Ezempilo, Amalungiselelo
"Olanzapine": ama-analogues, incazelo yokulungiselela, imiyalelo yokusetshenziswa
Ukuze ekwelapheni bayasangana okuguquguqukayo ukusetshenziswa kwezidakamizwa ngesisekelo lomcebo olanzapine. Kunemithi eminingi anamagama ahlukene ukuhweba, kodwa umphumela ofanayo antipsychotic. Omunye izidakamizwa ezinjalo kuba izidakamizwa "olanzapine" analogs eziqukethe ngezithako zawo isithako Imininingwane asebenzayo.
Incazelo ukulungiselela
Lokhu kwenziwa yi-ejenti antipsychotic "ALSI Pharma" Zao njengoba amaphilisi ukukhanya yellow, ukuma okuyinto ufana biconvex isilinda.
Isakhiwo izidakamizwa yakha izithako angasebenzi, okuhlanganisa microcrystalline cellulose uhlobo, monohydrate lactose, yamathebhu krospovidonovy, magnesium stearate. inani lawo likhuphuka e ezimbili, izikhathi ezintathu noma ezine, kuncike olanzapinovoy umthamo.
Izibhebhe Agcwele zonke esenikwe 7 izingcezu e amabhamuza iphakethe okungaba 4 noma 8 izingcezu.
Kusho "olanzapine" Umsebenzisi Isicelo ehlobene izidakamizwa antipsychotic neuroleptic okuyinto abonise ziyezwana ngoba serotonin, Dopamine, muscarinic, adrenergic futhi histamine yokwamukela kumiswa.
Khetha wanciphisa ukuhileleka excitatory we mesolimbic dopaminergic izinzwa, has umsebenzi okuncane striatal ezinzwa conduction, elawula ukusebenza yenjini. Kwehliswe amandla e ikhaliphe ezivamile zokuzivikela, uma usebenzisa umthamo ongaphakeme ngaphandle kokudala ubuthongo cataleptic.
Medicine "Olanzapine" kwandisa kusebenta anxiolytic test umsebenzi "anxiolytic" ngenkathi egijima. Wenza izimpawu zokuqaleka futhi ithele ephambene okuyize nemibono hallucinatory.
Yini isetshenziswa
Tablets "olanzapine" umphumela bafakela isimo schizophrenic lapho usukhulile esigabeni oyingozi, njengoba nokugcinwa futhi isikhathi eside ukuphathwa protivopovtornogo. Basuke esetshenziselwa disorder ingqondo nge izimpawu elinothile okwakuzoba okuyize, imibono hallucinatory kanye nezimpawu ezimbi ezifana aba ngokomzwelo, ekunciphiseni imisebenzi ebalulekile emphakathini, Ukuwohloka apharathasi vocal.
Izidakamizwa iqedwe yokuphindela nokuquleka bipolar disorder, uma ithebhulethi ngempumelelo aphathe izigaba eshintshashintshayo.
Ukulungiselela "olanzapine" esikhishwe abadala nge okuguquguqukayo iziyaluyalu affective ngesimo monotherapy noma ngokuhlanganyela ukuthaka imithi aqukethe lithium-ion noma valproic acid. Umuthi isetshenziswa ukwelapha amafomu acute ukwenama noma okuxubile yezenzo ukuthi kungenzeka izici ingqondo, kanye abe okusheshayo ushintsho izigaba.
Kusho kuhlangene nemithi fluoxetine izimo bacindezeleke okuhlotshaniswa okuguquguqukayo.
Imigomo yokusetshenziswa
Medicine isicelo "olanzapine" Umsebenzisi uncoma suku 0,005 ukuze 0.02 g ngomlomo ngaphandle ababambelela amandla imodi.
isimo schizophrenic iziguli Adult ziphathwe sokuphuza isilinganiso esengeziwe somuthi kokuqala yansuku zonke 0,010 g
Adult mania acute, ukucindezeleka okuguquguqukayo libhekene, kususwe isamba nsuku zonke olanzapine e 0.015 g, elawulwa esisodwa. Uma amaphilisi asetshenziswa zokulondoloza imithelela ngokuhlanganyela imithi esekelwe lithium ion noma valproic acid, bese yaphathwa umthamo wansuku zonke 0,010 g ngalinye kanye.
izinqubo bacindezeleke lapho usukhulile ngenxa bipolar disorder, khulula lemali nsuku zonke 0,005 g, is kuhlangene 0,020 g fluoksetinovogo izidakamizwa. Uma kukhona isidingo, wabe esenikwa ukuhlela nokushintsha kokudla nokufakwa kwemithi.
Ukuze ezigulini esezikhulile nge kungenzeka usongo ezinzima esingamahlalakhona kwezinso noma isibindi ezingamahlalakhona njengoba uma kukhona izingozi ezihlobene ubulili besifazane, senile ubudala lapho deceleration exchange olanzapine lemali yayo sokuqala nsuku kuyehla kube 0,005 g
la mathuluzi
Nomuthi "Olanzapine" nozakwabo unamagama ezahlukene ukuhweba. Basuke ezivezwa kokubili abakhiqizi ezifuywayo angaphandle.
Phakathi abakhiqizi Russian izinkampani spin-off 'izidakamizwa Technologies "ne izidakamizwa" Olanzapine-TL ", ngefomu ithebhulethi 0,0025 g ifilimu camera.
Okunye imithi yasekhaya kuyindlela yokuthola "Olanzapine", oluqanjwe JSC "North Star". Kukhona ithebhulethi nge enamathela ifilimu kanye umthamo we 0,005 g
ifektri Russian "Kanonfarma Production" JSC bakhiqiza izidakamizwa "Canon of olanzapine."
imithi Israeli ingumuthi "Olanzapine Teva," izinkampani ezikhiqizayo "Teva Pharmaceutical Enterprise Co., Ltd.".
Analogue Slovenian siyindlela "Zalasta Cu ithebhu", e izibhebhe 0,015 g emiselwe resorption. Made by ibhizinisi "Krka, Novo Mesto." Futhi idatha ekhiqizwa izidakamizwa "Zalasta" amaphilisi.
Swiss izidakamizwa Analogue kubhekwa "Zyprexa" njengoba lyophilisate ku izitsha eziyisikhombisa, kusuka lapho isixazululo Usululungele ekuphathweni esicutshini, umthamo we 0,010 e dispersible ithebhulethi ifomu 0.005 amagremu ukhona izidakamizwa "Zyprexa Zidis". Basuke ekhishwa 'Eli Lilly Vostok SA ". Ezimakethe ezithaka imithi kukhona "Zyprexa Adair" nomuthi oluyimpuphu okukhishwa 0.21 g
inkampani isiPolish "Polpharma" imithi ekhiqizwa "Normiton" amaphilisi nge enamathela emgodleni we 0.005 g
Izidakamizwa "Olanzapine" nozakwabo Hungarian ekhishwa 'Gédéon Richter "ngokuthi amaphilisi" Parnasan "futhi eyenza imithi isitshalo" EGIS "izidakamizwa athuthukile" Egolanza ".
Incazelo "Zalasta" izidakamizwa
Lokhu kubhekisela neuroleptic antipsychotic. amaphilisi Khanyisa ophuzi letiyindilinga, ukuma kancane biconvex namabala amnyama. Kukhona imithamo eziyisithupha: 0,0025 g, 0,005 g, 0.01 g, 0,015 g futhi 0.02 g olanzapine. izingxenye engeziwe kubhekwe Cellactose ngasebenzi, isitashi pregelatinized nommbila ifomu, emzimbeni aerosilovy isithako, magnesium stearate.
Ukumaka ifomu ithebhulethi "Zalasta" imfundo manual uchaza notation ngesimo yokuqoshwa kanye inkomba umthamo. Umthengi amaphakheji kukhona ipuleti contoured 7 amaphilisi. Babephethe ingaqukatha 4 noma 8 amabhamuza ezinjalo.
Lokhu ejenti neuroleptic ubukisa imisebenzi ezibanzi kwemithi. umphumela Antipsychotic elihlobene ne okwakheke interlock Dopamine yokwamukela hlobo. umsebenzi sine okubangelwa braking adrenoceptor amasayithi bakha kumiswa reticular kumaseli stem ingqondo.
umsebenzi Antiemetic kungenzeka esitobhini D 2 yokwamukela -dopaminovogo ingxenye ezonini inhlamvu-uhlobo esemgwaqweni maphakathi emetic.
indima Hypothermic Kwenziwa ekuvimbeni zokwakheka Dopamine yokwamukela kwezinhlobo kule ngxenye.
Medicine "Zalasta" imfundo manual kusikisela usebenzisa at ukubonakaliswa schizophrenic. Tablets bayakwazi ngenkuthalo ukugcina izinguquko izimpawu zokwelashwa ngesikhatsi ukwelashwa eside kweziguli kokuqala nethonya elihle izidakamizwa.
Kusho ukususa mania episodic efomini phakathi noma ibe yinkimbinkimbi. Tablets nokuziphatha isixwayiso zokukhwabanisa ukuphindaphinda kukhathazeka bipolar disorder kubantu ngeziqephu eshintshashintshayo.
Umuthi senzelwe abaphathi ngomlomo kanye ngosuku. izinhlayiyana zokudla musa kuthinte inqubo ukumuncwa olanzapine, okuyinto ikuvumela ukuthi usebenzise i-tablet nganoma yisiphi isikhathi. Lapho ukwesulwa izidakamizwa kancane kancane kufanele kuncishiswe umthamo.
Ukuze ekwelapheni iziyaluyalu schizophrenic isetshenziswa nokushintsha kokudla nokufakwa kokuqala 0,010 amagremu ngosuku.
Iziqephu of mania uqale iphathwa umthamo zonke izinsuku we 0.015 g, elawulwa kwelinye isicelo noma 0,010 amagremu lapho kuhlangene nezinye neuroleptics.
Ukuphindwa zokuvimbela okuguquguqukayo e attenuation sinyathelo kwenziwe izabelo eyinhloko nomuthi 0,010 amagremu ngosuku. Uma abantu ukuthatha ithuluzi ekhuluma mania episodic, tekubamba yokwelapha usebenzisa umthamo ofanayo. Kuyadingeka ukuba ukwandisa inani izidakamizwa uma kwenzeka episodic ukubonakaliswa entsha noma babeqoqana futhi bacindezeleke, kanye ukwengeza ekwelapheni kwemizwelo ukuphazamiseka.
I umthamo zonke izinsuku we nomuthi ukuze kuqedwe izifo ezibangelwa schizophrenic, iziqephu ukwenama nokuphazamiseka kwengqondo okuguquguqukayo isixwayiso eziphindaphindiwe usebenzisa kusuka 0,005 kuya 0,020 g, ukubaluleka zazo kuncike nemingcele emitholampilo ye nesineke.
Asebekhulile umthamo ephansi sokuqala kuze kube 0.005 g akukhuthazwa, Nokho, izenzo ezinjalo kuzosetshenziswa iziguli ezivela engu-65 ubudala, uma kukhona engcupheni.
Incazelo "Olanzapine Canon" izidakamizwa
Lesi senzo of neuroleptic nomuthi antipsychotic itholakala ifomu tablet camera nge emgodleni. Ukuma izibhebhe imikiswe nge evele ezimbili ayizindunduma ophuzi, okuqukethwe yangaphakathi nangebala.
It likhona imithamo ezimbili: at 0,005 g futhi 0.01 g olanzapine. Izithako asizayo zihlanganisa cellulose hydroxypropyl nge esikhundleni ongaphakeme, i-calcium hydrogen phosphate, sodium croscarmellose, mannitol, magnesium stearate.
kwakhiwa emgodleni ophuzi Opadry ifilimu is yohlobo yesibili, polyvinyl utshwala, macrogol, talc, ama-titanium dioxide, yensimbi oxide.
ukwelashwa izidakamizwa engabelwe abanokukhubazeka, ngokubamba nokusebenzisa iziguli omdala antirelapse eside anokugula okuthile schizophrenic.
I ikhambi wenziwa monotherapy futhi inhlanganisela ukuhambisana enkompolo lithium elinefomu eqinile zezigigaba ukwenama noma oxubile wokuhle okuguquguqukayo affective, okuyizinto Izinkulumo izigaba ingqondo futhi fast ezishintshayo. Imithi ukuvimbela ezinikezwa abantu abanale nkinga yokungadli kahle, onokuphazamiseka kwengqondo okuguquguqukayo, uma izidakamizwa basizwa ukuba babhekane esigabeni eshintshashintshayo.
Ekwelapheni abadala nokucindezeleka okubangelwa ukuphazamiseka kwengqondo okuguquguqukayo, kanye esitebeleni degree bacindezeleke ikhambi "Canon Olanzapine", a neuroleptic, ingahlanganiswa ejenti equkethe fluoxetine.
Uphuzwe ngomlomo, hhayi ukunamathela ekudleni. Umhlahlandlela incoma ukuthi umthamo zokwelapha we nomuthi, okuyinto ngosuku, inani 0,005-0,020 izindlela ezikhethiwe ngayinye esigulini ngasinye kuye izimpawu emtholampilo.
iziyaluyalu Schizophrenic isiguli esingumuntu omdala aphathe kokuqala nsuku nokushintsha kokudla nokufakwa imithi e 0.010 g, elawulwa ngesikhathi esisodwa.
Isimo okuguquguqukayo mania acute ukuqeda umthamo nsuku zonke zomuthi ukuze 0,015 g noma 0,010 g olanzapine kuhlangene ejenti equkethe lithium-ion noma valproic acid.
Ukunika amandla ukusetshenziswa okuguquguqukayo phakathi nokushintsha kokudla nokufakwa kokuqala nsuku wenziwa iziguli 0.010 wawenziwa uma yokwamukela a nomuthi ngoba mania acute, kufanele baragele phambili nokusebenzisa imithombo amanani efanayo.
iziyaluyalu bacindezeleke ezihambisana neziguli okuguquguqukayo omdala ziphathwe inhlanganisela 0,005 g futhi 0,020 g amalungiselelo olanzapine fluoksetinovyh okuyinto iphathwa kusihlwa.
umphumela Antidepressive zomuthi ebonakaliswa imali kusuka 0,006 kuya 0,012 amagremu nge nokushintsha kokudla nokufakwa avareji nsuku zonke e 0,0074 g umthamo nemithi fluoksetinovyh zokhahlamba kusuka 0,025 kuya 0,030 g Uma kukhona isidingo, kungenzeka ukuba abukeze nokushintsha kokudla nokufakwa kokubili izidakamizwa.
ifomu zokwelapha esitebeleni zokucindezeleka isuswa inhlanganisela 0,005 g futhi 0.02 g olanzapine izindlela fluoksetinovyh elawulwa kanye kusihlwa.
Incazelo "Zyprexa" izidakamizwa
Lokhu neuroleptic akhiqizwa ifomu tablet camera nge emgodleni. Kunezinhlobo ezine Isikali ekwakhiweni: 0,0025 at 0,005, 0,010 futhi 0,0075 for x, y okuyizinto notation ezifanele phezu «Lilly 4112», «Lilly 4115», «Lilly 4116», «Lilly 4117".
kwakhiwa izithako Akusebenzi ngesimo lactose, hydroxypropylcellulose, crospovidone, microcrystalline cellulose uhlobo kulesakhiwo imithi magnesium stearate.
Izibhebhe tihlelwe e amabhamuza 7 izingcezu iphakethe iqukethe 4 nentaba emaphaketheni.
Kukhona ifomu nqabela-omisiwe, senzelwe womshini izixazululo esicutshini. Yellow ketshezi Isikali 0.01g ezipakishiwe ku izitsha eziyisikhombisa. izingxenye Akusebenzi ezibhekwa monohydrate lactose futhi tartaric acid.
Umuthi ubukisa umphumela antipsychotic.
Isithako asebenzayo we nomuthi oziphatha njengongqingili ligand oluhlanganisa ne-serotonin, Dopamine, m-choline, H1-histamine futhi alpha1-yokwamukela zokwakheka adrenozavisimymi. Olanzapine kunomphumela abakhethayo ku isimo isimiso semizwelo.
Izidakamizwa "Zyprexa" imfundo on isicelo weluleka ukusebenzisa nge izigaba eqinile kuphazamiseka schizophrenic futhi ingqondo ukuthi ahambisana izimpawu ecacile okuyize, ukuhhema, umcabango iziyaluyalu, enobutha negcwele ukukhonza sengqondo osolisayo noma uhlobo ezingezinhle ngendlela ukukhishwa sakhe ngekwemiva netenhlalo, iziyaluyalu apharathasi vocal. Umuthi kuboniswa elokususa izimpawu yesibili affective kubangelwa iziyaluyalu schizophrenic.
I-Tablet "Zyprexa" imfundo manual incoma ukuphuza ngomlomo, nganoma isiphi isikhathi. Ukwelashwa kusenesikhathi ka umthamo owodwa kuyinto 0,010 g Ngemva kwalokho umthamo nsuku zonke zokhahlamba kusuka 0,005 kuya 0,020 g, okuyinto ziboshelwe isithombe lingaze.
Intramuscularly injected imithi, uma kunesidingo esiphuthumayo ayeke le excitation lengqondo uhlamvu kubantu abanegciwane lokusangana, onokuphazamiseka kwengqondo okuguquguqukayo, iziyaluyalu affective kanye komqondo.
Ngaphambi ukusetshenziswa, lyophilisate u buhlanjululwe in 2.1 komjovo ml naphakathi aqueous. Isixazululo cacisa tinge ophuzi.
Injabulo sezinzwa wesiyaluyalu schizophrenic futhi okuguquguqukayo suka endaweni-umthamo owodwa we-0,010
Uma ucabangela manje isiguli zokwelapha, abaphathi okuphindiwe Isikali 0,010 g okwenziwe ngemva 120 iminithi kusukela isicelo sokuqala kanye 0,010 g elandelayo idliwe emva kwemizuzu 240 kusukela isicelo sesibili.
Ukuze uthole olunye ukwelashwa izidakamizwa "Zyprexa" hambisa injalo ithebhulethi nge umthamo kusuka 0,005 kuya 0,020 g
Ukuyaluza e komqondo isuswe umthamo owodwa esicutshini ka 0,0025 ucabangela isithombe emtholampilo isiguli, wesibili ekuphathweni Isikali 0.005g kwenziwe emva kwemizuzu 120 kusukela isicelo sokuqala.
Incazelo yomkhiqizo "Adair Zyprexa"
Kube nomuthi "olanzapine" analogs ezikhiqizwayo in ifomu powder nge 0,405 g olanzapine in vials nge isipetu kuphela futhi inaliti.
Kusho "Adair Zyprexa" libhekisela antipsychotic izidakamizwa neuroleptic umsebenzi.
Imithi suppresses uwohloke osetshenziselwa nokugcinwa kanye eside ukwelapha protivopovtornogo schizophrenic nezinguquko zehloko ngama izimpawu ephezulu isivuno ngesimo okuyize, imibono hallucinatory futhi aba negative ngokomzwelo, mpilo apharathasi vocal.
Imithi aphathe iziqephu ezinzima ukwenama futhi kuhlanganiswe okuguquguqukayo, phakathi kwesikhathi lapho kungenzeka izici ingqondo futhi ushintsho ngokushesha ngezigaba.
Isikali kokuqala nsuku isetshenziswa 0.010 noma 0.015, lemali nsuku zonke zomuthi akhethiwe isiguli ngayinye, ikhumbula isithombe emtholampilo. Ngokuvamile esetshenziswa zokwelapha umthamo wansuku zonke kusuka 0,005 kuya 0,020 g
Ukwandisa umthamo kungaba khona kuphela ngesibusiso imiphumela vo. Ukwandisa inani izidakamizwa wenziwa ngezigaba, nsuku zonke.
ezigulini esezikhulile, kokuqala umthamo nsuku zonke phambi enganele izinso umsebenzi futhi isibindi uqoke 0.005 g
analogue izindleko
okunezinhlobonhlobo elikhulu antipsychotics ikuvumela ukuba ukhethe izidakamizwa kwesokudla, okuyinto efanelekayo ngekhwalithi kanye nezindleko. Imithi "Olanzapine" ngentengo elincane. Okufakiwe amaphilisi zingathengwa for ruble 290.
Izidakamizwa "Zalasta" intengo ruble 1370.
izindlela Expensive kubhekwe iphilisi "Zidis Zyprexa." Ukuze umkhiqizo iphakethe bakhokhele ruble 2370. analog ukubaluleka "Ku-Tab Zalasta" kuyinto ruble 1075.
On imithi "Zyprexa" intengo wathola Izibuyekezo ezingezinhle. A iphakethe amaphilisi 28 kubiza ruble 4760.
Ukuze kuleyo miphakathi eyayincishwe amathuba izotholakala izidakamizwa "Olanzapine", okuyinto encane kakhulu intengo.
Ukubukwa iziguli
Mayelana nemithi "Olanzapine" Izibuyekezo ungezwakala okuhle nokubi. Abaningi sidakamizwa sisiza ukuba babhekane nokucindezeleka futhi inciphise nemicabango engakhi ngemva kwezinsuku ezimbalwa zokwelapha. He kubhekwa omunye uyabaqinisa neuroleptics, okuyinto uthulisa nesineke, aqede konke ukwesaba nokukhathazeka.
Phakathi bokwenza ezishisa kakhulu zikhipha izinhlayiyana imiphumela engadingeki okuyizinto ezihlobene a okwehlisa lokugayeka kokudla, okuholela esisindo okwandisiwe nesineke. Somnolence, asthenia syndrome, isiyezi, igazi orthostatic lingase lehle uhlobo ingcindezi ukuthuthukisa izicubu zomzimba ezithambile ukuvuvukala kanye kome nolwelwesi lwamafinyila.
Kwezinye iziguli, ngisho umthamo elincane imithi kuyinto sine eqinile, kusukela lapho ukulala amahora angu-12 ngosuku.
Nokho Umzimba womuntu ezahlukene, kanye amaphilisi ngendlela ehlukile ngoba esigulini ngasinye. Ukuze ukukhethwa kwamathuluzi afanele kudingeka kudokotela.
Similar articles
Trending Now