Izidakamizwa "Sotageksal", analogs futhi impendulo kuyo

Arrhythmia - uhlobo kwenhliziyo, okuyinto lihlukile evamile itheku isigqi. Lapho arrhythmias kubantu kukhona oyedwa noma eziningana ukwephula inhliziyo. I zokugula Kungaletha njengoba imvamisa namandla okhulisa kwenhliziyo (tachycardia) futhi, Ngakolunye uhlangothi, ukwehla yabo (bradycardia). Ukuphazamiseka umsebenzi imisipha yenhliziyo nemithambo ku umuntu enempilo. Nokho, ezimweni eziningi, le arrhythmia kuyinto ngokuhlanganyela nezinye izifo zenhliziyo. isimo enjalo iyingozi e ukuthi excitability anda kwezicubu inhliziyo - myocardium, okungaholela ekugcineni yinhliziyo uma zingelashwa.

kukhona amalungiselelo akhethekile ukuze ukuzinza of kwenhliziyo, enye yazo "Sotageksal". Analogue zomuthi nayo kabanzi kwezokwelapha. Le mithi basonta iqembu imithi unomsebenzi antiarrhythmic, ne-beta-blocker. Lapho udle, bona ukuvimba ama-receptor beta-adrenergic, okuyinto zitholakala kule imisipha abushelelezi, imisipha inhliziyo nezinye izicubu, futhi banesibopho ukusabela komzimba emiphumeleni ukucindezeleka. kardioeffekt sekukonke ukunciphisa nobuningi ukushuba ukushaya kwenhliziyo, kunciphe inhliziyo conduction. Ngenxa yalokhu letindzala is yaphawula ukwehlisa wegazi ezindongeni izitsha yenhliziyo.

isidakamizwa

"Sotalol» (Sotalol) - yokutholwa ngegama ngamazwe emhlabeni zomuthi "Sotageksal". Analogs sokuqanjwa kungaba nomphumela ezahlukene, kodwa ezifanayo antiarrhythmic. Ingqikithi oyinhloko esebenzayo "Sotageksal" iqukethe sotalol hydrochloride. Ngaphezu kwalokho, ihlanganisa inombolo encane izingxenye asizayo. Phakathi kwabo, - cellulose, monohydrate lactose, isitashi ummbila, i-magnesium stearate nezinye binders.

Impilo eshalofini amaphilisi noma isixazululo komjovo uneminyaka engu 5.

"Sotageksal" analogue ukuqamba

Omunye ithebhulethi kwalo mkhiqizo iqukethe 40, 80 noma 160 mg lomcebo asebenzayo. It ikhiqizwa ikakhulu njengoba amaphilisi round White ne uhlangothi kancane convex kanye embossed kanye Sot isifinyezo. On the ngemuva ithebhulethi bisected esebenzisa sokuphuzisa for the lula izingozi. Zonke phama amabhamuza yizicucu 10, futhi amakhadibhodi amabhokisi. kunqwaba ngayinye zingaba phakathi amabhamuza 1 kuya ku-10 (kusukela izingcezu 10 kuya ku-100 amaphilisi).

Futhi, "Sotageksal" ikhiqizwa ngendlela isixazululo umjovo emthanjeni. ampoule ngasinye siqukethe 4 ml izidakamizwa. Ngo 1 ml Isixazululo 10 mg lomcebo eziyisisekelo okumsulwa. Umuthi kumele zivikelwe elangeni amnyama futhi endaweni eyomile, lapho izingane ukufinyelela lilinganiselwe.

Analogs ne esebenzayo izidakamizwa sotalol amaphilisi hydrochloride ekhiqizwa:

• "Sotaleks" (160 mg).
• "Soritmik" (by 0,16 g).
• "Sotalol Canon" (80 160 mg).
• "Darob" (80 160 mg).
• "Tenzol" (80 160 mg).

imiphumela kwemithi

"Sotageksal" analogue nama omqondofana zomuthi nethonya emelene arrhythmic. Lokhu kufezwa esenziwa ikhono lazo ukuvimba ama-receptor β-adrenergic futhi zivimbele iziteshi potassium. Izidakamizwa ukwandisa isikhathi pulses futhi reflex nezikhathi Atria futhi ventricles. Khulisa ithoni bronchial imisipha bushelelezi futhi imisipha ungqimba izindonga isitsha. Nciphisa contractility esivimba amanzi.

hydrochloride Sotalol has lonke iqoqo izakhiwo. Has a chronotropic negative, dromotropic, batmotroponoe nomphumela inotropic kwezidakamizwa German "Sotageksal". Analogs, okwakhiwa kwalo efanayo, ungase ube omunye brand name. Futhi bakwazi ukunciphisa kwenhliziyo ngamandla abo. Ngenxa yalokhu isidingo esivimba amanzi nomoya-mpilo ukusetshenziswa ancipha kakhulu. Futhi ngenxa yalokho, umthwalo inhliziyo kuyehla.

Absorption futhi kukhuthaza izidakamizwa

Izidakamizwa ukumuncwa kushesha. bioavailability Its 90%, kanye ukumuncwa - 80%. Phakathi 2.5-4 amahora emakamu esiphezulu isithako esisebenzayo kufinyelelwa ngemuva kokuthola plasma. Ngemva kokuphathwa emthanjeni, umphumela isivele sobala ngemva 5-10 imizuzu. Absorption kwenzeka ku-20% kangcono futhi ngokushesha uma ukuthatha imithi esiswini esingenalutho. Ngenxa yokuthi i-solubility we ketshezi amafutha sincane kakhulu, sotalol hydrochloride akufanele kuthathwe kanye kanye nemikhiqizo yobisi namafutha okuvela ezilwaneni.

Ngaphandle kokuba eboshiwe Amaprotheni egazi, umuthi kwasakazwa ezicutshini futhi izitho neuropathy ngokulinganayo phakathi 3-4 izinsuku yokwemukela njalo. Ngesikhathi esifanayo, futhi izuzwe nethonya elihle nomfutho wegazi ophezulu. Ngo cerebrospinal fluid lokuhlushwa izidakamizwa akuyona ezingaphezu kuka-20%. Isenzo emva umjovo uyaqhubeka kumahora angu-2. umphumela iphikelela ngemuva kokudla nokufakwa ngemlomo ngaloko lokusandza kwenteka amaphilisi "Sotageksal" emahoreni angu-12. Analogs zomuthi lichaza ekwakheni equkethe sotalol hydrochloride, futhi singangena umzimba nge nezinso excreted ku umchamo (90%) kanye indle ngokwesilinganiso kungakapheli amahora 10-20.

Yingakho iziguli eziphathwa kahle uhlelo kwezinso futhi urinary ikhombisa imithi esilinganisweni ezincane. Abantu abadala bavame waphawula ukuwohloka ezihlobene nokukhula umsebenzi so-renal. Lokhu kunomthelela yokuthi ketshezi uboniswa ngesilinganiso kancane futhi kungenzeka buthelela emzimbeni. Ngakho-ke, leli qembu iziguli izidakamizwa kusetshenziswe ngokuqapha futhi umthamo kunqunywa ngamunye.

Umuthi kuyasiza kulesetayelekile exchange oxygen kwezicubu, aqede ukucasuka, ukukhathazeka, ukucindezeleka nezinye izinto ezithinta nobuningi ukushuba Kufinyeta zenhliziyo.

"Sotageksal": yokusetshenziswa

Analogs zomuthi kanye ejenti asetshenziswa enegama yasekuqaleni lingaze arrhythmias inhliziyo, ukwelapha ventricular arrythmia. Kodwa kuba nomphumela ezahlukene in iziguli izifo ezifanayo. Ngakho-ke, kumele ukhethe udokotela emva luhlolo olunzulu futhi ngokuqinile ngomlomo.

Akuvamile ejenti esetshenziselwa nokwelashwa kweziguli abaye psoriasis (psoriasis) noma abanesifo sikashukela kanye kahle carbohydrate umzimba. Qaphela aqoke abantu banomlando yokungezwani komzimba ekhona, kusho "Sotageksal". Analogue ke unamandla yokuvimbela ukuzwela omzimba ezishukumisa nomzimba. Ngokucophelela imithi isetshenziswa ekwelapheni iziguli kanye ukumelwa inhliziyo, uthambekela ayimigodi njalo. Iziguli waba isilethikusebenza, arrhythmia ingozi lola ngesikhathi reception "Sotageksala".

Isikali nokwelashwa kwesikhathi

Kuye kobukhulu isifo uzimisele kanti isikhathi yokwelapha izidakamizwa "Sotageksal". Yokusetshenziswa (analogs ingaba nezinye iziqondiso zokuthi kufanelwe reception) iqukethe izincomo ezilandelayo:

• ithebhulethi kugwinyiwe lonke, hhayi baba imilutha ye futhi ugcwele amanzi;
• Reception wenziwa ngoba 1-2 amahora ngaphambi kokudla;
• ukuthatha imithi 2-3 izikhathi ngosuku.

Ukwelashwa kusenesikhathi umthamo wansuku zonke kumele singeqi 80 mg (1 tablet) nomfutho wegazi ophezulu kanye tachycardia. Nokho, ngenxa yokuntuleka kwezinhlelo ezibanzi wayefisa zokwelapha umphumela umthamo lenyuke. Kancane kancane, ngosizo esingaba izinsuku 2-3 of it is kushintshwe 240-320 mg ngelanga, kodwa esibhedlela. Indlela ephumelela kakhulu kuyinto ukwenyuka kancane umthamo 80 mg ngeliviki.

Umthamo esiphezulu kungenzeka amaphilisi 6 ngelanga izidakamizwa "Sotageksal". Analogue, umthamo okungase futhi anda uma udokotela ibona kudingeka, esiyakuqokwa ngamunye. Ngisho noma kukhona usongo ekuphileni, inani isithako esisebenzayo kumele singeqi 480 mg ngosuku.

Uma isiguli samanje kwezinso iziyaluyalu kokusebenza, lwemithi yokwelapha akhethiwe njengoba umsebenzi creatinine imvume. ukwanda kwalo (kufika ku-30 mg / amaminithi), umthamo ngokuvamile sehliselwe izikhathi ezimbili kuya ezine.

imijovo intravenous wenza kabili ngosuku, ihlukaniswe umjovo ezimbili ampoule of 2 ml. Isixazululo is injected kancane imizuzu engaphezu 5-7. Phakathi ukwelashwa, ukulawula edingekayo wegazi, ishayela, we nezinso uhlelo urinary, creatinine imvume e serum.

ubufakazi

Izimali ekhethelwe le yokwelapha lezi zifo:

• tachycardia, ventricular;
• Wolff - Parkinson - White;
• zenhliziyo;
• amabhithi ventricular ngaphambi kwesikhathi;
• mitral valve prolapse;
• Paroxysmal fibrillation atrial le Atria;
• nomfutho wegazi ophezulu (high blood pressure);
• nokwelashwa kwezinkinga isilethikusebenza (kwezinye izimo).

Ngo ezinzima kahle umsebenzi kwezinso, udokotela ubophekile ukuba ngokuqhubeka lokuhlushwa ketshezi asebenzayo in the serum igazi ukuze ulungise umthamo "Sotageksal" izidakamizwa. Analogs yezinkomba yokwamukelwa zifana. Kodwa, naphezu kwalokhu, abo esikhundleni esisodwa izidakamizwa kwabanye akuvunyelwe nakancane. Ukukhansela ukwelashwa okufanele kwenzeke ngokushesha, kodwa kancane kancane. kokusebenza okukhulu kungabangela Ukuwohloka isimo emtholampilo.

Izimo

Noma yimuphi ejenti antiarrhythmic abakwazi njalo zabelwe isiguli, kuhlanganise "Sotageksal". Analogs Izimo ziyefana, abakwazi isetshenziswe ngaphansi kwale mibandela elandelayo:

• hypersensitivity noma isici esiyingqayizivele izidakamizwa eziyisisekelo noma ingxenye asizayo;
• ubuthakathaka itheku engela;
• ukunciphisa olukhulu endleleni kwenhliziyo (bradycardia);
• ezingamahlalakhona obstructive izinqubo yamaphaphu;
• isifuba somoya ezinzima bronchial;
• ukwehluleka kwezinso;
• acute isilethikusebenza;
• oyingozi noma ezingamahlalakhona ukuhluleka kwenhliziyo;
• ukushaqeka cardiogenic;
• side qt isikhawu syndrome ;
• ubudala zezingane;
• njengemithi yokungezwani komzimba nokuthile, rhinitis iguliswa;
• bekhulelwe nangenkathi bencelisa,
• ingcindezi encishisiwe (hypotension);
• ukubulawa kwezinzwa okuvamile;
• esibhibhayo;
• neuropathy isifo semithambo;
• ukuthuthukiswa tachycardia uhlobo "pirouette" (isimo sitholakale isikhathi esiningi siye sitholakale kubantu besifazane kunabesilisa).

isipiliyoni Enough ne izidakamizwa ngesikhathi sokukhulelwa akuyona. Kuphela "Sotageksal" aqokwa ngesincomo izinkomba ezibalulekile. Nozakwabo e senyanga yokuqala futhi usongo ekuphileni kwengane, awathatha kungaholela izisu. idatha ucwaningo okunokwethenjelwa mayelana ukuvuma izidakamizwa abesifazane azalele namanje akanawo.

Ezinyangeni lokugcina yokwelapha kuyakuba khona kancane kancane encishisiwe izinsuku 2-4 ngaphambi kokubeletha, uma owesifazane enza ke ngesikhathi yonke inkathi yokukhulelwa. Lokhu kwenziwa ukuqinisekisa ukuthi usana azange abe yokucindezela imisebenzi yokuphefumula, bradycardia noma hypotension ngenxa izidakamizwa "Sotageksal".

Analogue esekelwe hydrochloride sotalol kufanele inqanyulwe ukuthatha uma umama osemncane kuyinto ibele, nomongo unekhono ukungena ubisi lwebele futhi ufinyelele lokuhlala eliphezulu khona. Uma izinkomba ukwelashwa kufanele kuqhutshwe, ukuthi ibele kungcono ukuyeka, esikhundleni oluhambelana ubisi ingxube ngokobudala wengane.

side effects kanye ukweqisa izidakamizwa

Kungaba nemiphumela engemihle kuya zenhliziyo, endocrine, urinary, zokuphefumula, wokugaya ukudla futhi uqondiswe isimiso sezinzwa esiyinhloko ukusetshenziswa kwesikhathi eside lesi sidakamizwa "Sotageksal". Analogs kubangele efanayo engemihle. Isiguli bangezwa:

• iphika, okwandisa ukuhlaselwa angina, izimpawu yinhliziyo, ubuhlungu benhliziyo, vasospasm, Raynaud Syndrome ;
• isicanucanu, ukuhlanza, uhudo, ubuhlungu esiswini, gassing ngokweqile, ukubuyisa, kunzima wamathumbu ukunyakaza, ezomile nolwelwesi lwamafinyila emlonyeni;
• ukukhathazeka, ukuyaluza, ukushaywa uvalo ngaphandle disorder, ukuhhema, kahle ngefanelo nangokuvumelana, ukulahlekelwa ukuzwa, ukushintshashintsha kwemizwelo, amehlo Isakhiwo sazamazama, ukukhathala, ukuphathwa ikhanda, isiyezi, ukungalali ngokwanele noma, ukozela Ngakolunye uhlangothi, anda, ukukhathazeka amaphupho, ukucindezeleka;
• conjunctivitis, keratoconjunctivitis, noma izinyembezi syndrome (ikakhulukazi uma kuhlinzwa iziguli ezifuna ukugqoka contact lens njalo), ukuvuvukala cornea, ukwehla zokunambitha nokuhogela, ubuhlungu iso, photophobia, kahle acuity ezibukwayo, ukuzwa;
• kahle kungakhuphula izinga likashukela (kubantu abanesifo sikashukela);
• bronchospasm, laryngitis, tracheitis;
• urticaria, dermatitis, isikhumba ukulunywa, erythema, psoriasis, angioedema, kukhuphuke ukujuluka;
• potency ukucindezeleka wesilisa, ubuhlungu ngesikhathi ejaculation, abesifazane - kwehle libido neziyaluyalu kokuya esikhathini;
• imfiva, ukuba buthakathaka kwezicubu, Ukudlikizela, cyanosis wemikhawulo.

Endabeni ka ukweqisa izidakamizwa singenzeka:

• ukucindezelwa of imisebenzi inhliziyo;
• iphika;
• asystole, yokufikelwa, ubuthakathaka, isiyezi;
• cyanosis ka emikhawulweni;
• imisipha amajaqamba;
• bradycardia ekuboshweni umnyuziki inhliziyo;
• ukushaqeka zenhliziyo;
• bronchospasm;
• tachycardia.

Naphezu izimpawu ezinjalo ezibucayi ukweqisa izidakamizwa, ukufa kuyinto ezingavamile. Lapho izidakamizwa ubuthi okokuqala udinga ukuthi ayeke ukuthatha imithi "Sotageksal". Analogs kanye imithi ejwayelekile sotalol hydrochloride kahle okukhiphayo kusukela pheshana emathunjini ngemva ukungenisa imithi umswakama. Endabeni ka ukweqisa izidakamizwa ukwelashwa lingaze kuboniswa. Ezimweni ubuthi sina ezidingekayo lavage esiswini kanye ukuhlanza, ukulondoloza ebalulekile yempilo imisebenzi yezitho zangaphakathi. Ukweqiwa ngokweqile ziyasuswa ngokuphelele hemodialysis. Umzimba ukwehlisa ushukela egazini kungenzeka ezigulini ahlale edla ukudla okuqinile noma ukulamba.

Analogs kanye imithi ejwayelekile "Sotageksala"

Sotalol hydrochloride eziqukethwe umkhiqizo kukhiqizwa waseSwitzerland eJalimane, ngaphansi kwegama ukuhweba "Sotageksal". Analogue yalo ziboniswa nezinye izidakamizwa ngezithako ezihlukahlukene, okuyinto ngaphezu umphumela antiarrhythmic dambisa kwemisipha izinhlungu zibe, ukunciphisa umfutho wegazi futhi sithuthukise ukusebenza Atria. Lezi zihlanganisa:

• "Inderal" "Inderal", "obzidan", "Pranolol" (isithako - propranolol) esetshenziselwa ukwelapha ischemia, arrhythmia kanye nomfutho wegazi ophezulu.
• "Pumpan" - ejenti homeopathic esekelwe izingxenye zemifino.
• "Magnerot" iqukethe magnesium orotate dihydrate isetshenziswa ekwelapheni ukuqina kwemithambo yegazi, izifo lipid umzimba.
• "Korvitol" (metoprolol tartrate) siyasebenza ngoba migraines.
• "Nebilet" (nebivolol hydrochloride) Kubonisani ophakeme wegazi, isifo ischemic.
• "Qudesan" (iconsi) - ibhekwa yemvelo kusekelwe coenzyme Q10 ngokuba nokwelashwa arrhythmias.
• "Etatsizin" (etatsizin) kusetshenziswa khona tachycardia;
• "Arrhythmia" "Amiodarone" (amiodarone hydrochloride) asetshenziswa inhliziyo, tachycardia, arrhythmia atrial.
• "Propanorm" (propafenone hydrochloride) isetshenziswa uma ventricular futhi arrhythmias supraventricular.
• "Neo-Giluritmal" (praymaliya bitartrate) kuboniswa ngenxa ventricular arrhythmias, tachycardia.
• "Korgard" (nadolol) utholwa for ekwelapheni pectoris angina, migraine.

Russia ukhiqiza "Sotalol Canon" futhi "Tenzol" nge isithako ezisebenzayo ezifanayo "Sotageksal". Analogue eMoldova, Ukraine futhi emazweni angomakhelwane Pharmacy lemelula kakhulu kunaloko izidakamizwa yasekuqaleni. Izindleko izidakamizwa kuncike kuzwe nomakhi. nemithi Domestic ngokuvamile ibe nenani kakhulu ngaphansana phesheya.

Izibuyekezo

Kube ukunciphisa okuphawulekayo kokuquleka imvamisa phakathi fibrillation atrial, uma wamukelwe ngokuqhubekayo "Sotageksal". Analogs Izibuyekezo nesineke akuzona omuhle ngakho. Akukhona njalo izidakamizwa ezivela abakhiqizi ezahlukene zifana, noma ngabe ukwakheka efanayo. Abaningi besaba ukuthi abakhiqizi abonakele abonisa lokuhlushwa enkulu isithako esisebenzayo iphilisi ngalinye kuka ngempela ukhona. Ngenxa yalokhu ukwelashwa abakwazi ukuletha imiphumela elindelekile. Uphenyo "Sotageksale" Ngokuphambene, izinganekwane oqondile. Yena ngempumelelo esetshenziswa ekwelashweni eyinkimbinkimbi izifo zenhliziyo emazingeni ahlukahlukeneko.

Ezimweni eziningi kukhona kancane kancane athuthuke esimweni jikelele iziguli kuncike ukwelashwa eziyinkimbinkimbi. Umuthi lubaluleke kokubili cupping, kanye nokuvinjelwa. Ukwahlulela ngokubukeka ukubuyekezwa iziguli kwathiwa unesifo "paroxysmal fibrillation," umuthi isiza ukugcina evamile inhliziyo isigqi (enikeziwe, uma wamukelwe ngokuqhubekayo yokwelapha yesondlo). Nokho, iziguli ukuthi akazange alinge ukukhulisa umthamo wabo siqu ngaphandle izincomo kadokotela ngenxa ingozi nemiphumela emibi kakhulu.

Ezinye Izibuyekezo akuzona nomphumela omuhle kakhulu idumela izidakamizwa. Kukholakala ukuthi ikhangiswe futhi ngeke bakwazi ukwelapha isifo sokulahlekelwa igazi, arrhythmias microbial, hypokalemia futhi hypomagnesemia. Kuyaphawuleka ukuthi hydrochloride sotalol Brands angaphandle kunzima ukuthola Pharmacy wendawo. Abantu ojwayele njalo usebenzise esebenzisa nobunzima nge yokufuna yayo. Ngakho-ke, ngaphambi kokuba baqale ukwelashwa, qiniseka ukuthi uzokwazi ukuqhubeka isikhathi eside.

Yini ayikwazi kuhlanganiswe reception "Sotageksala"

Phakathi ukwelapha kuyinto efiselekayo give up ukushayela, ngebhayisikili, isithuthuthu. Futhi eziyingozi yonke imisebenzi okudinga kunakwa futhi lengqondo okuhlushwa focus. Lapho ethola izimali ezongeziwe ekunciphiseni ingcindezi kungenzeka hypotension. Akuvunyelwe sihlanganise "Sotageksal" nge izidakamizwa ezifana:

• insulini, njengoba kakade kwandisa lokuhlushwa yayo egazini;
• ion ne-calcium abamelene;
• kusho jikelele noma ephefumula izinzwa;
• Mao inhibitor;
• iodine-equkethe lomcebo;
• isisu;
• alkaloids ergot;
• antidepressant tetracyclic.

Umuthi akuyona iqondiswa kanyekanye ne antiarrhythmics ekilasini mina III. Liphinde contraindicated ekwamukeleni kwezidakamizwa izidakamizwa, sedatives futhi antihistamine, antipsychotics, coumarin, relaxants. Futhi nomthelela namandla isimiso sezinzwa esiyinhloko ukucindezeleka. izinzwa esisodwa kuholela blood pressure kanye depresses izicubu esivimba amanzi. Akuvunyelwe ukwenza ukuhlolwa isikhumba ukucacisa izinhlobo nomzimba. Lokhu kwandisa ingozi anaphylaxis, angioedema futhi asphyxia.

Izidakamizwa "Sotageksal" eyakhishwa ngo Pharmacy ngu kadokotela. ukuphathwa Hlukanisa of arrhythmia ukuthi bangase baxabane sina ezingezinhle. Ngakho, ngaphambi kokuba athathe imithi, kufanele ngaso sonke isikhathi xhumana nodokotela.