"Moxifloxacin": yokusetshenziswa, incazelo, ukwakheka

I nomuthi "moxifloxacin" umphumela kwemithi ye iluphi okuzoxoxwa ngalo lapha, libhekisela eqenjini quinolones. Ithuluzi has a amagciwane, umphumela elwa namagciwane. Okulandelayo, bese sixoxa ngalokho esingadala imithi "moxifloxacin". Yokusetshenziswa, analogue nayo izofakwa kuboniswe esihlokweni.

umphumela

Kangakanani-ejenti asebenzayo "moxifloxacin"? Incazelo izidakamizwa kumele kuqale nge incazelo mshini umphumela wawo amagciwane. umphumela amagciwane kusho elihlobene ne okusithiyayo (ukucindezelwa) ka webhaktheriya topoisomerase IV futhi II. Lokhu, kuholela ukuphazamiseka izinqubo ukufanisana of umbhalo, ukulungisa DNA biosynthesis amaseli amagciwane abe nenkani. Ngenxa yalokho, lapho iza nokubhujiswa kwabo. Nomuthi "moxifloxacin" imfundo manual elizibiza ngokuthi okuvulekile spectrum antibiotic.

ukumelana

On umsebenzi elwa namagciwane izidakamizwa "moxifloxacin" musa kuthinte zezinqubo ukuyithukuthelisa ukumelana tetracyclines, macrolides, aminoglycosides, cephalosporins futhi penicillins. It ayifani kahle futhi umphumela cross-ukumelana. Kuze kube manje, amacala plasma ukuzinza awazange siyachazwa. Yokumelana nomuthi "moxifloxacin" bethuthukisa ngempela kancane ukuguquka kwezakhi zofuzo eziningi.

uhla umsebenzi

Kusho "moxifloxacin (imfundo manual - ubufakazi) kuthinta zamagciwane eziningi zama-bacterium Gram-HIV futhi Gram-negative, ama-bacterium acid-fast, anaerobes, angenziwa atypical (mycoplasma, chlamydia, njll), futhi amagciwane amelana macrolide ne-beta-lactam imithi engama-antibiotic .

ukuncela

Lapho ethola ukumuncwa ngomlomo izidakamizwa "moxifloxacin" ngokushesha futhi cishe ngokuphelele. bioavailability Ingabe Ohulumeni Banalo Lonke lapho zaphathwa ngemithambo yegazi nokusebenzisa izibilini - komyalelo wokungabi 91%. Lapho iqondiswa ngomlomo (mg 50-1200 umthamo, 600 mg / ngosuku izinsuku ezingu-10) pharmacokinetics komugqa izidakamizwa. Ubuningi esiphezulu nge mg 400 waphawula ngemva kwamahora angu 0.5-4. Lapho isicelo kanyekanye ne ukudla sifinyelele ukwanda kwesikhathi ubude Cmax (amahora amabili) bese ukunciphisa yayo ngo-16%. ngaleyo ndlela besikhatsi ukumuncwa uhlala ingashintshiwe. Noma kunjalo, lezi idatha akudingeki ukubaluleka emitholampilo evumela ukusetshenziswa kwezidakamizwa "moxifloxacin", kungakhathaliseki ukuthi ukudla. Ukulandela ukumnika olulodwa emthanjeni of mg 400 i okuhlushwa ihora esiphezulu kwenzeka ekupheleni ukumnika.

ukusatshalaliswa

Zingakadluli izinsuku ezintathu, kwesicelo kufinyelelwe zilingana. Sesibopho ukuthobisa plasma amaprotheni - cishe angu 45%. Lo mbhalo uthi ukusatshalaliswa angabacwasi ngokushesha izidakamizwa "moxifloxacin" kwezitho nezicubu. lamanani aphezulu ku izicubu wamaphaphu lwamafinyila bronchi, isikhumba kanye ongama izakhiwo, sinuses, foci ukuvuvukala. I ngamathe futhi interstitial nomuthi uketshezi itholakala amaprotheni itho olukhululekile, ifomu khulula. okuhlushwa yaso kunaleyo plasma. Ndawonye nale izidakamizwa itholakala esiningi kwezitho zomzimba nezicubu peritoneum zesifazane kwezitho zobulili oketshezini peritoneal.

umzimba

Medicine "moxifloxacin" (incazelo izidakamizwa kule idatha yesichasiselo Uqukethe ulwazi) uphasisa biotransformation sesibili. Kwezinso excretion lwenteke uhlelo kanye amathumbu angashintshiwe ngesimo sulpho compounds kanye glucuronide esingasebenzi. I metabolites atholakala plasma. okuhlushwa elingaphansi ukuthi we kwakwakhe yasekuqaleni. Ucwaningo luye lwabonisa ukuthi mikhiqizo nokucekelwa ungenalo elibi umzimba.

Kusho "moxifloxacin", okuyindawo ezinqunyiwe?

Umuthi Kunconywa ezithathelwanayo pathologies ukuvuvukala kule abadala cuphuluza nezilwanyana ezincane kokuba ukuzwela nalokho. Ikakhulu, i-ukufundwa okuhlangenwe exacerbation of ezingamahlalakhona ukucinana kwemigudu yokuphefumula ukugeleza, sinusitis acute, inyumoniya umphakathi aluthola (kubangelwa izinhlobo zama-bacterium bembonisa ukumelana amaningi t. H.-antibiotic). Kusho "moxifloxacin" yokusetshenziswa Kunconywa izifo kwezicubu ezithambile nesikhumba, izakhiwo ongama nzima izilonda (itheleleke unyawo sikashukela kanye), kanye nezifo naphakathi-besisu (izinqubo polymorphic, abscesses intraperitoneal nokunye). Inikezwa lapho nomuthi kusukela Streptococcus pneumoniae ukumelana emithini elwa namagciwane amaningi, kuhlanganise khona namagciwane amelana ne-penicillin, amaqembu amabili noma ngaphezulu izidakamizwa lesibili isizukulwane cephalosporins, macrolides, tetracyclines. Ngu izinkomba futhi zihlanganisa izilonda ukuvuvukala kwezitho okhalo imvelo ezingeyona inkimbinkimbi. Lapho endometritis futhi salpingitis zikhuthazwa ukuba nazo cabanga izindlela (njengoba kuboniswa exhunywe izidakamizwa "moxifloxacin" yokusetshenziswa). Eye amaconsi engabelwe conjunctivitis webhaktheriya, cuphuluza nezilwanyana ezincane nokuzwelana nomuthi. Kuyadingeka ukuba acabangele ukuphathwa akhona ezithathelwanayo pathologies ubuholi.

Nomuthi "moxifloxacin": umthamo kanye umzila yokuphathwa

Izimali esiqokiwe izibilini (ngomlomo) kanye ngemithambo yegazi. . Isikhathi impatho nomuthi "moxifloxacin", umthamo okuyinto - 400 mg / ngosuku, kuye ngohlobo nesifo esiphethe umuntu namandla ayo, kanye waphawula nomphumela oqabulayo:

• Exacerbation ka ezingamahlalakhona ukucinana kwemigudu yokuphefumula Yiqiniso - 5-10 izinsuku.
• Emphakathini atholwe inyumoniya - izinsuku 7-14 yokwelapha ezilandelanayo (emthanjeni kulandele engayitholi temlomo).
• izicubu zomzimba ezithambile, isikhumba (ayinzima), futhi sinusitis acute - ezinsukwini ezingu-7.
• Lapho izifo naphakathi-besisu (eziyinkimbinkimbi) - izinsuku 5-14 yokwelapha ezilandelanayo.
• Lapho nzima izilonda futhi izakhiwo ongama kwesikhumba - izinsuku 7-21.
• Ngo pathologies ukuvuvukala kwezitho okhalo - ezinsukwini ezingu-14.

Ukuze uthole olunye ulwazi, iqukethe exhunywe izidakamizwa "moxifloxacin" imfundo manual. Tablets akufanele bavunyelwe ukuhlafuna. Geza phansi kudingeka amanzi nomqulu omncane.

ukusetshenziswa kwasekhaya

Medicine "moxifloxacin" (amathonsi) kungenzeka zaphathwa iziguli ngonyaka. Prakthiza ebonisa ukuthi ngcono kuza kakhulu ngosuku lwesihlanu. Ngemva kwalokho kufanele uqhubeke nokwelashwa ezinye izinsuku 2-3. Iziguli esweni ethintekile bagxilisa inzondo iconsi kathathu ngosuku. Uma kungekho ukusebenza izinsuku ezinhlanu kufanele iphakamisa umbuzo ngokunemba yokwelapha noma uphethwe. Isikhathi ukwelashwa incike Yiqiniso bacteriological futhi emitholampilo ngobucayi egunjini lokuhlolwa kwezifo.

Ngaphezu kwalokho i-isixazululo ukumnika

Nomuthi "moxifloxacin" imfundo manual incoma ukuthi ufaka ihora. Umuthi ngaleyo ndlela kungaba undiluted noma ifomu lwenkomo olufakwe amanzi. Isixazululo iyahambisana sodium chloride -0.9%, amanzi umjovo, isixazululo dextrose at lokuhlushwa ngo-10% no-40%, 20% xylitol, "isikhali". Sebenzisa uketshezi esicacile kuphela. Ngemva dilution we nomuthi lihlala lisesilinganisweni izinsuku emazingeni okushisa okuvamile. Akufanele ibekwe ku izindlela esiqandisini. Uma ukumnika wenziwa iqondiswa namanye amanxusa, ngamunye elawulwa ngokwehlukile.

side effects

Ngenxa imithi yokwelapha "moxifloxacin" Cishe ukuthuthukisa izifo fungal, leukopenia, ukuntuleka kwegazi emzimbeni, thrombocytopenia. Kwezinye izimo, lokhu kwelashwa kukhona ukwanda prothrombin isikhathi, lokuhlala thromboplastin ukushintsha. Kwezinye iziguli lesi izidakamizwa kungabangela ukusabela kabi komzimba, edema laryngeal, urticaria, ukushaqeka anaphylactic, pruritus, eosinophilia, ukuqubuka. Ezimweni ezingavamile, kukhona Hyperglycemia, hyperlipidemia, hyperuricemia. Ekwelapheni nokugula ngengqondo kungenzeka. Ikakhulukazi, iziguli zingase zibhekane hyperactivity, ukukhathazeka, ukucindezeleka, depersonalization, ukuhhema, ukusabela zengqondo, ephelezelwa nemicabango yokuzibulala. Common side effects Ingahlanganisa ikhanda, isiyezi, ukundindizela, ukozela, ukudideka, ukunambitheka ukuzwela neziyaluyalu, ubuthongo thuthuva, disorientation. Kwezinye izimo, ngesikhatsi ukwelashwa ngemithi kungenzeka kahle ukubambisana, ukuquleka, ephelezelwa okunhlobonhlobo yomtholampilo, hypoesthesia, ukuphazamiseka lokuhogela. Iziguli kwadingeka eziya ziba zimbi yokukhuluma, ukunakwa, peripheral neuropathy, ukulahlekelwa amandla okukhumbula, polyneuropathy. Lapho isicelo ihlelwe ngokulandelana kwezihloko, umbono kungenzeka zimbi nakakhulu kuze ukulahlekelwa kwayo. Nokho, lona wamuva ubhekwa isimo lezivakashi.

Ithonya yisimiso senhliziyo nemithambo yegazi

Ingxenye umthelela isicelo zomuthi "moxifloxacin" kukhona prolongation qt-isikhawu in iziguli hypokalemia, palpitations, vasodilation, tachycardia. Imiphumela emibi engavamile zihlanganisa umfutho ophakeme wegazi kanye hypotension, tachyarrhythmias ventricular, nakwisyncope. Kakhulu akuvamile waphawula ukuboshwa inhliziyo. Okokugcina ikakhulukazi ejwayelekile abantu beyizidlova ischemia acute, bradycardia (isifo abalulekile).

Umthelela kwamanye izinhlelo kanye nezinhlaka

Kwezinye izimo, umuthi kungabangela iphika, kuhlanganise isimo somoya. Iziguli babonakala iziyaluyalu kule ipheshana wokugaya ukudla. Ikakhulukazi, ngokumelene isizinda ukwelashwa-emergent isicanucanu, ukuhlanza, uhudo, ubuhlungu esiswini. Bambalwa side effects ezibhekwa imnyama, dyspepsia, ukubuyisa, Gastroenteritis (ngaphandle erosive), ukuqunjelwa. Ezinye iziguli sezihlonziwe stomatitis, dysphagia, nesifo pseudomembranous. Therapy lingase anda transaminases, ukungasebenzi hepatic, ukuthuthukiswa kwesibindi fulminant, ukwehluleka hepatic okuholela okuyisimo esisongela ukuphila. Kakhulu akuvamile waphawula bullous ukusabela cutaneous (anobuthi epidermal necrolysis, Stevens-Johnson syndrome). Ezinye iziguli wazibonela myalgia, arthralgia, Ukudlikizela, kukhuphuke imisipha ithoni, tendonitis, ukuba buthakathaka kwezicubu. Imisipha esengxenyeni uyadabuka kungavuka Ezimweni ezingavamile, samathambo, Gait ukuphazamiseka ngenxa ukulimala uhlelo zemisipha. Iziguli ezelashelwa isifo ngemithi nakho kungaba iziyaluyalu waphawula kohlelo urinary. Ikakhulukazi, imakwe amanzi emzimbeni (sokucasuka uhudo noma ukwehla ivolumu ketshezi idliwe), ukungasebenzi kwezinso, esingamahlalakhona. Common imiphumela emibi ibandakanya ukujuluka, ubuhlungu nonspecific, ukucobeka. Esikhathini emthanjeni Cishe thrombophlebitis noma phlebitis.

Ngubani hhayi eyabelwe izindlela?

Kwezokwelapha "moxifloxacin" Izimo zimi kanje:

• Imisipha esengxenyeni zokugula emlandweni ezenzeka ngenxa yokwelapha quinolone imithi elwa namagciwane iqembu.
• Ukutholakala elongate qt-isikhawu (azalwa naso noma bathenga).
• Electrolyte thuthuva (ikakhulukazi hypokalemia uncorrected).
• Bradycardia (isifo abalulekile).
• Inhliziyo ukwehluleka enciphile ejection umsebenzi e-ventricle engakwesobunxele.
• Ukwephulwa inhliziyo isigqi (emlandweni).

Lapho ukungezwani ne-lactose, zikashukela-galactose malabsorption, lactase ukuntula nayo Kunconywa nomuthi "moxifloxacin" (izidakamizwa Ukwakheka yakhiwa lactose, ngakhoke pathologies okukhulunywa afakiwe ohlwini). Alinikeziwe kusho abakhulelwe noma lactating. Tablets kanye nekhambi wavunyelwa ukuba iziguli uya khona iminyaka engu-18 ubudala. izidakamizwa ezinconyiwe uma hypersensitivity kuya izingxenye.

ezimweni ezikhethekile

Kudingeka ukuqapha ekumisweni izidakamizwa iziguli sezinzwa uhlelo kwezinso ukuthi kubenza bavame ekuthuthukiseni nokuquleka. Iqembu ingozi kuhlanganisa iziguli ezine uthi proarrhythmic. Lezi zihlanganisa, ngokukhethekile, zihlanganisa ischemia acute, ikakhulukazi kwasebekhulile futhi abesifazane. Futhi bagcine ngokuqapha in iziguli isibindi sibe sesomile. Isikali ukulungiswa kungadingeka ngesikhathi okuhambisanayo yokwelapha izindlela wehlise lokuhlushwa potassium.

Ukuze uthole ukwaziswa okwengeziwe,

Prakthiza libonisa ukuthi isidakamizwa kahle kubekezelelwe iziguli eziningi. Ochwepheshe ngokuvamile libeke ithuluzi izilonda zaso. Lokhu kungenxa yokuthi i-izidakamizwa has a ukusebenza kahle kuqhathaniswa eliphezulu amagciwane amaningi. Nokho, kukhona njalo ingozi emibi, okuyinto ezifakwe umkhiqizo uxwayisa "moxifloxacin" imfundo manual. Analogs zomuthi uma isidingo kufanele ithathe udokotela ngamunye. Miselela ithuluzi can izidakamizwa ezifana: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" nabanye. Lapho imiphumela emibi, ziwohloke abukhali nesenzakalo izimpawu ezingenziwanga ezichazwe isifinyezo, kufanele afune usizo lwezokwelapha ngokushesha. Uma usebenzisa amathonsi kufanele zigweme ukuthintana esiningi ngokweqile amehlo izidakamizwa. Uma lokhu kwenzeka, udinga ngokushesha ngangokunokwenzeka ngokuba namanzi amaningi. Endabeni ka ukweqisa izidakamizwa isithuthukisi amathuba okuba nemiphumela engemihle.

Ekuphetheni

Umuthi 'moxifloxacin "kubhekwa elwa namagciwane ngokwanele ezinamandla. Ngokuqondene nalokhu kakhulu it is hhayi Kunconywa ukuba baphule kadokotela udokotela. Ikakhulukazi, kumayelana inombolo kanye nokuvama izindlela isicelo. Musa idlule umthamo. umjovo i-intravenous kufanele kwenziwe ucwaningo ekhethekile ngumuntu abasebenzi ilungu afanelekayo uzokwazi ukusiza uma kunesidingo. Kufanele akazibekanga medicate. In the ukungabikho imiphumela yokwelapha edingekayo ukuze abone udokotela. Ngaphambi nje kokuba uPawulu usebenzise izidakamizwa "moxifloxacin" kufanele ufunde ngokucophelela imiyalelo.