Umuthi 'Citalopram ": izibuyekezo odokotela

Yeka indlela abaphumelela kahle imithi efana "citalopram"? Uphenyo odokotela mayelana lo mkhiqizo okwelapha ngayo izinto kwalesi sihloko. Futhi, inikeza ulwazi mayelana yini ebangela side effects, wathi izindlela, indlela yokuqhuba reception yayo efanele lokho izakhiwo pharmacodynamic ke anazo.

Ukwakheka, incazelo lomuthi, ezakheke kanye nokupakisha

Ngayiphi ifomu ungakwazi ukuthenga imithi "Citalopram"? Nobufakazi bathi iketango ikhemisi iyithuluzi edayiswa ifomu iphilisi we-lenticular wangakwesokunxele nomumo isiyingi, embozwe ezimhlophe ifilimu enamathela. I Sectional engu- lo muthi has a ungqimba kancane aphuzi kwangaphakathi.

Ukuthi yini ehilelekile 'Citalopram "izidakamizwa? Imiyalelo, ukubuyekezwa babike ukuthi isithako zomuthi kuyinto into of the gama elifanayo - citalopram, okuyinto uvezwa uhlobo hydrobromide. Ngokuphathelene izingxenye elisizayo, asetshenziswa njengoba microcrystalline cellulose, isitashi pregelatinized, futhi magnesium stearate.

Kufanele kuqashelwe ukuthi le-ejenti ifilimu enamathela ehlanganisa polyvinyl utshwala, Opadry II, macrogol, talc futhi titanium dioxide.

Ngo ukudayiswa wayebheka izidakamizwa ingena amaseli nentaba wenza PVC noma se-aluminium, okuyinto tihlelwe ebhokisini elenziwe amakhadibhodi.

izici Pharmacodynamic ka antidepressant

Uyini izidakamizwa "Citalopram"? Izibuyekezo bathi lokhu kuyinto antidepressant. indlela yayo yesenzo lihlotshaniswa nokucindezela (abakhethayo) serotonin reuptake umlamuleli ekhona synapse of amangqamuzana ezinzwa, kanye nomphumela sakugcina phezu reuptake ka neurotransmitters Dopamine futhi norepinephrine. Kufanele kuqashelwe ukuthi ithuluzi akusho abonise ikhono ukuxubana ezihlukahlukene ezenza (ngokuhlukahluka okuthile kweminye serotonin, Dopamine, H1-histamine, adrenoceptors, receptor m-cholinergic, Gaba receptor futhi benzodiazepine receptor).

Asinakusho ukuthi izidakamizwa "citalopram", ukubuyekezwa abalwe ngezansi, kuyasiza ngcono isimo lesiguli, suppresses ukukhathazeka, kwehlise neluvalo, ukucindezeleka, aqede dysphoria, futhi aqede abayimilutha. Ngaphezu kwalokho, cishe akalokothi abangele nomphumela soporific.

Ngokusho ochwepheshe, umphumela nzile zaleli izidakamizwa waphawula emva kwezinsuku 7-10 emva ukusetshenziswa okuqhubekayo.

Kinetic ikhono nomuthi

Kuyini sici pharmacokinetics zomuthi "Citalopram"? Izimpendulo libike ukuthi Selilonke lokuhlushwa izidakamizwa esebenzayo egazini kwenzeka kungakapheli amahora amane emva ukungenisa. Izinguquko ku ezingeni kwakhona komugqa.

I bioavailability zomuthi osondela 80%, futhi isibopho ukuze plasma amaprotheni 79%.

Egazini citalopram elikhona ifomu yayo yasekuqaleni. Le into uguqulwa by namachibi, demethylation futhi deamination. Ingxenye-ukuphila le ngxenye izinsuku ezingu 1.5. Yena waxoshelwa ne umchamo futhi ngokusebenzisa leli pheshana emathunjini.

Izinkomba kadokotela antidepressant

Kungani sidinga ithuluzi ezifana "citalopram" ukwenzani? Uphenyo odokotela bathi izidakamizwa ukhonjiswa reception ku:

• netwetwe disorder;
• iziqephu bacindezeleke severe okusesilinganisweni.

Kufanele kuphawulwe ukuthi linqume le imithi kufanele kuphela kube abanolwazi lochwepheshe.

Izimo izidakamizwa isiqu

Kungaphansi kwaziphi hhayi izimo ungasebenzisa izidakamizwa "Citalopram"?

Izibuyekezo ukhombise Izimo ezilandelayo ukuze ukusetshenziswa kwalesi imithi:

• yobudala ezincane lesiguli (ngokuvumelana manual, ukuphepha nokusebenza ngempumelelo kwalezi amaphilisi kulonyaka ungazange sezisunguliwe);
• ukuzwela High isiguli ukuba citalopram, kanye noma yiziphi izinto zalo asizayo;
• ngenkathi ethola nge inhibitor ka monoamine oxidase kuhlanganise moclobemide, selegiline, linezolid (kungakapheli amasonto amabili ngemuva ukuqedwa nokuphathwa yabo);
• ngenkathi izidakamizwa qt ngelula inkathi ECG (s kuhlanganise pimozide) kanye kwelulwa azalwa naso we isikhawu).

Antidepressant "Citalopram": yokusetshenziswa

ochwepheshe lezivakashi baphikisa ngokuthi kufanele kucatshangelwe izidakamizwa, kuye ngokuthi isimo lesiguli. "Citalopram" kuthathwe ngomlomo kanye ngosuku. Ngakho amaphilisi kungukuthi ezokuhlafunwa wageza phansi esincane ketshezi.

Lo muthi ingasetshenziswa nganoma isiphi isikhathi sosuku kungakhathaliseki ukudla (mhlawumbe ngesikhathi esifanayo).

Lapho ukwelashwa ukucindezeleka iqala kokuthola 20 mg ngosuku. Kuye ukusabela lesiguli siqu kanye kobukhulu bokucindezeleka, umthamo kungenziwa lenyuke kuya esiphezulu, okungukuthi ukuba mayelana 40 mg ngosuku.

Njenganoma uvalo disorder kufanele kuthathwe imithi "Citalopram"? iziguli Izibuyekezo bathi kulokhu izidakamizwa esebenzayo inikezwa umthamo 10 mg ngelanga (1 ngesonto), bese-ke luyanda 20 mg ngosuku. Ngakho, umthamo wansuku zonke zomuthi bathembele siqu nesineke impendulo. Ngemva kwalokho bangase lemali ngenhla zomuthi senyukela 40 mg ngosuku.

Abantu abaneminyaka engama-65 "Citalopram" yobudala ebekiwe umthamo 10 mg. Kuye kobukhulu ukucindezeleka kanye impendulo eyodwa, kungase kunyuke kuze kufike 20 mg ngosuku.

Lapho kahle umsebenzi izinso, kuhlanganise ezingamahlalakhona ukwehluleka kwezinso at nature ngokulinganisela nobukhali ababuthakathaka, indlela ukuhlela eziyalezweni nokushintsha kokudla nokufakwa liyadingeka. Ukuze labo ezinzima kwezinso esingamahlalakhona imvelo kudinga ukunakekelwa okukhethekile ukukhethwa umthamo zokwelapha.

Lapho kahle umsebenzi sesibindi, kuhlanganise ukwehluleka hepatic ngokulinganisela nobumnene, umthamo kokuqala umuthi 10 mg nsuku zonke (zokuqala 2 amaviki). Kuye ukusabela siqu, kungaba senyukela mg 20. Abantu abanegciwane le-ezinzima hepatic esingamahlalakhona imvelo kudinga ukunakekelwa okukhethekile e Ukukhetha umthamo.

Abantu nge umsebenzi eliphansi isoenzymes njengoba CYP2C19, sokuphuza isilinganiso esengeziwe somuthi sokuqala 10 mg ngelanga (amasonto ama-2). Kuye impendulo eyodwa, kungaba senyukela mg 20.

Ngokusho imiyalelo, umphumela zokwelapha ngemva nokuphathwa a antidepressant kuncike isivele sobala ngemva kwamasonto 2-4. Kulokhu, isikhathi inkambo yokwelapha kunqunywa ngezimo zesiguli futhi tolerability yokuphathwa. Ngokuvamile, izidakamizwa Kunconywa ukuthatha cishe 6 izinyanga.

Khansela nomuthi

Okushiwo ngabantu ngalokho ukusabela zenzeka esitobhini abukhali izidakamizwa, "Citalopram" Izibuyekezo? Ubani osithathile leli thuluzi, lithi izimpawu ezivukayo emva ukumisa okungazelelwe ukusetshenziswa le imithi akuyona ejwayelekile. Ngokuvamile, iziguli ukubika omnene isiyezi, isicanucanu, ukutubeka komzimba, ikhanda, ukuqwasha, paresthesia, uvalo ukuhlanza nokundindizela.

Ngakho, ngesikhathi beqeda yokwelapha by ithuluzi kufanele uqede ke kancane kancane, phezu amasonto ambalwa. Lokhu kuzovumela iziguli ukuthi ugweme nokuqaleka. Njengomthetho, kwanele ukuba amasonto amabili, nakuba esimweni ngasinye umbuzo kufanele lihlukaniswe udokotela umuntu ngamunye. Ngakho-ke, abanye abantu kungathatha izinyanga 3 noma ngaphezulu.

ukusabela ezingezinhle ngemva kokuthatha antidepressant

Hlobo luni ukusabela kufanele bazazi umlingisi negative iziguli, ngaphambi kokuthatha imithi "Citalopram"? Izibuyekezo mayelana engemihle bathi, njengoba kwaba njalo endabeni ka-ukusetshenziswa neminye imithi SSRI, ku isizinda "Citalopram" iziguli yaphawula imiphumela engathandeki. Nokho, kufanele kuphawulwe ukuthi bonke ababuthaka kakhulu futhi idlule.

Ngokuvamile, izigameko ezingezinhle ezavela lemihlangano isidakamizwa kuncike waphawula phakathi 2 amaviki wokuqala yokwelapha. Ngesikhathi esifanayo zingabantu buthaka okuningi nge ngcono isimo lesiguli.

Ngakho, "Citalopram" kungabangela imiphumela emibi efana:

• ukuzwela High, ukuyaluza, ukusabela anaphylactic, ikhanda, ukukhathazeka depersonalization, kwehle libido, ukulahlekelwa amandla okukhumbula;
• ubudlova, ukwephulwa orgasm kwabesifazane, mania, maphupho, ukukhathazeka, ecabanga ukuzibulala ukudideka, isiyezi;
• ukozela, ukundindizela, lokuhlushwa kahle, ukuyaluza, ukusangana, Ukudlikizela;
• Isasasa, disorder extrapyramidal, migraine, ukopha, libido owandiswayo;
• isicanucanu, ukopha izifo zabesifazane, paresthesia, ukuhlanza, palpitations, serotonin syndrome, ukushaywa uvalo ngaphandle kwesizathu izinkinga zokulala, bruxism, ukuvuvukala, ukucobeka, isifo sohudo,

• akathisia, ukopha emathunjini, umfutho wegazi ophakeme, nomlomo owomile, tachycardia, dyspnea, ukuqunjelwa, bradycardia, ubuhlungu besisu, ukukhwehlela;
• enkeneneza ezindlebeni, isifo sokusha kwesibindi, hypotension orthostatic, rhinitis, ukunambitheka nasiphazamiso, encishisiwe blood pressure, ukuphazamiseka visual, arrhythmia, ejaculation disorder, sinusitis, ukuphazamiseka yokuhlala, galactorrhea, nezinkinga zobulili, kwehle esesuthi, hyponatraemia;
• kwesisindo, polyuria, isifiso sokudla kakhulu, nokulimala, uketshezi ukungadli adh, izinguquko electrocardiogram, ukuqubuka kwesikhumba, ukukhishwa Alopecia, isisindo somzimba, edema angioneurotic, hypokalemia, ukuchama ubuhlungu, ukulunywa;
• photosensitivity, kukhuphuke ukujuluka, kwengozi ukulimala kanye waphuka, urticaria, pyrexia, purpura, myalgias, Yawning, arthralgia nabanye.

Amacala izidakamizwa ukweqisa izidakamizwa

Izidakamizwa "citalopram", analogue zazo ezibalwe ngezansi, angabangela izimpawu ezilandelayo ukweqisa izidakamizwa: Isakhiwo sazamazama, Ukudlikizela, ukuhlanza, tachycardia, ukozela, abafundi osuke usuvulekile, bradycardia, hypotonia, noma umfutho wegazi ophakeme, isicanucanu, isikhumba cyanosis, serotonin syndrome, i-bundle block legatsha, ukuyaluza , isiyezi, esingamahlalakhona senhliziyo ebuthaka, stupor, hyperventilation, ukujuluka, arrhythmia ventricular, arrhythmia atrial, equlekile.

izidakamizwa ekuhlanganyeleni

Kubhekwe yokukhalaza kahle nabanye nemithi. Ngakho-ke, layo co-ekuphathweni is contraindicated ne ejenti ezilandelayo:

• Mao inhibitor (angagcina nemiphumela emibi, kuhlanganise serotonin syndrome).
• Izidakamizwa isikhathi nenkathi qt (kungaholela ukuphazamiseka inhliziyo isigqi, okwagcina kungaba ebulalayo).
• "Pimozide" (mhlawumbe ayewukela qt isikhawu).

Kufanele kuqashelwe ukuthi le co-isimiso sokuqondisa 'Citalopram "nezinye izidakamizwa kunganciphisa embundwini kokuquleka. Ngaphezu kwalokho, lokhu izidakamizwa akuyona efiselekayo ukuhlanganisa serotonergic ejenti, nemithi equkethe St John sika wort inhlama, anticoagulants ngokungaqondile, "warfarin", utshwala, desipramine.

izidakamizwa ezifanayo

Kuyini kubhekwe analogue imithi? Yikuphi okungcono? "Citalopram"? Izibuyekezo bathi izidakamizwa ungayithola enye by imithi ezilandelayo: "Paxil", "cytological" "Pram", "Sedopram", "u-Oprah", "Umorap", "Siozam", "Tsitalorin" "Cipramil", "Tsitalek" "Tsitalift", "Tsitalon". Konke lezi zimali kufanele inikwe kuphela udokotela abanolwazi.

iziguli eziningi kakhulu abanesifiso sokwazi lokho kungcono: "Citalopram" futhi "Paxil"? Izibuyekezo Ochwepheshe ukubika ukuthi izidakamizwa sokuqala kuphumelela kangcono kunokuthi wesibili. Kufanele kuqashelwe ukuthi le miphumela engemihle ezenzeka ngemva isicelo "Paxil", kukhona evelele. Ngakho-ke, odokotela abaningi batusa uyisebenzisa "Citalopram".

Ukukhulelwa webele

Wathi antidepressant akufanele zaphathwa abesifazane abakhulelwe nabancelisayo. Ukusetshenziswa kwalesi izidakamizwa e yokuthathu yesithathu ungase ube nomthelela omubi ukuthuthukiswa psycho-ngokomzimba ingane. I ukwephulwa ezilandelayo nazo zingaba khona: cyanosis, ukucindezeleka zokuphefumula, kahle kungakhuphula izinga likashukela, iphika, ukuhlanza, Ukudlikizela, liqhaqhazela, izinga lokushisa ukungazinzi, uvalo nobunzima yokudla, ukucasuka, imisipha umfutho wegazi ophakeme, ukuqwasha, hyperreflexia, njalo ekhala, ukucobeka, ukozela.

Antidepressant "Citalopram": Izibuyekezo

Lapho IBS izidakamizwa ezinqunyiwe ngokucophelela okukhulu. Lokhu kungenxa yokuthi ukuqokwa kwakhe kungenzeka babhebhethekisa enzima kanjalo isimo lesiguli.

Bathini mayelana abathengi izindlela samanje? Iziguli eziningi ikusho yimpumelelo ukwelashwa umphumela "Citalopram" izidakamizwa. Ngemva Ukuqalwa okwelashwa, imizwelo yabo iye yathuthuka ngokushesha kakhulu. Nokho, abanye abasebenzisi zithi Imiphumela zokwelapha ziye akalindanga, kusukela izidakamizwa kuye kwabangela ukuthuthukiswa yenombolo amathuba okuba nemiphumela engemihle.

Ngokuqondene odokotela, nabo bathi "Citalopram" antidepressant kuyindlela esebenza kahle kakhulu futhi ngempumelelo, kodwa ezimweni lapho ungakuvumeli ukuba ukuthuthukiswa amathuba okuba nemiphumela engemihle. Ngakho-ke, odokotela abaningi zama ukuba linqume le imithi kuphela ezimweni ezimbi kakhulu futhi ngemithamo omncane. Uma ku ngesonto lokuqala ukwelashwa kungekho ukusabela ezingezinhle sezihlonziwe ke ukwelashwa ngalo muthi uqhubeke ukwanda abanye e umthamo yayo (uma kunesidingo).