Isidakamizwa "Ranitidine": izinkomba zokusetshenziswa, ukwakheka kanye nezakhiwo

Izifo zesigubhu sezinyosi - inkinga evamile kakhulu ethinta abantu kungakhathaliseki ubudala nobulili. Isibonelo, i-gastritis ivame ukutholakala phakathi kwentsha, futhi ngezinye izikhathi ezinganeni ezincane. Ngenhlanhla, imithi yesimanje inikeza izimali eziningi zokwelapha izinqubo zokuvuvukala kwegciwane lokugaya. Futhi omunye wabo umuthi "Ranitidine". Izimpawu zokusetshenziswa kule mithi zikhulu kakhulu. Ngakho-ke yini ehlanganisiwe ekubunjweni kwayo nokuthi ithuluzi elinjalo liphumelela kanjani?

Isidakamizwa "Ranitidine": ukwakheka kanye nesimo sokukhululwa

Into esemqoka yomuthi yi-ranitidine hypochloride. Ngokwemvelo yayo, i-powder granular yombala omhlophe (ngezinye izikhathi nge-tinge ephuzi) enephunga elimangalisayo lesulfure nokunambitheka okubabayo. Lezi zinto zinezakhiwo eziphikisanayo ngokuphathelene ne-histamine H2 receptors.

Isidakamizwa sitholakala ngesimo samathebulethi, noma njengesixazululo sokuphathwa kwe-intramuscular noma intravenous. Kukhona amaphilisi okuthiwa "ama-effervescent" wokulungiselela isisombululo se-aqueous.

Amaphilisi ayindilinga, i-biconvex, enekhava elikhanyayo le-orange ngaphezulu. Njengoba izinto ezisetshenzisiwe zisetshenziswa: i-lauryl sulfate ye-sodium, i- microcrystalline cellulose, i- colloidal silicon dioxide, isitashi sommbila, i-magnesium stearate, i- titanium dioxide, i- hypromellose, i-polyethylene glycol 6000, i-ethylcellulose nodayi ophuzi.

Kuze kube manje, izinkampani zezokwelapha zinikeza amaphilisi ane-150 mg noma 300 mg wezinto ezisebenzayo. Izixazululo zokufakelwa zitholakala ku-glass ampoules we-2 ml.

Izakhiwo zamakhemikhali zesidakamizwa "Ranitidine"

Njengoba sekushiwo kakade, into esebenzayo enkulu yalesi sidakamizwa ivinjelwe yi-H2-histamine abafundisi. Lesi sidakamizwa sithinta ngokuyinhloko umsebenzi wama cell parietal of the mucosa esiswini. Ngaphansi kwethonya laso, ukukhululwa kwe-hydrochloric acid kuvinjelwe, okuholela ekunciphiseni umthamo wejuji esiswini esiyimfihlo , kanye nokuncipha kwe-asidi yayo. Ngendlela, yingakho isidakamizwa esithi "Ranitidine" sokuguquka kwenhliziyo siyasebenza kakhulu.

Kumele kuqashelwe ukuthi abavimba be-histamine receptors banciphisa ukuxilongwa kwe-enzyme yokugaya (pepsin) enjusi yesisu. Ukucindezelwa kokufihla kwakha izimo ezifanele zokuphulukisa izilonda embranini yamangqamuzana, okuyinto ngokwemvelo eyenza inqubo yokuphulukisa.

Ngaphezu kwalokho, izingxenye ezisebenzayo zalesi sidakamizwa zithinta indawo ye-gastroduodenal, okwandisa umsebenzi wezinhlelo zokuzivikela zendawo, okwandisa ukufihla kwemfihlo yokuzivikela yokuvikela. Isidakamizwa siphinde siphuthumise inqubo yokuvuselelwa.

Ngalokhu, lo muthi awunayo yingozi emzimbeni. Ikakhulukazi, ayithinti ukuhlushwa kwama-calcium ions egazini, aliphazamisi uhlelo lwe-endocrine, aluthinti izinqubo ze-spermatogenesis. Imiphumela yezifundo futhi yabonisa ukuthi lesi sidakamizwa asinayo i-carcinogenic effect futhi ayibangeli ukuguqulwa komzimba. Ngakolunye uhlangothi, i-substance esebenzayo igxila emkhakheni we-placental kanye nobisi lwebele.

Ngemuva kokuthatha le mithi, isheshe ifakwe ngodonga lwegciwane lokugaya. Ukugxila okuphezulu kwegazi kugcinwa ngemva kwamahora angu-2-3. Ezimweni eziningi, umphumela uhlala ngamahora angu-12. Esikhathini sokusebenza kwesimetabolism sishintshwa kancane esibindi. Kususwe ngokugcwele emzimbeni wezinso zingakapheli usuku ngemuva kokuthatha.

Isidakamizwa "Ranitidine": izinkomba zokusetshenziswa

Lesi sidakamizwa sisetshenziswa kabanzi njenge-antiulcer. Noma kunjalo, kunezinhlupho eziningi lapho odokotela beka khona imithi ebizwa ngokuthi "ranitidine". Izinkomba zokusetshenziswa zilandelayo:

• Ukuphuza kakhulu;
• Isilonda se-Peptic sesisu nesisu somncane;
• Namuhla, izidakamizwa "i-Ranitidine" ne-gastritis zisetshenziswa kakhulu;
• Isibonakaliso ekusetshenzisweni kwayo kubuye kube nesifo esophagitis, esibangelwa ukuphonswa kokuqukethwe kwesisu noma okuhlobene nokuphulwa kobuqotho bezincubu ze-mucosal;
• Lesi sidakamizwa sisiza abantu abane-dyspepsia uma kuhambisane nobuhlungu obukhulu be-epigastric obuhlobene nokudla;
• Isidakamizwa sisetshenziselwa ukwelashwa kwezicubu ezithile ezinobuthi;
• Njengokwelashwa okusizayo okusetshenziselwa ukufisa i-pneumonitis nesifo samathambo;
• Leli phepha liyingxenye yokwelashwa kokuphaphaza ezingxenyeni ezingenhla zesistimu yokugaya ukudla;
• Njengemithi yokuvimbela imithi inikeza iziguli ezitholwe ukuhlinzwa ezingxenyeni zomuthi wamathumbu.

Kumele kuqashelwe ukuthi izifo ezinzima akuzona kuphela izifo ezidinga ukwelashwa nomuthi "Ranitidine". Izinkomba zokusetshenziswa zihlanganisa nokuvimbela ukukhushulwa kwe-gastritis engapheli kanye nesilonda se-peptic.

Ungayithatha kanjani imithi ngendlela efanele?

Yiqiniso, ngaphambi kokuqala le mithi, udinga ukubonisana nodokotela. Zonke izilinganiso zenziwa ngabanye, kuye ngokuthi ubudala nesimo sesiguli, uhlobo lwesifo, inhloso yokwamukelwa (ukwelashwa noma ukuvimbela):

• Iziguli zabantu abadala ziboniswa ukuthatha amaphilisi ngesilinganiso somuthi osebenzayo 150 mg kabili nsuku zonke. Kwezinye izimo, odokotela batusa ukuthatha amaphilisi amabili ngesikhathi esisodwa ngaphambi kokulala.
• Ukuvimbela ukuphuma kwegazi, isiguli senziwa nge-intramuscularly (noma nge-intravenously) ku-0.05-0.1 g nge-periodicity yamahora angu-6-8 (uma kunesidingo, umthamo unganyuka ube ngu-0.9 g).
• I-adolescents, njengomthetho, thatha 150 mg kabili ngosuku.
• Lapho ukwelashwa izidumbu ezinobungozi, umthamo ophakanyisiwe ngu-150 mg wezinto ezisebenzayo kathathu ngosuku.

Ngokuvamile, isikhathi sokwelashwa amaviki amane kuya kwangu-8. Uma kungumbuzo wokuvimbela, ezinye iziguli zinconywa ukuba zithathe izidakamizwa izinyanga ezimbalwa, futhi ngezinye izikhathi unyaka wonke, kodwa ngaphansi kokuqondiswa njalo kukadokotela kanye nokuhlolwa okujwayelekile okuphela kwesikhathi.

Ukuqhathaniswa nokusetshenziswa kwesidakamizwa "Ranitidine"

Njenganoma imuphi omunye umuthi, lesi sidakamizwa asikwazi ukusetshenziswa yizo zonke iziguli. Ikakhulukazi, ayivumelekile ukuthi isetshenziselwe ukuphatha abesifazane ngesikhathi sokukhulelwa kanye ne-lactation, njengoba izinto ezisebenzayo zingena kalula ubisi bese zidlulisa umgoqo ophansi. Ukuqhathaniswa kwe-contraindication yi-hypersensitivity kunoma yisiphi isisetshenziswa sezidakamizwa. "Ranitidine" ayisetshenziselwa ukwelashwa kwezingane ezingaphansi kweminyaka engu-14 ubudala.

Ngaphezu kwalokho, le nsimbi isetshenziswa ngokuqapha ekwelapheni iziguli ezitholakale zikwazi ukungenwa kahle kwe-hepatic noma ye-renal, kanye ne-porphyria enzima ne-cirrhosis yesibindi.

Imiphi imiphumela emibi engenzeka ngesikhathi sokwelashwa?

Ngeshwa, izingxenye ezisebenzayo zalesi sidakamizwa zithinta cishe zonke izinhlelo zomzimba. Ngakho-ke, kwezinye iziguli, izidakamizwa zingase zihlotshaniswe nokunye ukubhekana okubi:

• Ngokuvamile wayebheka ikhanda, ukulala, ukukhathazeka okwandayo, ukukhathala, isizungu, umbono obonakalayo. Ezimweni ezimbi kakhulu, lesi sidakamizwa singabangela ukudideka, ukuthuthukiswa kwezimo ezicindezelayo, ukutholakala kwama-hallucinations.
• Ukuphazanyiswa okungenzeka kwenqubo ye-cardiovascular, ikakhulukazi, ukwehlisa ukucindezeleka kwegazi, i-aplastiki noma i-hemolytic anemia, i-arrhythmia, i-tachycardia, i-thrombocytopenia, i-thrombocytopiaa, esingaphansi kwe-bone marrow hypoplasia.
• Ukuphendula okwenziwe nge-allergenic kuvame ukuhambisana nokubukeka kwezikhumba nokukhwehlela, umkhuhlane, ukuvuvukala, i-erythrema. Ngokuvamile kakhulu, lesi sidakamizwa siholela ekushusweni kwe-anaphylactic.
• Mhlawumbe ukubukeka kwesicanucanu nokuhlanza, ubuhlungu esiswini. Ukungaqabukeli kakhulu ukwelashwa kuholela ekwakhiweni kwe-pancreatitis nezinye izinhlobo ze-hepatitis.

Uma kunemiphumela emibi, yeka ukuthatha imithi bese uchaza udokotela.

Ulwazi olwengeziwe mayelana nemithi

Ngaphambi kokuqala le mithi, njengomthetho, kuhlolwa ngokucophelela, ngoba kubaluleke kakhulu ukuhlola ukungabi khona kwezicubu ezimbi emathunjini nasemathunjini amancane. Iqiniso liwukuthi izidakamizwa zingasunduza izimpawu ezisemqoka zomdlavuza.

Ukwelapha isikhathi eside iziguli ezinomzimba omzimba obuthakathaka nokukhathala komzimba kungabangela ukulimala kwamagciwane kumathisomusi esiswini.

Ukudla kwe- "Ranitidine" kufanele kukhishwe kancane kancane, kunciphise umthamo nosuku nosuku. Ukukhanselwa okubukhali kwemithi kungabangela ukuhlukumeza kwesilonda se-peptic.

Isidakamizwa "Ranitidine" sithintana kanjani nezinye izidakamizwa?

Ngokuvamile, ukwelashwa kuhilela ukusebenzisa le mithi kanye nezidakamizwa ngesikhathi esifanayo, okunciphisa ubuhle besisu esiswini. Ezimweni ezinjalo, ikhefu phakathi kokusetshenziswa kwezidakamizwa kumele kube okungenani amahora angu-1-2.

Isidakamizwa esithi "Ranitidine" senza kube nzima ukuthola uketshezi lwe-ketoconazole, futhi kugwema ukuvimbela umzimba emzimbeni we diazepam, metronidazole, lidocaine nezinye izidakamizwa. Ngendlela, ukubhema kunciphisa kakhulu umphumela wokuthatha le mithi.

Isidakamizwa "Ranitidine": ukubuyekezwa kweziguli

Ukubuyekezwa kweziguli ezisebenzise lesi sidakamizwa kuningi kakhulu. Abantu baqaphela umphumela obonakalayo wezokwelapha. Isidakamizwa esithi "Ranitidine" sisiza ukuqeda ukushaya kwenhliziyo, kunciphisa izimpawu eziyinhloko zesifo sangasese. Izinzuzo zalesi sidakamizwa zingabalwa futhi zingabizi kakhulu. Ukusabela okubi kwenzeka ngokungajwayelekile.