"Teopeka" (300 mg): yokusetshenziswa, izinkomba, umkhiqizi

Abantu somoya, uyazi ukuthi isikhathi kubaluleke kangakanani ukusiza nge bronchospasm. Ngezinye izikhathi isenzo efanele kulesi simo esinzima kungasindisa ukuphila. A indima ebalulekile ekutholeni abantu abavela nezinkinga emaphashini ukudlala bronchodilators.

Incazelo ukulungiselela

"Teopeka" (300 mg), yokusetshenziswa olubonakaliswa kule iphepha kuyinto amaphilisi ezimhlophe ploskotsilindricheskoy ukuma isiyingi, okuyinto Agcwele emasakeni nentaba. The main isithako zomuthi kuyinto theophylline. okuhlushwa yayo iphilisi elilodwa ekulungisweni le fomu 300 mg.

Lokhu kuhlangana kanjani imithi?

Ngu wesenzo kwemithi ye theophylline, okuyinto esuselwe purine, kuba nethonya ezivimbela phezu phosphodiesterase. Isithako asebenzayo amabhlogo izidakamizwa ethize purine receptor, kuvusa ekamu sokuzuza izicubu emadepho, kwehlisa ikhono bushelelezi kwemisipha izicubu ungenwa, kuncishiswe inani khulula calcium ion, okuyinto uthuthe ngokusebenzisa cell ulwelwesi.

Make liphinyiselwe vasodilating umphumela reception "teopeka" ukulungiselela (300 mg). Yokusetshenziswa uchaza impahla njengoba nethonya imithambo yegazi neuropathy. Theophylline kwandisa ukugeleza kwegazi ngohlelo kwezinso, ikhuthaza ukuphumula bronchial bushelelezi muscle igazi emithanjeni yakhe. Futhi, ngenxa yesenzo ingxenye esebenzayo libhekene njengoba nomuthi wokwandisa umchamo. Theophylline kuvimbela ukukhululwa kwe izinto ngaphandle nangaphakathi, ingqondo impendulo iguliswa kanye kwandisa ukuzinza insika cell ulwelwesi. Uma hypokalemia nesineke izidakamizwa esebenzayo iyanda ukupholisa.

Theophylline kusiza kujwayeleke ukusebenza zokuphefumula, isebenze isikhungo okuhambisanayo ubuchopho, kuphumele kangcono igazi elingenawo umoya ukugcwaliswa, ke kunciphisa lokuhlushwa-carbon dioxide. Izidakamizwa "teopeka" ekhuthaza diaphragm, wabangela ukuba usike. Iphinde kukhulisa inani lo inkomba mucociliary imvume umsebenzi iyanda imisipha zokuphefumula futhi intercostal.

Theophylline kuholela mikrotsirkullyatsiyu evamile igazi kunciphisa thrombus ekwakhekeni, isici suppresses ethize futhi aqede aggregation platelet amaseli. izidakamizwa futhi kuthuthukisa ukugeleza izinga igazi, kwandisa ukumelana deforming erythrocyte izici.

"Teopeka" (300 mg), ngaleyo ndlela kuncishiswe ingcindezi Imininingwane ku yokujikeleza kwegazi eliya emaphashini, futhi kunciphisa ukumelana kule yamaphaphu isimiso semithambo yegazi. Ngenxa yalokho, ithoni integuments isikhumba, izinso kanye nobuchopho incipha. Ngenxa yalokho ekutholeni theophylline imakwe ukukhuthazwa yenhliziyo ukugeleza kwegazi, bandisa inkonzo inhliziyo, ukwanda lamaseli esivimba amanzi emangalisa budinga nomoya-mpilo, ophilisayo ishayela, ngamandla Kufinyeta inhliziyo anda.

Pharmacokinetics futhi pharmacodynamics zomuthi

Emva isiguli wathatha iphilisi ne theophylline, izidakamizwa is egxile ngokuphelele kusukela pheshana emathunjini. Ukudla neziphuzo kuyalithinta ngesilinganiso ukumuncwa zomuthi, kodwa degree of ukumuncwa futhi imvume uhlala ingashintshiwe. Njengoba i-plasma amaprotheni sibopha 40% we ketshezi esebenzayo. umzimba Theophylline kwenzeka esibindini ngu cytochrome P450.

Excretion of metabolites akhiqizwa ifomu asebenzayo nge izinso, kodwa 10% of the izidakamizwa siqedwa injalo yasekuqaleni. Ezinye izici nomthelela obonakalayo on umzimba theophylline. Ukubhema, ukudla imithi ethile, imikhuba yokudla, comorbidities, ubudala, sikwazi ukulungisa ku-exchange of ketshezi asebenzayo emzimbeni womuntu. Ukunciphisa imvume theophylline siyenzeka ephashini edema, isifo sesibindi, COPD, futhi senhliziyo.

Ubani ongafaka ukwamukela leli thuluzi?

Kukhona imibandela ayezosebenza ngaphansi kwayo lapho "teopeka" (300 mg). Yokusetshenziswa uchaza lezi zifo ezilandelayo:

• Ukucinana kwemigudu yomoya emaphashini obstructive ngefomu ezingamahlalakhona;
• ukulala zokuphelelwa umoya;
• emphysema;
• somoya;
• nomfutho wegazi ophezulu yamaphaphu;
• inhliziyo yamaphaphu.

Futhi, lesi sidakamizwa "teopeka" okubuyayo okungase kusetshenziswe ngokuhlanganyela nezinye izidakamizwa ekwelapheni kwezinso edema nemvelo. Iziguli uqaphele kahle eliphezulu ithuluzi nokwamukeleka yayo ekwelapheni izifo umgudu wokuphefumula.

Izimo

Nokho, lokhu izidakamizwa ingasetshenziswa hhayi wonke umuntu, ngoba ukuba khona eziningi izexwayiso kusuka izimali. "Teopeka" Izimo zimi kanje:

• oluhambisana unhlangothi uhlobo;
• isithuthwane;
• opha pheshana emathunjini emlandweni;
• isilonda kwetinhlavu ngokweqile, izitho zokugaya;
• tachycardia ngonya okusezingeni eliphezulu;
• nomfutho wegazi ophezulu noma hypotension;
• hypersensitivity;
• kolwelwesi, ephelezelwa ne-asidi eningi;
• Izingane ezineminyaka engu-12.

Ephambi kwezinduna okungenani eyodwa yalezi syndromes nezimo theophylline izidakamizwa kufanele uhlukane

side effects

Kukhona ngempela iqembu elikhulu ohlangothini-imiphumela ekuthatheni "teopeka" ukulungiselela (300 mg). Yokusetshenziswa lamasheya abo ku ukubonakaliswa letindzala:

• iziyaluyalu isimiso sezinzwa: ikhanda, isiyezi, ubuthongo thuthuva, ukungahlaliseki, ukukhathazeka anda kanye nobuhlungu, ukuzamazama;
• ukungasebenzi ezisekujuleni kwenhliziyo futhi igazi izitsha: tachycardia, arrhythmia, hypotension, imvamisa anda ukuhlaselwa angina, angina zamanga;
• ukwephulwa emathunjini ukusebenza evamile: isicanucanu, gastralgia, ukuhlanza, isilungulela, Reflux, exacerbation izilonda, uhudo, kwehle esesuthi;
• kuwukubonakaliswa komzimba: ukuqubuka kwesikhumba, imfiva, ukulunywa;
• phakathi kwezinye izigameko ezingezinhle ezavela ekuthatheni izidakamizwa beziphawuleka: tachypnea, albuminuria, diuresis anda, ubuhlungu sternum, hematuria, siwasebenzise, kukhuphuke ukujuluka, gipoglekemiya.

Ngokuvamile, ukulungisa umthamo ukuze wehlise imiphumela emibi kuyehla noma eyeka ngokuphelele.

Indlela ukuthatha izidakamizwa?

Kusho kusukela ukucinana kwemigudu yokuphefumula, njengokuthi "teopeka" abelwa kuphela udokotela ukuba khona kanye umthamo wabo kuyakhethwa umuntu ngamunye. Isilinganiso nome nsuku kulingana 400 theophylline mg. Uma isiguli idlulisa izidakamizwa kahle, khona-ke ngemva kwezinsuku 2-3 kusukela komthamo wokuqala imithi, ivolumu kunyuke ngo-25% futhi iqhubeke ngokubona udokotela.

Lapho ethola izindlela kusukela ukucinana kwemigudu yokuphefumula "teopeka" e umthamo zonke izinsuku we esingaphansi 900 mg ukulawula theophylline okuqukethwe akudingekile e umthamo wegazi lesiguli. Uma uhlola ukubonakaliswa ukudakwa, nesidingo esiphuthumayo ukusungula ukulawula ezingeni lokuhlushwa isakhi esiyinhloko esebenzayo egazini. Kuhle kukhombisa 10-20 micrograms ml ngayinye. Uma okuqukethwe theophylline wegazi lesiguli lingaphezulu kunokuvamile, ukuthuthukiswa waphawula ukusabela okungekuhle. Kulokhu-ke kuyadingeka ukunciphisa umthamo zomuthi, kanye nomphumela oqabulayo kuyoncipha.

Kuke kwenzeke yini kube ukweqisa izidakamizwa?

Bronchodilators ezifana "teopeka" kungase kubangele iziyaluyalu ezibucayi umzimba uma kwenzeka yokweqisa. Lapho ifaniswe kahle inani lansuku zonke izindlela ukuthola lezi zimpawu ezilandelayo zingase ziphakame:

• kwehle esesuthi;
• ukuqwasha;
• isifo sohudo,
• ventricular arrhythmias ukuma;
• tachycardia;
• ukopha wokugaya ukudla;
• tachypnea;
• eliqhaqhazelayo;
• ukukhathazeka;
• ngamanzi kwesikhumba ;
• anda excitability;
• Ukwesaba ukukhanya;
• ngiphalaza igazi.

Ingase futhi ukuthuthukisa ubuthi ezinzima, esizibonakalisa zimpawu ezilandelayo:

• okuvela zesifo sokuwa;
• hypokalemia;
• ukwehluleka kwezinso, myoglobinuria;
• hypotension;
• ukudideka;
• Hyperglycemia;
• lactic umzimba.

Okufanele ukwenze kuleli cala?

Uma kunobufakazi izimpawu noma izinsolo kubo Kudingeka wenze umzamo wokuzimisela lavage esiswini, ukunikeza chelators nesineke, laxatives, izidakamizwa, kanye ukuhlela diuresis plasmasorption, hemodialysis futhi hemosorption. Uma isiguli ukuba ukuquleka, bese kunconywa ukwethula yokwelapha-oksijini emthanjeni "Diazepam" eyokusiza ukuba ziyobopha ngempumelelo ekuthatheni. Endabeni isicanucanu liphinyiselwe nokuhlanza Kufanele umise emthanjeni "Ondansetron" izidakamizwa "Metaklopromida".

Imiphi imithi angeke kuhlanganiswe "teopeka"?

Bronchodilators ezifana "teopeka 'akumele sithathe kanye macrolide-antibiotic" Allopurinol "," cimetidine "," Lincomycin "," isoprenaline ", kanye izinto zokuvimbela inzalo ngomlomo ngoba le mithi banciphisa imvume theophylline.

It is hhayi Kunconywa ukuba sihlanganise edonsa beta-blocker, ikakhulukazi okungezona abakhethayo, ne izidakamizwa "teopeka", kusukela okungenzeka ukuthuthukisa constriction bronchial kanye ukwehla bronchodilator umphumela theophylline.

Uma "teopeka" isicelo kanye "Furosemide" caffeine kanye nezinye izinto zishukumisa beta-2 adrenergic receptor, umsebenzi ingxenye yayo eyinhloko kakhulu anda. Uma kuhlangene theophylline "Aminoglutitemidom", indaba lokuqala luqala ngenkuthalo excreted emzimbeni futhi ukusebenza kwawo ngempumelelo amathonsi.

"Acyclovir" uyakwazi ukwandisa lokuhlushwa esebenzayo isithako "teopeka" esemqoka futhi kukhulisa imiphumela emibi reception yayo. imihlola efanayo abona othile ewunikela ngesikhathi co-zinikwa theophylline izidakamizwa "Dialteazem", "Felodipine" "Verapamil", "Nefedipin". Lezi imithi musa ukushintsha umphumela bronchodilator Nokho, isiguli ingase ibe nezimpawu ezithile of ukusabela ezingezinhle noma ukweqisa izidakamizwa.

Into "Disulfiram" uyakwazi okwandisa theophylline igazi izinkomba esibucayi enobungozi lesion anobuthi. "Propranolol" Ngokuphambene, kunciphisa "teopeka" imvume we ketshezi esebenzayo. Lokuhlushwa theophylline luyanda somestnom reception yayo nge "enoxacin" futhi fluoroquinolones. Lapho ukwelashwa theophylline incipha nekusebenta lithium nosawoti.

Uma kuhlangene ukwelashwa nge "pentobarbital", "Carbamazepine", "i-Isoniazid", "rifamycins", "sulfinpyrazone" imvume anda "teopeka" futhi kunciphisa ekulenzeni libe namandla. Lapho concomitantly nge theophylline "phenytoin" kukhona okusithiyayo mutual ingxenye esebenzayo e umthamo wegazi lesiguli.

Le mihlahlandlela kuqakathekile kakhulu, bangayinaka lugcwele izinkinga zempilo. Ngakho-ke, ngaphambi kokuthatha "teopeka", ufunde imiyalelo ngokucophelela. Futhi uma zelashelwa yimiphi imithi ngenhla, bonana nodokotela wakho.

Indlela ukuthenga izidakamizwa nokuthi izidakamizwa kuwufanele?

Uma kucatshangelwa Izimo sina futhi side effects lokhu izidakamizwa, "teopeka" eyakhishwa ngo Pharmacy kuphela kadokotela.

Izidakamizwa "teopeka" Intengo isilinganiso eRussia ruble 160, okwethulwa Pharmacy yizimboni ahlukahlukene. Olunye uhlobo - lo ikhambi "Borschagovsky CPP SPC" weenhlahla Ukraine. Izindleko Its ruble 155. ukukhiqizwa Russian of "teopeka" izidakamizwa, 300 mg Kwenziwa ngesikhathi amabhizinisi JSC "Pharmaceutical ibhizinisi" futhi "Valens". le mithi abiza ruble 290 futhi ruble 190 ngokulandelana.

Ngokuvamile, lesi sidakamizwa "teopeka", intengo kwamukelekile, kubhekwe imithi ethengekayo izakhamuzi eziningi zethu. Uma eqhathaniswa nozakwabo European leli thuluzi ishibhile. ukukhiqizwa Russian of "teopeka" isidakamizwa wakwenza okungabizi.

Kuxwayisa lapho ukuthatha imithi

Lapho ethola "teopeka" izidakamizwa, ukubuyekezwa zazo akhayo, kufanele sinake ulwazi olulandelayo. Uma isiguli esingamahlalakhona senhliziyo noma inhliziyo, isifo sokuqina kwemithambo yegazi, zenhliziyo, isilonda emathunjini, isifo sesibindi, umdlavuza wesinye, Reflux oesophageal, ukukhulelwa, i-hypothyroidism noma propensity lenyuka cishe, le theophylline izidakamizwa kufanele kuthathwe ngokuqapha.

Izingane ezingaphansi kweminyaka engu-12 ubudala futhi iziguli esezikhulile "teopeka" abamiselwe akuvamile.

Mhlawumbe ukusetshenziswa amafomu rectal zomuthi, kodwa kumele kusetshenziswe ngokuqapha e pathologies we ingemuva kanye nesifo sohudo syndrome. Iziguli ukuluthwa ukubhema iphuzu ukwehlisa umphumela ukwelashwa "teopeka".

Kubhekwe inadmissible ukwelashwa ngokuhlanganyela theophylline futhi xanthine nemikhiqizo. Uma isiguli esikhulile uzwakalise izifo concomitant, igciwane lohlobo, isifo sesibindi, izitsha inhliziyo futhi igazi, lo dokotela kuyadingeka ukuze alungise umthamo wezokwelapha.

Ngingakujabulela yini umuthi kwabesifazane abakhulelwe?

Owesifazane okhulelwe le nomuthi kuboniswa ngenxa khona izinkomba ezinzima kusukela theophylline uyakwazi ukungena placenta. Uma reception "teopeka" libonisa umdlezane, le lactation kufanele inqanyulwe.

Leli bhukwana inguqulo lula nemiyalelo egcwele, okuyinto unamathele izidakamizwa "teopeka". Kumele ufunde ngokucophelela ngaphambi kokuwusebenzisa. Uma kukhona into udidekile noma ungaqiniseki, bonana nodokotela wakho.