"Atorvastatin": ukubuyekezwa, analogs, ukwakheka kanye yokusetshenziswa

Umuthi ezivamile eklanyelwe ukwehlisa amazinga cholesterol inani LDL iyona "Atorvastatin". Nobufakazi ngakho edidayo, nakuba izinga umkhiqizo kuqinisekiswa izifundo zokwelapha. Ngesikhathi esifanayo izidakamizwa has esincintisana agcwele eyodwa kuphela - "Rosuvastatin" (kanye imithi ejwayelekile yayo). Ngoba kusobala ukuthi "atorvastatin" ukulungiselela kobufakazi nesineke lungapheli Imininingwane umgomo. Ngakho, ukuhlola nemiphumela yayo edingekayo analysis eningiliziwe lo mshini wezenzo futhi izinhlinzeko zoMthetho imiyalelo enamathiselwe ukusetshenziswa.

Lefundo izidakamizwa izidakamizwa kwebalingisi

Atorvastatin kungokwalabo ikilasi kwemithi ye kwesizukulwane sesithathu statin. Ngu ezivimbela enzyme obangela zamagama endogenous cholesterol, kunciphisa inani le-atherogenic Esilula ingxenyenamba. Low-Ukuminyana ingxenyenamba (LDL) kungayandisa sebethule cholesterol kanye kubangele izimpendulo mzimba e endothelium, ngenxa okuyinto uqwembe asathuthuka.

Njengezinye statin, atorvastatin iyehlisa inani LDL, futhi ngenxa yalokho kakhulu kubamba ukukhula uqweqwe. Kulesi ukuthambekela involution yayo ningagcini, futhi ububanzi a ukuxhumelela imithambo yenhliziyo (noma iyiphi enye atherosclerotic), kona akushintshi. Umthelela emitholampilo - ingasheshi ukuthuthukiswa isifo senhliziyo, cerebrovascular noma ezingamahlalakhona lwemithambo esingamahlalakhona yezingalo nemilenze aphansi.

"Atorvastatin": izinkomba ukusetshenziswa

Ngaphambi ethatha liyadingeka ukuchaza izimpawu ukusetshenziswa zomuthi. Basuke lisuselwa indlela eyisisekelo isinyathelo futhi ahlobene nomphumela ane-ukwehlisa. Ibhanga izinkomba:

• lezinceku (ngofuzo) hypercholesterolemia, heterozygous;
• polygenic (primary) IIa ekilasini hypercholesterolemia ngokuvumelana Fredrickson;
• Inhlanganisela (IIb) dyslipidemia;
• Homozygous hypercholesterolemia omkhaya;
• hypertriglyceridemia (ukwelashwa nge statin lihambisana yokudla nokuvivinya umzimba);
• izimo ezihlobene ne izilonda atherosclerotic semithambo wenhliziyo odongeni, ubuchopho, izinso, emikhawulweni;
• nomfutho wegazi ophezulu kanye ingozi eliphezulu zenhliziyo;
• nokuvimbela acute izenzakalo yenhliziyo ngokumelene isizinda izilonda ekhona atherosclerotic kwemithambo yegazi yenhliziyo;
• nokuvinjelwa esivimba amanzi kabusha infarction noma unhlangothi-cerebral palsy.

Lezi ukufundwa ukunquma amacala lapho kuyadingeka ukuqashwa kukaNksz "Atorvastatin" izidakamizwa. Odokotela mayelana nesicelo yayo uqinisekise ngokucacile lesi sidingo. Kuyiqiniso efakazelwe ukuthi statin, kuhlanganise "Atorvastatin" nge imithi ejwayelekile yayo eminingi kuphephe kakhulu kardioform acetylsalicylic acid, nakuba ukusiza ngendlela efanayo kakhulu ukunciphisa amathuba wokuthuthukisa esivimba amanzi infarction bese uphinda amacala kuqala.

izidakamizwa analogue

Zonke amaphilisi "Atorvastatin", okuyinto Izibuyekezo ingafundwa ngezansi, ekhishwa izinkampani ezahlukene ezenza imithi. Ngokuvamile, amagama imithi Ushintshe, ebavumela ukuba ngaphansi kwe-patent. amagama Trade analogue, okungukuthi, izidakamizwa eziqukethe atorvastatin njengoba ingxenye esebenzayo, lokhu okulandelayo: "Anvistat" futhi "Atokord", "Atomas" futhi "Ator", "Atorvoks" futhi "Atoris", "Vazotor" futhi "Lipoford" "Lipitor" futhi "Liptonorm", "Novostat" futhi "Torvazin", "Torvakard" futhi "Tulip".

Futhi, abanye abakhiqizi ukukhiqiza imithi yabo "Atorvastatin" (ungafunda ukubuyekezwa ngezansi) ngaphansi efanayo egameni lendawo yokuhweba. "Actavis", "vertex", "Izvarino Pharma", "ALSI Pharma", "Canon Pharma" Obolentsenskoe inkampani eyenza imithi, "Protek-SVM", "North Star", Tabuk Pharmaceuticals, TEVA Pharmaceutical Industries, nabanye ukukhiqiza Igama lomuthi esakhiwa INN ( "atorvastatin") futhi aduduze bendabuko. Isibonelo "Atorvastatin Teva", ukubuyekezwa zazo ukuqinisekisa ukusebenza yayo emtholampilo.

isakhiwo

Njengoba unamathele izidakamizwa 'atorvastatin' yokusetshenziswa, ukubuyekezwa kanye nemihlahlandlela yomtholampilo awaqukethe ulwazi mayelana nomehluko phakathi amafomu umthamo. Ekusebenteni, ukungathandi izinto ezifanayo ezikhona, futhi alawule Dynamics isenzo zokwelapha. Okuqakathekileko ngokushesha kangakanani kufika nomphumela oqabulayo umthamo. Yingakho ekwakhiweni "Lipitor" kukhulunywe zomuthi yasekuqaleni.

Ifomu Isikali yakhiwa amaphilisi calcium atorvastatin kanye igobolondo. Lesi sakamuva, esikhundleni salokho, siqukethe ayi-calcium carbonate, microcrystalline cellulose, monohydrate lactose, polysorbate 80, i-sodium croscarmellose, magnesium stearate, hydroxypropylcellulose, talc, ama-titanium dioxide, i-polyethylene glycol, hydroxypropylcellulose, emulsion simetikonovoy, benzoic futhi sorbic acid.

Attached original izidakamizwa "Atorvastatin" imfundo manual (izibuyekezo futhi kuleli phuzu) ayiqukethe ulwazi mayelana isisindo ingxenye ngayinye. Lena imfihlo kwezentengiselwano inkampani American Pfizer HCP CORPORATION. izilinganiso ifomu "Lipitor" okunjalo kwenza sikwazi ukuyifinyelela lokuhlushwa njalo atorvastatin egazini.

Kuhlanganiswe ifomu "atorvastatin"

Lapho belungela ukuya khona "Atorvastatin" intengo (kobufakazi nesineke siliqinisekise) utholwa yibo anhlobonhlobo iziguli. Kuyinto imithi ophephile ukuthi zingahlanganiswa nezinye amakilasi izidakamizwa. Ngokuvamile, "atorvastatin" nezinye statin akhiqizwa todvwa, okungukuthi, kwelinye thebhulethi isithako eyodwa kuphela. Nokho, kunezinhlobo elihlangene.

Izibonelo zibandakanya izidakamizwa ezilandelayo: "Kaduet", "Duplekor", "statin". Lapha, "atorvastatin" is kuhlangene amlodipine, okuvimba ama-calcium channel, okuyilona elisebenzayo futhi ngokuvamile sisetshenziswa ekwelapheni iziyaluyalu zenhliziyo. Umthamo zomuthi ikhethwa udokotela.

Standard Isikali "atorvastatin"

Izidakamizwa "Atorvastatin", izinkomba, amareferensi nezincomo ukusetshenziswa emitholampilo ye okuyinto sicabanga e ukubuyekeza kwethu, itholakala imithamo emithathu ejwayelekile: 10, 40 no-20 mg. A kuhlanganiswe ukulungiselela "Kaduet" iqukethe 10 mg atorvastatin futhi amlodipine 5. "Statin" ikhiqizwa amafomu amabili: 10/5 futhi 10 / 10mg. Lapho belungela ukuya khona "Duplekor" 4 umthamo atorvastatin futhi amlodipine: 10/5, 10/10, 20/5, 20/10 mg. Lokhu kunciphisa inani amaphilisi iziguli ukusebenzisa futhi statin kanye blocker-calcium channel for ekwelapheni izifo. Lokhu kufezwa futhi ukwehla izindleko zokwelapha.

Ukukhetha "atorvastatin" esiyingqayizivele

izindlela Okokuqala ehlanganisa atorvastatin sabanjwa ukuthengiswa "Lipitor". Lona imithi yokuqala, okuyinto eyenziwa uvivinyo. Kamuva Kwakukhona nezinye izidakamizwa ngaphansi amanye amagama. Ukuze ukubhaliswa edingekayo kuphela isiqinisekiso esisemthethweni bioequivalence "Lipitor." Okwamanje, kungaba ukuziqhayisa a abakhiqizi ambalwa. Ngakho-ke, ukuthola udokotela ukuze izidakamizwa ekhona "Atorvastatin" analogue yalezi Izibuyekezo kufanele uzifunde ngokucophelela.

Ngokuvamile, udokotela uncoma umuthi ikufakazele bioequivalence "Lipitor" futhi ingabe nomphumela ezichazwe imiyalelo enamathiselwe. Izindleko "Lipitor" itholakala, akunzima ukuba sikuzuze ngoba uswidi. Nokho, akukashicilelwa iziguli izindawo ezivele zikhona ngenxa yokukhubazeka isifo ovamile. Kulokhu, labo imithi ezingahle zinqunywe wumgomo concessional zilawulwe Centre izivivinyo nezivivinyo imithi. ukusebenza kwabo sabonakala.

Nobufakazi mayelana "atorvastatin"

On the ukulungiselela "Atorvastatin" Ukubuyekeza iyiphi isiguli singenakukwazi afaneleke, ngoba ngaphandle ekuhloleni iphrofayela lipid akunakwenzeka ukuba wahlulele imiphumela izidakamizwa. Ngakho-ke, ukuze kuqinisekiswe ukusebenza kahle, kufanele sihlaziye izinguquko lipid izingxenyana zaso. Ngaphezu kwalokho, noma yimuphi "Atorvastatin", ukubuyekezwa olutholakalayo eziningi ezinkulu, inikeza ulwazi ukusabela ezingezinhle. Okuvame kakhulu imiphumela nomzimba. Ubuthi uphansi futhi ngokuvamile imperceptible. Nokho, noma kunjalo ukubukeka cytolysis syndrome futhi transaminases ukwanda mithathu kudinga ukususwa zomuthi.

Iziguli bathi imiphumela anobuthi awavamile. Ngenxa yalesi sizathu, iziguli eziningi belulekwa ukuba izidakamizwa abangane nezihlobo, nakuba ukuphela edingekayo kokubonisana yezokwelapha, ukuhlolela ubungozi kanye nokuzimisela kwamafrakshini wegazi lipids. Ngaphezu kwalokho, abantu abaningi ababesebenzisa izidakamizwa nhlobo izakhiwo kunikezelwe, isibonelo, ukuthi uyakwazi ukwehlisa isisindo somzimba.

Kodwa sihlolisise isidingo abe kuqhathaniswa "Atorvastatin" Izibuyekezo izidakamizwa. Neminye ke asifanele, futhi kungenziwa kuphela iqondiswa ngokuhlanganyela imithwalo nokudla. Kuhlanganiswe ukusetshenziswa "atorvastatin" nezinye ejenti lipid-ukwehlisa, njengoba ngokuvamile Kunconywa ukuba abantu ngaphandle nokwelapha, kuholela rhabdomyolysis kanye esibindini obabubangwa.

Uphenyo odokotela mayelana izidakamizwa

On the ukulungiselela "Atorvastatin" Ukubuyekeza udokotela kubaluleke ngaphezu ukubuyekeza lesiguli. Kuyefana nasendleleni nezinye izidakamizwa. Ngokuvamile, ukubuyekezwa zonke izazi izifushaniso elichaza ukuphepha izidakamizwa nokuphumelela kwaleso sembatho. It wehlisa ikholesteroli inani LDL, kube kwandziswa HDL. Lokhu kuqakatheke khulu ngoba ikuvumela ukuba ukhula qwembe atherosclerotic, futhi uyephuza ukuqala isilethikusebenza.

Dynamics umphumela hypocholesterolemic ekulungiseleleni "Atorvastatin" (Ukubukeza cishe bonke odokotela kuqinisekisa ke) kuyinkomba kakhulu. Kokulinganisa sephrofayela serum lipid kutfolakala ngekhatsi izinyanga 1.5-2. I "rosuvastatin" kutholakala phakathi kwezinsuku 30-50. Nokho, nakuba "atorvastatin" izifundo zokwelapha okwengeziwe ukuze ngisekele ukusebenza yayo kanye nokuphepha. Ngokuvamile, lezi izidakamizwa ezimbili ezinhle, ngalinye elikwazi ingase isetshenziselwe ekwelapheni hypercholesterolemia futhi prophylaxis iziyo.

Izindleko izidakamizwa

Umuthi 'Atorvastatin "intengo (izibuyekezo eziningi ngalokhu svidelstvo) ezahlukene kuye ngokuthi umenzi. Eqolo kuyinto "Lipitor" - isidakamizwa yasekuqaleni. ukwelashwa Inyanga izindleko ruble 900-1100 lapho ithola umthamo 40 mg. Ngezinye izilinganiso nsuku zonke 20 mg ukwelashwa izindleko ruble 800-900. IsiZulu "Lipitor" ishibhile.

Izindleko zokwelashwa nyangazonke "Atoris 40 mg" ruble 500, kuyilapho kokuthola 20 mg - ruble 200. I "Atoris" - kuyinto bioequivalent "Lipitor" izidakamizwa, esikhundleni ngokugcwele. Kukhona futhi izidakamizwa eshibhile, "Torvakard" "Lipitor", "Torvas" izindleko zokwelapha nyangazonke umthamo zonke izinsuku we-40 mg ruble 300 eshibhile. Futhi intengo ukwelashwa nge umthamo zonke izinsuku we mg 20 kuyoba ruble 100-150.