"Nebilong": yokusetshenziswa. "Nebilong": ukubuyekezwa kanye analogue

"Nebilong" kuyinto izidakamizwa ngempumelelo ekwelapheni izifo ezihambisana ne kahle inhliziyo umsebenzi. Ubungcono do emva uyisebenzisa inyanga eyodwa. Ngemuva kwesicelo "Nebilonga" ishayela kwesejwayelekile wegazi lazo wawungcono, ukuphumula semithambo kufinyelelwe, myocardium ihlinzekwa-mpilo okwanele. Cishe kuzo zonke izimo yalokho omuhle yokwelapha lugcinwa isikhathi eside.

Ukwakheka, Ukwakheka

Umuthi itholakala amaphilisi. ithebhulethi ngamunye ingaqukatha 2.5, 5 noma 10 mg isithako esisebenzayo. Umuthi senziwa ngesisekelo nebivolol hydrochloride. Kulaba excipients ekhona ukubunjwa povidone, i-lactose, magnesium stearate. Ukwakheka kulekelelwa talc, microcrystalline cellulose, sodium dioctyl sulfate, colloidal Silicon dioxide, i-sodium croscarmellose, Beta-cyclodextrin.

imiphumela kwemithi

"Nebilong" imfundo manual ekhombisa njengendlela yokuthola kokuba e oyiyo enantiomers ezimbili (L- kanye D-nebivolol). D-nebivolol - abakhethayo kakhulu, ukuncintisana β1-adrenoceptor blocker, L-nebivolol emnene imithambo yegazi, yandisa kubo, okuyinto ngenxa inchubo endothelium semithambo (Ukukhululwa vasodilating ukushintshashintsha kwezwi isici).

Nebivolol kunciphisa umfutho wegazi nokushaya kwenhliziyo, umphumela lilondolozwe hhayi kuphela isimo quiescent kodwa ingaphansi komthwalo. Emva kokuthatha umuthi nxazonke kanye kwesokunxele ventricular izingcindezi ekupheleni-diastolic ziyancipha, kukhona nethonya elihle omunye nemisebenzi eyenziwa inhliziyo - diastolic. Ngenxa isicelo "Nebilonga" ejection ingxenyenamba ukwanda, abantu IBS imakwe umphumela antianginal.

isinyathelo Hypotensive amaphilisi athathwa "Nebilong" Umhlahlandlela kuchaza ukwehla umsebenzi ohlelweni renin-angiotensin. isinyathelo Antiarrhythmic ibangelwa ukunciphisa AV-conduction futhi ucindezele normal automaticity inhliziyo. Ngasekelwa umphumela hypotensive kwenzeka ezinsukwini ezingu-7-14 yokwelashwa, ngokuvamile - ngenyanga. yi Esitebeleni ekuthatheni amaphilisi waphawula ngemva amabili nezinyanga zokwelashwa.

Pharmacokinetics

Umuthi udle, ugxile kahle, le nqubo kuphumelele ngokufanayo kungakhathaliseki ukudla. Umzimba esibindini abuye acedzele kumiswa gidroksimetabolitov asebenzayo. I bioavailability isilinganiso emva isicelo yangaphakathi umuntu nomuthi nge umzimba okusheshayo 12%, lesi sibalo kuphakame kakhulu kunalokho nge umzimba kancane. Njengoba umzimba iziguli singenzeka ngamazinga angefani, "Nebilong" manual Kunconywa ukusetshenziswa izici ngazinye umzimba wesiguli. With umzimba kancane asetshenziswa ngemithamo ongaphakeme zomuthi. Ngo izifundo nge exchange okusheshayo izinto senzeka isigamu-ukuphila cishe amahora angu-10, ezigulini abe umzimba kancane, isigamu-nokuphila kukhuphuke ngo izikhathi 3-5. Ngemva kwezinsuku eziyisikhombisa okwelashwa, mayelana 38% wathola izidakamizwa excreted ngu izinso, mayelana 48% "Nebilonga" elikhona kwesihlalo. Ukwakheka umchamo uba esincane imithi ingashintshiwe - kuze kufinyelele 0.5%.

ubufakazi

On isicelo "Nebilong" imfundo ingasetshenziswa ophakeme wegazi, ngokuba ukuqaliswa izinyathelo in iziguli CAD (neziqubu angina) kanye nokusetshenziswa kwe-therapy eziyinkimbinkimbi yinhliziyo yefomu ezingamahlalakhona.

Ukwelashwa nge izidakamizwa "Nebilong"

nomfutho wegazi ophezulu

iziguli Adult iqondiswa 5 mg "Nebilonga", elihambisana ekwakhiweni ithebhulethi iyona umthamo wansuku zonke. Umuthi Kunconywa ukuba asebenzise nsuku zonke ngesikhathi esifanayo. A nomphumela elincane lubonakale emva amaviki amabili okwelashwa, buphawuleka kakhulu, he is a yanga ukwelashwa wenziwa. Tablets efanelekayo ukuqaliswa monotherapy futhi ngelashwa ukusetshenziswa okudidiyelwe izidakamizwa, nakho nemiphumela hypotensive. Abantu abathatha "Nebilong AM", ukulaya Kunconywa ukuze bathole umphumela eyengeziwe ukuze usebenzise "Hydrochlorothiazide" ka 12.5-25 mg. Ukuphathwa kanjalo kuhlanganiswe kungayandisa isenzo "Nebilonga", kodwa kungenziwa kuphela ngemuva kokuthola iseluleko udokotela ukuba khona.

ukuhluleka Ngenhliziyo ifomu okungamahlalakhona

Okokuqala umthamo elincane nomuthi, udokotela kancane kancane kwandisa, banikezwe izici nesineke. Ukuze ekwelapheni amafomu okukhulu "Nebilong" akulungile, nangaphansi kwezimo ezinjalo, abanye izidakamizwa ziye zasetshenziswa. Ngokuvamile kuqala elibekelwe 1.25 mg izidakamizwa ukusetshenziswa kanye nsuku zonke, futhi ngemva kwamasonto 1-2 umthamo kungase kukhule ku 5 mg, futhi kamuva - abafika kwabangu-10 mg. I umthamo wansuku zonke kumele singeqi 10 mg nomuthi "Nebilong". Yokusetshenziswa ebonisa ukuthi lapho besanda kuqala yokwelapha isiguli ishiywa ngaphansi observation amahora amabili ngemuva ukungenisa ithebhulethi, wenze ngalinye okwandisa umthamo izindlela. umthamo Ukwandiswa zingancishiswa futhi uma isidingo sikhona.

Uma izimpawu yinhliziyo uvele ngaphezulu ukungabekezelelani evelele noma isiguli izingxenye izidakamizwa watholakala, ukunciphisa umthamo izidakamizwa noma ukukhiqiza ukuqedwa yayo. Ngokuvamile, ukuhluleka kwenhliziyo, ifomu njalo "Nebilongom" iphathwa ngokushesha. Lapho ukwelashwa okuhloswe ngalo ukuqeda kwezimo ezinjalo, ukuqedwa zomuthi ukuba kancane, awukwazi ukwenza lokhu ngqo, ngoba kungenzeka inkinga zaba zimbi. Uma ukhansela izidakamizwa isonto ngalinye kungehlisa izinga umthamo ngesigamu. Ngokuthatha amaphilisi "Nebilong AM" imfundo manual sihlinzekela kwezithibelo ezithile.

imikhawulo:

• esingamahlalakhona kwezinso. Okokuqala, i-therapy usebenzisa 2.5 mg zomuthi ngosuku, umthamo kungenziwa lenyuke kamuva, kodwa kumele singeqi 5 mg.
• yobudala Abadala. Umthamo kokuqala singadluli 2.5 mg uma kunesidingo, kuvuselwa 5 mg. Ngemva kweminyaka engu-65, zidinga ukuhlolwa njalo we nezinso (eyodwa njalo ngemva kwezinyanga ezine kuya kweziyisihlanu).
• Ukukhulelwa. Usana angagcina ezinye izifo, lokhu kuhlanganisa ukukhubazeka zokuphefumula, kahle kungakhuphula izinga likashukela, hypotension, bradycardia, abesifazane abakhulelwe ngakho izidakamizwa ezinqunyiwe kakhulu kuyaqabukela. Uma umuntu wesifazane okhulelwe isebenzisa "Nebilong" yokukhansela yakhe liyadingeka amahora 48-72 ngaphambi kokubeletha. Uma lokhu kungeke kwenzeke, usana kufanele libukwe amahora 48-72.

Izimo

"Nebilong H" imfundo manual sivimbela ukusetshenziswa kulezi zimo ezilandelayo:

• ubudala esingaphansi iminyaka engu-18;
• hypersensitivity kuya izingxenye izidakamizwa;
• bronchospasm, isifuba somoya (umlando);
• pheochromocytoma, okuyinto engakaze zelashwe ngaphambi kokuba;
• lactic umzimba;
• kanzima okwenzeka isifo sesibindi, yokwehluleka kwesibindi ukusebenza;
• hypotension e ngabanye ukucindezela 90 mm HG noma ngaphansi kabani systolic. Article.
• AV-block (grade mina, III), bradycardia, okuyinto kuhambisana kwenhliziyo elihambisana 60 bpm. ngomzuzu;
• ngesikhathi abantwana, ibele;
• ukwehluleka oyingozi inhliziyo ukuma;
• izinkinga nge kwegazi neuropathy, ngokuzwakala ezicacile;
• ukushaqeka cardiogenic, isimo lapho kubalulekile ukusebenzisa izidakamizwa isotropic;
• ngalesi sifo, itheku ogulayo ephelezelwa.

ngokuqapha liyadingeka uma kuqokwa izidakamizwa iziguli izimo:

• sikashukela;
• psoriasis (umlando);
• Prinzmetal angina.

side effects

Ekwelapheni kusho "Nebilong" imfundo manual, ukubuyekezwa uthi ematfuba okuvela ethile emibi, okuyinto ziyabonakala umsebenzi we zenhliziyo, wokugaya ukudla bese izinhlelo sezinzwa. Phakathi kwezinye ukwephulwa - bronchoconstriction ukuphendula ezithinta isimo isikhumba.

Izixwayiso

"Nebilong" kungase kuzenze zibe namandla luvelo izinto ezixabana nomzimba, okuyinto okusongelayo ukuthuthukiswa wokusabela ezinzima anaphylactic.

ukwelashwa izidakamizwa akuphazamisi ezingeni glucose emzimbeni ebukhoneni sikashukela, kodwa zonke iziguli leli qembu babe ukusebenzisa imithi ngokuqapha. Njengoba sikashukela futhi i-hyperthyroidism izidakamizwa kungase kufihle izimpawu of tachycardia, kuba evelele ngenxa ukudamba ngokushesha ezibhebheni.

Uma iziguli ezinezinkinga e umgudu wokuphefumula isetshenziswa "Nebilong" imfundo manual yazisa nge ematfuba inzuzo constriction we yomoya e COPD. The kungenzeka ngokuhlanganisa izidakamizwa nezinye izidakamizwa kumele ihlolwe nodokotela wakho.

"Nebilong" kuthinta ikhono ukushayela imoto, kungaholela ukukhathala nesiyezi.

analogs

Kungenzeka okunye esikhundleni kwezidakamizwa ayikuvumeli ukusetshenziswa kwezidakamizwa "Nebilong" imfundo manual. Izidakamizwa analogue zihlanganisa "Nebilet", "Binelol". Ngu esikhundleni futhi zihlanganisa "Nebikor" futhi "Nebivator".

Izibuyekezo

Njengoba nokubuyekezwa, umuthi ngempumelelo uma isetshenziswe ngendlela efanele. Kubalulekile ukusebenzisa imithi bese ulandela izincomo zonke kadokotela. I nomuthi inikezwa ne contraindications izici nesineke, okuholela nomphumela omuhle. lokho ukwelashwa hhayi kungaholela ekwakhiweni yemiphumela emibi, udinga sihlale njalo siqaphele ngezimo zesiguli.