"Insulin isophane": yokusetshenziswa, analogs

Isifo sikashukela - isifo esiyingozi kakhulu, okuyinto, ngeshwa, kungenakususwa ngokuphelele. Njengoba wazi, ku isizinda isifo khona kungukuphula uketshezi hormone ezicutshini pancreatic. Futhi iziguli kaningi linqume zokwenziwa insulini "Isophane". Lokhu kwaziswa elawula izinga ushukela egazini, ukuqinisekisa ukusebenza evamile wonke umzimba.

Yiqiniso, iziguli unesithakazelo kunoma yiliphi ulwazi olwengeziwe mayelana izidakamizwa. Njengoba kuthinta umzimba semi zokwenziwa insulini "Isophane"? Imiyalelo, Izimo, ukuxakeka kungenzeka ngesikhathi yokwelapha - iphuzu elibalulekile, okuzoxoxwa ngayo kulesi sihloko.

ukukhululwa Ifomu

Kuyinto imfihlo ukuthi isifo sikashukela isifo ovamile futhi iyingozi edinga ukusetshenziswa kwezidakamizwa ezihlukahlukene, kuhlanganise insulini. "Isophane" - lo egameni lendawo yokuhweba noma izidakamizwa, okuyinto inhlanganisela semi okulungiselelwe hormone. izidakamizwa Iyatholakala ngesimo isixazululo kwezokuphatha ongama. Umuthi okuthengiswa ingilazi izitsha eziyisikhombisa ngesikhathi 10 ml umthamo 40ME / ml. Ukulungisa isixazululo usebenzisa manzi ahlanzekile ngoba umjovo.

Uma nezinye izidakamizwa ne ukwakheka efanayo kanye izakhiwo njengoba insulin "Isophane". Synonyms ke - ke 'Insuman', 'Protafan "futhi" Himulin ". Kufanele ngokushesha kuthiwe imithi enjalo okunikelwa kadokotela kuphela, noma kubanikela endocrinology.

Yini izakhiwo izidakamizwa?

Insulin "Isophane" kuyinto hormone semi zokwenziwa esesikhundleni ezifanayo kodwa ngesikhathi esifanayo nomongo ekhiqizwa amanyikwe womuntu. Umuthi kunciphisa inani glucose egazini ngokuqinisa izinqubo lipogenesis futhi gluconeogenesis.

i-hormone Zokwenziwa baxhumana insulini receptor of cell ulwelwesi, isebenze izinqubo umzimba ngaphakathi engqamuzaneni. Ngemva kokungenisa zamagama waphawula ukusebenza enzyme ethile, kuhlanganise glycogen, pyruvate kinase futhi hexokinase.

I siba nomphumela singabonakala ngemuva kwamahora 1-1.5 kuphela ngemva kokuphathwa yesixazululo. Kuye umthamo futhi umzimba wesiguli umsebenzi maximal we-insulin zokwenziwa waphawula ngemva kwamahora angu-4-12 ngemva kokuphathwa. Umthelela Uthatha amahora 11 kuya 24.

I izinkomba main ukusetshenziswa

Ukulungiselela "insulin Isophane" isetshenziswa uhlobo sikashukela (ifomu insulini ancike) yesibili. Iphinde isetshenziselwe i-insulini yesikhashana. Ngezinye izikhathi ukwelashwa okunjalo liyadingeka nesifo sikashukela Uhlobo lokuqala. Ngokwesibonelo, ukwethulwa isixazululo batusa ukuthi iziguli uma ejenti hypoglycemic ungayeki umphumela oyifunayo.

Ukwethulwa kwe-insulini womuntu liyadingeka emva nezinqubo ezithile zokuhlinza. Lokhu imithi isetshenziswa kanye sikashukela sokukhulelwa mellitus (lolu hlobo sifo kwenzeka kwabesifazane ngesikhathi sokukhulelwa). Insulin omama batusa ukuthi uma ukwelashwa Ukudla akanayo umphumela oyifunayo.

Semi-zokwenziwa insulini "Isophane": yokusetshenziswa

Ngo uhlobo labantu abanesifo sikashukela yesibili zidinga ukwelashwa impilo yonke. Umthamo inani nsuku zonke, esimisweni sokuqondisa - konke lokhu kunqunywa endocrinology yakho. Kubalulekile ngokuqinile zonke iziqondiso okhokhelwayo. Kukhona ezinye imithetho jikelele elokusebenzisa izidakamizwa "insulin Isophane".

• Isixazululo yakhelwe kuphela abaphathi ongama. Ezimweni ezingavamile, udokotela wakho angase Sisikisela imithi iqondiswa intramuscularly. imijovo intravenous zivinjelwe.
• Umuthi akufanele iphathwe endaweni efanayo.
• Okokuqala sidinga nithintithe isitsha izikhathi ezimbalwa, bese ushayele ngenani elithandekayo isixazululo isipetu (umthamo kushintshwe ngamunye).
• Umjovo kumele kwenziwe ngokushesha ngemva ugcwalisa isipetu.

I izitsha eziyisikhombisa ikhambi ubekwe kwisiqandisi at 2-8 degrees Celsius. Ngaphambi ukwethulwa izidakamizwa kuyadingeka ukukala amazinga igazi glucose. Akunakusetshenziswa abakwazi ukusebenzisa imithi uma ukuqaphela turbidity yesixazululo, ukwakheka imali kwi ezindongeni ibhodlela.

Ingabe kukhona Izimo?

Umuthi anezinye Izimo - idatha uqukethe imiyalelo ukusetshenziswa. "Insulin Isophane" alisetshenziswa in iziguli kahle kungakhuphula izinga likashukela. Izimo uyalandisa insulinoma futhi hypersensitivity kuya izithako izidakamizwa. Kufanele kuqashelwe ukuthi ngezinye izikhathi ukushintsha indawo umjovo kungaholela ukusabela iguliswa futhi ukubukeka nezinye imiphumela emibi.

Imiphumela engemihle

Lokhu ukulungiselela kuyadingeka in iziguli insulini ancike ngifundise ngesifo sikashukela. Nokho yokwelapha lihlotshaniswa yezinkinga eziningana. Yikuphi ukwephulwa kungaholela ukusetshenziswa kwemithi "insulin Isophane"? Umhlahlandlela uqukethe ulwazi olulandelayo:

• Ukuze uhlu iziyaluyalu ezivamile zihlanganisa ukusabela kabi komzimba, okuyinto ahambisana ukubukeka ukuqubuka, kanye urticaria, iconsi elibukhali blood pressure, kukhuphuke izinga lokushisa komzimba nokugeleza ukubukeka edema.
• umphumela eziyingozi yokwelapha insulini kuyinto kahle kungakhuphula izinga likashukela - isimo elinesimo ukwehla amazinga kashukela egazini. Izimpawu zihlanganisa isikhumba ugodo, ukushaya kwenhliziyo okusheshayo, ukukhathazeka nezinkinga ukulala, umuzwa njalo indlala. ukuhlukumeza okunjalo ngokuvamile ngenxa Isikali ayilungile, noma ukwehluleka ukuhambisana nalo iziqondiso kadokotela. Emacaleni angu-olunzima, sibangelwa ikhoma hypoglycemic.
• Ukuqaliswa ukwelashwa kwezinye iziguli elihlobene ne ongaboni. Okuningi sikhathazeke ngakho ngeke kukusize ngalutho-ke, ngenxa yokuthi ezikhathini eziningi, le miphumela emibi hamba bebodwa.
• Ukuze uhlu yezinkinga kungenzeka zihlanganisa ukusabela immunological, nayo bavivinywe ukuzivumelanisa ukuma komzimba insulini.
• Ekuqaleni isidakamizwa kungenzeka isikhumba ukusabela, kuhlanganise ububomvu kanye ukulunywa. Futhi ukudlula bebodwa.
• Ukwethulwa ukuphuza amaphilisi amaningi kakhulu igcwele okuthile engqondweni. Kukhona ukucasuka kakhudlwana, ukukhathazeka, ukushintsha indlela yokuziphatha, ukuthuthukiswa zokucindezeleka.

Kuyaqondakala ukuthi isingeniso insulin "Isophane" kufanele kube ngokwesimiso sansuku lwentiwe udokotela. Yeqa umjovo ephelezelwa ukuthuthukiswa lactic sikashukela.

Insulin "Isophane": nozakwabo

Ngo inqubo yokwelapha yesimanje, insulini womuntu zokwenziwa (ukuchayeka semisebenzi kanye esimaphakathi) asetshenziselwa ukulawula glucose ezingeni womuntu hormone okuthiwa i analogs, futhi Izingxube yalo. Yiqiniso, emakethe ezithaka imithi inikeza eziningi izidakamizwa ukuze zibasize okwesikhashana ukuqeda izimpawu zesifo sikashukela.

Ukuze uhlu analogue zihlanganisa izidakamizwa ezifana "Aktrafan", "Biogulin", "Diafan". Kwezinye izimo, iziguli ukuthatha imithi Kunconywa "Protafan", "Humodar", "Pensulin". Akukubi futhi kubhekwe insulins "isizinda" kanye "Verein". Kuyaqondakala ukuthi amahomoni - izidakamizwa sina futhi uwasebenzise ngokuzimela noma ngabe yikuphi engenakwenzeka. Kuphela udokotela ungakhetha Analogue, futhi ukunquma umthamo. Ngokwesibonelo, ukuba khona isixazululo okungenani olulodwa okufakiwe kwezinye iziguli kungabangela omkhulu impendulo iguliswa kuze kube ukushaqeka anaphylactic.

Ulwazi mayelana nokuxhumana neminye imithi

Ngaphambi ukwelashwa okufanele yazisa udokotela ukuthi ngiphuza imithi. Zokwenziwa insulini isinyathelo okuthuthukiswa ekuphathweni kanyekanye ne sulfonamides, adrogenami futhi Anabolic steroid, mao inhibitor, izidakamizwa nonsteroidal antiinflammatory. Umthelela hypoglycemic evelele okwengeziwe isizinda ukusetshenziswa ngesikhathi esisodwa "Isophane" izidakamizwa ketoconazole, cyclophosphamide, i-quinine, chloroquine, nemithi quinidine equkethe lithium. By the way, therapy is hhayi Kunconywa ukuba uphuze utshwala, njengoba Ethanol sithuthukisa umphumela zokwenziwa insulini.

Estrogens, kontsratseptivy temlomo, glucagon, heparin, ama-hormone egilo buthaka umphumela umuthi. Kunjalo-nicotine, insangu, i-morphine, isisu ethile (isib thiazide futhi loop), tricyclic antidepressant.

Kunoma ikuphi kubalulekile ukuqonda ukuthi ngaphandle kwemvume kadokotela Awukwazi ukushintsha umthamo noma esimisweni sokuqondisa we-insulin. Ukubukeka kahle futhi ukusabela ezingezinhle kufanele zibikwe endocrinology bayahlanganyela.