Ukulungiselela "i-Pentas": imiyalo yokusetshenziswa, i-analogues nokubuyekezwa

Ngabe imiphi umthamo abayalela ngayo imishanguzo ye-Pentasa? Imiyalo yokusetshenziswa, ukubuyekezwa kanye nokwakhiwa kwezidakamizwa kuxoxwa ngezansi. Okunye okuyizinto ezikulesi sihloko ulwazi ngolwazi lokukhululwa kwalo muthi kanye nezakhiwo zalo.

Ukwakhiwa, izinhlobo zemithi

Kunezinhlobo eziningana zokukhululwa kwezidakamizwa ezibuzwayo. Cabanga nje manje.

Isidakamizwa esithi "Pentasa" - amaphilisi (500 mg, 100 mg) isenzo eside. Bomhlophe nge-gray tinge, futhi banamabala amaningi amnyama, ajwayelekile, ayenobungozi, isici kanye nemibhalo ebhalwe phansi.

Into esebenzayo yalesi sidakamizwa i-mesalazine. Okunye okuhlanganisiwe ekubunjweni kukhona izithako ezingasebenziyo ngendlela ye-povidone, i-ethylcellulose, i-magnesium stearate, i-talc ne-microcrystalline cellulose.

Ekuthengisweni kwesidakamizwa esithi "Pentasa" (amaphilisi), isithombe esinikezwa kulesi sihloko, siza kubhalisa, okusemaphaketheni ekhadibhodi.

Kumele kuqashelwe ukuthi imithi ephathelene nombuzo ingathengwa ngendlela ye-suppositories, ama-granules okukhulunywa ngokukhululeka kanye nokumiswa kwama-rectal.

I-Pharmacology yomkhiqizo wokwelapha

Iyiphi imithi yama-Pentasa? Imfundo yokusetshenziswa ithi le nsizakalo inomphumela olwa nokuvuvukala futhi isetshenziselwa ukwelapha isifo seNNC nesifo sikaCrohn.

Izakhiwo eziphikisanayo nezidakamizwa zalesi sidakamizwa zibonakala kuphela ngokusetshenziswa kwendawo. Lokhu kubangelwa ukuhlanganiswa kwama-leukotrienes kanye ne-prostaglandins, kanye nokuvimbela umsebenzi we-lipoxygenase (neutrophilic). Ngaphezu kwalokho, lesi sidakamizwa sikwazi ukunciphisa ukusondelana kwama-immunoglobulins nge-lymphocytes futhi kuvimbele ukubola, ukufuduka kanye ne-phagocytosis ye-neutrophils.

Izici zamathumbu

Amaphilisi asePentasa (amathebulethi), okwakhiwa ngawo ngenhla, kubonisa umsebenzi ophikisana nomzimba wokulwa ne-cocci no-Escherichia coli. Ibuye ibe nomthelela we-antioxidant ngenxa yekhono lomuthi osebenzayo wokubopha ama-radicals (oksijini) mahhala nokuwabhubhisa.

Ukusetshenziswa kahle kwalesi sikhungo kunciphisa kakhulu ingozi yokubuyela esibhedlela sikaCrohn, kuhlanganise nabantu abane-leitis (isikhathi eside sesifo).

Isimiso sokusebenza kwedivaysi yezokwelapha

Imithi ye-Pentasa isebenza kanjani? Imiyalelo yokusetshenziswa iqinisekisa ukuthi umphumela wokwelapha walesi sidakamizwa ubonakala ngokushesha ngemuva kokuxhumana kwendawo ye-mesalazine ne-mucosa emathunjini.

Ngemva kokuthatha isidakamizwa somlomo, ithebhulethi idiliza ngokushesha ibe ama-microgranules asebenza njengefomu ehlukile futhi ikhulule imithi esebenzayo, i-mesalazine, kancane kancane. Lokhu kuqinisekisa ukuphumelela kwemithi phezu kwe-12-finger kuya rectum kunoma iyiphi i-pH.

I-Pharmacokinetics ye-agent

Ukunakekelwa kwemithi yamaPentasa kanjani? Imfundo yokusetshenziswa ikwazisa ukuthi ama-microgranules of amaphilisi okubola afika ku duodenum phakathi nemizuzu yokuqala engu-60.

Cishe amaphesenti angama-30-50% esithathwe athelwa emathunjini amancane. Ukuxhunyaniswa kwe-mesalazine ne-plasma amaprotheni ngu-43%, futhi ama-acids N-acetyl-five-aminosalicylic - 73-85%.

I-Mesalazine, kanye nemithombo yayo ayifinyeleli kwi-BBB. Izakhiwo eziqhamukayo zezidakamizwa ezibonakalayo kuphela uma usebenzisa imithi ephakeme (cishe 1500 mg ngosuku).

Ukwakhiwa kwe-mesalazine kuvezwe emanzini emathumbu nasesibindi. Lesi sici siphuthumisiwe emcinini, ubisi lomama kanye nesikhumba.

Izimpawu zokusetshenziswa komuthi

Iziphi izimo ezingase ziboniswe izidakamizwa "I-Pentas"? Izimpendulo zongcweti zithi le mithi ibonakala kahle uma:

• I-colontic ulcerative engapheli;
• Isifo sikaCrohn.

Ukuvimbela ukusetshenziswa komkhiqizo wokwelapha

Ngaphansi kwaziphi izimo ngeke ukwazi ukusebenzisa ithuluzi elinjenge- "Pentasa"? Imiyalelo (amaphilisi nezinye izinhlobo zezidakamizwa zinokuphikisana okufanayo) kukhuluma ngokuvinjelwa okulandelayo:

• I-Diathesis i-hemorrhagic;
• Izifo zegazi;
• Isikhathi sokubamba iqhaza;
• Ulcer we-tract digestive;
• Amaviki amabili okugcina angu-2-5 wokukhulelwa;
• Ukungabi ne-glucose-6-phosphate dehydrogenase;
• Kudala kuze kube seminyaka emibili;
• Ukuhluleka kwezintambo kunzima;
• Ukuziphendulela ngokwezinto ezidakamizwa;
• Ukuhluleka kwe-Hepatic kunzima.

Ngokunakekelwa okukhethekile, lesi sidakamizwa kufanele sisetshenziswe ku-trimester yokuqala yokukhulelwa, kanye nokungaqiniseki kwe-hepatic kanye ne-renal.

I-Pentasa imithi: imiyalelo yokusetshenziswa

Ukukhethwa kwendlela yokulinganisa yalesi sidakamizwa kuncike ekutheni indawo yendawo yokwelapha isifo esiyinhloko, kanye nesilinganiso sezilonda zamathumbu.

Ama-suppository "ama-Pentas" nokumiswa kunqunyelwe izinhlobo ze-distal zesifo (proctosigmoiditis). Kulesi simo, amakhandlela asetshenziswe izikhathi ezintathu ngosuku nge 500 mg.

Ukulungiswa komlomo kwePentasa (amaphilisi) kunqunywe kanjani? Imiyalo yokusetshenziswa ithi lolu hlobo lwemithi lunconywa ukuba lusetshenziselwe kuphela izinhlobo ezivamile zezifo. Ukuze kuvikelwe ukuphindaphinda nesifo sikaCrohn, imithi isetshenziswa izikhathi ezine ngosuku (1 g yemalazine). Mayelana nokuvimbela ukubuyela kabusha kwe-NNC, kulokhu, lesi sidakamizwa sinqunywe kathathu ngosuku nge-500 mg.

Uma lesi sifo siqhubeka, inkambo yokwelashwa kufanele ihlale amasonto angu-8-12. Kulesi simo, imishanguzo ye-400-800 mg kufanele ithathwe nsuku zonke (izikhathi ezintathu ngosuku).

Ezimweni ezimbi, ukwanda kwansuku zonke nsuku zonke kuya ku-3-4 amagremu kungenzeka.

Amathebulethi "ama-Pentas" kufanele athathwe ngokushesha ngemva kokudla, ngaphandle kokuhlafuna nokugeza ngamanzi alula.

Imiphumela emibi

Kwezinye izimo, izidakamizwa ezibuzwayo zidala imiphumela emibi elandelayo:

• Stomatitis, ukuthuthumela kwamaphethelo, umlomo owomile, isizungu, isicashu, imizwa ecindezelekile;
• Ukwehla kwesifiso, umuzwa wokushaya kwenhliziyo okusheshayo, ukushaya isisu, ukuphefumula okuncane nokusebenza komzimba, ukuhlanza;
• I-Hematuria, isifo sohudo, i-tachycardia, i-hepatitis, ubuhlungu obuseduze;
• Ukwandisa ama-enzyme yesibindi, ukuguquguquka kwengcindezi yegazi, ukungena kwe-pancreatitis, polyneuropathy;
• I-Crystalluria, i-tinnitus, i-proteinuria (i-protein secretion), i-migraine ikhanda;
• U-Oliguria, i-leukopenia, i-anuria (ukungabikho kokuvuthwa), i-thrombocytopenia, ukwakheka kwe- nephrotic syndrome ;
• I-Hypoprothrombinemia, i-agranulocytosis, i-eosinophilia, i-anemia.

Kumele kuqashelwe ukuthi ngemuva kokuthatha lesi sidakamizwa esigulini kungabonwa: i-oligospermia, i-alopecia, i-photosensitivity, ubuthakathaka emaphethelweni, i-lupus-like syndrome, yehle ukukhiqizwa kwemithombo yamanzi, i-mumps.

Ukudlula ngokweqile ngomkhiqizo wokwelapha

Ukudlula ngokweqile kwezidakamizwa okucatshangelwayo kubonakaliswa ukulala okukhulu, isicashu, i-gastralgia, ukuhlanza nokubuthakathaka kuwo wonke umzimba. Ukuqeda izimpawu ezinjalo kudinga ukugcoba ngesisu ngesikhathi esifanele, kanye nokuqokwa kwamakhemikhali kanye nokuphathwa kwe-post-syndrome therapy.

Ukusebenzisana kwezidakamizwa

I-Pentasa imithi inganciphisa izinga lokumunca kwe-cyanocobalamin. Futhi, i-mesalazine ithuthukisa ukusebenza kwama-agent we-uricosuric (kufaka phakathi abavimbela ukuvimbela ama-tubular).

Kumele kuqashelwe ukuthi lo muthi ukwandisa ulcerogenicity of glucocorticosteroids, ifinyelela umphumela we rifampicin, ukwandisa uketshezi we methotrexate futhi unomphumela we-hypoglycemic kwi-derivatives ye-sulfonylureas, i-spironolactone, i-sulfonamide ne-furosemide.

Ulwazi olukhethekile

Uma ungaphuthelwa umthamo we-mesalazine, kunconywa ukuba uyithathe kanye nesikhathi esizayo noma esikhathini esiseduze kakhulu. Uma kunezinamba ezimbalwa ezilahlekile, kufanele uthintane nodokotela ngokushesha. Ngesikhathi esifanayo kunqatshelwe ukuyeka ukwelashwa ngokwakho.

Ngesinye isikhathi, ngokumelene nesizinda sokusetshenziswa kwesidakamizwa esibuzwayo, iziguli zibhekwa emcimbini we-stain kanye nama-lens othintana ne-yellow-orange hue.

Ngenkathi yokwelapha nge-mesalazine, ukulawulwa kwezokwelapha okuqhubekayo phezu komsebenzi wesimiso somuthi wesiguli kuyadingeka. Kubuye kudingeke njalo ukuqhuba ukuguqulwa kwesiguli kanye negazi lakhe (ngesikhathi sokulashwa, futhi ngemuva kokuqedwa kwayo).

Kungenzeka ukuthi ukutholakala kokungalungi ngokumelene nesizinda sokuthatha le mithi kwanda kulabo "abacebileyo".

Ngokuthuthukiswa kwe-syndrome ye-syndrome engavumelani nesithako esisebenzayo, ukulungiswa kwe- "Pentasa" kukhanseliwe ngokushesha.

Imithi efanayo kanye nokubuyekezwa kwabathengi

Uyazi ukuthi yini engayifaka esikhundleni semithi ebuzwayo? Udokotela ophethe kufanele akutshele ngalokhu. Njengomthetho, izidakamizwa ezilandelayo zibhekwa njengezifana nale mithi: Mesakol, Salosinil, Salofalk, Mezavant, Mesalazin, Asakol.

Kuthiwani abathengi ngalesi sikhungo? Ngokwezibuyekezo zabo, le mithi imithi ephumelela kakhulu engathengwa kunoma iyiphi ikhemisi. Iziguli zithi iMesalazine ayiyona nje indlela yokwelapha, kodwa futhi ekuvimbeleni isifo sikaCrohn, kanye nesifo sofuba esiswini.