"Hydrea": imfundo manual, izibuyekezo, izithombe, analogue

Izidakamizwa "Hydrea" kungokwalabo anticancer izidakamizwa. Umuthi kunomphumela cytostatic, lo mshini okuyinto esekelwe okusithiyayo we-DNA zamagama, kanye nemiphumela RNA namaprotheni zamagama sishoda.

Ngayiphi ifomu ke ekhiqizwa izidakamizwa, ukuthi siqukethe?

I nomuthi kukhishelwa ngesimo amaphilisi wenza hydroxycarbamide based, okuyinto mg 500 e capsule ngamunye. Umuthi itholakala umfuma ingilazi (amaphilisi 100), noma iphakethe ibhamuza (10 amaphilisi). Yezingxenye asizayo esetshenziswa magnesium stearate kanye citric acid. Futhi, ukwakheka kulekelelwa ne-sodium ne-hydrogen phosphate dihydrate futhi monohydrate-lactose.

I izinto eziyimisebenzi igobolondo amaphilisi "Hydrea" Iziqondiso titanium dioxide, udayi kanye gelatin. kwakhiwa Umbhalo is by ink okuyinto etholakala ngenxa elibona nxazonke propylene glycol, Shellac, utshwala (isopropyl, methylated ezimbonini kanye N-butyl), namanzi ahlanzekile nensimbi oxide abamnyama.

pharmacodynamics

Umuthi kuyinto antimetabolite, umphumela walo kubonakala iseli umjikelezo S isigaba. "Hydrea" ivumela ukuyeka ukuthuthukiswa lamaseli interphase G1-S, okuyinto ebaluleke kakhulu lapho kanyekanye ne yokwamukela nomuthi eyenziwa radiotherapy, njengasezulwini G1 isigaba isimila cells nozwelo ngemisebe ukuphi. Ukulungiswa sithuthukisa isenzo ribonukleoziddifosfatreduktazoy wayenethonya (RNA reductase inhibitor). Ngokusebenzisa engasenamahloni DNA zamagama alo, kodwa ayiphazamiseki protein ne-RNA kumiswa.

Pharmacokinetics

Absorption zomuthi e pheshana emathunjini "Hydrea" imfundo manual uchaza ngesivinini esingakanani ngaphandle bathonywa ukudla futhi kuholela ekuzuzweni kwemiPhumela ezingeni esiphezulu lomcebo asebenzayo emzimbeni cishe amahora amabili ngemuva ukusetshenziswa izindlela zangaphakathi. I nomuthi sidlula umgoqo gazi ebuchosheni, elinesimo ukusatshalaliswa okusheshayo ekhona ascites nasoketshezini cerebrospinal. Umuthi is zanqwabelana erythrocyte futhi leukocyte kancane excreted ngaphakathi amahora amathathu kuya kwamane. umzimba kwengxenye esibindini. Iningi izidakamizwa excreted ngu izinso ngesimo hydroxyurea, i isikhathi eyisibonelo kule nqubo amahora ayishumi nambili. It akashintshi ezinye ukubukeka kwaso, inani elincane esuswa nomzimba umchamo. Ngohlelo zokuphefumula ipheshana izidakamizwa excreted njengoba carbon dioxide. Emva kokuthola "Hydrea" imfundo umemezela ukuqedwa wako ngosuku. Njengoba ingxenye enkulu yale izidakamizwa sidlula izinso, ezigulini abe zokugula kwezitho, ukunciphisa umthamo izidakamizwa.

ubufakazi

"Hydrea" imfundo on isicelo ikuvumela ukwabela ngaphansi kwezimo ezinjalo umzimba:

• melanoma;
• wegazi myelogenous;
• umdlavuza, ukuthuthukiswa esithinta wesibeletho, iphaphu, wendlala, ikholoni noma amaqanda (Ukwelashwa kufanele kuhlanganiswe);
• osteomyelofibrosis;
• erythremia;
• khona ngesimo abulalayo izimila entanyeni ekhanda, ngaphandle nje kuyinto umdlavuza othinta izindebe (kukhona isidingo ukwelashwa olunzulu);
• thrombocythemia Essential;
• horionepitelioma kwesibeletho;
• acute lymphoblastic leukemia ukugeleza;
• thrombocytosis njengoba izinkinga zokwenza myeloproliferative syndrome;
• isifo Hodgkin sika;
• okuvela Ukudlulela komdlavuza, ezilimaza indlala mammary nasesiswini.

Izimo

Kukhona amacala lapho ukwelashwa Akwamukelekile kusho "Hydrea". Imithi imfundo unqabela ukhombe ezimweni ezinjalo:

• ukuzwela ePhakeme ukuba amaphilisi;
• thrombocytopenia futhi leukopenia ngamazinga engaphansi kuka 100,000 futhi 2500 / ml ngokulandelana;
• sokukhulelwa, ukuncelisa ubisi lwebele.

Nakuba kulezi zimo ezilandelayo kanye izidakamizwa is hhayi contraindicated, lapho wamiswa futhi isicelo sidinga ukunakekelwa okukhethekile:

• zikashukela-galactose malabsorption;
• zokungezwani ne-lactose;
• yokuntuleka lactase;
• Heavy ageleza anaemia;
• ukungasebenzi kwezinso nesibindi.

Uma isiguli kwake ngaphansi ukwelashwa ngamakhemikhali noma ukwelashwa ngemisebe, ingozi acute erythema emisebeni kanye nokuthuthukiswa myelosuppression, Ngakho-ke, kulesi simo, futhi, kudingeka ngobumnene ukusebenzisa imithi.

Phakathi ukwelashwa kudingeka ukuvimbela inzalo ethembekile, uma nokho ukukhulelwa, isiguli kufanele bazazi ingozi ukuthi ikhona i-fetus. Ngenxa Ukungena zomuthi ku obisini lwebele kukhona nabesifazane ababemkhalela, ukuncelisa, kubalulekile ukuba ayeke lolu hlobo yokudla. Uma izidakamizwa sihlelelwe ukukhansela, onguchwepheshe kufanele bacabangele amaphuzu ahlukahlukene ngaphambi kuzovumela isiguli lokukwenqaba esekelwe reception amaphilisi "Hydrea".

ukwelashwa

Phakathi impatho nomuthi "Hydrea" imfundo manual incoma usebenzisa ngemithamo ezahlukene ejenti ezifundeni ezehlukene, banikezwe izici nesineke.

Uma isiguli kunzima ukugwinya capsule, kuyamukeleka kuvulwa izidakamizwa ukuncibilikisa emanzini. Ezimweni ezinjalo, i-ejenti kumele ukuphuza ngokushesha. Kumele kukhunjulwe ukuthi akubona bonke izingxenye amaphilisi chaza emanzini, asele phezulu. Iziguli belashwa "Hydrea", kubalulekile ukuba siphuza neziphuzo kakhudlwana.

wegazi Myelogenous (ifomu ezingamahlalakhona)

Ukwelashwa wenziwa ngaphandle kokuphazamiseka. Isizathu salokhu siwukuthi yonke kilogram esisindo uthethe 20-30 mg zomuthi. Lokhu yangosuku, izidakamizwa edliwe kanye nsuku zonke. Ithuba ukuhlola ukusebenza yokwelapha ubelokhu ekhona ngoba 1.5 izinyanga kokusebenza yayo. Uma imiphumela emihle kubalwe, ukwelapha kungaba isikhathi eside ngokwanele (e isidingo sayo), ngesikhathi ewa amazinga zegazi kanye leukocyte ngezansi kuyinsakavukela yayo imisiwe. Uma emva kwezinsuku ezintathu (hhayi ngaphambi) igazi wabuyela esimweni esivamile, ungaqalisa kabusha yokwelapha nge "Hydrea". Yokusetshenziswa ebonisa ukuthi leli thuba elihle kangaka uyeza masinyane.

erythremia

Umthamo oyifunayo ekuphathweni nsuku zonke 15-20 mg. Njengasendabeni yabase langaphambilini, leli nani izidakamizwa ibalwa amakhilogramu esisindo ngayinye. Usuku isiguli uqobo iqondiswa 1 noma 2 amaphilisi. umthamo Lokugcina esigulini ngasinye kunqunywa isisindo sayo, incike inani izidakamizwa lapho zegazi kanye namazinga hematocrit izimiso ezijwayelekile.

thrombocythemia Essential

Umthamo kokuqala amakhilogramu esisindo ngayinye elihambisana 15 mg. I umthamo wansuku zonke is kushintshwe ngamunye ukuze izici ezibalulekile babe ezingeni lelifanele. Uma kungavunyelwe ukwelashwa izidakamizwa "Hydrea" imfundo omqondofana udokotela ehlola futhi ikhetha indlela okufaneleka kakhulu kunokunye.

melanoma

Nge izimila ezinkulu zokwelapha kungase kube into noma ngakanye namkha okuqhubekayo, ngokulandelana, umthamo ledzingekako nomuthi ngamunye kilogram of isisindo 80 mg noma 20-30. Ngezinye amasonto amathathu, isikhathi imithi yokwelapha okuqhubekayo nsuku zonke baphuze kanye. Uma yokwelapha yenziwa ngezikhathi izinsuku ezintathu, aphuze nabo kanye, kodwa umthamo ephakeme.

Carcinoma (lesion wesibeletho, ekhanda noma emqaleni)

Per amakhilogramu umzimba isisindo iphelile 80 mg izidakamizwa. Umthamo oyifunayo imithi edliwe njalo ngemva kwezinsuku ezintathu (kanye).

side effects

Lapho ukwelashwa "Hydrea" imfundo, ukubuyekezwa babike ezinye imiphumela emibi ohlelweni hematopoietic, abakaze, urinary, zokuphefumula kokudla. Futhi, kungenzeka isikhumba abathintekayo futhi ezihlobene zabo kungenzeka ukuthuthukisa ngegciwane ezinjalo, njengoba esibhibhayo. Can imakwe nezinye ukusabela ezingezinhle.

I inani lentengo lomuthi, analogue

Thenga iphakheji "Hydrea" kungabangwa ruble 243-250. (20 amaphilisi). Phakathi esikhundleni - amalungiselelo aqukethe isithako ezisebenzayo ezifanayo "Hydrea" namaphilisi nomphumela ofanayo.

Kulaba omqondofana ungathenga "hydroxyurea" noma "Hydroxycarbamide Medak." Lapho unqabela ukwelashwa "Hydrea" umhlahlandlela, analogs kungenziwa kukhethwe inqwaba ukuthaka imithi, njenge "Tromboreduktina" "amyl FS", "Kolotekana", "Milanfor", "Prospidin", "iritis", "halava", "Estratsita" "Irinotela", "Kamptotekana" noma "Estratsita". Ungathenga esikhundleni ezifana "Agrilin", "Kamptera" noma "Erivedzh". Phakathi izindawo kukhona izenzo ezifanayo "Aranoza", "Irinaks", "Arglabin". Uhlu imithi efanayo bakha 'Zaltrap "," Irnokam "," Geksalen ". Ingelapheka "Proksifeinom", "Gikamtinom", "Campto", "Verotekanom", "Hloditanom", "prospidin", "Onkofagom", "irinotecan" noma "Velcade".

Izibuyekezo

iziguli eziningi zikholelwa ukuthi incazelo ngaphambi kokuqala ukwelashwa kufanele uhlole kusho "Hydrea" imfundiso. Izithombe phambi futhi ungakwazi ukubuka post-ukwelashwa. Ukwahlulela ukubuyekezwa, abantu bakhetha aphathwe kuphela ngaphansi kweso lwezokwelapha kanye ingozi hhayi ukuzithiba medicate, njengoba lokhu kuyingozi, siphuza neziphuzo kakhudlwana. Uma kungenjalo ukuphuza umuthi is kuhlangene ukwelashwa ngemisebe, imiphumela emibi noma avele (ezimweni lapho ngingekho ngaphambili), noma babe kubi nakakhulu. Kodwa awusebenzi ngaso sonke isikhathi kwenzeke.