"Rosuvastatin": yokusetshenziswa, ukubuyekezwa. Eshibhile Analogue "rosuvastatin"

Umuthi 'Rosuvastatin "iye kusukela ngo-2003 eyaziwa futhi inikezwa njengendlela statin Generation IV. Kuyinto inhibitor yesimanje kanye eliphezulu ye-gamma-methylglutaryl-CoA reductase. Lokhu enzyme unesibopho synthesis cholesterol emzimbeni womuntu. okusithiyayo kwalo kuholela ekuncipheni cholesterol endogenous futhi kuncishiswe ingozi yesifo senhliziyo.

Ngaphezu "rosuvastatin" kukhona nozakwabo ekilasini eziningana, amalungu eqembu statin. Lokhu "Simvastatin" "Pravastatin", "cerivastatin," "Lovastatin," "Fluvastatin," "Atorvastatin", "pitavastatin." kusebenta Clinical nesivinini ukunciphisa inani cholesterol kanye ongaphakeme-ukuminyana "Rosuvastatin" yesibili kuphela "pitavastatin," okuyinto okwamanje asetshenziswa kabanzi ngenxa semininingwane kancane zanqwabelana zokwelapha.

Kuze kube manje, "atorvastatin" lisetshenziswa kaningi kunamanye ama-statin ngoba lokho kuwukuphela esibanzi kunazo base ucwaningo ubufakazi ukusebenza yayo emtholampilo. Futhi, yena imithi ejwayelekile yakhe ishibhile, "rosuvastatin". Kodwa njengoba umphumela wokugcina (ukuzinza sephrofayela lipid of plasma) ishesha, bese uqala ukusebenzisa kabanzi. Lena mkhiqizo izinga ngempela, okuyiwona wona kufanele bakhokhe intengo.

Beka "rosuvastatin" e pharmacotherapy

Lapho belungela ukuya khona isicelo "Rosuvastatin", naphezu khona lozakwabo ekilasini, sasivumela ezibanzi. Kuchazwa izinkomba kanye contraindications kungagcini. Zabonisa samanje cishe zonke izinhlobo hypercholesterolemia neziyaluyalu lokugayeka kokudla lipid. Ukwehla atherogenic lipid amafraktjhini ube nemiphumela elihle umzimba. Ngenxa yalokhu, amathuba ukuthuthukiswa izilonda atherosclerotic kuyehla, yokuphila kanye neminyaka okulindeleke (nekhwalithi) ukwandisa kancane.

Ukulungiselela "Rosuvastatin" ingase isetshenziselwe nokuvimbela izifo zenhliziyo abaziphatha ngayo. Kugcine niche pharmacotherapy ukhona ngenxa yokucindezela izinqubo isifo sokuqina kwemithambo yegazi kanye kuqiniswa endothelial koqweqwe. Njengoba infarction palsy futhi inhliziyo ukuthuthukisa kusukela thrombosis acute ehola imithambo ke umphumela emitholampilo esiza ngempela ukuvimbela izenzakalo acute yenhliziyo.

Yokusetshenziswa

Njengoba unamathele izidakamizwa "Rosuvastatin" imfundo manual (analogue mibhalo etholakalayo) iqukethe uhla emincane izinkomba ukusetshenziswa. Nokho, lokho akusho kuqukethe ukwaziswa nesineke ukuthi iyadingeka ngaphambi zisebenzisa ukucacisa ingxenyenamba cholesterol. Esikhathini esizayo, ushintsho yabo izobheka ngempumelelo emitholampilo ukwelashwa ngezilinganiso ezithile. Futhi isitatimende liqukethe ulwazi mayelana siphephe nezici yokwelashwa, Izimo, kanye njalo kakhulu futhi okuphawulekayo engemihle.

izinkomba

Phakathi kwazo zonke izifo ezihlobene nokwanda plasma lipid amafraktjhini, iqokomisa ezinye izinkomba zokwelapha:

• lezinceku heterozygous (ngofuzo) hypercholesterolemia;
• oluthathwa by Fredrickson hypercholesterolemia polygenic uhlobo IIa;
• dyslipidemia kuhlangene, oluthathwa Fredrickson kanjani IIb;
• Homozygous ngofuzo (ngofuzo) hypercholesterolemia;
• i-coronary, palsy noma kwezinso ukuqina kwemithambo yegazi, occluding mafutha anciphisa isikhala esingaphakathi we Umthambo;
• Isifo sokuqina kwemithambo yegazi kwemithambo yegazi wemikhawulo aphansi, kuhlanganise Leriche syndrome ;
• hypertriglyceridemia (IV uhlobo ngokuvumelana Fredrickson);
• ekwelapheni isilethikusebenza nobuchopho, kusukela esikhathini acute;
• nokuvinjelwa isilethikusebenza nonhlangothi.

Izimo

Noma yimuphi eshibhile analog "rosuvastatin" has okufanayo side effects ngokuthi "Crestor" yasekuqaleni. Ngesisekelo bohlu lwabo Izimo kwakhiwa, okuyinto zimi kanje:

• hepatic cytolysis syndrome isifo nge hepatocytes futhi ukwanda ezingaphezu kwezintathu-ngeshumi transaminase lokuhlala;
• yokwehluleka kwesibindi, isifo sokuqina kwesibindi kanye izikolo 9 Ingane-Pugh;
• ezingamahlalakhona kwezinso ukwehluleka inkomba imisebenzi nge creatinine imvume ngaphansi kuka-30 ml \ imiz.
• Myopathy yanoma yimuphi umsuka;
• komzimba nezinto yezingxenye ekwakhiweni noma "Rosuvastatin".

Kukhona iqembu nezinye Izimo for 40 mg Isikali:

• ezingamahlalakhona ukwehluleka kwezinso nge imvume inkomba creatinine ezingengaphansi kwezingama-60 ml \ imiz.
• iyiphi myopathies lezinceku;
• ukusetshenziswa concomitant nge fibrates;
• ukuluthwa utshwala;
• uhlanga Mongoloid;
• ukusebenzisa i-statin okokuqala.

Izici zomuthi

Zonke "rosuvastatin" - izidakamizwa, analogue okutholakalayo kabanzi emakethe. Futhi ngokukhetha ethile igama le-brand, isiguli kufanele uthathe imithi futhi. Okungukuthi, sokushintshela kwelinye imithi akanangqondo. Sam izidakamizwa esithathwayo ngaphandle kokubheka ukudla nganoma isiphi isikhathi sosuku. Kunezindlela nezinye izincomo ezimbalwa ochwepheshe ababeke wasebenza statin isizukulwane sokuqala. Ziqukethe ulwazi statin kufanele kuthathwe ngesikhathi sokulala. Nakuba kungeyona zibaluleke kakhulu, njengoba nje umuthi sathathwa cishe ngesikhathi esifanayo njalo.

Lawula isimo yabo kumele kube njalo kuze wamukele "Rosuvastatin" (analogue). Izibuyekezo uvumele izazi zifezeke amaqhinga engcono observation. Ikakhulukazi, ngemva kokumiswa khona hypercholesterolemia kufanele uqale ukuphuza ama-izidakamizwa nge umthamo esinqunyiwe. Ngemva 2 izinyanga ka elibukhali - lipidogram ngokuphindaphindiwe okwenziwa sibukeze umsebenzi aminotransferases.

Uma kukhona ukuzinza sephrofayela lipid of plasma, kuyadingeka ukuqhubeka nokuthola ku umthamo ofanayo. Uma cholesterol Imininingwane sisalokhu siphakeme, kanye nenani eliphansi ukuminyana cholesterol kakhulu ziyancipha, okwandisa umthamo edingekayo. Uma transaminase anda kathathu, kudinga ukususwa statin. Kumele waphawula ikakhulukazi ukuthi ukuthambekela kokuncane kunakho konke kuya kubangele cytolysis yazo zonke statin kuyinto "Rosuvastatin." Analogs (Ukraine futhi kancane kancane ukuguquguquka kusukela "atorvastatin" ukuze "rosuvastatin") kilasi eziphephe kancane. A "pitavastatin" uhlala okungenani wafunda.

Analogs "rosuvastatin"

Njengoba isifaniso, "rosuvastatin" ( "Crestor") kakade inikeza imikhiqizo ezingaphezu kuka-10. Phakathi kwabo, "AKORT", "Merten", "Rozart", "Rozistark" "Rosuvastatin Canon", "Rosuvastatin SOTEX" "Rosuvastatin NW", "Rozulip", "Rozukard", "Roxer", "Rustor" " Tevastor ". Izindleko sibanikeze ihlukile, kanye nekghono. Ngoba intengo lezi izidakamizwa zingahlukaniswa izigaba ezintathu:

• ngamanani aphansi (ruble 250 kuya 650), "Rosuvastatin NW", "Rosuvastatin Canon", "AKORT" "Rosuvastatin SOTEX";
• amanani esijwayelekile (ruble 400 kuya ku-900), "Merten", "Rozart", "Roxer", "Rozukard", "Tevastor", "Rozulip";
• amanani entengo aphezulu (ruble 1100 kuya 2200): "Crestor".

ukuhlaziywa intengo wawenziwa uqhathanisa izindleko zemithi, isisindo kwakwakhe esebenzayo okwakukhona 10 mg. Ububanzi intengo ibonisa izindleko ngenyanga eyodwa yokwelapha ane-ukwehlisa. Eshibhe analog "rosuvastatin" oluqanjwe "Northern Star". "Rosuvastatin Canon" futhi "AKORT" futhi ukuhluka ngentengo. izindleko zabo mancane amathuba okuthi ingashintsha kuye kokushintshashintsha kwamanani okuhwebelana.

Ekuhlaziyeni eshibhe ejwayelekile "CRESTOR"

Umuthi 'Rosuvastatin "ezikhishwe AstraZeneca, ubizwa ngokuthi" Crestor ". Lona imithi yokuqala, okumele abe kuqhathaniswa bonke abanye. Kuyefana nasendleleni amazwana: isici umkhiqizo othize ejwayelekile kufanele esekelwe ukuqhathanisa sayo "Krestorom". Kodwa ngenxa yezindleko ngobuhle okusezingeni eliphezulu, iziguli eziningi ngokushesha saqala ekwelapheni hypercholesterolemia nge imithi ejwayelekile ishibhile.

Inhloso Imininingwane Ochwepheshe kuphela anganikeza e ukubuyekeza, ngubani babhekana ukusetshenziswa imithi ejwayelekile futhi "rosuvastatin" kanye "CRESTOR" yasekuqaleni. A isetshenziswa lesi sidakamizwa "imiyalelo Rosuvastatin 'ukusetshenziswa, kobufakazi nesineke nesipiliyoni emitholampilo kuzovumela ezinye iziguli ukukhetha ethile egameni lendawo yokuhweba noma.

Izibuyekezo ongoti "Crestor" futhi imithi ejwayelekile

Qhathanisa "CRESTOR" kwenziwe kuphela ochwepheshe Russian Society of nezenhliziyo. Lolu lwazi ngokuvamile owanyatheliswa ephephabhukwini "pharmacotherapy Rational e nezenhliziyo." Ikakhulukazi, it ukhuluma izindaba of bioequivalence ka ejwayelekile izidakamizwa "Crestor". Ngokusho ngemiphumela yocwaningo pharmacoeconomic luye lwabonisa ukuthi izidakamizwa "Merten", "Rozart", "Roxer", "Rozukard" futhi "Rozulip" "Crestor" bioequivalent.

Lokhu kusho ukuthi noma yimaphi "rosuvastatin" Lesi siqhathaniso kunomphumela zokwelapha afana izidakamizwa yasekuqaleni lelinenombolo lefana nobukhali engemihle. Nakuba imithi "Rosuvastatin NW", "Rosuvastatin Canon", "Rosuvastatin SOTEX" futhi "AKORT" e novivinyo olunjalo azisetshenziswa. Ngoba lezi izifundo imininingwane kungukuthi uxhaso ngokuzimisela yizinkampani ezithaka imithi, ulwazi ewumphumela umgomo futhi ihlangabezana izici zokwelapha ekwelapheni hypercholesterolemia. Nokho, imiphumela kuphela imithi ejwayelekile angaphandle.

Izibuyekezo ochwepheshe imithi ejwayelekile ishibhile "rosuvastatin"

Analogue wanamuhla "rosuvastatin" ezishibhile kumelwe sizibonakalise bioequivalence zabo "Crestor" bese ngokuzenzakalelayo uthola inhlonipho ochwepheshe. Ngaphandle bioequivalence izifundo nochwepheshe yishoni kuphela izici zokwelapha isicelo. Omunye wabo lokhu: uma esetshenziswa nozakwabo njalo eshibhile "rosuvastatin" (izidakamizwa ohlwini ngenhla), imvamisa izigigaba ezingezinhle ofana noka abona othile ewunikela ngesikhathi usebenzisa ejwayelekile bioequivalent "Crestor".

Ekushintshashintsheni ku-plasma lokuhlushwa "rosuvastatin" ezivela ukusetshenziswa kwe-ngomthamo ifomu okuqinile yenziwe ngohlobo oluhlukile, ezibhekwa abangelutho kuleli cala. Ngenxa ezishibhile Analogue Russian of "rosuvastatin" ungakwazi ngempela esikhundleni sokuqala izidakamizwa "Crestor" nezidakamizwa yayo ejwayelekile ekwelapheni hypercholesterolemia.

Izimpawu iziguli Izibuyekezo

Ngokusho izimpendulo iziguli ababelana emibonweni yabo mayelana nokusetshenziswa kwezidakamizwa nodokotela wakho, kukhona isiphetho eziningana okunengqondo. Okokuqala, iziguli izahlulelo mayelana nekhwalithi izidakamizwa nganhlanye. Okwesibili, ngenxa imperceptible nomphumela nesineke basemtholampilo ukunamathela ekwelashweni uphansi, nakuba impatho kubalulekile ukuvikela ingozi izenzakalo acute yenhliziyo. Okwesithathu, iziguli livame ukwenza ihaba ngezinto ukubaluleka side effects, babukele phansi Dynamics sephrofayela plasma lipid.