"Flosteron": yokusetshenziswa (imijovo), ukubuyekezwa, Izimo

Asho izidakamizwa "Flosteron"? Yokusetshenziswa (imijovo), izimpendulo aboniswa ngezansi. Siphinde ngikuxoxele onjani sakhiwo izidakamizwa ukuthi kuthiwa ngakho, iziguli ukuthi unakho side effects kanye yimuphi Izimo kufanele wazi ngaphambi kokusebenzisa imithi ngendlela efanele.

Ukwakheka yezokwelapha kudivayisi, emabhokisini futhi ngendlela

Kuyini imithi ukukhululwa ifomu "Flosteron"? Yokusetshenziswa (imijovo), ochwepheshe zangempela asho ukuthi leli thuluzi angathengwa kuphela ngesimo ukumiswa, okuyinto senzelwe umjovo.

I izinto asebenzayo lokhu ukulungiselela yilezi ezilandelayo: betamethasone dipropionate futhi betamethasone disodium phosphate. Ngo ukudayiswa ukumiswa iza ampoules, okuyinto ezibekwe nentaba plastic emaphaketheni.

Izimfanelo kwemithi zomuthi

Liyini ikhambi njengoba "Flosteron"? Yokusetshenziswa (imijovo), libuyekeza odokotela bathi ukuphumelela kwalesi izidakamizwa ngenxa ngezithako zawo.

Betamethasone kuyinto zokwenziwa corticosteroids. Anakho desensitizing, eqeda ukuvuvukala, antishock, anti-iguliswa, immunosuppressive nomphumela anti-anobuthi. Futhi, nomuthi kwandisa excitability isimiso sezinzwa, kunciphisa inani eosinophils futhi zigcine ama-lymphocyte, kwandisa isibalo kwamangqamuzana egazi abomvu (ngenxa sithuthukiswe ekwakhiweni erythropoietins).

ejenti kubhekwe kalula ihlangana receptor cytoplasmic kuvusa RNA zamagama, ukwakha eziyinkimbinkimbi, okuyinto angena kuyi-nucleus yengqamuzana.

mshini wezenzo

enza lesi sidakamizwa "Flosteron" umjovo kanjani? Ubizwa bahileleke cishe zonke izinqubo umzimba emzimbeni.

umzimba lipid. Ukulungiswa kwandisa zamagama we-hormone yegilo-zikhuthaza, futhi of acid okunamafutha (ngaphezulu). It redistributes amanoni kuholela hypercholesterolemia.

Amaphrotheni umzimba. Nomuthi "Flosteron" kabani Ukwakheka ngabe amelwe ngenhla, kunciphisa inani amaprotheni ku-plasma. Ngakho-ke kwandisa Coefficient albumin futhi globulin albumin zamagama ukwenyuka izinso futhi isibindi, kodwa futhi sithuthukisa amaprotheni catabolism ezicutshini izicubu.

umzimba carbohydrate. Okushiwo ngabantu ngalokhu ochwepheshe izidakamizwa? Kuthiwani kuye ukushiya izibuyekezo? "Flosteron" - a nomuthi esiyingqayizivele okuyinto sithuthukisa ukumuncwa carbohydrate kusukela ipheshana wokugaya ukudla, kwandisa zamagama futhi umsebenzi aminotransferases fosfoenolpiruvatkarboksilazy ukuthi asihole ukusebenza gluconeogenesis, futhi kwandisa supply glucose kusukela kwesibindi emgudwini wegazi.

Amanzi futhi electrolyte umzimba. Ukwelapha "Flosteronom" ikhuthaza Na + futhi egcina amanzi emzimbeni, kukhuthaza excretion of K Kunciphisa ukumuncwa Ca ²⁺ kusukela amathumbu, Ukufikelwa ukushisa ke enkothweni, futhi kwandisa excretion ngu nezinso.

I izakhiwo zomuthi

Yini izakhiwo izidakamizwa "Flosteron"? Yokusetshenziswa (imijovo), ukubuyekezwa bayatshelwa ukuthi ukusetshenziswa kwezidakamizwa has miphumela elandelayo:

• Anti-inflammatory. Lo mphumela lihlotshaniswa ukwehla kwenani insika amaseli ukukhiqiza asidi i-hyaluronic kanye nokucindezela balamuli ukuvuvukala ukuthi akhishwa eosinophils.
• Antiallergic. ukuchayeka okunjalo ithuthukiswe ekuphenduleni nokucindezela uketshezi kanye synthesis mediators njengemithi yokungezwani komzimba nokuthile, kanye okusithiyayo of histamine ukukhululwa kwe basophils futhi insika amaseli.
• Anti-esinobuthi antishock. Lo mphumela ngenxa ukwanda wegazi, wehlise permeability semithambo futhi kusebenze kwezindonga enzyme isibindi.
• Immunosuppressive. Lo mphumela kubangelwa okusithiyayo we ukukhululwa kwe cytokines kusukela macrophage nama-lymphocyte.

Pharmacokinetics izindlela

Indlela aphathe izidakamizwa amuncwa umzimba isikhathi eside? Yini abantu bathini mayelana lemibono? "Flosteron" - umuthi i-umjovo intraarticular. Ngemva uyisebenzisa nomuthi esiphezulu plasma lokuhlushwa kufinyelelwe ngemva cishe isigamu sehora.

Umuthi sibopha ukuthi amaprotheni kalula futhi sidlula izithiyo igazi-izicubu, kuhlanganise esinomhlapho.

Umzimba kwenzeka nomuthi isibindi. kwakhiwa Ngakho metabolites ikakhulu esingasebenzi. Lokukhipha ke nge izinso, kanye esincane kanye Bile wamabele ubisi.

Izinkomba zomuthi

Ngingakusebenzisa kanjani lokhu izidakamizwa "Flosteron" e-psoriasis, samathambo kanye nezinye izifo? Uhlu izinkomba ithuluzi izokwethulwa ngezansi.

Njengoba ukwelashwa ngezihloko ezihlukene:

• I-naphakathi-articular ukuphatha khona synovitis, kanye nezinye izifo rheumatism esiwohlozayo (noma kunjalo ayikwazi ukusetshenziswa ne -osteoarthritis amalunga omzimba hip) ;
• okolosustavnogo ngoba umjovo intraarticular nezifo rheumatism ukuvuvukala (seronegative spondylitis, i-rheumatoid arthritis, samathambo e letindzala zezinzwa izicubu isifo), psoriatic sokuqaqamba kwamalunga tenosynovitis futhi izilonda emalungeni, isifo sokuqaqamba kwamalunga, crystalline sokuqaqamba kwamalunga posttraumatic;
• ukwelapha izilonda ukuvuvukala kwezicubu periarticular (epicondylitis, bursitis, tenosynovitis, plangarnye fasciitis futhi tendinitis);
• ukuze ishuthekwe lesion ekwelapheni izifo zesikhumba (endabeni uma kungekho mpendulo kwezinye izindlela zokwelapha izici zendawo): psoriasis, folliculitis sclerosing, Alopecia areata, keloids, eczema nummular, granuloma annulare, ulele planus, isikhumba sarcoidosis, dermatitis, sikashukela lipodystrophy kanye omzimba izicubu erythematosus discoid.

Njengoba ekwelapheni letindzala ka:

• letindzala izidakamizwa umphumela "Flosteron" lisetshenziswa kuphela uma izifo iguliswa ezithile (Quincke edema, rhinitis iguliswa, isinambuzane inezindosi, isimo somoya nokungezwani komzimba nezinto izidakamizwa).

Izidakamizwa "Flosteron": contraindications ukusetshenziswa

Ngaphambi kokufaka isicelo umkhiqizo ngaphansi nokucabangela kufanele uqinisekise ukuthi ufunda imiyalelo enamathiselwe. Lokhu kungenxa yokuthi i-nomuthi asebenzayo has inqwaba amathuba okuba nemiphumela engemihle. Cabanga uhlu kubo njengamanje:

• kwamathambo;
• isilonda peptic we duodenum noma esiswini, diverticulitis, anastomosis emathunjini;
• ukufiphala;
• thrombophlebitis;
• Cushing Syndrome;
• sofuba;
• isimo ngemuva kokuhlinzwa futhi ukulimala kabi;
• sikashukela;
• idiopathic purpura thrombocytopenic (kwezokuphatha esicutshini kuphela);
• fungal acute, amagciwane izifo ezibangelwa amagciwane (uma ukwelashwa okufanele akuyona eyenziwa);
• post-yokugoma kwesikhathi (2 izinyanga ngaphambi futhi amasonto amabili);
• ukungabi khona izimpawu ukuvuvukala emalungeni;
• periartrikulyarnye ukutheleleka, ezithathelwanayo (noma okuthiwa ukonakala) ukuvuvukala kwamalunga;
• chrezsustavnoy imigqa ephezulu nephansi;
• Ukungazinzi we ngokuhlanganyela ngenxa yokuqaqamba kwamalunga;
• arthroplasty kwangaphambili;
• necrosis (aseptic) epiphyses lamathambo obumba ngokuhlanganyela;
• ezinzima deformity ngokuhlanganyela kanye amathambo ekubhujisweni;
• esasikhipha kuya Achilles umsipha;
• lactation;
• ukopha uhlamvu sokugembula;
• ukuzwela anda ukuze betamethasone umuntu, kanye nanoma iyiphi enye ejenti ingxenye.

Ngenxa yokuthi lesi sidakamizwa "Flosteron" iqukethe Gcoba i-Benzyl utshwala, kungase akufanele isetshenziswe neonates nezingane iminyaka emithathu.

Izindlela Yokusebenzisa kanye Isikali

Nomuthi "Flosteron" psoriasis (ukubuyekezwa nomuthi izokwethulwa ngezansi), kanye nezinye izifo asetshenziswa parenterally. Ngamanye amazwi, lo nomuthi ngaphansi ukucatshangelwa abavunyelwe ukusebenzisa i naphakathi-articular, okolosustavnogo kanye nokuphathwa intradermal. Kufanele kuphawulwe ukuthi izimo ezehlukile iqondiswa intramuscularly.

Dose abadala nabantwana kunqunywa ngamunye. ivolumu kwakho kuncike uhlobo kobukhulu isifo, impendulo esiguli, ubukhulu nendawo joint, kanjalonjalo.

ekuphathweni Periarticular futhi intraarticular:

• amalunga omzimba ezinkulu (ngokuvamile inqulu) - 2.1 ml;
• amalunga omzimba ezinkulu (ehlombe, amadolo, iqakala) - 1 ml;
• amalunga omzimba isilinganiso (izindololwane, isihlakala) - 0.5-1 ml;
• amalunga omzimba amancane (interphalangeal, metacarpophalangeal, sternoclavicular) - 0.25-0.5 ml. Acute sokuqaqamba kwamalunga gouty kudinga ukusetshenziswa kusuka 0.5 kuya 1 ml umkhiqizo.

Imijovo emalungeni esikhulu kufanele kwenziwe akukho kuka 3-4 izikhathi ngonyaka. A umthamo owodwa we izidakamizwa akufanele futhi iyophakama kuno-0.2 ml ^{cm2 ngayinye.}

kokuziphatha Wasekhaya:

• tendonitis futhi tenosynovitis - 0.5 ml;
• bursitis - mayelana 0.25-1 ml (esigabeni abukhali 2 ml);
• fibrositis mayelana - 0.5-1 ml.

Umuthi isetshenziswa njalo emavikini 1-2. Uma kudingeka, ekwakhiweni kwelinye isipetu abangu elixutshwe izinzwa wendawo.

ekuphathweni lefundo komzimba:

• Isikali olulodwa - kusuka 1 kuya 2 ml (intramuscularly kuphela).

I nomuthi is injected imisipha gluteus ezijulile.

Izingane ezivela 3 kuya 5 iminyaka umthamo kokuqala 2 mg, futhi eminyakeni 6-12 - 4 mg.

ukweqisa izidakamizwa

Endabeni ka ukweqisa izidakamizwa iziguli elandelayo izimpawu kungenzeka: ukuyaluza, isicanucanu, ukuqwasha, ukuhlanza, ukudangala nesasasa. ukusetshenziswa isikhathi eside izimali e imithamo ephezudlwana izidakamizwa kubangela myopathy, ukukhumuzeka kwamathambo, egcina amanzi, Cushing Syndrome, kukhuphuke blood pressure kanye okusithiyayo we cortex operation adrenal. Ngoba impatho labanti ladzingekako kute kuncishiswe inani izidakamizwa, bese ngokuphelele yokuqeda ke.

Imiphumela engemihle amathuluzi

Izidakamizwa "Flosteron" akumele zisetshenziswe ngesikhathi sokukhulelwa. Lokhu kungenxa yokuthi lokhu izidakamizwa has omningi engemihle. Zingase senziwe yingxenye yazo zonke izinhlelo eziyishumi nemitshingo.

• uhlelo endocrine: hirsutism, ukwehla ukubekezelelana glucose, ngokobulili ukuthuthukiswa retardation ezinganeni kanye intsha, isifo sikashukela steroid, nokunye.
• Ukugaya: esophagitis erosive, candidiasis oropharyngeal, pancreatitis, isicanucanu, kwehle, njll ..
• Izikebhe inhliziyo arrhythmia, hypercoagulation, bradycardia, thrombosis emithambo yegazi, nokunye.
• isimiso sezinzwa: ukusangana, ikhanda elibuhlungu, sengqondo ukwenama-bacindezeleke, ukucindezeleka, ukuba nesiyezi, disorientation, pseudotumor cerebellum, bajabula, ukukhathazeka, uhlanyiswa, njll ...
• Imiqondo: izinguquko trophic we-cornea, ukulahlekelwa ngokuzumayo umbono, subkalsulyarnaya ale nkinga, izifo zamehlo, diplopia, exophthalmos, nokunye.
• Umzimba: hypernatremia, hypocalcemia, sodium ne nokugcinwa oketshezini inzuzo isisindo emzimbeni.
• uhlelo zemisipha: imisipha umsipha ukudabuka, ukukhula retardation ezinganeni, ukukhumuzeka kwamathambo, myopathy steroid, proximal buthakathaka kwezicubu, ukulahlekelwa yemisipha.
• Skin futhi nolwelwesi lwamafinyila: yoma kwesikhumba, petechiae, ehlambulula kwesikhumba, ecchymosis, induna steroid, kancane ukuphulukiswa amanxeba.

izidakamizwa ekuhlanganyeleni

Ngaphambi isicelo izimali ezidingekayo ukuze sithole ukuthi kungenzeka ngesikhathi esifanayo namanye nemithi ukusebenzisa izidakamizwa "Flosteron".

• Nokuvinjelwa kwandisa imisipha ngesikhathi usebenzisa ezinye corticosteroids.
• Kusebenta betamethasone ngokuphawulekayo encishisiwe uma iqondiswa kanye phenobarbital, rifampicin, phenytoin futhi carbamazepine.
• Ukwabelana izidakamizwa "Flosteron" futhi ritodrine contraindicated, njengoba le nhlanganisela kungabangela edema yamaphaphu.
• Nge isicelo olulodwa yokugoma namagciwane (bukhoma) kwandisa ingozi yokutheleleka futhi kusebenze amagciwane.
• Ukulungiswa kwandisa ubuthi asparaginase incipha umphumela somatotropin, futhi kunciphisa umzimba cyclosporin.

"Flosteron" noma "Diprospan": okuyinto engcono?

Ingqikithi asebenzayo kokubili imali kuyinto ukwakheka efanayo, kodwa ezifanayo. Kodwa naphezu kwalokhu, izindleko zokuqala incane kakhulu kunaleyo yesibili. Kokunye, lokhu kubangelwa ukuthi nomkhiqizi izidakamizwa. Nokho, abanye ochwepheshe bathi "Flosteron" umuthi ngaphezulu. Ngesikhathi esifanayo, siphawula ukuthi kukhona impela eningi okubuyayo mayelana nomuthi "Diprospan". Iziguli zithi umuthi ingasaphathwa imiphumela emibi. It cishe akusho baxabane nomzimba futhi kwamukeleka aphila kahle. Ngesikhathi esifanayo babe ungaphenduli kahle imithi, "Flosteron", ebhekise ukwehluleka yayo. Nokho, kufanele kusho ukuthi zonke luyingxenye ngabanye lapha.

By the way, umbuzo we esikhundleni ngenye indlela okufanele unqume kuphela emva kokubonisana udokotela wakho.

analogue kwezimali

Ngaphezu lesi sidakamizwa "Diprospan" isidakamizwa "Flosteron" unezinye nozakwabo. Lezi zihlanganisa izidakamizwa ezilandelayo: "Akriderm" "Betamethasone Sodium phosphate", "Akriderm yaseGhent" "Betamethasone valerate," "Betnoveyt", "Tselederm", "Beloderm" "Betamethasone dipropionate," "Beloderm Express", " Tseleston "," Diprospan "," Betazon "," Celestoderm-in, "" Betamethasone "," Betliben "," Kuterid ".