"Metformin" izidakamizwa. Izibuyekezo. abstract

Izidakamizwa "Metformin" libhekisela temlomo ejenti hypoglycemic iqembu biguanide. Uma usebenzisa iziguli sikashukela izidakamizwa kwehlisa amazinga igazi glucose ngu ezivimbela gluconeogenesis esibindini, kanye ekunciphiseni ukumuncwa yayo kusukela isimiso sokugaya ukudla bungene. Ngenxa ukwanda ukuzwela kwezicubu insulin kwandisa yayo (glucose) ukusetshenziswa. Nomuthi "Metformin" (imibono kusukela ochwepheshe kulo mdlalo) kunemiphumela ku lipid umzimba. Lesi sidakamizwa sisiza ukunciphisa triglyceride, LDL cholesterol e serum. Umuthi futhi kunciphisa (kuzole) esisindo anda. Lapho engena phakathi ukumuncwa kusho komyalelo wokungabi 48-52%. Nge ukusetshenziswa ngesikhathi esisodwa ukudla ukumuncwa kuyehla. Ubuningi esiphezulu kufinyelelwa amahora 2-3. Umuthi akuyona kakhulu nakanjani plasma amaprotheni, it is akheka kancane.

"Metformin" lisho ukuthini. isicelo

Akunikeze imithi ngesikhathi Uhlobo lwesibili lwesifo sikashukela (sikashukela) e abadala (ikakhulukazi ukukhuluphala) ngokungabi bikho umphumela umsebenzi, ukwelashwa Ukudla. Nomuthi "Metformin" (ukubuyekezwa odokotela ukusekela lokhu) ingasetshenziswa kokubili njengoba monotherapy futhi njengoba ingxenye temlomo ejenti hypoglycemic noma nge-insulini. Umuthi nayo zaphathwa izingane kusukela eminyakeni eyishumi nge abanesifo sikashukela sohlobo 2 njengoba monotherapy noma njengengxenye umthelela ehlangene.

Izimo

Nomuthi "Metformin" (ukubuyekezwa odokotela ukuxwayisa ngale) akufanele kuthathwe uma sikashukela ikhoma, precoma, ketoacidosis, hypersensitivity. Izimo phakathi izwe acute bemvelo, abasafufusa nge Amathuba nesenzakalo nezinkinga kwezinso. izidakamizwa ezinconyiwe e isimo hypoxia, ngesikhathi amanzi emzimbeni, zokugula zokuphefumula, izilonda ku ezinso i nature esithathelanayo, sepsis, ukushaqeka, yokwehluleka kwesibindi, acute utshwala poisoning, lactic acidosis, umlando kanye. Akunconyelwe kwezidakamizwa izimpawu emtholampilo elikhethiwe pathologies oyingozi noma ezingamahlalakhona ezingaba avuse izicubu hypoxia. Izimo ezinjalo zihlanganisa acute yinhliziyo, zokuphefumula, ukuhluleka kwenhliziyo kanye nabanye. Hhayi prescribers ezingaphansi kweminyaka engu-iminyaka eyishumi, kuncike ukudla encishisiwe-kilojoule amaningi. Isexwayiso esibonise lapho ukuphatha asebekhulile (engaphezu kwengu-60) iziguli kabani imisebenzi zixhumene ne kokuvivinya umzimba.

side effects

Umuthi 'Metformin "(imibono kusukela ochwepheshe kulo mdlalo) kungabangela Ukuwohloka esesuthi, ukuhlanza, isicanucanu, ukunambitheka thuthuva, uhudo, ukuqubuka, i-erythema, nezinye isikhumba ukubonakaliswa nomzimba. Ukuze uthuthukise tolerability emathunjini Kunconywa ukwandisa umthamo kancane. Ngesisekelo yokwelapha waphawula ubuhlungu besisu, isifo sokusha kwesibindi, iziyaluyalu umsebenzi isibindi. Njengomthetho, izimo okukhulunywa ngaso imiphumela emibi izidakamizwa. Against ngemuva ukusetshenziswa nokunwetshiwe angagcina Vitamin kwamaphutha B12, i-folic acid.