Analogs futhi yokusetshenziswa "lomefloxacin"

Yini esikhundleni umuthi ezifana "lomefloxacin"? Analogs zomuthi, injongo yayo, nemikhawulo ukuze ukusetshenziswa izakhiwo zokwelapha zichaziwe ngezansi. Uyofunda mayelana nendlela yokusebenzisa kahle leli thuluzi, futhi kulokho umthamo.

Ifomu zomuthi, kwikhava yawo, futhi ingxenye yalo izingxenye

Yikuphi iphakethe itholakala izimali? Lapho enikeza imfundo on isicelo? "Lomefloxacin" - i-tablet, ubekwe amabhamuza futhi zahlanganiswa ngo iphepha amaphakethe, kanye isifinyezo.

Yiziphi izithako kuhlanganisa izidakamizwa? Isithako asebenzayo we umuthi lomefloxacin hydrochloride. Futhi-ke kuhlanganisa nezinye izingxenye asizayo.

I izakhiwo zokwelapha zomuthi

Yiziphi amaphilisi "lomefloxacin"? Manual ithi imithi amagciwane elwa namagciwane okungokukaNkulunkulu izimali iqembu antibiotikopodobnyh, okungukuthi, fluoroquinolones, futhi imele isizukulwane le mithi yesibili.

Yini ebangela kusebenta elwa namagciwane izidakamizwa ehilelekile? izakhiwo ezinjalo "lomefloxacin" Tablets (400 mg) etholwe sibonga yokuthi nempahla yabo asebenzayo uyakwazi nomphumela ivimbela ku-DNA gyrase (okuyi-enzyme webhaktheriya) ohlinzekela supercoiling. Ngaphezu kwalokho, le-ejenti kudala kwakwakhe esitebeleni (eziyinkimbinkimbi) nge tetramer yayo futhi kuphazamisa DNA umbhalo kanye ukufanisana lamaseli webhaktheriya, okubangela ukubhujiswa kwabo okwalandela.

Umsebenzi uzwakalise we nomuthi livela amagciwane kuqhathaniswa ezingezinhle aerobic ezifana gonococci, Salmonella, Pseudomonas, haemophilus futhi Escherichia coli, ikholera lwegciwane, meningococci, Shigella, Morganella nokunye. Futhi nomuthi "lomefloxacin" (400 mg) ezicindezelayo ukusebenza ngosuku Proteus, chlamydia, Campylobacter, mycoplasma, legionella, abanye pneumococci futhi staphylococci.

Asinakusho ukuthi izidakamizwa wathi kakhulu ngempumelelo yokulwa nesifo sofuba Mycobacterium. Uyakwazi ukunciphisa isikhathi ukususwa kwabo, kanye resorption okuqala e lingene etholakalayo.

Zokwelapha umphumela "lomefloxacin" kuphawula ngisho at lokuhlala yayo ongaphakeme egazini. Uma lokhu ukumelana is waphawula kakhulu kuyaqabukela.

ikhono Kinetic amaphilisi okwelapha

Ugxile kangakanani wathi nomuthi? Elikushoyo ngakho yokusetshenziswa? "Lomefloxacin" has absorbency ezinhle. Emva kokuthola imithi isiqongo plasma yayo lokuhlushwa kutfolakala ngekhatsi imizuzu 55-85.

I amaprotheni oketshezi olungenambala olusegazini sibopha emuthini kuphela 10%. Futhi, ine ukumuncwa impahla yayo okuhle izitho ezihlukahlukene nezicubu (kuhlanganise umthondo, amalunga, izindlela zokuphefumula, ENT izitho, izitho okhalo, amathambo, esiswini, izicubu ezithambile, njll), lapho okuqukethwe kwawo ngaphezulu izikhathi 5-7 plasma.

Kufanele kuqashelwe ukuthi eminye lomefloxacin akheka futhi yakha nemikhiqizo eminingana.

Inkathi excretion zomuthi kuyinto amahora 9. Lokukhipha ke nge uketshezi ijabulise e umchamo (70-85%) kanye indle (25-30%).

Izinkomba ukwakhelwa izindlela

Bambalwa abantu bazi, kodwa ekhemisi ngamaketanga zingatholakala hhayi iphilisi "lomefloxacin" kuphela, kodwa futhi izidakamizwa "lomefloksatsin + pyrazinamide + ethambutol + Prothionamide + pyridoxine". Kulokhu kokubili nomuthi wathi akhonjiswa ukusetshenziswa ku:

• izifo (ubovu) isikhumba futhi izicubu zomzimba ezithambile (kuhlanganise ukusha, amanxeba elinegciwane, njll);
• osteomyelitis;
• i-chlamydia kanye isipatsholo (kuhlanganise Blepharoconjunctivitis futhi conjunctivitis chlamydial);
• Kwesisu ipheshana izifo (isb, ikholera, uhudo, i-typhoid fever, salmonellosis);
• Izifo ezihlobene nokuphefumula (kuhlanganise ukucinana kwemithambo yomoya emaphashini, uhlobo yansukuzonke);
• biliary ipheshana izifo;
• izifo endaweni urogenital (isib urethritis, prostatitis, cystitis, pyelonephritis);
• isifo sofuba yamaphaphu (kufaka phakathi ekwelapheni abantu abane amafomu ngokushesha ethuthuka lesi sifo, kanye ukumelana lenyuka ukuze "isoniazid" futhi "rifampicin" futhi ukumelana nokwelashwa ngamakhemikhali);
• ngaphambi nangemva kokuhlinzwa transurethral (kuphela ngezinhloso prophylactic).

Uvala ukuqokwa amaphilisi elwa namagciwane

Kwezinye izimo, awukwazi ukusebenzisa izidakamizwa ehilelekile? Yini lokhu ekutshela imfundo manual? "Lomefloxacin" is contraindicated ukusetshenziswa ku:

• sokukhulelwa;
• ibele;
• ukuzwela siqu izidakamizwa bohlanga fluoroquinolone;
• njengoba izingane (mhlawumbe okusithiyayo yentuthuko lwamathambo).

Yokusetshenziswa

"Lomefloxacin" - ngamaphilisi kuphela oboniswa ukungenisa. Kufanele kuthathwe kanye ngosuku, kungakhathaliseki ukuthi ukudla, ukuphuza mayelana 230 ml amanzi avamile.

Ubude yokwelashwa nale imithi incike uphethwe, kanye kobukhulu isifo futhi nozwela lwegciwane.

Ayinzima acute ukucinana kwemigudu yokuphefumula kanye bronchopneumonia ukugeleza iphathwa umthamo mg 400 zomuthi phezu izinsuku eziyishumi.

Ekwelapheni chlamydia (urogenital), kuhlanganise izifo ezibangelwa amagciwane kanye chlamydial, gonococcal futhi chlamydial, iziguli iqondiswa 400-600 mg izidakamizwa ngosuku, ne ubude lokusebenza izinsuku 28.

Ukwelashwa nokuvikelwa uyahluleka uma elwa nokuphuza nzima inyumoniya futhi ezingalapheki ukucinana kwemigudu yokuphefumula uhlobo eyenziwa ngezilinganiso nsuku elilingana 400-800 mg izidakamizwa, emavikini amabili.

Lapho mycoplasma ukutheleleka kubhekwe izidakamizwa elibekelwe 400-800 mg ngosuku, ne isikhathi kokuphathwa izibhebhe 3 amaviki.

ngomgudu womchamo izifo ezithathelwanayo amenable yokwelapha 400 mg zomuthi. Nale ekwelapheni izimo ayinzima kwenziwe izinsuku 5, futhi kuyinkimbinkimbi - ezinsukwini ezingu-14.

Ngo isipatsholo acute izidakamizwa "lomefloxacin" Kunconywa ukuthatha umthamo 600 mg. Njengoba for ifomu njalo lesi sifo, nokwelashwa kwayo Kwenziwa parallel immunotherapy ethize. Kulokhu, thatha imithi ku umthamo ofanayo nsuku zonke izinsuku 5.

Ukwelashwa nokuvikelwa isifo sofuba yamaphaphu kungathatha izinsuku 14-30 (kwezinye izimo izinyanga 3). isifo okunjalo nokwelapha izidakamizwa umthamo mg 200 kabili ngosuku.

Lapho uzwakalise pathologies kwezinso noma uhlobo olumaphakathi, kanye nabantu ababhekene hemodialysis, "lomefloxacin" iphathwa e isamba 400 mg ngosuku, ne ukwehla wayo ukuze mg 200.

Lo mkhuba uhlamvu omubi

Imiphi imiphumela emibi ongaba kubangele amaphilisi "lomefloxacin"? Qondisa amaphuzu eyasabela ngayo:

• bronchoconstriction, kukhuphuke isikhwehlela uketshezi, isicanucanu, ukukhwehlela, dysphagia;
• dyspnea, ukuhlanza, izifo zokuphefumula, uhudo, goiter;
• izimpawu zomkhuhlane, dysgeusia, ubuhlungu epigastric, ukuvuvukala;
• ekuphakameni enzyme isibindi, kome umlomo, ukopha emathunjini;
• ukuqunjelwa, arthralgia, ithole amajaqamba, ushintshe ulimi umbala, myalgia;
• pseudomembranous nesifo, ubuhlungu bekhanda, izinguquko esesuthi, vasculitis, isiyezi;
• ukuqwasha, webele isisa emuva, ukukhathala, uvalo umuzwa ukucobeka jikelele, ukucindezeleka, ukuzamazama;
• hyperkinesia, ukukhathala, Ukudlikizela, ukusangana;
• ubuhlungu emehlweni, umsindo, futhi ubuhlungu ezindlebeni;
• dysuria, kukhuphuke ukuqhanyelwa, hematuria, paresthesias;
• crystalluria, angaboni kahle;
• albuminuria, glomerulonephritis, Leucorrhœa, edema, polyuria, epididymitis, nobunzima ukuchama, orchitis, tenesmus;
• cyanosis, anuria, hypotension, lezinkinobho, tachycardia, arrythmia, ubuhlungu isizalo, bradycardia;
• ukopha intermenstrual, thrombocytopenia, candidiasis lwesitho sangasese sowesifazane, isilethikusebenza, zenhliziyo, phlebitis;
• ukuqhubeka yinhliziyo futhi angina, purpura, iziyaluyalu cerebrovascular, ukulunywa kwesikhumba;
• embolism yamaphaphu, photosensitivity, ukwandisa fibrinolysis, amawala, lymphadenopathy, ukuqubuka;
• epistaxis, erythema (abulalayo), uzizwa Ukugodola, sifo, ukushisa komzimba;
• superinfection, kahle kungakhuphula izinga likashukela, Candida, lokujabulela ukoma.

Ukweqisa izidakamizwa amaphilisi

Nge ukweqisa izidakamizwa amaphilisi "lomefloxacin" iziguli ukuzwa isicanucanu, izilonda erosive we mucosa emathunjini, ayewukela ka qt-time, isiyezi, ukuquleka, ukudideka, kanye anda ukusabela ezingezinhle.

Ngenxa hemodialysis ukweqisa izidakamizwa kusho kubhekwe ukwelashwa ayizwakali ngenhla izimo Kwenziwa ngesisekelo izimpawu ekhona.

Ukuxhumana nezinye izidakamizwa

Nge inhlanganisela "lomefloxacin" nge "theophylline" umzimba wakhe cishe engasenamahloni.

Lapho ukuphatha kanyekanye ka antacids futhi sucralfate akhiwa chelate izakhiwo ezinciphisa bioavailability of lomefloxacin. Yingakho isikhawu phakathi yokwamukela wathi ukuthaka imithi kufanele okungenani 4 amahora.

ukusetshenziswa ahlangene "lomefloxacin" futhi ebulilini caffeine bandisa nenxenye ukuphila lakamuva.

Ekwelapheni sofuba akumele kwenziwe parallel yokwamukela izimali "rifampicin", kungenjalo lokho kuyoholela ukuphikisana senzo.

ukwelashwa Ngesikhathi ama-NSAID kwandisa ubuthi izidakamizwa kungabangela nokuquleka.

"Lomefloxacin" bakwazi ukwandisa nekusebenta anticoagulants kwezokuphatha ngomlomo.

Imithi, okuyizinto blocker of uketshezi ijabulise, zivimbela excretion of "lomefloxacin".

izincomo ezithile

Uma isifo so-renal kudinga ukulungiswa esiyisibopho umthamo, okuyinto incike QC amamethrikhi.

Zonke yokwelapha udinga uyeke ithonya eside kwanoma iyiphi imithombo UV ukukhanya, kuhlanganise elangeni.

Vitamin ejenti zihlanganisa izithasiselo ehlukahlukene amaminerali kufanele kuthathe imizuzu 120 ngemva noma ngaphambi kubhekwe amaphilisi kokuthola.

izidakamizwa ezifanayo

Nomuthi "lomefloxacin" inezinto eziningi analogue. The main esikhundleni izidakamizwa ochwepheshe cabangela lokhu okulandelayo: "Abaktal", "Elefloks", "Zanotsin", "TSifran", "Avelox", "Tsiprolet", "Zofloks", "tsiprinol", "Kvintor" "Ciprofloxacin", "Levofloxacin "" tarivid "," Levotek "," pefloksatsina "," Levofloks "," Ofloxacin "," Norbaktin "," Ofloks "," norfloxacin ".

Tablets "lomefloxacin": Izibuyekezo

Lapho ngokucacile ejenti ezithathelwanayo ozwelayo isizukulwane sesibili ka fluoroquinolones, kanye ukukhethwa efanele ngemithamo kwezokwelapha kanye nokwelashwa isikhathi eside, ukubuyekezwa mayelana izindlela samanje kumane omuhle.

Ngokusho kwemibiko iziguli, lokhu izidakamizwa okuye kwaba uqobo njengenhlangano umuthi elwa namagciwane ukuthi ngokwanele iphatha nezilwanyana ezincane ezihlukahlukene sokugembula. Nokho, abanye abasebenzisi zithi izidakamizwa ngezinye izikhathi kubangela ukuthuthukiswa ethile emibi, kodwa njengoba umthetho, bayagula ezichazwe ngokwemvelo noma ngokwabo ngokushesha ngemuva kokuphela yokwelapha.