"Azarga" (iso amaconsi): yokusetshenziswa, intengo, kanye nokubuyekeza. Ingabe kukhona iso Analogue amathonsi "Azarga"?

enza lesi sidakamizwa "Azarga" (iso amaconsi) Kanjani? Imiyalo le ndlela, imiphumela engemihle, contraindications izinkomba ukusetshenziswa izokwethulwa kulesi sihloko. Ngaphezu kwalokho, uyofunda ngalokho sinezici kwemithi lokhu izidakamizwa, kanjani futhi kulokho imithamo kumele kusetshenziswe, kuzokwenzekani uma ukweqisa izidakamizwa, nokunye.

Ifomu ukukhululwa izidakamizwa zendawo oyiyo

Ngayiphi fomu enikeziwe ekhemisi izidakamizwa "Azarga"? Eye lehla - kuba kuphela indlela ukukhululwa izidakamizwa. 1 ml izidakamizwa linaso izingxenye esebenzayo njengoba ngesimo timolol maleate in inani 5 mg kanye brinzolamide (10 mg).

Kufanele kuqashelwe ukuthi le "Azarga" kusho nomuthi ifaka izinto asizayo. Lezi zihlanganisa mannitol, disodium edetate, sodium hydroxide, i-sodium chloride, benzalkonium 50% chloride, tyloxapol namanzi ahlanzekile. Ingabe ayatholakala emakhemisi "Azarga" iconsi weThrojani umfuma 5 ml.

Izimfanelo kwemithi amaconsi

Yini izakhiwo ingabe lesi sidakamizwa "Azarga" (ngeso amaconsi), isiqondiso lapho kuqukethwe ibhokisi ibhokisi kanye izidakamizwa? Njengoba kushiwo ngenhla, nomuthi ethulwa yakhiwa 2 ingxenye esebenzayo eyinhloko. It timolol futhi brinzolamide. Lesi sakamuva kuyinto inhibitor ka anhydrase carbonic II. Ngenxa-ke emzimbeni womuntu kubambezela kumiswa ion Bicarbonate, futhi zanciphisa sodium ne ezokuthutha uketshezi. Le nqubo kuholela ukwehla zokukhiqiza amahlaya aqueous emzimbeni ciliary isitho ezibukwayo. Lokhu kuphumela ukwehlisa ingcindezi intraocular.

Kepha timolol ke lena beta-blocker okungahambisani obulimaza nonozwela isimiso sezinzwa futhi akusho zivimbela imisipha inhliziyo. Ngemva ukusetshenziswa lendawo, kunciphisa kumiswa umswakama futhi kukhulisa outflow yayo.

Pharmacokinetics zomuthi

ngabe izidakamizwa amuncwa umzimba, "Azarga" (iso amaconsi)? Imiyalelo kulesi sici inikeza ukuthi ukusetshenziswa ngezihloko ezihlukene izingxenye asebenzayo ezifana brinzolamide futhi timolol, bayakwazi ukungena kwegazi. Ingqikithi mithandazo angena erythrocyte ngemva abakhethayo sesibopho ukuthobisa anhydrase carbonic II. ebudlelwaneni bayo nalowo plasma amaprotheni cishe 60%.

Brinzolamide akheka ngu O-dealkylation, N-dealkylation kanye namachibi N-propyl ohlangothini chain. It is esephetha ngu izinso ngefomu ezingaguquliwe isamba 60%. Ngakho-20% livela umzimba womuntu ngokuthi metabolites.

Timolol ukuncela nkathi amahora 5 ngemuva kokusebenzisa ngezihloko ezihlukene izidakamizwa. Umzimba efana senzeka ngezindlela ezimbili: ethanolamine ukwakha ohlangothini amaketango iringi thiadiazole, futhi ukwakha i-ethanol ohlangothini uchungechunge nitrogen morpholine futhi iqembu carbonyl okuyinto ixhunywe nitrogen.

metabolites Timolol futhi kwakhiwa kuthiwa excreted ikakhulu nge nezinso. Zilinganiselwa ku-20% we indaba uboniswa ifomu zinjalo.

Izinkomba ngoba ukusetshenziswa kwezimali

Kwezinye izimo, izidakamizwa zisebenzisa "Azarga"? Eye amaconsi sabelwe khona ekunciphiseni isigqugquzeli ingcindezi intraocular, okuyinto elakhiwe ngenxa ukuvula-engela glaucoma. Futhi, ke livame ukusetshenziswa in iziguli nomfutho wegazi ophezulu ocular. Kodwa lokhu kuphela uma monotherapy bekulokhu enganele ukwehlisa ingcindezi.

Izimo ukusetshenziswa kwezimali zendawo

Kwezinye izimo, awukwazi ukusebenzisa izidakamizwa "Azarga" (iso amaconsi)? Imiyalelo kwaleli thuluzi iqukethe uhlu kahle esikhulu ka Izimo. Cabanga-ke manje:

• anda ukuzwela isiguli sulfonamides;
• isifuba somoya, kuhlanganise umlando;
• Hypersensitivity kuya izingxenye izidakamizwa;
• obstructive izifo zamaphaphu okungamahlalakhona, okuyinto zenzeka kanzima kakhulu;
• lactic hyperchloraemic;
• hyperreactivity bronchial;
• hypersensitivity kuya beta-blocker;
• itheku bradycardia;
• ubudala zezingane (iminyaka engu-18);
• AV-block II no III degree;
• lactation;
• ukuhluleka kwenhliziyo (esibi kakhulu);
• ngesikhathi sokukhulelwa;
• ukushaqeka cardiogenic;
• isicelo ngesikhathi esisodwa inhibitor (TEMLOMO), anhydrase carbonic;
• rhinitis iguliswa, eligeleza kunzima kakhulu;
• Ukuvalwa ukufiphala;
• ezinzima esingamahlalakhona kwezinso.

imithi ethatha Ohlakaniphile

Manje uyazi, ngaphansi kwanoma yimuphi ngeziphambeko it is hhayi Kunconywa ukusebenzisa imithi, "Azarga". ku isicelo yomhlahlandlela ithuluzi liqukethe ulwazi mayelana amacala lapho kufanele lusetshenziswa ngokuqapha okukhulu. Kulolu hla, iziguli ezinemishini Prinzmetal angina, i-hyperthyroidism, ukunikezwa kwe-central, neuropathy iziyaluyalu kwegazi futhi hypotension.

Kufanele kuqashelwe ukuthi i-nokwelashwa kweziguli pseudoexfoliation futhi pigmentary imithi glaucoma engayitholi lilinganiselwe. Ezimweni ezinjalo, ingcindezi intraocular kufanele ziqashwe njalo.

Okumele kuqashelwe kudingeka ukwabela izidakamizwa iziguli ukusabela anaphylactic. Leli qiniso kungenxa yokuthi iziguli ezifana kokuthola beta-blocker, ziyamelana nemithi imithamo kokujwayelekile epinephrine ekwelapheni ukusabela anaphylactic.

Njengoba kushiwo ngenhla, brinzolamide futhi timolol ukwazi ibhekane ukumuncwa letindzala. Kulokhu, ingxenye yokuqala kungadala imiphumela emibi nezitsha uhlelo, inhliziyo negazi zokuphefumula. Kule ndaba, kunconywa ukuqapha isimo lesiguli ngaphambi naphakathi ukwelashwa.

Beta-blocker kuyabekwa ngokucophelela okukhulu e iziguli sikashukela nokuthambekela kahle kungakhuphula izinga likashukela. Lokhu kungenxa yokuthi lezi zimali kalula imaski izimpawu kahle kungakhuphula izinga likashukela oyingozi.

Ngaphambi kokuba ahlinzwe beta-blocker kufanele ikhishiwe (izinsuku 2). Ngempela, ngesikhathi ukubulawa kwezinzwa okuvamile, bayakwazi ukunciphisa ukuzwela esivimba amanzi stimulation (nozwela), okuyinto ebalulekile inhliziyo umsebenzi.

Izidakamizwa "Azarga" okuyinto libuyekeza izokwethulwa ngezansi, iqukethe brinzolamide okuyinto sulfonamide. Njengoba sazi ukuthi ukusetshenziswa ngezihloko ezihlukene kwenzeka ukumuncwa letindzala we nomuthi, iziguli bangase balwisane ukusabela ezingezinhle ukuthi kuyizinto lezi izinto.

side effects

Eye lehla "Azarga", intengo ephakeme ngokwanele ukuthi ube ezibanzi engemihle. Sichaza ngokuningiliziwe.

• iziguli Local aphendule izidakamizwa. Ngo-10% amacala in iziguli wawubona hyperemia conjunctival, ukuguguleka corneal, izinyembezi, angaboni kahle, ukucasuka kwezitho ezibukwayo kanye nomzimba angaphandle isasasa. Ngo 1% eziguli waphawula punctate keratitis, iso ocucuzayo, conjunctivitis nomzimba, itchiness emehlweni, ubuhlungu iso, effusion ekamelweni anterior, blepharitis, ukungakhululeki emehlweni, crusting egama-Isivalo, erythema amajwabu amehlo futhi amehlo uhlobo.
• Lefundo engemihle. Ngo-10% amacala kukhona dysgeusia, futhi 1% - ukwehla komfutho wegazi, ukuqwasha, rhinorrhea, obstructive nesifo samaphaphu, kahle izinwele ukukhula, ubuhlungu oropharynx, ulele planus nokukhwehlela.

Kufanele kuphawulwe ukuthi nemiyo asebenzayo enjalo, ezifana brinzolamide, kungadala ukwahluka ezilandelayo: mydriasis, keratitis, edema ijwabu leso, keratopathy, iso edema, ukwanda kumbiwa emsipheni optic, simila subconjunctival, isici ka epithelium corneal, lesikhumba sclera, waqinisa intraocular, inhlabathi ku-cornea, iso komzimba nezinto, ukwakheka ukukhubazeka corneal, umbono kahle, edema corneal, conjunctivitis, lacrimation yanda, ukuvuvukala nezindlala meibomian, hypoesthesia iso, umbono double, izinyembezi okonyunktivit, photophobia, pterygium, kwehle acuity ezibukwayo futhi photopsia. Phakathi letindzala side effects kungenzeka abantu bengasinaki, ukucindezeleka kuqashelwe, kwehle libido, inkumbulo ukungakhuli, amaphupho amabi, motor ukungasebenzi, somnolence, uvalo ukulahlekelwa amandla okukhumbula neziyaluyalu we CNS.

Ukuze ekwelapheni yini imiphumela emibi ekuphuzeni imithi ongisekelayo lingaze. Kumele ngokushesha siyakazwe cool amehlo amanzi.

Izidakamizwa "Azarga" (ngeso amaconsi): Imiyalelo

Intengo yaleli izidakamizwa zingase zihluke, kuncike inethiwekhi ekhemisi. Sebenzisa izidakamizwa kumele zithunyelwe endaweni. Ngaphambi ukusetshenziswa, isitsha kumele kakhulu ukunyakaza.

Encwadini umthamo amathonsi "Azarga"? Imiyalelo kulesi sici iqukethe ulwazi olugcwele ngale ndaba. Ngokusho ke, umuthi iqondiswa iconsi esweni ngalinye sac conjunctival. Ukuze afeze le nqubo kuyinto efiselekayo kabili ngosuku.

Ukuze ugweme ukuthuthukiswa letindzala side effects ngemva kokusebenzisa izidakamizwa kutuswa ukukhanya umunwe ingcindezi ekhoneni engaphakathi iso (e projection endaweni ye-yolk sac lacrimal). inqubo enjalo kumele kutsatse emaminithi okungenani ezimbili. Lokhu kwehlisa kakhulu letindzala ukumuncwa izindlela.

Uma ukusetshenziswa imithi iye uphuthelwe, ukwelapha kufanele waqhubeka schedule nge umthamo olandelayo. Ngalesi umthamo noma kunjalo akufanele idlule iconsi ngamunye sac conjunctival kabili ngosuku.

Kuleso simo, uma udokotela indawo umuthi izidakamizwa glaucoma "Azarga", kutuswa ukuba usebenzise kuphela ngosuku olulandelayo.

ukweqisa izidakamizwa

Okwamanje yiluphi ulwazi ku amacala ukweqisa izidakamizwa abikwe. Nokho, ezimweni ezinjalo, kukhona amathuba anda engemihle.

Izixwayiso uma usebenzisa izidakamizwa, ukubuyekezwa

Iziphi izici babe ngeso lehla "Azarga"? Iziguli amazwana ngazo abasakwazi edidayo. Ngokwesibonelo, abadala carbonic anhydrase inhibitor, ezisetshenziswa ngomlomo, kungenzeka kungithinte ikhono ukwenza umsebenzi odinga ukubambisana noma ukunakwa owengeziwe. Lo mphumela kufanele kucatshangelwe uma sabele izidakamizwa ukuze odokotela.

Ngo ukusetshenziswa ngezihloko ezihlukene izidakamizwa ezigulini ukugqoka contact lens, kubalulekile ukuqapha isimo cornea. Lokhu kungenxa yokuthi carbonic anhydrase inhibitor ngokuvamile iholela ukuphazamiseka hydration yayo. Ngaphambi kokufaka isicelo lens kusho kutuswa ukususa. Faka ngibabone desirably ngaphambili kuka ¼ ihora ngemva ukusetshenziswa kwezidakamizwa.

It is hhayi Kunconywa ukuba uthinte ichopho ibhodlela kunoma iyiphi indawo. Kungenjalo-ke kungenzeka ukusilaphazeka. Ngemuva kokusebenzisa weThrojani imithi kufanele ngokushesha shaqa.

Ukuxhumana nezinye izidakamizwa

Kungakanani kukhona iso lehla "Azarga"? intengo zabo impela high. Ezinye ekhemisi amaketanga ukulungiselela esinjalo isicelo nezokusigcoba angathengwa at 950-1050 ruble Russian.

With ukusetshenziswa ngesikhathi esisodwa izidakamizwa nge ngomlomo anhydrase carbonic inhibitors (isib izidakamizwa "Diakarb", "Sulfadiurin", "Fonurit", "Glaupaks", "Dilamoks" nokunye.) Kwangathi ukwandisa letindzala engemihle.

Ngokucophelela okukhulu ukuhlanganisa leli thuluzi nalawo troleandomycin, ketoconazole, ritonavir, itraconazole futhi clotrimazole.

Kukhona kungenzeka inzuzo isinyathelo hypotensive kanye deceleration of kwenhliziyo ekwamukelweni ingxenye esebenzayo - timolol - ne-calcium channel blocker (isib izidakamizwa "Verapamil," "Amlodipine" "Diltiazem", njalo njalo.), Beta-blocker, guanethidine, parasympathomimetics, glycosides inhliziyo namanxusa ukwelapha arrhythmias inhliziyo.

Ukuncishiswa kwenhliziyo yabonakala ukusetshenziswa ngesikhathi esisodwa izinto quinidine noma cimetidine.

eyedrops Analog "Azarga"

Cishe bonke mithi analogue yabo. Lokhu kwenza kube nokwenzeka ukuba ayeke ekwelapheni isifo ekhona ngisho nalapho engekho imithi udokotela.

Ngakho uyini Analogue of "Azarga" ngeso lehla iyona engcono kunazo? A impendulo ecacile yalo mbuzo kunzima ngempela. Phela, izidakamizwa ezifanayo zinhle ngendlela yazo. Ngaphezu kwalokho, bangase babe ehluke ngokuphelele-side effects kanye contraindications. Ngakho-ke, ngaphambi kokuzisebenzisa, qiniseka bonana nodokotela wakho kuqala.

Ngakho yini okumele uyenze uma isiguli ayikwazi ukuthenga ngeso lehla "Azarga"? Kuvele Analogue kwaleli thuluzi Ungahlala kungatholakala ekhemisi. Ukuze wenze lokhu, kufanele ukhumbule igama lakhe.

Ngakho, i-analogo zomuthi zihlanganisa imithi ezilandelayo (ngeso amaconsi):

• "Teva-Timolol".
• "Timolol Oftan."
• "Inderal".
• "Duoprost".
• "Arutimol".
• "I-EU Betalmik".
• "Timolol bufus".
• "Timadren".
• "Betoptik".
• "Timolol-akos".
• "Betoptik C".
• "Timolol-DIA."
• "Betoftan".
• "Timolol-lens".
• "Ganfort".
• "Timolol-Betalek".
• "Glautam".
• "Timolol-dolobhana".
• "DuoTrav."

Yiziphi ezinye izidakamizwa Ungashintshanisa izidakamizwa "Azarga"? Kuvele Analogue of ithuluzi kufanele ngempela zihlanganisa izithako ezisebenzayo ezifanayo ngokwako. Phakathi leyo mithi okulandelayo:

• "Timolol".
• "Betaxolol."
• "Timolol-Mez".
• "Okupres-E."
• "Kombigan".
• "Okumol".
• "Ksalakom".
• "TimoGeksal".
• Eye Gel "Oftan Timogel".
• "Ksonef".
• "Optibetol".
• "Niolol" ijeli iso.
• "Ksonef BC".
• "Timolollong".
• "Okuker";
• Eye lehla ngaphandle nezivimbelakuvunda "timolol-dolobhana".
• "Okumed" nokunye.