifomu lethebulethi elinesilinganiso se-meloxicam kwelinye ithebhulethi ka-7.5 noma engu-15 mg kufanelekile. Amaphilisi e-dose ephakeme asemngciphekweni wokuphuza isigamu, okukuvumela ukuba ulungise ukutholakala kwemithi uma kungekho amaphilisi omthamo ophansi. Le fomu ifomu kufanelekile yokwelashwa kwesikhashana.

Ifomu lokufakelwa yisisombululo se-1% sezinto ezisebenzayo, okukhishwa ngo-1.5 ml ku-ampoules "Revmoxicam". Imiyalelo ngezinga kanye nesivinini senzalo ibeka indawo yokuqala, okufanele ifakwe ekucabangeni uma ukhetha ifomu lokulinganisa.

Ukuze kusetshenziswe ama-rectal, i-suppositories ene-doloxicam 0.015 g isetshenzisiwe. Isisekelo samakhandlela amafutha ezilwane, lapho into esebenzayo isatshalaliswa ngendlela efanayo.

Indlela umuthi usebenza ngayo

Isenzo sokulwa nokuvuvukala, isifo se-analgesic ne-antipyretic sesidakamizwa esithi "Revmoxicam" sisekelwe emandleni okusebenza okunciphisa izinqubo ezihambisana nokuhlanganiswa kwezidakamizwa ze-prostaglandin. Yilezi zinhlanganisela ezihlanganisa izinqubo zokuvuvukala.

Isiqondiso semithi "Revmoxicam" sokusetshenziswa sisichaza njengesidakamizwa esivikelekile kuqhathaniswa nezinye izidakamizwa eziphikisana nezidakamizwa. Lokhu kungenxa yokunciphisa ukuphela kwe-enzyme cyclooxygenase type 2, okuholela ekukhiqizweni okunciphise kwe-prostaglandin kanye ne-prostacyclin izinto eziphethwe ukuvuvukala. Isidakamizwa sinomthelela omncane ohlobo lwe-cyclooxygenase, yingakho i-prostaglandins ye-gastroprotective ne-thromboxanes ikhiqizwa ngesilinganiso esifanele futhi isebenza njengendlela yokuzivikela kwesimiso sokugaya ukudla ekuthuthukiseni ukusabela okungathandeki.

Isithako esisebenzayo sokulungiselela "i-Revmoxicam" (ama-ampoules) ichaza imilayezo yesicelo njengengxenye engaphazamisi amangqamuzana wezicubu zomzimba futhi ayivimbeli ukukhiqizwa kwama-proteoglycans, okubonwa uma kuphathwa ngayo, isibonelo, i-indomethacin.

Imithi ayishintshi i-platelet aggregation kanye nobude bokuphuma kwegazi, njengoba kwenzeka ngesenzo se-diclofenac ne-ibuprofen.

Ama-analogues

Emakethe yezokwelapha, kunezinhlobo eziningi zemithi eguquguqukayo, efana nomphumela kanye nokwakheka kumuthi "Revmoxicam". Ukufundiswa kwama-analogues kubhekwa njengama-synonyms, aphinde akhiqizwe ngendlela yokulungiselela isiJalimane sokuqala i- "Movalis" yenkampani ethi "Boehringer Ingelheim" ngendlela ethile yokulinganisa.

Izinhlobonhlobo zemithi ezisekelwe ku-meloxicam zenza ukuba iziguli ziphathwe njenge-European (Meloksikam-Teva, Mirlox, Meloks), kanye nemithi yasekhaya ehlukahluka kakhulu emanani. Phakathi kwemithi ejwayelekile yokukhiqizwa kweRussia, kukhona "Movasin", "Lem", "Meloksikam", "Arthrozam", "Ameloteks."

Izinhlobo ezihlukahlukene zezidakamizwa-izilinganiso zezitshalo ezihlukahlukene zokukhiqiza zikhuluma ngokusetshenziswa okukhulu kwemithi esekelwe ku-meloxicam.

Kungani usebenzise

Ukuze kulungiselelwe imiyalo "Revmoxicam" yokusetshenziswa kwamagciwane, amaphilisi kanye ne-suppository kunconywa ukwelashwa kwezinhlungu, ukuvutha nokucubungula izinhlelo ohlelweni lwesishukela, njenge-arthrosis, i-arthritis ye-rheumatoid, i-osteoarthritis, i-anondlosid spondylitis.

Ngokomsebenzi wesenzo, le-ejenti kufanelekile ukuphatha izinqubo ezihlukahlukene zokuvuvukala emzimbeni womuntu. Akuzona zonke izinkomba ezikhona ezifaka imithi "Revmoxicam" (amakhandlela) imfundo. Ezinsini zokubeletha umuthi usetshenziselwa kakhulu ukwelashwa kwezinqubo zokuvuvukala kwezitho zangasese zomzimba, isibonelo, ama-ovaries. Noma kunjalo, ukuqokwa okunjalo kungenziwa kuphela odokotela ozofika, ozobe esungula ukukala nokuthatha isikhathi sokwelashwa.

Ukusebenzisa amaphilisi

Isidakamizwa efomu elibhekiwe sihloselwe ukuphathwa ngomlomo. Ukwamukelwa kwe-meloxicam kusuka ohlelweni lokugaya ukudla kwenzeka ngokushesha futhi kungu-90%. Ukudla akuthinti ukungena kwe-meloxicam ngokusebenzisa i-mucosa yamathumbu.

Thatha imithi "Revmoxicam" (amaphilisi), imfundo iyala kanye nokudla ukunciphisa ingozi yokuthuthukisa ukusabela okungadingeki ohlelweni lokugaya. Ithebhulethi kufanele igonywe ngokuphelele, ungayiphuli noma uyiqede, vele uphuze amanzi amaningi. Isikhathi sokwelapha kanye nesilinganiso somuthi kuxhomeke ekuqotheni kwesifo futhi kunqunywa udokotela oya khona.

Ukwelashwa kwe-osteoarthritis kubantu abadala kanye nezinsana ezineminyaka engu-15 ubudala kuyenzeka ngomthamo wansuku zonke we-7.5 mg. Uma kunesidingo, udokotela angakwazi ukuphindaphinda umthamo wansuku zonke.

Ukwelapha isifo samathambo esifubeni kanye ne-anondlosing spondylitis kubantu abadala nabasakhulayo kusukela eminyakeni engu-15 kwenziwa nge-dose yansuku zonke ye-15 mg. Isilinganiso sincishisiwe sibe ngu-7.5 mg kuphela ngemva kokuthola amadokhumenti amahle avela emithwalweni ephezulu ye-dose.
Uma kukhona okudingekayo ekuthuthukiseni ukusabela okungalungile, iziguli zibekiwe ukuba zithathe izidakamizwa ezingeni eliphansi kunazo zonke ezingaba ngu-7.5 mg.

Ukusetshenziswa kwamagciwane

Ukuze wenze isinyathelo esisheshayo, isidakamizwa esithi "Revmoxicam" (imijovo) sisetshenzisiwe, imiyalelo yokusetshenziswa ichaza umjovo wesibeletho somzimba wesizalo. Lolu hlelo luboniswa kubantu abanezifo zendlela yokugaya ukudla. Lokhu kungenxa yokuthi isisu noma amathumbu akonakaliswe amaphilisi omuthi "Revmoxicam". Imiyalo yokusetshenziswa kwe-shots iseluleka ukungena endaweni ye-quadrant yangaphandle yamazinyo, ejulile ngaphakathi kumisipha.

Isikhathi sokwelapha kanye nesilinganiso semithi kuncike ebuchosheni besifo futhi kunqunywa udokotela oya khona.

Kubantu abadala kanye nezinsana ezisukela eminyakeni engu-15 ubudala zibeka umthamo we-drug "Revmoxicam" imfundo yokusetshenziswa, imijovo yenziwa kanye ngosuku. Ngokuvamile, kusuka ku-0.75 kuya ku-1.5 ml yesisombululo se-meloxicam. Isidakamizwa esithi "Revmoxicam" ngesimo somjovo singasetshenziswa isikhathi esingaphezu kwezinsuku ezingu-5, bese ushintshela emafomu ethebulethi ale mithi.

Ngemuva kokuphathwa kwezidakamizwa, isisetshenziswa sayo esisebenzayo sithatha i-100% ohlelweni lwegazi oluhle, olubonisa ukutholakala kwezinto eziphezulu.

Akuzona zonke iziguli ezivunyelwe ukuphakanyiswa kwezidakamizwa "Revmoxicam", imfundo yokusetshenziswa kwezijovo kubantu abanesifo sokuqhaqhazela nokuqeda amandla, itusa ukuqhuba nge-7.5 mg meloxicam. Ngesikhathi esifanayo, izinkomba zalezi zitho kufanele zihlolwe ukuze kuvikelwe ukuwohloka kwesimo.

Uma usebenzisa izinhlobo eziningana zezidakamizwa "i-Revmoxicam" ngesikhathi esifanayo, kunconywa ukuhlanganisa amajojo, amaphilisi noma i-suppository ukuze umthamo onconywa ukuba ungenwa nsuku zonke awuphezulu kakhulu.

Imiyalo yokusetshenziswa kwamakhandlela

Imithi ingasetshenziselwa ngokuqondile ngokufaka injini ye-suppository engxenyeni ye-rectum yokumuncwa okuqhubekayo kwezinto ezisebenzayo ngemithambo yegazi ku-rectum nokuqhubeka kokungena kwe-meloxicam egazini legazi.

Ukuze kusetshenziswe le nqubo, udinga ukulungiselela ngaphambi kokuphatha ukuhlanzeka. Amakhandlela ethi "Revmoxicam" okusetshenziselwa ukusetshenziswa uncoma ukukhipha futhi ukujova ngezandla ezihlanjululwe kahle, ukuze ungagciwane ukutheleleka embhalweni wesilwane.

Amakhandlela alokhu kulungiselelwa akhiwa ngamafutha aqinile, asheshe acibilike ezandleni, ngakho-ke ukungeniswa kwe-suppository ngemuva kokuvula iphakheji eliyinhloko kufanele kube ngokushesha. Isikhathi sokusetshenziswa nomthamo kuxhomeke kuhlobo lwesifo kanye nesilinganiso sokuqina, kodwa kunoma yikuphi konke yonke imiyalelo inqunywe udokotela.

Ukusetshenziswa okunembile kwe-meloxicam kuvumela ukuba ixhumane kahle ne-systemic bloodstream, nge-biovailability of about 90%. Okuqukethwe okusimama okwelapha eplasma yegazi kwenzeka ngemuva kwezinsuku ezingu-5 kusukela ekuqaleni kokulashwa.

Kubantu abadala nabantu abasha kusukela eminyakeni engu-15 yekhandlela elithi "Revmoxicam", imiyalo yokusetshenziswa imisela ukusebenzisa okungaphezu kwe-1 suppository kanye ngosuku.
Isilinganiso esiphezulu se-meloxicam ngosuku kufanele sibe ngu-15 mg, okuhambisana ne-suppository engu-1.

Ngokwemiyalelo yokusetshenziswa, ukuphathwa kwe-rectal kwesidakamizwa kungabi ngaphezu kweviki, futhi ukuze ukwelashwa okunye kufanele kudluliselwe ekusetshenzisweni kwamafomu okubhekwa kwemithi "Revmoxicam."

Uma ungakwazi ukusebenzisa lesi sidakamizwa

Akunakwenzeka njalo ukusebenzisa imithi "i-Revmoxicam", imfundo yokusetshenziswa ihlanganisa uhlu lwezingqinamba, lapho le mithi ingasetshenziswanga khona.

1. Njengoba ukwandiswa komuntu ngamunye ku-oxycam nezinye izidakamizwa ezingezona ukuvuvukala okungezona-steroidal, le mithi ikhanseliwe.
2. Ungasebenzisi ifomu lamathebulethi ezigulini ezibhekene nokungenwa kahle kwe-glucose ne-galactose, ngezibonakaliso zokuntuleka kwe-lactase nokungahambisani nomuntu ngamunye kumamolekli we-galactose.
3. Ukwelashwa ngezidakamizwa kuphikisana nabantu abanezifo zesilonda esiswini esiswini nase-duodenum, abanezifo zesibindi, abanesifo senhliziyo kanye nokuhluleka kwezinso ngesimo esibi, kubantu abathola umthambo we-coronary bypass ukuhlanganiswa.
4. Ungasebenzisi lesi sidakamizwa ezigulini ezisengozini enkulu yokugaya igazi, ikakhulukazi uma kune-cerebrovascular noma i-bleeding manifest in the gastrointestinal bleeding.
5. Isidakamizwa esithi "Revmoxicam" ngesimo samakhandlela asisetshenzisiwe ezigulini ezinezifo ezinama-rectum zemvelaphi ehlukahlukene. I-Contraindication nayo inqubo yokuvuvukala ye-rectum.
6. Abesifazane abakhulelwe nabancelisayo, izingane ezingaphansi kweminyaka engu-15 ubudala, lo muthi awunqunyelwe ngenxa yomphumela wayo onobuthi emzimbeni okhulayo.
7. Isidakamizwa esithi "Revmoxicam", umjovo, umyalelo uvimbela ukusetshenziswa komjovo othomathile, owamukelekayo kuphela we-intramuscular in muscle gluteal.

Ngokuqapha ukubeka izidakamizwa ezigulini ezine-asthma, i-cirrhosis, ukuphela kwamanzi, ukugula kwamanzi, uhlelo lwe-urinary, ukwehluleka kwenhliziyo, ukunciphisa ukugeleza kwegazi.

Iziguli ezigugile, abantu abanomzimba obuthakathaka noma abakwelapha i-anticoagulant kufanele bathathe le mithi ngaphansi kokuqondiswa udokotela.

Ukunakekelwa okukhethekile kudinga ukwelashwa kwabantu abadakamizwa abaye babe nesilonda se-peptic esiswini nase-duodenum nezinye izifo zesigamu sokugaya esikhathini esidlule.

Ukuhlanganiswa neminye imithi

Ukuhlanganiswa ngezidakamizwa ngezidakamizwa kanye nomuthi "Revmoxicam" kungakwazi ukuthuthukisa noma ukunciphisa ukusebenza kwabo, kubangele ukusabela okungadingeki.

• Ukusetshenziswa okuhlangene kwemithi ye-meloxicam kanye ne-non-narcotic analgesic kuholela engozini yokwanda yezilonda emlonyeni wamangqamuzana wezitho zokugaya noma ngisho nokuphuma kwegazi.
• Akunconywa ukuhlanganisa ukulungiselela "i-Revmoxicam" ngemithi ye-anticoagulant kanye ne-thrombolytic enikeza i-antiaggregation yamaseli egazi.
• Ukwamukelwa ngesikhathi esisodwa kwe-meloxicam kanye ne-diuretics ngokumelene nesimo sokuphela kwamanzi emzimbeni kungabangela ukuhluleka okukhulu koqhwala kubantu abanjalo. Uma kuvela ekwamukelweni akunakwenzeka ukwenqaba, ukuqapha okuqhubekayo kwezinso zezinso kuyadingeka .
• Isicelo esisodwa singabangela ukwehla komthelela wokwelapha we-intrauterine contraceptive, beta-blockers, i-vasodilating, izidakamizwa zokudla kanye nemithi ehilelekile ekuvimbeleni i-enzyme yokuguqula i-angiotensin.
• Ngokuhlanganiswa ne-methotrexate, umuthi "i-Revmoxicam" uyakwazi ukwandisa umthelela onobuthi kumaseli egazi, futhi ukuphathwa ngesikhathi esisodwa nge-cyclosporine kuholela emthelela omubi emsebenzini wezinso. Uma kunesidingo sokuba inhlanganisela enjalo, ukuqapha ngezikhathi ezithile isimo segazi eduze komsebenzi wokusebenza kanye nezinso kuyadingeka.
• Isenzo sesidakamizwa senzelwe ukwandisa izingxube ze-lithium ions e-plasma yegazi. Ukuhlanganiswa kwe-colestyramine nokulungiselela "i-Revmoxicam" kuholela ekunciphiseni esikhathini sokuqedwa kwezinto ezisebenzayo.
• Isenzo salesi sidakamizwa esingavimba ukuvuvukala sihloswe ekushintsheni ukusebenza emsebenzini wezidakamizwa ze-hypoglycemic, okufaka phakathi nalawo aqukethe i-insulin. Kulezi ziguli ezinezinga eliphezulu likashukela egazini, ukuthatha isidakamizwa esithi "Revmoxicam" kudinga ukulawula okuqukethwe kweglucose egazini legazi ukuze kulawulwe umthamo wemithi ye-hypoglycemic.

Ukubuyekeza mayelana nomuthi

Njengoba kubonakala, ububanzi bezidakamizwa "i-Revmoxicam" buhlukile, imiyalelo ayichazi imiyalo, kodwa ichaza yonke imiphumela engathandeki ekusetshenzisweni kwalolu remedy, konke ukuphikisana nokusebenzisana. Ukwaziswa okunjalo akusho ukuthi zonke izinkinga ezimbi kufanele zenzeke ngemuva kokuthatha imithi esekelwe ku-meloxicam. Ukwelashwa kungenziwa ngaphandle kwemiphumela engathandekayo emzimbeni, futhi umphumela wokwelashwa uzobonakala. Umzimba ngamunye ungumuntu ngamunye futhi uphendula ngokuhlukile ngezinto ezihlukile.

Njengoba sekuphawuliwe, akuzona zonke izinkomba zokusetshenziswa ezichazwe emiyalweni, kodwa kuphela lezo eziphathelene nokwelashwa okungavamile kwesistimu ye-musculoskelet.

Ukuba yisidakamizwa esiphikisayo, isidakamizwa esithi "Revmoxicam" sitholile uhlelo olubanzi lokuphathwa kweziphuzo, njengengxenye yokwelashwa okuyinkimbinkimbi yokuvuvukala ku-prostatitis engapheli, izinqubo zokuvuvukala endaweni yokubeletha.

Ukuze ususe masinyane isifo sobuhlungu, ngincoma ukujova imijovo nge-"Revmoxicam" ukulungiselela. Amazwana mayelana nokusebenza kwalezi zijovo zizwakala kahle.

Esinye isiguli cishe sishesha ngokushesha, ubuhlungu buyaqhubeka, omunye umuthi awuhambisani, futhi udinga ukufuna indawo.

Ukuze kusetshenziswe izimo zesifo sofuba, amaphilisi e-meloxicam asetshenziswa, okungathathwa isikhathi eside, kepha ukwelashwa okunjalo kungabangela ukuphazamiseka kokugaya abantu abaningi, okudinga ukuhoxiswa kwemithi.

Kukhona ukubuyekezwa okuhle kokwelashwa okuhlangene kwe-adnexitis, uma kuhlanganiswa nezidakamizwa ezivimbela ukuvuvukala, isilondolozi se-"Revmoxicam" sisetshenziswa.