ImpiloAmalungiselelo

Umuthi 'Remicade ": yokusetshenziswa, ngempela

Ngokuphumelelayo kusho "Remicade"? Yokusetshenziswa, ukubuyekezwa nesineke lomutsi izokwethulwa ngezansi. Futhi kulesi sihloko, uzofunda mayelana nganoma iyiphi izimo, libeke izidakamizwa ukuthi unakho contraindications nemiphumela engemihle, okuyinto izingxenye bayingxenye ke nokunye.

Ifomu, ukwakheka

Ukulungiselela "Remicade" ikhishwa ngesimo powder lyophilized senzelwe ukulungiswa isixazululo ukumnika. Isithako asebenzayo we umuthi infliximab. Ibuye ibe izingxenye ezengeziwe njengoba polysorbate 80, i-sodium ne-hydrogen phosphate dihydrate, sucrose kanye monohydrate sodium dihydrogen phosphate.

izakhiwo Key

Iyini imithi "Remicade"? Iziyalezo yokusetshenziswa Lithi kuyinto umenzeli immunosuppressive.

Kokuqhubeka ngaphakathi emzimbeni, umuthi uqala uxhumana amafomu encibilikayo futhi transmembrane ka tumor necrosis-alpha (TNFα), ukunciphisa umsebenzi wabo ngu ekwakhekeni eziyinkimbinkimbi esitebeleni.

ochwepheshe Ucwaningo zisikisela ukuthi asebenzayo izidakamizwa izidakamizwa kunciphisa kokuziphatha yeselula (ukuvuvukala), futhi inani izimpawu ukuvuvukala kule ezindaweni ezithintekile emathunjini. Ngakho lapho lungukuphulukisa sasivumela okusheshayo ulwelwesi lwamafinyila.

Pharmacokinetics

Yiziphi imingcele pharmacokinetic uye imithi "Remicade"? Qaphela, isimo impendulo umjovo owodwa emthanjeni of infliximab e isamba ukufika kuma-20 mg / kg kulandelwa ukwanda ezilinganiselwe emakamu walo omkhulu.

isicelo okuphindiwe kwe- izidakamizwa kubangela ukunqwabelana okuncane lomcebo abakhuthele serum.

Izindlela ukuqedwa izidakamizwa engakaze siyachazwa.

izinkomba

Ukuze lokho ngezinhloso kungenzeka izidakamizwa esimisiwe 'Remicade "? Ukusetshenziswa kwalesi imithi okuboniswe kulezi zimo ezilandelayo:

  • rheumatoid arthritis efomini asebenzayo (uma iziguli ziphathwe izidakamizwa antiinflammatory laliwukuthi ayizwakali). Ukwelashwa kwenziwa lihambisana "methotrexate". Le nhlanganisela ikuvumela ukwehlisa izimpawu zesifo, kanye ngcono joint iyonke.
  • isifo Crohn ezigulini omdala. Kulokhu kuyasiza "Remicade"? Umhlahlandlela uthi ukwelashwa nale ukulungiselela okufanele iqhutshwe uma ukungabekezelelani noma ukwehluleka, kodwa futhi nge Izimo emuthini ojwayelekile. Ngo kokutshelwa ngokukhubazeka kwengane "Remicade ikhuthaza ukuqedwa kwazo zonke izimpawu isifo, nokugcina ukuthethelelwa nokwelashwa ngokushesha amanxeba, fistula lokuvalwa ngcono isimo lesiguli.
  • isifo Crohn e intsha. Ukwelashwa nale izidakamizwa wenziwa uma ukungabekezelelani noma ukwehluleka, kodwa futhi nge contraindications isikimu ejwayelekile yokwelapha. Nomuthi "Remicade" kunciphisa izimpawu futhi isekela ukuthethelelwa futhi kuthuthukisa izinga lempilo seziguli ezisencane.
  • Esidalwa yizilonda emathunjini sibe nesifo kwabadala. Izidakamizwa "Remicade", okuyinto Izibuyekezo abekwe ngezansi, iqondiswa kwenzeka ukuthi yokwelapha kodokotela kwaba ayizwakali. Ukwelashwa lokhu ejenti kunciphisa izimpawu zesifo, le mucosa emathunjini sokuphulukiswa, zincishiswe noma ukuqedwa GCS imithamo. Kufanele kuphawulwe ukuthi, ngemva ukunikezwa ithuluzi aqede isidingo ukuhlala esibhedlela.
  • Esidalwa yizilonda emathunjini sibe nesifo ezinganeni. Ukwelashwa nale izidakamizwa elibekelwe izingane ezineminyaka engu eminyakeni 6-18, uma wazibonakalisa ayizwakali yokwelapha kodokotela.
  • Ankylosing spondylitis (ngezimbobo yokwelapha nokungasebenzi). Njenganoma uphethwe kusiza imithi "Remicade"? Yokusetshenziswa ibika ukuthi leli thuluzi kunciphisa izimpawu zesifo kanye ngcono ukusebenza kwamalunga.
  • Psoriasis (ngezimbobo yokwelapha nokungasebenzi). Njengoba e-psoriasis ekusizeni "Remicade"? ochwepheshe lezivakashi bathi lokhu izidakamizwa kunciphisa ukuvuvukala esikhumbeni futhi normalizes inqubo keratinocyte kwamangqamuzana.
  • arthritis psoriatic (i standard yokwelapha nokungasebenzi). I nomuthi "Remicade" iqondiswa lihambisana "MTX" noma njengoba monotherapy nge Izimo noma ukungabekezelelani kuya yokugcina. Ngenxa yalokho, ukuphathwa kunciphise izimpawu zesifo sokuqaqamba kwamalunga, iziguli ngcono umsebenzi ukusebenza, kanye kunciphisa izinga phambili radiographic e arthritis psoriatic.

Izimo

Ukwelashwa "Remicade" kungavunyelwe ukuziphatha lapho:

  • inqubo ezinzima ezithathelwanayo (isib sepsis, ithumba, isifo sofuba, izifo ezibona intuba) ;
  • ukuzwela anda isiguli infliximab namaprotheni murine kanye nanoma yiziphi ezinye izingxenye zomuthi;
  • ngaphansi kweminyaka eyi-6 (izilonda emathunjini futhi isifo Crohn);
  • ukhulelwe;
  • ukuhluleka kwenhliziyo;
  • ngaphansi kweminyaka eyi-18;
  • ibele.

Izidakamizwa "Remicade": yokusetshenziswa. Futhi lapho ukungena (uma kuphela esibhedlela)?

imithi Okubukwe kufanele sinikezwe kuphela ngaphansi kokuqondisa onguchwepheshe (esibhedlela ie) onendlu nesipiliyoni of ukuxilongwa kanye nokwelashwa ngempumelelo izifo ngenhla.

Isixazululo sivela dropwise ngemithambo yegazi imizuzu engaphezu 120. Izinga akufanele futhi iyophakama kuno-2 ml ngomzuzu. Ukuqalisa izinqubo ezidingekayo nokusetshenziswa kohlelo ukumnika.

Umthamo zomuthi incike ubufakazi.

rheumatoid arthritis

Ngo enjalo uphethwe umsebenzi umthamo kokuqala kufanele ibe mayelana 3 mg ngayinye kg. I nomuthi iqondiswa ngokuphindaphindiwe uma sebehlanganisa amasonto angu 3-6. Khona-ke ulisebenzise njalo ezinyangeni ezimbili.

Uma kwenzeka ukuthi umphumela zokwelapha engakaze kufinyelelwa, ucabangela ekunqanyulweni yokwelapha.

Ngokuvamile umuthi "Remicade" nge -rheumatoid arthritis iqondiswa kanye "methotrexate".

izilonda emathunjini

Kokuqala Isikali lapho kokutshelwa ngokukhubazeka kwengane 5 mg ngayinye esisindo kg. Umthamo efanayo izidakamizwa iqondiswa Ngemva kwamasonto 3-6. Khona-ke imithi eyenziwa njalo ezinyangeni ezimbili.

Uma kudingeka, umthamo kungenziwa lenyuke-10 mg ngayinye kg. Umthelela ukwelashwa uvame ukubonakala engakapheli amasonto angu-14. Kuleso simo, uma kungenjalo, kufanele uqhubeke nokwelashwa.

arthritis psoriatic

Psoriatic sokuqaqamba kwamalunga izidakamizwa "Remicade" yaphathwa i umthamo kokuqala 5 mg ngayinye kg. I nomuthi iqondiswa ngokuphindaphindiwe uma sebehlanganisa amasonto angu 3-6. Khona-ke ulisebenzise njalo emavikini 7-8.

Akunikeze imithi kungenziwa kuhlangene "methotrexate".

isifo Crohn

Ngo kokutshelwa ngokukhubazeka kwengane abadala ziboniswa ngemithamo eyodwa 5 mg ngayinye kg. Uma umphumela zokwelapha engakaze izuzwe kule minyaka 2 amaviki, umuthi amankeyane.

Uma omuhle izidakamizwa action, amaqhinga alandelayo:

  • Isixazululo saphathwa ku umthamo ofanayo njengoba kule ukumnika lokuqala, kwabe sekuthi ngemva kwamasonto 3-6 basetshenziswe. Ngemva kwalokho, ukwenza imijovo njalo ezinyangeni ezimbili. Uma kudingeka, umthamo kungenziwa lenyuke-10 mg ngayinye kg.
  • Umuthi iqondiswa kuphela uyahluleka uma elwa nokuphuza amasonto uma hhayi abadala kuka-16 ngemva kokusetshenziswa okokuqala.

isifo Crohn ezinganeni ezincane

Crohn emaphakathi noma ezinzima ezinganeni ezingaphansi kweminyaka engu-18 kuhilela ukusetshenziswa i umthamo kokuqala 5 mg ngayinye kg. imijovo okwalandela kumele kwenziwe emasontweni 3-6. Khona-ke imithi isetshenziswa njalo ezinyangeni ezimbili, uma kudingeka, kushintshwe a umthamo 10 mg ngayinye kg.

Ngokuvamile, izidakamizwa is kuhlangene immunomodulators 6-mercaptopurine, "azathioprine" noma "methotrexate". Uma umphumela zokwelapha engakaze izuzwe (amasonto 10-11), ukusetshenziswa kwezidakamizwa kuyinto engathandeki.

isifo Crohn kuhambisana fistula

A umthamo owodwa we izidakamizwa ngesikhathi kokutshelwa ngokukhubazeka kwengane 5 mg kg (e abadala). Imithi uphinde usetshenziswe ngemva amasonto 3-6. Uma umphumela zokwelapha emva 3 imijovo is hhayi waphawula ke okunye ukwelashwa okungalungile.

Nge umphumela omuhle izidakamizwa, amaqhinga alandelayo:

  • kokuboshelwa ndawonye ngemva kwamasonto 3-6 bese njalo ezinyangeni ezimbili;
  • the nomuthi iqondiswa at lokubuya kwesifo uma kwathatha isikhathi esingaphansi kwamasonto 16.

ankylosing spondylitis

Njenganoma uphethwe ukusetshenziswa kwezidakamizwa "Remicade"? Yokusetshenziswa ithi kule isifo umthamo kokuqala zomuthi kufanele kube 5 mg ngayinye kg. Emva kwalokho, izidakamizwa iqondiswa ngemva kwamasonto 3-6.

Ukwelashwa akufanele baqhubeka uma, engakapheli amasonto ayisithupha umphumela akusilo obonakalayo.

psoriasis

Esikhathini nokwelashwa psoriasis sokuqala umthamo 5 mg izidakamizwa ngalinye kg. isicelo okuphindiwe kwe- nomuthi unikezwe ngemva kwamaviki angu 3-6, bese - kanye njalo emavikini ayisishiyagalombili.

Uhlelo lokulungiselela i-isixazululo ukumnika

Isixazululo kufanele uzilungiselele kanje:

  • It sinquma umthamo kanye nenani izitsha eziyisikhombisa.
  • I powder umuthi ziyoncibilika 10 ml ketshezi usebenzisa isipetu. Ukuze wenze lokhu, susa kuphela cap isitsha (plastic), futhi ukusula ngesivalo ngotshwala. Inalidi sifakwe ngokusebenzisa isikhungo yayo, futhi uketshezi uqondiswa ogangeni.
  • Isixazululo kwakudalwa ngokucophelela (ukunyakaza ukujikeleza) kuze powder siphela. Izidakamizwa ketshezi kufanele bube yizinombolo kungekho nto enemibala emihle noma ophuzi tint. Uma ngesikhathi ukuxuba Foam isitsha kwakhiwa, kubalulekile sokunika isixazululo imizuzu 5. Yokugcina umthamo amafomu Ingase ithanyelwe ayevumela izinhlayiya emihle.
  • Umthamo isamba imithi kushintshwe 0.9% chloride (250 ml) isixazululo sodium. Ngenxa yale njongo ketshezi lelungiselelwe yengezwe ibhodlela, okuyinto vele iqukethe i-sodium chloride. Bobabili izingxenye ngokuphelele exubile.
  • Isingeniso ekulungisweni Kwenziwa kungakadluli amahora angu-3 emva nokulungiselela yesixazululo izidakamizwa.

Akuvunyelwe faka izidakamizwa nezinye ejenti ngokusebenzisa uhlelo lokusebenza efanayo. Uma kukhona izinto zangaphandle noma izinhlayiya opaque ikhambi, it is hhayi Kunconywa.

Inani ongasebenzi umuthi okumele zisetshenziswe.

side effects

Uma usebenzisa nomuthi, okulandelayo ohlangothini ukusabela:

  • ukucindezeleka, ukunganakwa, ukukhathazeka anda, isiyezi, somnolence, uvalo ukulahlekelwa amandla okukhumbula, sengqondo, ikhanda;
  • edema yamaphaphu, sinusitis, bronchoconstriction, dyspnea, nokungezwani komzimba nezinto, inyumoniya, epistaxis, ukucinana kwemigudu yokuphefumula, pleuritis;
  • conjunctivitis, keratoconjunctivitis, endophthalmitis;
  • ukuvuvukala kanye ngomgudu womchamo izifo;
  • amagagasi, ukuphazamiseka kwegazi neuropathy, bradycardia, ecchymosis, hematoma, zibe semithambo, nakwisyncope, palpitations, cyanosis, petechiae, arrhythmia;
  • thrombocytopenia, ukuntuleka kwegazi emzimbeni, neytrotsitopeniya, leykotsitopeniya, lymphopenia, lymphadenopathy, lymphocytosis;
  • cheilitis, ukuqunjelwa, cholecystitis, Reflux, diverticulitis nohudo, ukucanuzela kwenhliziyo, ukuqunjelwa, kahle isibindi umsebenzi;
  • ukuqubuka kwesikhumba, isikhumba esomile, Alopecia, seborrhea, ukulunywa, imihuzuko, amawala, ukujuluka anda, dermatitis, fungal, amaqhubu hyperkeratosis, Erysipelas, kuphula umthetho we-ibala lesikhumba, kuqhuma bullous.

Izibuyekezo sokulungiselela

Manje uyazi ukuthi ukusebenzisa izidakamizwa "Remicade". Yokusetshenziswa zomuthi iye echazwe ngenhla.

Ezimweni eziningi, kubhekwe indlela ukuba ubhekane nezingcindezi msebenzi. Ngakho-ke, impendulo ezigulini etholakala kakhulu omuhle. Abantu abasebenzisa le solution, ukubika ukuthi emva umjovo we ubuhlungu asisekho cishe ngokuphelele. Nokho, ezinye iziguli besaba ithemba, lokho kungase kubangele.

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