Bile acid sequestrants, izidakamizwa: uhlu

okunamafutha sequestrant acid izidakamizwa abizwa ngokuthi, bekwazi ukunciphisa igazi cholesterol. Lesi sidakamizwa asizayo isetshenziswa ekwelashweni. Kukhona ngezigaba ocacile izidakamizwa lipid-ukwehlisa, okuyinto ukuvimbela cholesterol kwemiqondo egazini. ejenti Sequestering zifakiwe kule ngezigaba. Kuyinto okunemibandela iqukethe ahlukahlukene, okuyinto efana lo mshini wezenzo. eyaziwa kakhulu Bile acid sequestrants - izidakamizwa "Colestipol", "Cholestyramine", "colesevelam."

Ingozi yesifo senhliziyo kuyehla sequestering izakhiwo, kuhlanganise ischemia. isipiliyoni Clinical kuqinisekisa ukusebenza SCF e la maphuzu alandelayo:

• yezinkinga uhlamvu yenhliziyo is ekunqandeni;
• nokufa encishisiwe kusukela isilethikusebenza.

Ukwakheka kwamakhemikhali le mithi ebavumela ukuba zihlanganisa imikhakha ion exchange inhlaka. Lokhu eliphezulu yamangqamuzana isisindo zokwenziwa compounds okuyinto empeleni polymers zingaxazululeki abaqinile neqembu naphakathi aqueous ku ion exchange inqubo. Yilokho sequestering Bile acid.

Lo mshini wezenzo izidakamizwa

Igama elithi "sequestrant" kusho "yisivikelo", ukuthi kwenzekani umzimba womuntu kwemihlambi Bile acid. Cholesterol sibopha nge Bile acid, athwala cholesterol kusukela kwesibindi ukugeleza ukuze sizimisele yini ukwenza zamagama. Bile acid afundwa isimiso sokugaya ukudla bungene ngaphambi kokuba afinyelele emathunjini lapho ingaziwa khona ugxile. Ngenxa yalokho, umzimba eziningi izinto ezibalulekile ukuze kube nokuphila.

Imiphumela abaphumelelayo lipoproteins ukuthi abe kwabantu aphansi. Lokhu okuthiwa cholesterol embi.

Njengoba umsebenzi Bile acid sequestrants (amalungiselelo ukuchaza kabanzi ngezansi).

Sequestrants kungukuthi angena egazini, imiphumela emibi ngakho uma ikhona, isezingeni eliphansi, futhi zivela kakhulu kuyaqabukela.

Abesifazane abakhulelwe lactating angasetshenziswa lezi izizathu. Futhi, izingane nentsha kanye hypercholesterolemia ngofuzo zithatha lezi izidakamizwa ukubambezela yonke inqubo. Kuyinto isimo ngofuzo yomzimba, lapho evelele cholesterol aphezulu kanye nemiphumela okuholela.

Uma ukuphatheka FFA evamile, ungasebenzisa kubo u-Adalberto isikhathi eside. Noobyazatelno kudingeka ukulawula cholesterol, ama-enzyme isibindi kwemisipha izicubu.

Statin lihambisana FFA aphumelela kakhudlwana nge Yiqiniso nokunwetshiwe yokwelapha. A cholesterol embi kuyehla ngesigamu. Uma kukhona hyperlipidemia kuhlanganiswe (uma eziningi amafutha egazini), khona-ke imiphumela kuyoba ngcono by 70-75%. Njengoba isenzo umzimba ku Bile acid sequestrants? I ukwakhiwa bubekezelelwa ngokuvamile kahle.

Yiziphi imiphumela emibi?

Imiphumela engemihle zenzeka kakhulu akuvamile. Uma kunjalo, khona-ke into embi ngoba umzimba akusho aguquke. Noma kunjalo, abanye abantu kungenzeka ibonakalisa zimpawu ezilandelayo sishesha:

• ukuqunjelwa;
• ukuqunjelwa (dyspepsia);
• isicanucanu;
• ngokweqile igesi kumiswa emathunjini (ukubuyisa);
• ukuvuvukala;
• isilungulela, futhi yikho okuvame kakhulu ohlangothini umphumela Bile acid sequestrants.

Ukuze ugweme abantu basabele ngendlela embi phezu ingxenye yomzimba, udinga siphuza neziphuzo kakhudlwana futhi udle ekuqaleni imithi ngemithamo emincane.

Lapho esetshenziswa FFA izingane kudingeka ukuba linqume yensimbi kanye folic acid. ukwelashwa kanye kanye nezinye izidakamizwa kungabangela ukumuncwa abampofu izingxenye asebenzayo. Lapha kubalulekile ukugcina mithetho elandelayo: sequestering baphuze ihora ngemva ukusetshenziswa kwezinye izindlela, futhi amahora amane ngaphambi.

Kakhulu akuvamile kungenzeka ubuhlungu bemisipha (myalgia), ukuvuvukala pharynx (emphinjeni). Kakhulu akuvamile okuvela ukukhwehlela, ubuhlungu emuva, abandayo.

Izimo

Ingabe Izimo sequestering Bile acid? Izidakamizwa ongabekiwe kulezi zimo ezilandelayo.

Lapho hyperlipidemia uhlobo 3 no-4 (lazo ezithusayo pathologies ka esimiso senhliziyo nemithambo yegazi) akunconywa sequestrants. Angamvusa triglyceride egazini. Lapho ehlaselwa Bile imbobo (biliary isifo sokusha nokuphelele isimiso biliary) akakwazi nika idatha ukuthaka imithi. Uma umuntu ohlushwa ukuqunjelwa njalo, umuthi ungakwazi senze isimo sishube. isifo sezinso, izilonda esiswini, hemorrhoids, ukopha disorder - konke contraindications SLC.

Ngokunakekela linqume kubo abantu nge izinkinga zesisu, malabsorption syndrome (kahle ukumuncwa emathunjini, kanye nezakhi ezibalulekile kunzima ukuhlala emzimbeni).

Okungenzeka isici esiyingqayizivele nje.

Ukubukeka elandelayo ngesikhathi ethandwa kakhulu Bile acid sequestrants. Izidakamizwa (uhlu Ungahlola udokotela wakho) uzobe wahlela ukuze kusuka ethandwa kakhulu okungenani ethandwa.

Umuthi 'Cholestyramine "

Ibizwa nangokuthi "Cholestyramine". Compound kuyinto zingaxazululeki ion exchange inhlaka. It kuholela ukuncipha amazinga egazi cholesterol ngumuntu ikota. Ingabe esebenzayo esibophezelayo Bile acid whereupon they behlukene umzimba womuntu. Uma izidakamizwa kuyadingeka ukuze baphuze isikhathi eside, kuyobe sekudingeka ukwenze lokho zisebenzisa amanzi amaningi. Statin ukuthuthukisa imiphumela, kodwa ingqondo kuyehla egazini. Lapho eneminyaka engu-eminyakeni engu-60 enqunyiwe ngokuqapha.

Nomuthi "Colestipol"

Kuyinto copolymer okusezingeni eliphezulu zingaxazululeki. Izakhiwo uxhumano nomsebenzisi Bile acid kancane nakakhulu kulo ukwedlula "Kolestiramin".

Izinkomba, side effects kanye Izimo ziyefana lonke iqembu izidakamizwa. Inhlanganisela "Kolestepola" futhi statin ukunikeza umphumela engcono.

Izidakamizwa "colesevelam"

Ayikho ukunambitheka izakhiwo abuhlungu umkhiqizo kunomthelela iqiniso ukuthi uya iyasetshenziswa uma ziqhathaniswa neminye imithi.

Ingabe idatha sequestering Bile acid imiphumela emibi?

imiphumela omubi pheshana emathunjini beziphawuleka. Ukusabela neminye imithi ungapheli. "Colesevelam" ingase isetshenziselwe ekwelapheni abesifazane abakhulelwe kanye lactating.