Medicine "Trimektal": yokusetshenziswa, intengo, analogs kanye nokubuyekeza

"Trimektal", okuyinto eziyisisekelo isisekelo trimetazidine ketshezi asebenzayo kungokwalabo iqembu izidakamizwa nesenzo anti-hypoxic ubuntu, futhi isetshenziswa ngokuyinhloko nezenhliziyo ngenjongo kuqiniswa of uhlelo senhliziyo nemithambo yegazi. I nomuthi ngokuvamile ababelwe kuzo njengoba asekelayo / ukulungiswa kusho ukulapha eziyinkimbinkimbi futhi ukukhuthazwa yeselula inqubo umzimba kunomthelela nokwenziwa ngcono okuphelele isimo lesiguli.

Khipha ifomu kanye nokwakheka

Kukhona izinhlobo eziningana ukukhiqizwa "Trimektal" izidakamizwa. Yokusetshenziswa kusikisela ukuthi lokhu kungase kube okuqinile gelatin capsule (10/20 by amabhamuza noma amayunithi polymeric ka capacitance amabhange amayunithi 60) kanye tablet igobolondo ulwelwesi, retarding ukukhululwa kwe-reagents (anamabhamuza 10/20/30 izingcezu. iyiphi emaphaketheni plastic phezu PC 60/100/120.). Isakhi esiyinhloko ezimweni zombili izenzo trimetazidine dihydrochloride. Nokho, isimo izidakamizwa, okuyinto esivela izinga esincishisiwe ukumuncwa futhi umzimba, has a ezahlukene egameni lendawo yokuhweba noma - "Trimektal CF".

imiphumela kwemithi

Njengoba ukulungiselela antihypoxic "Trimektal" (yokusetshenziswa kulokhu ihlinzeka ngezigaba esicacile kwemithi kanye ugcizelela ukubaluleka kokubili izakhiwo zalo antioxidant) has a oqondile "ginger" nomthelela izinzwa ubuchopho kanye cardiomyocytes. Ngakho izidakamizwa isilinganiso kwandisa ukusebenza kwabo. Ukuphumelelisa umphumela cytoprotective - yalokho engokwemvelo ekukhuleni ezingaba amandla amangqamuzana isizinda nokwenza egcwele umoya-mpilo ukusetshenziswa mode.

Ingqikithi asebenzayo ayivumeli ukusikwa indlela we myocardium ngu "ukongiwa" we enele ka phosphocreatine. Uma ukwephula asidi-base zilingana 'Trimektal "elawula lokuhlushwa i-calcium ne-sodium, isb kungenalo ngokweqile ekuqongeleleni amagama ahlobene of lezi zinto ku cardiomyocytes kanyekanye normalizes potassium ion ibhalansi kumaseli. Empini yokulwa ne angina imithi kuzibonakalisa njengoba imbangela neutralizer impande: nokwehlisa nitrate ukusetshenziswa kuholela yokuthi ngemva kwezinsuku ezingu-14 yokwelapha iziguli waphawula intuthuko yokumelana ukucindezeleka ngokomzimba (ukubaluleka wegazi amathonsi kubonakale encishisiwe).

Absorption futhi umzimba

kinetics kwemithi zomuthi "Trimektal" yokusetshenziswa ezichazwe umbono amafomu yayo ukukhululwa. Ikakhulukazi, okuqukethwe capsule, eba phakathi umzimba ngokushesha kakhulu (futhi cishe ngokugcwele) okugaya leso GI isikhawu. amahora amabili ngemuva kokuthola esiphezulu waphawula plasma lokuhlushwa reactants. A umthamo owodwa we-20 mg ingxenye esebenzayo ichaza at 55 ng / ml.

Ngokuphathelene degree of nokusakazwa kwezingxenye asebenzayo, sesibopho ukuthobisa plasma amaprotheni, ngokuvamile ingeqi 16%. Nokho gistogematicalkie trimetazidine kunqotshwe izithiyo sasivumela kalula. Babalelwa ku-60% we umthamo excreted ezingaguquliwe emchamweni, ne wokuqala 50% - kungakapheli amahora 4-5.

Ngebanga lalokho, "Trimektal CF" (ithebhulethi ifomu yokukhiqiza), sibonga nolwelwesi ekhethekile, inikeza emakamu esiphezulu e-plasma reactants amahora amathathu. Ingxenye-ukuphila, kuye ngokuthi engu-iziguli zingase isukela amahora 7 kuya ku-12.

izinkomba ngoba

Amacala kadokotela izidakamizwa isimiso sokuqondisa 'Trimektal "imfundo manual ichaza lokhu okulandelayo:

• nokuvinjelwa angina pectoris (njengengxenye ukungenelela eziyinkimbinkimbi zokwelapha);
• ukuphazamiseka chorioretinal imvelo semithambo;
• isiyezi sokucasuka ukungalingani obusebenzayo yisimiso senhliziyo nemithambo yegazi;
• kokuzwa ukungakhuli (inani izinqubo ischemic e apharathasi vestibular).

Ngaphezu kwalokho, udokotela angase anqume ukuthi nokunwetshiwe ukusetshenziswa kwezidakamizwa e ekuvalweni erosions ebalulekile retina.

Indlela isicelo futhi umthamo Kunconywa

Umuthi esithathwayo ngomlomo ngqo ngesikhathi sakusihlwa. Isikhathi inkambo isethwe udokotela (ngesisekelo lapho ngihlolwa enemininingwane nokwenza uphethwe).

Ukuze uthole izenzo ifomu capsule okulinganiselwa ku ngesilinganiso 40-60 mg / ngosuku (kudingeka uqede izikhathi 2-3).

Endabeni ukulungiselela "Trimektal MV" (yokusetshenziswa kulo mongo Kuthi sihluke izincomo ngenhla), ngokuvamile inikezwa iphilisi elilodwa ekuseni nakusihlwa.

side effects

Kanye ngcono ukusebenza ngezinye izikhathi kwenzeka futhi side effects yezingxenye asebenzayo. Ngokuphathelene kungenzeka komzimba nezinto ukusetshenziswa amaphilisi "Trimektal" imiyalelo ukulungiselela ukusetshenziswa, intengo zazo ulandele - impilo lesiguli, uthi:

• Kwezinye iziguli kungase kube ukucasuka wendawo kwesikhumba;
• ukusetshenziswa isikhathi eside zomuthi kakhulu ezingavamile disorder waphawula uhlelo ukudla (isicanucanu, ukuhlanza);
• Ngezinye izikhathi imiphumela engemihle yokwemukela njalo obonakaliswe ikhanda migraines;
• umugqa igazi imisipha yenhliziyo ngezinye izikhathi ngaphansi imithwalo ngokweqile, okubonisa isidingo Isikali ukunciphisa.

Ngokulinganiswa izidakamizwa "Trimektal MV" imfundo manual uthi:

• ukuthuthukisa hypotension orthostatic kanye kumiswa "othi awube" ubuso bakhe akunakwenzeka (nesineke engaphansi okunemibandela ayizinkulungwane ngayinye);
• Ukungadli ipheshana wokugaya ukudla (ubuhlungu besisu, uhudo, ukuhlanza, njll ...) - kaningi (ezingaphezu kwekhulu icala ngabanye ukuthatha izidakamizwa).

Ngaphezu kwalokho, kungase kube zimo lapho ukusetshenziswa amaphilisi ekukhishweni sokulungisa reagents zingaba imbangela engenza ngihlale ngizizwa ngikhathele esethola, liqhaqhazela, akinesia, futhi urticaria.

Izimo ukuqokwa

Sibheka anti-hypoxic kusho "Trimektal". Yokusetshenziswa, intengo izidakamizwa, amagama izidakamizwa, ume-in, kanye ezihlukahlukene uchwepheshe imicabango yabantu okwethulwa lo mbiko ukuze wazi nezilaleli nesithakazelo. Lesi sidakamizwa anezinye Izimo ngokulinganayo olufanele zonke izinhlobo ukukhululwa (amaphilisi / amaphilisi).

Imithi aluboniswa uma:

• kwatholakala ukuthi unesifo esingamahlalakhona kwezinso (inqobo imvume <15 ml / iminithi);
• isiguli inezimpawu kuphazamiseka obusebenzayo kwesibindi;
• isiguli kungazange kufinyelele engu-iminyaka eyishumi nesishiyagalombili;
• wazilandela ngokunembile acute ukusabela iguliswa uphiko lwezidakamizwa.

Phakathi kwezinye Izimo - nokukhulelwa kanye lactation.

Izixwayiso futhi mshini izidakamizwa ukuxhumana

"Trimektal", intengo zazo sehluka kakhulu (kuye ngokuthi indlela udaba bese izwe ukwakhiwa -. Ruble 300-1100), hhayi wadalula indlela engathí sina ucwaningo lwezempilo ngendaba ekuxhumaneni nezinye imithi. Ngenxa yalesi sizathu, ukhulume lo mshini inhlangano imiphumela eziyinkimbinkimbi kungenziwa kuphela esekelwe okutholakele etholwe ngenxa umsebenzi laboratory ne trimetazidine - the Isakhi esiyinhloko nomuthi kuchazwe. Kuyaphawuleka ukuthi trimetazidine udlala indima umsebenzi anti-ischemic ka amplifier, okuyinto is phetho yokwamukela nezinye izidakamizwa antianginal. Imininingwane olunye uhlobo ezihilela reagents "Trimektala" awazange uyalandelwa.

imiyalelo ngokukhethekile ukuqokwa izidakamizwa:

• ayikwazi ukusetshenziswa ezinsukwini zokuqala esibhedlela, uma lokho sitholakale angina engazinzile (noma indawo ukuba PIS);
• Ubudlelwano phakathi edonsa amaphilisi (amaphilisi) 'Trimektala "kanye nesenzakalo isifo i-Parkinson, okuyinto sivezwe kula okhulisa / attenuation ka liqhaqhazela, kube nesidingo ukuqapha okwengeziwe isiguli (kuba survey gqwa wezinzwa);
• ngoba iziguli abaneminyaka engaphezu kuka-75 yebo zokwelapha igcwele yezinkinga izinso, ngakho isinqumo sokugcina udokotela;
• ukwephulwa of lengqondo ukusabela cuphuluza trimetazidine, - kuyisisekelo ukubonakalisa mayelana nokufaneleka ukusetshenziswa kwemithi ezimweni lapho isiguli aphume esibhedlela, futhi umsebenzi wakhe lochwepheshe ehlangene usongo yokuthola yokulimala okuhlobene nomsebenzi.

Uhlolojikelele analogue

Okuvame kakhulu izisusi ukulungiselela "Trimektal" (analogs izidakamizwa esebenzayo okuyilona elisebenzayo futhi trimetazidine):

• "Trimetazidine-Biocom MV", eRussia;
• "Trimetazid", Poland;
• "Trimethyl", India
• "Antistius", eRussia;
• "Medarum 20", eRussia;
• "Preductal MV", France;
• "Rimekor MB", Ukraine.

Naphezu jikelele chemical ifomula, isenzo ejwayelekile emzimbeni kungase kube kancane ehlukile kunaleyo yasekuqaleni. Ngakho-ke, ukukhetha umuthi othize - akubona udokotela.

Medicine "Trimektal": imibono nemizwa

Izinkinga zempilo ezihlobene nempikiswano fibrillation lwemithambo, ngokuvamile ngesibhamu izingxoxo thematic. Ngifisa ukuzwa imibono iziguli kanye nabantu imfundo yezokwelapha mayelana izidakamizwa "Trimektal" (ukubuyekezwa, avame ukuba ithoni ngokomzwelo positive) musa nobunzima ekutholeni ulwazi. Nokho, ngisho ukuhlaziywa olukha phezulu imibono ebonisa ukuthi ngqo target kuthinta iphuzu nokungakhethi umbono. Ngemva imithi wathi ezimweni eziningi okunqunyiwe "in the eziyinkimbinkimbi," okungukuthi, kanye neminye imithi.

Ngokwesibonelo, iqembu elikhulu kakhulu iziguli, futhi lihambisana - iziguli ngubani kwavele Yiqiniso zokwelapha ngesisekelo "Trimektala" imibiko yabo asihlole bukhomba ku yokuthi inqubekelaphambili ebonakalayo zokunqanda izifo ezifana nomfutho wegazi ophezulu chronic senhliziyo, lesi sidakamizwa singanikezwanga .