Izidakamizwa "Nise". Yokusetshenziswa

Ukuthaka imithi izidakamizwa esebenzayo okuyinto nimesulide ifa nomthelela obonakalayo eqeda ukuvuvukala kanye analgesic. Ngempela buyisidakamizwa non-steroidal "Nise". Isetshenziselwa ukwelapha isifo samathambo sibe, i-osteoarthritis, samathambo, myalgia, arthralgia, bursitis, tendinitis, algodismenorei ukuze kuxazululeke nasezinkingeni ezilandela ngemva kokuhlinzwa ubuhlungu posttraumatic, ubuhlungu zamazinyo ikhanda, imfiva genesis ezahlukene. Iyatholakala ngesimo amaphilisi kokuba umbala omhlophe nge umthunzi aphuzi, futhi gel (ecacile, ukukhanya yellow noma ophuzi) ukusetshenziswa yangaphandle. Izibhebhe letiyindilinga, ukuma biconvex futhi surface bushelelezi. Ubude 100 mg 1 sibhebhe sinamaphutha Nimesulide izidakamizwa "Naiz". Ukufundiswa uhlu adjuvants: corn isitashi, microcrystalline cellulose, hydrogen -calcium ne-phosphate, sodium isitashi glycolate, magnesium stearate, talc aziphothula, colloidal Silica anhydrous. Ngo 1 g 1% ijeli iqukethe 10 mg nimesulide. Gel nezinsizasenzo yilezi: propylene glycol, N-methyl-2-pyrrolidone, macrogol, carbomer 940, isopropanol, hydroxyanisole butylated, potassium phosphate, thimerosal, amanzi, isithokela.

Ngokokuqala ngqá umuthi equkethe nimesulide, wadedelwa ngo-Italy (isibonelo, «Aulin» futhi «Mesulid») ngo-1985 futhi okwamanje lutholakala emazweni angaphezu kuka-50: France, Portugal, Greece, eSwitzerland, Belgium, eMexico nase Brazil . Nokho, izidakamizwa kanye nimesulide e-United States kungukuthi ithengiswe. Medicine "Nise" umhlaba unayo equivalent, zitholakale ngaphansi kokulandelayo zokuhweba :

• «Sulide», «Mesulid», «Nimalox» (Brazil, Greece);
• «Aulin», «Mesulid» (Italy);
• «Coxtal» (China, Czech Republic, Bulgaria);
• «Sintalgin» (Brazil);
• «Eskaflam» (Brazil, Mexico);
• «Octaprin» (Pakistan);
• «Nise» (India, e-Russia, Venezuela, eVietnam, Ukraine);
• «Nilsid» (Egypt);
• «Ainex», «Drexel», «Edrigyl», «Enetra», «Donulide», «Heugan», «Mesulid», «NeRelid», «Nexen», «Minapon», «Nidolon», «Nilden» (Mexico) ;
• «Nimed», «Nimesil», «Nimutab», «Nimedex», «Nimdase», «Nimopen-MP» (India);
• «Nisulid», «Nodard», «Nicip», «Nimcap» (India);
• «Novolid», «Relmex» (Ecuador);
• «Remisid» (Ukraine);
• «Scaflam», «Sulidin», «Scaflan» (Turkey);
• «Modact IR" (Pakistan).

Umuthi has a indlela okusheshayo kakhulu futhi multifactor isinyathelo, kuhlanganise kuyalithinta inhibitory ku-enzayimu Cox-2 (cyclooxygenase isoforms omunye olawula kumiswa prostaglandins kusukela arachidonic acid). Ngakho-ke, lesi sidakamizwa "Nise" lisetshenziswa ekwelapheni anhlobonhlobo izimo ukuvuvukala. Manual uncoma ukusebenzisa kwayo i-ekwelapheni izinhlungu acute, ukuphathwa siyefana osteoarthritis dysmenorrhoea oyinhloko (eyindilinga isimo sokugembula ezinsukwini zokwehlukaniswa, ebonakaliswa sebuhlungwini obunzima besisu) e sobusha nesokuba umuntu omdala. Nimesulide siye sathuthukisa ezokuphepha pheshana emathunjini iqhathaniswa nezinye ama-NSAID.

Njalo ukulungiselela "Nise" inikezwa ngokucophelela okukhulu. Umhlahlandlela uxwayisa iziguli ezinesifo senhliziyo, unomfutho wegazi ophakeme, isifo sikashukela sohlobo lwe-II. Kodwa abantu abadala akudingeki yokulungiswa kokudla nokufakwa lwemithi. ukusetshenziswa eside zomuthi kudinga ukuqapha esihleliwe nezinso isibindi. Ukubukeka ukusabela ezingezinhle (ngesimo isilungulela, isicanucanu, ukuhlanza, uhudo, gastralgia, ulceration we mucosa emathunjini, ikhanda, isiyezi, uketshezi nokugcinwa, nokungezwani komzimba nezinto kuhlanganise ukuqubuka kwesikhumba, ukushaqeka anaphylactic) iyona isignali kudokotela . Naphezu kweqiniso lokuthi imikhiqizo equkethe nimesulide, eningi, ukuba esikhundleni "Nise" kunoma yiziphi analogue ngaphandle udokotela is hhayi Kunconywa.

"Nise" esiyingozi izidakamizwa ukweqisa izidakamizwa. Umhlahlandlela lichaza izimpawu zaso. Lezi zihlanganisa ukozela, ukucobeka, isicanucanu, ukuhlanza, ukopha emathunjini, umfutho wegazi ophakeme. Ungezwa ubuhlungu e esifundeni epigastric, ukucindezeleka zokuphefumula, ukwehluleka oyingozi so-renal, ukusabela anaphylactic, futhi equlekile. Endabeni ka ukweqisa izidakamizwa ayikwazi ukusetshenziswa kunoma isihlungu, ngoba nje alikho, ngakho udokotela ekunika yokwelapha lingaze. Esikhathini amahora zokuqala ezine ngemva okuvela nanoma yiziphi lezi zimpawu isiguli sagezwa esiswini futhi unike namalahle isebenze. Hemodialysis kulokhu akuyona ngempumelelo. Lapho ukuphatha izidakamizwa kudinga ngokucophelela uma kanyekanye ne nimesulide babelwe izidakamizwa ezifana "Phenytoin", "Digoxin ', isisu, izidakamizwa lithium nezinye ama-NSAID, antihypertensives, antidiabetics," cyclosporin "futhi" MTX ". Ngakho-ke self "Nise" akuvunyelwe.