"Luminal": imiyalelo ukusetshenziswa olusanda kuzalwa

Uyini izidakamizwa "Luminal"? Imiyalelo nokubonakaliswa lokhu izidakamizwa kuzoxoxwa ngezansi. Siphinde ukuchaza izakhiwo kwemithi zomuthi, imiphumela engemihle kanye contraindications.

Ukwakheka izidakamizwa futhi ngendlela

Equkethe izidakamizwa "Luminal"? Yokusetshenziswa ibika ukuthi lichaza ekwakheni lokhu ekwakhiweni kuhlanganisa isithako esebenzayo ezifana phenobarbital. Futhi kubhekwe izindlela kuhlanganisa izingxenye ezilandelayo ezengeziwe: amazambane isitashi, gelatin, talc ne-calcium stearate.

Ukulungiselela "Luminal", izinkomba lapho ethulwa lapha, is imakethwa ngesimo powder senzelwe isixazululo umjovo. Futhi leli thuluzi angathengwa ngesimo izibhebhe 100 mg, okuyinto Agcwele ukunquma nentaba cell kanye emaphaketheni ezenziwe iphepha, ngokulandelana.

Umthelela zokwelapha zomuthi

Kuyini lokhu imithi ngokuthi "Luminal"? Yokusetshenziswa uveza ukuthi lokhu remedy has sine okuyiluthayo nemiphumela anticonvulsant.

Okubukwe nomuthi uyakwazi ezikhandla isinyathelo suppressive (non-abakhethayo) ohlelweni womuntu sezinzwa, futhi zivimbele endaweni ethile (ngokuvamile sezinzwa) cortex ukunciphisa umsebenzi locomotor, ukuthuthukisa ukozela kanye ukupholisa.

Izidakamizwa "Luminal" imfundo on isicelo okuyinto kwisitaki iphepha kuyinto barbiturate enamandla kakhulu. Its izakhiwo sine-okuyiluthayo kubangelwa okusithiyayo of umsebenzi emangqamuzaneni okuthiwa kusebenze kumiswa reticular we nuclei we thalamus, brainstem, kanjalo kuthiye nokuxhumana wathi izakhiwo kanye cortex cerebral.

Izici izidakamizwa

Kuyini izidakamizwa emangalisayo "Luminal"? Yokusetshenziswa (izinsana iyindlela ebekiwe ngokuvamile kakhulu) uthi ukulala odalwe lolu barbiturate, uma kuqhathaniswa nabangu nosawoti has a isakhiwo ehluke ngokuphelele. Njengomthetho, ukuthuthukiswa nomphumela okuyiluthayo ngemva kokufaka lokhu imithi zenzelwe imizuzu 35-65 futhi kuthathe amahora 6-9.

Asinakusho ukuthi ikhambi ngaphansi ukucatshangelwa ziphephile liphinyiselwe izakhiwo anticonvulsant. Basuke kubangelwa ithonya izidakamizwa izindawo ezithile zesimiso sezinzwa. Uma usebenzisa lokhu izidakamizwa iziguli kwehle excitability neuronal kuzoni epileptogenic okuyinto evimbela ukuvela nokwanda pulses. Futhi ku isizinda "Luminal" kusho ekuvimbeni ephezulu imvamisa esithweni izinzwa, ukwanda embundwini ukushukuma kagesi esifundeni motor cortex cerebral.

Ngaphezu kwalokho, i-izidakamizwa inikezwe elinesimo umphumela encane analgesic kanye antigiperbilirubinemichesky. Futhi asikabi eqinisa ukusabela komzimba ezishukumisa ezibuhlungu.

imithamo Small "luminal" sizole, futhi okusezingeni eliphezulu -ugnetayut umoya medulla izikhungo kanye t. D.

izici kinetic

ngabe izidakamizwa amuncwa umzimba, "Luminal"? Yokusetshenziswa ibika ukuthi ngaphakathi emzimbeni ke sibhekana a ukumuncwa kancane futhi ephelele. I bioavailability ye-ejenti imayelana 80%, futhi isibopho ukuze plasma amaprotheni - 30%.

Isithako asebenzayo zomuthi lingena obisini lukamama, kanye placenta. Ngaphezu kwalokho, kungenziwa basakaza emisipheni fetus.

Excretion "luminal" kwenzeka nge izinso ngefomu ithuthuke noma ngesimo metabolites. Ukuze phenobarbital libhekene ekuqongeleleni wawubona ngempela. Ukungasebenzi kahle we nezinso kubangela prolongation yesenzo.

Izidakamizwa "Luminal": izinkomba ukusetshenziswa

Kubhekwe umuthi ezinqunyiwe abadala hhayi kuphela, kodwa izingane nezinsana zabo. Njengomthetho, isetshenziselwa:

• hyperbilirubinemia;
• isithuthwane;
• ngqi (ukulapha adjuvant);
• ekwelapheni acute nokuquleka convulsive.

Asinakusho ukuthi leli thuluzi angabelwa ukuba ukuphathwa elihlangene njengoba izidakamizwa sine ukuze kuqedwe nokukhathazeka, ukwesaba nokucindezeleka.

Uvala ukusetshenziswa

Manje uyazi ngaphansi kwaziphi izimo iziguli ekunike umuthi "Luminal". Izinkomba ukusetshenziswa kwalesi izidakamizwa ziye abalwe ngenhla. Ngokuphathelene Izimo ke Zithwala ezifana:

• sensitivity high emuthini;
• isibindi ezinzima nokulimala kwezinso;
• nezinhlobo ezahlukene zokuphikiswa porphyria;
• lactation nokukhulelwa.

Nomuthi "Luminal": yokusetshenziswa izingane kanye nabantu abadala

Ukusetshenziswa kwalesi izidakamizwa kumele ngokuqinile wabonisa. Ukusetshenziswa Its idinga ukukhethwa ngezifiso ukwelashwa lwemithi, umthamo, kanye nesikhathi lapho akuxhomekile nje kuphela esimweni uhlobo ukugeleza sifo, kodwa futhi eminyakeni lesiguli kanye nezinye izici.

Ngokusho imiyalelo, isilinganiso esisodwa umthamo nokubika amathuluzi abadala kuyinto 10-200 mg. Thatha amaphilisi anjalo kufanele kube izikhathi 1-3 ngosuku.

Njengoba izingane kuzalwa, ngabo umthamo izidakamizwa ibalwa okusekelwe esisindo (isisindo 1-10 mg / umzimba kg kathathu ngosuku).

Uma isetshenziswa ukwelapha izifo uhlobo ukumnika izidakamizwa, isilinganiso esithathwa omdala 100-1400 mg (ukumnika ngomjovo), noma 10-200 mg (i ujove esicutshini).

Ukubalwa umthamo isihloko imithi yezingane nakho ezenziwe ngokusekelwe isisindo sengane.

Ngokusho ochwepheshe, ngemva kokuphathwa emthanjeni, "luminal" umphumela walo omkhulu kufinyelelwe kungakapheli imizuzu 35.

side effects

Ingabe amathonya amabi ku umzimba womuntu izidakamizwa "Luminal"? Yokusetshenziswa (kusuka yokungezwani komzimba kusho aluboniswa) uveza ukuthi ekwelapheni idatha imithi isiguli singase ukuthuthukisa ezihlukahlukene amathuba okuba nemiphumela engemihle ethinta zonke izitho ezibalulekile kanye nezinhlelo. izimpawu ezingathandeki ubuthakathaka, ukukhathala, ukozela, ukucindezeleka futhi ataxia. Kungenzeka futhi ukuthuthukiswa thrombocytopenia, agranulocytosis, nokungezwani komzimba nezinto nokuphazamiseka-calcium umzimba.

amacala ukweqisa izidakamizwa

Nge ukweqisa izidakamizwa of "TMB" iziguli kaningi kakhulu ukuphathwa ikhanda, nystagmus, isiyezi, ataxia, izinkinga zokuphefumula, ukucobeka, ubuthakathaka, inkulumo ukungakhuli, ukozela, kushintsha izinga lokushisa komzimba, ukuvukwa amadlingozi, komfutho wegazi nezinye ukwehluleka. Ezimweni eziyinkimbinkimbi, kukhona: bradycardia noma tachycardia, edema yamaphaphu, ukudideka, arrhythmias, ikhoma, inyumoniya nokunye.

Ukuqeda lezi zimpawu kuyinto enqunyiwe lavage esiswini kanye ukwelashwa ngokukhishwa kobuthi egazini.

izidakamizwa ekuhlanganyeleni

Isicelo se-ejenti kubhekwe lihambisana izidakamizwa ezicindezelayo HC, methylphenidate noma mao inhibitor kwandisa lokuhlushwa isithako yayo asebenzayo indlela yokwakheka plasma, okuyinto kuholela umphumela esinobuthi okusithiyayo we-NA.

Inhlanganisela "Luminal" nge corticosteroids, chloramphenicol, corticotropin, dacarbazine, cyclosporine, digitalis glycosides, quinidine, metronidazole, tricyclic antidepressant, carbamazepine, anti-kokuquleka, okuqondene succinimides iqembu, doxycycline, anticoagulants, chlorpromazine, fenoprofenom, vitamin D ne-Phenylbutazone kunganciphisa isikhathi isinyathelo ngamandla le mithi ukwandisa umzimba wabo, kanye umthwalo isibindi.

ukwelashwa ngesikhathi esifanayo ne acetazolamide kungase neqhaza ekuthuthukiseni yamathambo futhi osteomalacia. Valproic acid ithuthukisa phenobarbital lokuhlushwa igazi, okuyinto kubangela ukupholisa evelele kanye ukucobeka.

Ukusebenzisa "luminal" kanye nimodipine, "Verapamil" futhi felodipine kunciphisa lokuhlushwa zabo egazini.

Ingxube nomuthi nge maprotiline sithuthukisa umphumela wawo inhibitory ku-NA, kunciphisa umphumela barbiturates anticonvulsant kanye nombundu convulsive.

Active isithako "luminal" paracetamol kungehlisa ukusebenza kahle futhi kwenyuswe ukuthuthukiswa hepatotoxicity. Lapho kuhlangene i-folic acid kunciphisa nekusebenta phenobarbital.

Pyridoxine kwehlisa umfutho lokuhlushwa phenobarbital, futhi primidone, felbamate futhi, Ngakolunye uhlangothi, ifake.

Analogs zomuthi kanye nentengo yayo

Umuthi eziyisisekelo ezibhekwa analogue izindlela ezifana "Barbinal" futhi "Dormiral".

amaphilisi Izindleko "Luminal" (100 mg, 10 nama-PC.) Of ruble 1100 nangaphezulu.

ulwazi oluthile

Kanyekanye reception "luminal" kusukela ethanol futhi ethanol-izindlela kungaba ngokuphawulekayo ngcono umphumela inhibitory zomuthi nesimiso sezinzwa isiguli. Ngakho-ke, utshwala nezinye isithako nomuthi okwelapha utshwala ngesikhatsi ukwelashwa nalezi ejenti kuthiwa contraindicated.

Izibuyekezo

Izibuyekezo Iningi le ukulungiselela ukushiya abanezingane ezincane. Bathi izidakamizwa "Luminal" ukulwa okuhle nezifo ezifana nesifo sokuwa nemibandela convulsive. Futhi ngokuvamile imithi isetshenziswa njengengxenye ukwelashwa, umphelelisi amaphilisi ezinhlungu yakhe.

Iziguli eziningi bathi nekusebenta okusezingeni eliphezulu zomuthi "Luminal". Noma kunjalo, ngokushesha sasithi ekwamukelweni izimali okufanele ngokuqinile ulandele umthamo kanye inhlanganisela yayo nezinye izidakamizwa.

Ngezinye izikhathi kubhekwa umuthi osetshenziselwa ukwelapha abantu dystonia semithambo, okuyinto kuhambisana neziqubu uvalo. Ukwelashwa nokuvikelwa leli thuluzi kuyasiza kulesetayelekile ngezimo zesiguli, ikakhulukazi uma kwaba imithi eyengeziwe, dilates imithambo yegazi kanye nokuzikhulula ekucindezelweni zibe.