Isifo Cushing sika - isifo nge pituitary hyperfunction

Izifo Cushing noma Cushing sika - isifo okuyinto kubangelwa kokunikezwa kwe-ngxenye, pituitary nezindlala adrenal ukuthuthukiswa izilonda eziyinkimbinkimbi. Lesi sifo kwase kuqala esachazwa H. Cushing ngo-1924, futhi ngo-1932 Cushing exhumene ukuthuthukiswa yayo nge pituitary adenoma.

Izimbangela isifo Cushing sika adenoma basophilic we Lobe pituitary anterior noma kwandziswa kwelinani letikhungo basophilic pituitary amaseli. Lezi zinguquko bungase bubangelwe ubuchopho kuhlasimulise futhi emqondweni, encephalitis, endocrine iziyaluyalu.

Ngesisekelo isifo - hyperproduction ka pituitary i-hormone adrenocorticotrophic, elibangela ukwanda synthesis cortisol by the nezindlala adrenal.

isifo Cushing sika - emitholampilo isithombe

Lesi sifo eba kancane kancane. Iziguli esekhala ubuthakathaka jikelele, ukozela, ukunganakwa, ukukhuluphala ezithuthukayo. Ukukhuluphala sihlasela kakhulu engxenyeni engaphezulu kuphela yomzimba. Ngenxa yalokhu, iziguli kwakhiwa ubuso benyanga, emahlombe egcwele, okhalweni, nge uhlasela mncane, ngemilenze atrophic futhi shins. Kukhona ukoma nokuxebuka kwesikhumba, umzimba izinwele iphethini leduna abesifazane, nge nokulahlekelwa ngesikhathi esisodwa izinwele ekhanda, le feminization babantu. On isikhumba esiswini, emahlombe, webele avele imivimbo dystrophic ebanzi anombala obomvana ngokunsomi. Ngokuhamba kwesikhathi, ukuthuthukisa imisipha yoma nemilenze, ziyancipha amandla abo. Ukuthuthukisa nomfutho wegazi ophezulu kanye isifo so-renal, ukuxakeka palsy futhi isifo sokuqina kwemithambo yegazi.

isifo Cushing kuholelaphi ukuhlukumeza amaminerali umzimba, umphumela okuyinto ukukhumuzeka kwamathambo. Ngenxa kwamathambo nazo ezilahlekelwe futhi ecindezeleke ezinzwa izimpande, kukhona ubuhlungu obukhulu e emikhawulweni, emgogodleni, wazakhela ugobile yomgogodla thoracic kumiswa kyphosis, waphuka sokugembula. calcium ne cholesterol inyuka igazi. Engasenamahloni ukumuncwa glucose, okuholela ekuthuthukiseni sikashukela. nokuthambekela okwandayo ukuze bathuthukise ukopha kabi ephulukisa amanxeba. Iziguli esekhala nezinkinga zobulili, kwehle libido futhi potency, avele iziyaluyalu kokuya esikhathini. nezifo zengqondo ezingenzeka, ukucindezeleka, hypochondria, sengqondo.

Of inhliziyo eba hypertrophy kwesokunxele ventricular tachycardia, abulalayo nomfutho wegazi ophezulu yesibili. Lapho isifundo izinso zembula proteinuria, kwehle glomerular filtration isilinganiso kanye kwezinso ukugeleza kwegazi. Mhlawumbe ukuthuthukiswa nezibazi kwezinso umsebenzi untula kwazo lezi zitho. Ezinye iziguli nge ezinso zitholiwe.

sitholakele isifo

isifo Cushing sika sitholakale ubambe Yekhanda x-ray kanye ocwaningweni umthelela sella, tomography ngekhompyutha Yekhanda, kanye nezindlala adrenal, izifundo semithambo - angiography. ukuhlolwa Laboratory kutholakale izinga hormone i-cortisol egazini kanye nenani ngama-corticosteroid umchamo.

isifo Cushing sika - Ukwelashwa

Ukukhetha impatho ixhomeke imbangela yesifo nayo kobukhulu ukubonakaliswa emitholampilo ye isifo.

Okwakuhlalwa kuzo lapho kusaqalwa ebekiwe imithi izidakamizwa ukuthi ukunciphisa uketshezi hormone adrenocorticotropic futhi corticosteroids. Isetshenziswa njengesici izidakamizwa antihypertensive, ukwelashwa lingaze. Inkambo zokwelapha ihlala izinyanga eziyisishiyagalombili. Uma kungekho ukusebenza, amafomu ezinzima kakhulu lesi sifo, linqume ukwelashwa ehlanganisa ukwelashwa ngemisebe nokuhlinzwa (ekususweni pituitary noma adrenalectomy).