"Stamlo": ukubuyekezwa, analogs. Yokusetshenziswa "Stamlo"

Ukuze aphansi blood pressure, odokotela bavame ukusebenzisa imithi esekelwe amlodipine. Omunye zindlela buyisidakamizwa "Stamlo".

incazelo

Lesi sidakamizwa senziwa yinkampani Indian, "kusho uDkt Reddy sika Laboratories Ltd.".

Medicine "Stamlo" sikhombisa umphumela umthamo ancike isikhathi eside zokwelapha.

Njengoba dihydropyridine esuselwe oyibamba amlodipine ingxenye libhekisela isizukulwane sesibili Ca ²⁺ abamelene, okuyinto ukuvala iziteshi, transmissive calcium ion.

ifomu Isikali

Ithuluzi iyatholakala ngemithamo ezimbili: 0.005 futhi 0.010 amagremu esebenzayo isithako ingxenye.

umthamo engezansi nomuthi "Stamlo" imfundo echazwe amaphilisi round nge surface emhlophe noma kakhulu ezimhlophe, okuyinto flat, emaphethelweni has simise chamfered. Ngenjongo akubiza isidakamizwa esisodwa indiza equkethe ecindezela «R 177" ngakolunye - uhlukanisa ingozi isicelo.

A umthamo enkulu lesi sidakamizwa "Stamlo" uchaza abstract njengoba indawo ye-tablet okusaqanda nge white noma awube mhlophe biconvex ebusweni. Ngenjongo akubiza isidakamizwa esisodwa indiza lapho ecindezela «R», ngakolunye - sisetshenziswa, inkomba inani "178". Solid Isikali amayunithi ayatholakala ibhamuza amaphakethe of izingcezu 14 e amaphakethe aqukethe imivimbo ezimbili iphakethe.

izingxenye izidakamizwa

Isithako asebenzayo zomuthi kuyinto usawoti amlodipine besylate uhlobo, e imali 6,42 mg kanye 12,838 okulingana 0,005 futhi 0,010 g amlodipine okumsulwa.

Ngo ukwakheka ithebhulethi "Stamlo" kungathola izingxenye ngasebenzi, okuyinto amelwa zesandulela microcrystalline cellulose uhlobo, sodium isitashi glycolate, aerosil emzimbeni, i-magnesium stearate.

mshini wezenzo

Ama-molecule abophele yokwamukela amlodipine amaqhubu dihydropyridine iziteshi uhlobo Ilokhi Ukungena kancane kancane kwezinto calcium ion okuqondene ungqimba yesibili enikeza antihypertensives nomsebenzi antianginal.

Yokusetshenziswa "Stamlo" lithi kwakuyidili imithi esihlinzeka nokwehlisa transmembrane inguqulelo Ca ²⁺ ion ku bushelelezi imisipha amaseli odongeni semithambo.

Lapho umsebenzi antianginal uvuleke izitsha ezinkulu nezincane lwemithambo yenhliziyo kanye nohlobo neuropathy. Ephambi kwezinduna ubuhlungu besifuba incipha izimpawu ithi ischemic of imisipha yenhliziyo.

Umuthi ihlinzeka umphumela ababuthakathaka natriuretic, okusithiyayo of platelet wokuhlanganisa amaseli, kukhuphuke glomerular filtration isilinganiso.

Ukunwetshwa arteriole ezikude kubangela kuncipha ukumelana ingqikithi neuropathy embhedeni semithambo, Layisha encishisiwe ku izicubu esivimba amanzi zinkulu, ukunciphisa umoyampilo yamangqamuzana adingekayo inhliziyo.

Reception kusho iziguli ezine nephropathy sikashukela owenza microalbuminuria ngaphezulu evelele.

Isenzo zomuthi akukushintshi umzimba lipid amazinga esegazini.

umsebenzi zokwelapha kwenzeka ngemva kwamahora amaningana futhi igcinwe usuku olulodwa.

Yini isetshenziswa

Amaphilisi ukusiza ubuhlungu ukuphathwa esifubeni okuzenzakalelayo ngokomzimba.

Yokusetshenziswa "Stamlo" incoma ukuthi ukwanda wegazi. Ingasetshenziselwa eyedwa noma inhlanganisela nomunye umuthi antihypertensive.

Indlela

Tablets "Stamlo M" imfundo manual itusa ukuba aphathe lwemithambo abanomfutho wegazi ophakeme isimo futhi ubuhlungu besifuba sokuqala umthamo 0,005 g ukuthi isiphuzo izikhathi 1 ngosuku. Inani esekelwa amlodipine ngesikhathi ingcindezi ephakeme kuyinto 0,005 amagremu ngosuku. Umkhawulo kuvunyelwe umthamo wansuku zonke izimali kumele singeqi 0,010 g

Futhi angina nokuguqulwa ngesikhathi umsebenzi ziphathwa umthamo 0,005 ukuze 0,010 amagremu ngosuku.

Inani yokulungiswa nomuthi "Stamlo M" is hhayi lwenziwa uma kuhlangene isisu thiazide, angiotensin ukuguqulela enzyme retarders, beta nitrate nemithi adrenoblokatornymi kanye nethonya eside futhi nitroglycerin sublingual.

Lapho umsebenzi hypotensive isiguli abaneminyaka, ngokwanda kancane, nge ongaphakeme yemisipha, ukungasebenzi kwesibindi isetshenziswa umthamo lokuqala nomuthi 0,0025 Ukuze ogulayo ezinjalo, umthamo kuboniswa ukuze bayothola ukwelashwa antianginal at 0.005 g

Uma kukhona ukwehluleka izinso ke ulungise inani amlodipine akudingekile.

Izici yokwelashwa

Ngu izidakamizwa "Stamlo" imfundo on imibiko mayelana nokwenzeka elisetshenziswa iziguli eziningi ze-monotherapy. Uma kukhona ukungabi umsebenzi antihypertensive, yengezwe ukulungiswa angiotensin-ukuguqulela enzyme inhibitor, isisu izakhi thiazide, alpha ne-beta adrenoblokatornye nemithi.

Phakathi imithi idinga ukuqapha isisindo umzimba womuntu kanye sodium eyanele, izincomo wezokudla kufanele ilandelwe.

Izibhebhe kungenzeka zifakwe monotherapy, basuke kuhlangene izidakamizwa antianginal umsebenzi iziguli refractory emiphumeleni ngemithamo oqabulayo nitrate kanye izinto beta-adrenoblokatornyh.

Ukuvimbela ukopha, ubuhlungu futhi overgrowth kwezicubu ezinsinini, prophylaxis zamazinyo kudinga ukuvakashelwa njalo futhi ngezikhathi ezithile kuze kube wamazinyo.

Izinto ukuthi block slow Ukungena kwe-calcium ion ngokusebenzisa imigudu do hhayi imbangela umzimba asabela ngayo ukwesulwa nomuthi, kodwa-non-ukwelashwa kufanele kancane kancane ukunciphisa umthamo.

Okuqukethwe potassium cations, ushukela egazini, i-cholesterol, triglyceride molecule uric acid kanye creatinine egazini akusho ziyahlukahluka bedle amaphilisi "Stamlo".

Ezigabeni zokuqala okwelashwa, iziguli kungenzeka ukozela noma isiyezi, edinga ngokuqapha ngesikhathi ukushayela ezokuthutha.

Ubani akufanele bathathe

Yokusetshenziswa "Stamlo" ngempela iqukethe uhlu Izimo, lapho iziguli ongabekiwe amaphilisi. Lezi zihlanganisa:

• lwemithambo hypotension e ezinzima lapho systolic ingcindezi Inkomba ngezansi 90 mm HG;
• kollapsicheskoe futhi uhulumeni shock cardiogenic;
• engazinzile ubuhlungu besifuba, ngaphezu sebengavela;
• inkathi abantwana ibele;
• ukuzwela ngokweqile ukuze izithako imithi dihydropyridine compounds.
• Ungayisebenzisi ithuluzi engu-18 ubudala, njengoba engakaze kungase kutholakale umsebenzi ephephile.

Dinga sokuqapha ukusetshenziswa ezigulini eziye a ezingamahlalakhona ukwehluleka dekompensatsionnaya uhlobo inhliziyo imisipha, elithambile noma okusesilinganisweni ephakeme blood pressure, yomthambo i-aorta ne-mitral ifomu vasoconstriction, esivimba amanzi acute esivimba amanzi zinkulu, ngokweqile ushukela, ukuhlukumeza kwesibindi kokudla kwamafutha.

ukusabela ezingezinhle

on isicelo "Stamlo" manual ukhuluma zonke nemiphumela ebuhlungu, iyona nesenzakalo zazo kungenzeka ngemuva kokuthatha imithi.

Ngesikhathi inhliziyo futhi semithambo uhlelo has umphumela amlodipine nge obhekwe beats inhliziyo, iphika, decompression olusobala, nakwisyncope, vasculitis ukuphendula, ukuvuvukala inqubo emilenzeni aphansi kanye izingalo.

On isimiso sezinzwa futhi zokuphefumula imithi Uhlelo usebenza nge okuvela ubuhlungu ekhanda, ukukhathala, imizwa yethu ishintshashintsha, yokufikelwa, iphika, ukucindezeleka, ukukhwehlela noma rhinitis.

Kusukela imithi kungaba ukuhlanza, ngifike ngibuyise esiswini ubuhlungu, ukuthuthukisa pancreatitis, kolwelwesi kanye jaundice, nomlomo owomile, peristalsis eziphukile, ukwandisa lokuhlushwa enzyme hepatic.

Izinguquko ohlelweni urogenital, owabonakaliswa nesifiso sokufuna njalo noma kubuhlungu peeing, khulula kahle, nocturia, kwehle potency.

Skin ukusabela elihlobene ne xeroderma nezinwele, purpura, yisishiso komzimba epithelium, pruritus, amawala, angioedema.

Ohlelweni amlodipine zemisipha kubathinta uwukwenza ukubukeka arthralgia, samathambo, ubuhlungu emuva futhi ukuba buthakathaka kwezicubu.

Izitho umqondo uhlushwa ukuthuthukiswa umbono double, ukuvuvukala conjunctiva, iso iziyaluyalu futhi emizweni zokunambitha bezibona, enkeneneza ekhanda, iso yokuhlala, kome cornea kanye ulwelwesi lwamafinyila.

Indlela uxhumana imithi

Njengoba unamathele nomuthi "Stamlo" yokusetshenziswa amaphilisi akukhuthazwa ukuhlanganisa izinto zivimbela namachibi of microsomal. Bayamthonya, ikhuphula izinga plasma amlodipine, isibalo sezikhungo izinqubo engadingeki. Inhlanganisela nge inductors okuyinto ukusheshisa hepatic microsomal enzyme, kube nomphumela omubi.

umsebenzi Antihypertensive buthaka bedle nonsteroidal izidakamizwa eqeda ukuvuvukala. sodium Indomethacin ilibele prostaglandin zamagama ivinjelwe izinso, futhi-alpha-agonists estrogen futhi kubambezela excretion ion Na ^+, kuba nomphumela sympathomimetic.

Warfarin, digoxin, cimetidine futhi pharmacokinetic amagugu musa ukushintsha izici amaphilisi.

Antianginal futhi isenzo hypotensive zingaqiniswa thiazide, "loop" isisu, beta-adrenoblokatornymi izindlela, verapamil, angiotensin ukuguqulela enzyme inhibitor, nemikhiqizo kamanyolo.

Izinto equkethe Ca ²⁺ ion, blokatorny encishisiwe nomthelela iziteshi calcium.

Ukubonakaliswa umphumela Neurotoxic kwemithi lithium iyakhula amlodipine, esibonakala by isicanucanu, uhudo, ukuhlanza, liqhaqhazela, ataxia, tinnitus.

Amiodarone, alpha-blocker, quinidine, antipsychotic neuroleptic izidakamizwa izinto uthayiphe okwengeziwe emsebenzini hypotensive.

ukusetshenziswa ngokweqile

Nge ukweqisa izidakamizwa zomuthi "Stamlo" Umhlahlandlela uchaza izinguquko, elinesimo ukwehla osobala ingcindezi, Kufinyeta njalo kwenhliziyo, ngokweqile vasodilation neuropathy.

imisebenzi nazo kubhekwe ukususa ngokweqile elihlobene nezidakamizwa lavage esiswini, wokuqoka sorbents. Kubalulekile ukubuyisela umsebenzi izitsha emaphashini, inhliziyo negazi, ukuqapha ukusebenza kwabo. Kumele lugcinwe esimeni esihle kwamalungu omzimba, ukulawula ivolumu umchamo.

yokuvula amakhala ezisetshenziswa ukuzinza ithoni semithambo. Ukuqeda ngemiphumela Ilokhi ijabulise, i-calcium emthanjeni isetshenziswa ngendlela gluconate.

izidakamizwa Okufanayo

Ukuze izidakamizwa "Stamlo" nozakwabo iyatholakala e imithamo ezimbili: 0.005 futhi 0.010 g amlodipine. Ukwakheka qualitative izithako ngasebenzi izibhebhe ezivela abakhiqizi ezahlukene ingahluka kancane, ke akuphazamisi bioavailability.

Izidakamizwa "Amlodipine" ekhiqizwa "ALSI Pharma" CJSC. Njengelinye lamazwe ezishibhile Indian izidakamizwa analogue. It has umsebenzi antianginal futhi antihypertensive.

ontanga Russian ingumuthi "Vero Amlodipine" oluqanjwe "Veropharm" OJSC, futhi lisho "Amlodipine-Biocom" isitshalo "Biocom" CJSC.

I nomuthi "Amlodipine-Teva" ukhona ngemithamo ezimbili: 0.005 futhi 0.010, le imithamo emibili ethulwa amaphilisi ezimhlophe kokuba round biconvex ukuma, ibhalwe ukuthi "AB 5" noma "AB 10". inkampani Iyatholakala Hungarian ezithaka imithi "TEVA Prayvet Co. Co., Ltd. '.

Izidakamizwa "Amlodipine Sandoz" ezivezwa nkampani Slovenian "Sandoz" ngesimo flat, nxazonke ithebhulethi amayunithi kokuba ingozi futhi chamfer.

Izibuyekezo

Iziguli eziningi njenge thuluzi ngenxa ukusebenza yayo futhi amanani ezingabizi. Mayelana imithi 'Stamlo "Izibuyekezo ungezwakala kokubili imvelo emihle nemibi. Omunye amaphilisi nesineke ukukusiza ukwehlisa high blood pressure, abanye abakwazi ukulungisa nomfutho wegazi ophezulu.

Ngaphezu kwalokho, izidakamizwa ungakwazi avuse ukutubeka komzimba, isiyezi, ukukhathala, ukushintshashintsha kwemizwelo, amehlo ukozela kanye nesicanucanu. Kulokhu, ngokuthatha amaphilisi kumelwe zilahlwe.