"Ovenkor": imiyalelo yokusetshenziswa. Izidakamizwa ezinciphisa i-Lipid

Ngeshwa, izinga le-cholesterol eliphakeme liyinkinga abantu abaningi ababhekene nayo, ikakhulukazi ekugugeni. Ukuqoqwa kwalesi sitho emzimbeni kuholela emiphumeleni enzima, kuhlanganise nokuphazanyiswa kokusebenza okuvamile kwesimiso senhliziyo. Ezimweni ezinjalo, iziguli zivele zidinga izidakamizwa ezinciphisa i-lipid-downing.

Yiqiniso, imakethe yesimanje yemithi inikeza ukhetho olukhulu lwemithi enjalo. Ngokuvamile odokotela batusa iziguli ezithola lesi sidakamizwa "i-Ovenkor". Imiyalo yokusetshenziswa lapha elula ngokwanele, ukusabela okubi kuvele kungavamile, kodwa umphumela obonakalayo ubonakala amasonto ambalwa emva kokuqala kokwelapha. Ngakho iyini le thuluzi? Yiziphi izakhiwo onayo? Ingabe kukhona ukuphikisana? Izimpendulo zale mibuzo ziyoba nesithakazelo kubafundi abaningi.

Ukwakhiwa kanye nefomu lokukhululwa

Isidakamizwa esithi "i-Ovenkor" umuthi otholakala ngesimo samathebulethi ajikelezayo enekhanda eliyinkimbinkimbi yefilimu. Into eyinhloko esebenzayo lapha i-simvastatin. Ngendlela, ekhemisi ungathenga umuthi onomthamo we-10 noma 20 mg wezithako ezisebenzayo kuthebhulethi ngayinye.

Ngokwemvelo, ezinye izinto ezisizayo zikhona ekubunjweni. Ikakhulukazi, i-lactose, i-butyl hydroxy anisole, kanye ne-citric acid, i-microcrystalline cellulose, i-oil castor, i- magnesium stearate, i- ascorbic acid, i-starch yamabele, i-talc, i-titanium dioxide, i-polyethylene glycol 4000, i-hydroxypropylmethylcellulose kanye nesitashi esandulele isetshenziswa ekukhiqizeni.

Izakhiwo zomzimba

"I-ovenkor" imithi enezinto eziningana eziwusizo. Ukungenelela emzimbeni, into esebenzayo yesidakamizwa ingene ekuphenduleni komzimba, lapho umsebenzi we-enzyme ethize HMG-CoA reductase inqatshelwe. Yilezi zinto ezenza kuqala izigaba zokuqala ze-cholesterol synthesis.

Ngakho-ke, lesi sidakamizwa sinciphisa izinga le-triglycerides kanye ne-lipoproteins elincane e- plasma yegazi, okusho ukuthi, kunciphisa i-cholesterol engqikithi. Ngokuhambisana nalokhu, lo muthi ukwandisa okuqukethwe kwe-lipoprotein ephezulu, okuthinta kahle umsebenzi womzimba.

Kubalulekile ukuphawula ukuthi izinguquko ezibonakalayo zivela emavikini amabili ngemuva kokuqala kwesidakamizwa. Ukuze kutholakale umthelela omkhulu wezokwelapha, inkambo yokwelashwa kwamaviki angu-4-6 adingekayo. Njengomthetho, umphumela womuthi uyama emva kokuqedwa kwamaphilisi - uma ukudla kungalandelwa kanye nezinye izincomo zikadokotela, izinga le-cholesterol liqala kancane kancane ukubuyela ezinkomba zokuqala.

Isidakamizwa sisheshe sikhangiswe ngodonga lwegciwane lokugaya. I-concentration enkulu yezinto ezisebenzayo egazini igcinwe emva kwamahora angu-1-2.5 emva kokuthatha iphilisi. Izinga lokubopha amaprotheni e-plasma ngu-95%. I-metabolism yalesi sidakamizwa ivela ezinhlobonhlobo zesibindi. Inqwaba ye-metabolites isuswa emzimbeni kanye namathole. Cishe ngo-10-15% uhamba nomchamo.

Izinkomba eziyinhloko zokusetshenziswa

Kumaphi amacala okufanelekile ukuthatha izidakamizwa "i-Ovenkor"? Izimpawu zokusetshenziswa yiziphi iziphazamiso ezihlobene nokuqoqwa nokwandisa ezingeni le-cholesterol emzimbeni. Ngokuvamile, odokotela banikeza lo muthi iziguli ezine-hypercholesterolemia eyinhloko, ikakhulu lapho ukudla okunempilo, ukulahlekelwa isisindo, ukuzivocavoca kanye neminye imisebenzi engekho umphumela okulindelekile. Inkambo yokwelapha ivimbela ukuthuthukiswa okuqhubekayo kwe-coronary atherosclerosis.

Izidakamizwa ezinciphisa i-Lipid nazo ziyasebenza ezinhlotsheni ezihlanganisiwe ze-hypertriglyceridemia ne-hypercholesterolemia, ezingalungiswa izindlela ezingezona ezomuthi.

Kwezinye izimo, umuthi unqunyelwe iziguli eziphethwe yisifo senhliziyo. Ikakhulukazi, isetshenziselwa ukuvimbela ukungena kwe-myocardial infarction. Isidakamizwa sinciphisa ukuthuthukiswa kwesifo sokuqina kwesifo sofuba emithonjeni ye-coronary, kunciphisa amathuba okubeka ingozi ezinkambisweni ze-revascularization, futhi kunciphise amathuba okuthuthukisa izinkinga zenhliziyo ezifana nokuhlaselwa kwe-ischemic nokuhamba kwesikhathi.

Ukulungiselela "Ovenkor": imiyalelo yokusetshenziswa

Ngaphambi kokuqala ukwelashwa, isiguli kumele sithole ukuhlolwa okuphelele kwezokwelapha. Udokotela kuphela ongenza ngendlela efanele yokwelashwa nomuthi "Ovenkor". Imiyalo yokusetshenziswa iqukethe izincomo ezijwayelekile kuphela.

Njengomthetho, iziguli zinconywa ukuba zithathe izidakamizwa kanye ngosuku, mhlawumbe kusihlwa (isibonelo, ngaphambi kokulala). Izinga lokukhangisa akuxhomekile ekudleni kokudla, kodwa ithebhulethi idinga ukugezwa phansi ngamanzi amaningi. Umthamo wansuku zonke ngokuqondile uxhomeke esimweni sesiguli kanye nemigqa esuka ku-10 ukuya ku-80 mg we-simvastatin. Ukushintsha isisu (ukunciphisa noma ukwandisa) kufanele kwenziwe ngezikhathi zamasonto amane. Ngokwezibalo, umthelela omkhulu wezokwelapha ezimweni eziningi utholakala ngokudla kuka-20 mg wezidakamizwa ngosuku. Kuwo wonke ukwelashwa, isiguli kufanele sinamathele ekudleni okuphansi kwe-cholesterol.

Ingabe kukhona ukuphikiswa kokungeniswa?

Iziguli eziningi zinentshisekelo ngemibuzo yokuthi zonke izigaba zeziguli zingathatha umuthi "i-Ovenkor". Imfundo yokusetshenziswa ithi umuthi unama-contraindications amaningi, okumele ufundwe. Okokuqala, kufanelekile ukukhuluma ukuzwela okwenyuka kwe-simvastin, izidakamizwa zochungechunge lwe-statin, kanye nezinto ezisizayo ezikhona ezibhebheni.

Lo muthi awunqunyelwe iziguli eziphethwe yi-porphyria, izifo ezithile zemisipha yamathambo (isibonelo, i-myopathy), kanye nokuhlukunyezwa okukhulu kwesibindi, ezihlobene nomsebenzi okwandisiwe we-enzyme. Lesi sidakamizwa asisetshenziselwa ukuphatha izingane nentsha, abesifazane abakhulelwe (kukhona ubufakazi bemiphumela emibi emntwaneni).

Ukuphikisana okuhlobene okubandakanya ukuqubuka kwamanzi, ukutheleleka okunamandla, ukuphazamiseka kwe-endocrine , ukuphazamiseka kwamagciwane nokudakwa ngokweqile. Futhi, umuthi awunqunyelwe iziguli ezanda ukubhekana nokuhlukunyezwa okukhulu, ukuhlinzwa noma ukuguqulwa kwesitho.

Imiphumela emibi engenakwenzeka kanye nezinkinga

Kwezinye izimo, ukwelashwa kungase kuhlotshaniswe nezinye izinkinga. Ngokuyinhloko, ngezinye izikhathi iziguli zikhononda ngezidakamizwa zesistimu yokugaya, ezihambisana nesisindo esibuhlungu, ukuhlanza, izifo zesibindi, ubuhlungu besisu. Okungavamile ukubona ukwanda komsebenzi we-enzyme yesibindi, ukuthuthukiswa kwesifo sofuba, ukuvuvukala kwama-pancreas.

Isidakamizwa singasithinta kakhulu isimiso sezinzwa. Ngokuyinhloko, ukwelashwa kungahambisana nokuphulwa okunjalo njengenhloko eqhubekayo, umbono obonakalayo, izinzwa ezingasebenzi, kanye nokuzondeka nokulala. Ngokuvamile kaningi ukubona ukuthuthukiswa kwe-asthenic syndrome, i-peripheral neuropathy, kanye nokuvela kwama-parasthesias nama-cramp muscle.

Kungase kube nemiphumela emibi kusuka ohlelweni lwe-musculoskeletal. Ezinye iziguli zakha ama-myopathies ne-myalgias, i-rhabdomyolysis encane kaningi. Futhi, ukuphendula okwenziwe okwenziwe ukugula, okuhambisana nokukhwabanisa isikhumba, ukuhlambalaza, i-urticaria, ukuvuvukala, ukuphefumula, ukukhanya okushisayo, ukukhwabanisa isikhumba. Ngokuvamile kancane kunokwanda komzwelo ekukhanyeni, ukuthuthukiswa kwe-vasculitis, i-arthritis, i- angioedema. Ezinye imiphumela emibi zibandakanya i-potency yehlile, i-anemia, inani lezinhliziyo ezikhuphukile, ukwehluleka okukhulu kwe-renal.

Ukudlula ngokweqile, izimpawu zalo kanye nezindlela zokwelashwa

Eqinisweni, amacala okudlula ngokweqile alotshwe ngokungajwayelekile futhi, njengoba umthetho, ehambisana nokukhushulwa kwemiphumela emibi. Uma lesi sidakamizwa sithathwe maduzane, kunconywa ukuthi senze ukuhlanza, hlambulula isisu futhi uthathe i-sorbent. Ukwelashwa kulokhu kuwuphawu oluphawulekayo. Kubaluleke kakhulu ezinsukwini ezimbalwa zokuqala ukuqapha umsebenzi wezinso nesibindi. Endabeni yokuthuthukiswa kokuhlukunyezwa kwezinso (kungavamile kakhulu) nezinye izinkinga ezinkulu, i-hemodialysis iboniswa.

Ukusebenzisana nezinye izidakamizwa

Ngaphambi kokuqala ukwelashwa, qinisekisa ukwazisa udokotela wakho ngemithi oyithathayo okwamanje. Ukuhlanganiswa kwama-antifungal agents (isib. Ketoconazole) nalesi sidakamizwa kwandisa ubungozi bokungaboni kahle. Ngendlela efanayo, i- "Ovencor" ixhumana ne-cytostatics, immunosuppressants, fibrates nezinye antibiotics. Ukwamukela okufanayo ngesikhathi esisodwa "kwe-Ovenkor" ngezinga eliphezulu le-nicotinic acid. Ngendlela, isikhathi semithi odokotela bayasikhuthaza kakhulu ukuba bayeke ukusebenzisa ijusi lamagilebhisi.

Zikhona yini izihlobo eziphumelelayo?

Ngeshwa, ngesinye sezizathu noma akuzona zonke iziguli ezifanele le mithi. Ngakho-ke, abaningi banesithakazelo ukuthi kungenzeka yini ukufaka esikhundleni sesidakamizwa "i-Ovenkor" ngento ethile? I-Analogues, yebo, ikhona.

Isibonelo, amathuluzi afana neVazilip, Zovatin, Zokor, kanye ne-Simvastatin abhekwa njengezikhundla eziphumelelayo. Izakhiwo ezifanayo zamakhemikhali zine "Simgal", "Simvor" ne "Holvasim".

Kunoma yikuphi, kunengqondo ukuqonda ukuthi awukwazi ukuyeka ngokweqile ukuthatha isidakamizwa "i-Ovenkor". Ama-analogues angakhethwa kuphela ngumchwepheshe wezokwelapha. Ukuzivocavoca kungaholela emiphumeleni engemuhle futhi eyingozi.

I-analogue yokulungiselela "i-Simvastatin": imiyalo yokusetshenziswa, intengo

Lesi sidakamizwa i-analog eqondile ye "Ovencor", ngoba iqukethe ingxenye esebenzayo efanayo. Yingakho iziguli eziningi zinesithakazelo kolwazi olwengeziwe mayelana nemithi "Simvastatin". Imfundo yesicelo, intengo, izakhiwo - konke lokhu, izikhathi ezibalulekile kakhulu.

Isidakamizwa sitholakalayo ngendlela yamathebhulethi futhi siphethe cishe ukubunjwa okufanayo. Unomzimba ofanayo we-hypolipidemic, wehlisa i-cholesterol egazini. Isimiso sokusebenza silingana - umthamo wansuku zonke unqunywe umthamo owodwa, futhi ngokuya ngesimo sempilo yesiguli, kungaba kusuka ku-5 ukuya ku-80 mg we-simvastatin.

Kodwa inani lomuthi lingaphansi kakhulu. Isibonelo, amaphilisi angu-30 anesilinganiso se-10 mg azokukhokhela ama-ruble ayi-100, futhi i- "Simvastatin" ku-20 mg cishe ama-ruble angu-150-200 (ngenani elifanayo lamaphilisi). Ngenxa yezindleko eziphansi, iziguli eziningi zikhetha lo muthi othile.

Kungakanani umuthi?

Abantu abaningi banesithakazelo kolwazi olwengeziwe mayelana nomuthi "Ovenkor". Inani, ama-analogues, impendulo yesiguli yizindaba ezibaluleke kakhulu. Ngaphezu kwalokho, iziguli eziningi, izindleko zesidakamizwa esinikeziwe zibaluleke kakhulu.

Ngakho-ke i-"Ovenkor" izobiza malini. Intengo, Yebo, incike ezintweni eziningi. Isibonelo, ngokucabangela kuyadingeka ukuthatha umqine-umakhi, umthamo kanye nenani lamathebulethi, kanye nenqubomgomo yentengo yesitolo sezidakamizwa, njll. Cishe ama-ruble angu-450-550 ungathenga iphasela lamaphilisi angu-30 "i-Ovenkor" (20 mg). Intengo yenani elifanayo lamaphilisi, kodwa ngesilinganiso se-10 mg i-ruble engama-350-400 kancane.

Ukubuyekezwa kweziguli nodokotela mayelana nomuthi

Abantu abaningi bafuna ulwazi oluthe xaxa mayelana nalo muthi. Yini ngempela i- "Ovencor"? Ukuphawula kodokotela ngalesi sidakamizwa kungcono kakhulu. Ochwepheshe bathi lo muthi ubekezeleleke kahle iziguli. Ngaphezu kwalokho, kusiza ukunciphisa i-cholesterol ngokushesha futhi kuvimbele ukuthuthukiswa kwemiphumela eyingozi.

Yini iziguli ngokwawo ezishoyo mayelana nokulungiselela "i-Ovenkor"? Ubufakazi balesi siguli buqinisekisa ukuthi umuthi uyasiza ekubhekaneni nezinkinga eziningi, ikakhulukazi uma uzihlanganisa ngezinqubo zokwelapha ezingekhozo zokwelashwa. Ezinye iziguli zihlakulela imiphumela emibi eyenzeka ngokunciphisa emkhakheni wansuku zonke. Mhlawumbe ukuhlukunyezwa okuwukuphela kwezindleko zezidakamizwa, ngoba kukhona ama-analogs ashibhile futhi angabizi kakhulu.