Umuthi 'Avastin ": Nobufakazi

Umuthi 'Avastin "iyithuluzi yesimanje yokulwa nomdlavuza. Isetshenziselwa ukwelapha ezihlukahlukene zomdlavuza, kuyasiza ukucindezela ukubukeka Ukudlulela ukunciphisa microvascular permeability futhi ukumisa ukuqhubeka kwesifo. Namuhla, abantu abaningi, iziguli ezinomdlavuza iphathwa ukwelashwa izidakamizwa "Avastin". Izibuyekezo ngakho zihlukile. Kukhona izibonelo Dynamics omuhle ekwelapheni izifo kanye nokubuyekeza eziningi ngobuze izidakamizwa. Abanye abantu "Avastin" kubangela eyaba nemiphumela emibi.

isakhiwo

The main esebenzayo isithako "Avastin" - bevacizumab. Umuthi okuthengiswa njengoba CONCENTRATE, eyenziwe isixazululo ukumnika emthanjeni. "Avastin" Ayinambala noma uba nombala brown ukukhanya. Sales zingatholakala ezimbili "zezikhala Avastin" zehlukene lokuhlushwa isithako esebenzayo eyinhloko: 100 mg / 4 ml bese 400 mg / 16 ml.

ubufakazi

Umuthi kuboniswa ngenxa lezi zifo ezilandelayo:

• Umdlavuza webele emabangeni yokugcina lapho Ukudlulela iqala.
• Kwezinso cell carcinoma.
• umdlavuza colon.
• Non-ezincane umdlavuza cell wamaphaphu.
• Glioblastoma (yansukuzonke).
• ezihlobene ubudala ukonakala macular (AMD), isimila endaweni okolomakulyarnoy, rinopatiya sikashukela.
• Okwamanje ke buthola umfutho ukusetshenziswa "Avastin" zamehlo. Ukubuyekezwa ukwelapha izifo iso ezihlobene sokugembula ukukhula semithambo, omuhle.

Izimo

Ngokuhambisana imiyalelo izidakamizwa akufanele isetshenziswe "Avastin" Ezimweni ezinjalo:

• Ephambi kwezinduna ukuzwela anda isiguli kwenye yezingxenye eziqukethwe nokulungiselela.
• Ngenkathi bekhulelwe nangenkathi bencelisa. Izifundo umphumela "Avastin" kulesi sigaba sama-iziguli sezenziwe. Kuyaziwa ukuthi ketshezi izidakamizwa zingene yi-placenta, okungase kuholele ekubeni uthunyelelwe nokucindezela angiogenesis umbungu. Abantu besifazane abane-yokuzala, kutuswa ukusebenzisa zokuvimbela inzalo ethembekile izinyanga okungenani eziyisithupha emva kokwelashwa nale izidakamizwa. Ngaphezu kwalokho, uma kunesidingo, "Ukwelapha Avastin" watusa ukumisa ibele, njengoba kungabangela ukukhula kahle kanye nokuthuthukiswa usana. Nokho, lolu cwaningo engakaze kungase kutholakale.
• yobudala Wezingane.
• Ngo ukwehluleka kwezinso nesibindi. Ucwaningo umphumela izidakamizwa kulesi sigaba sama-iziguli lwenziwe.

ukusabela ezingezinhle

Ezinye iziguli ziba nemiphumela emibi uma unikwe ukwelashwa "Avastin". Izibuyekezo zisikisela ukuthi impendulo izidakamizwa Ingaba yinto engathí sina ngempela:

• Perforation yokusetshenziswa pheshana emathunjini.
• Ukopha, e Umq. H. Lung.
• thromboembolism ekhipha igazi enhliziyweni.

Futhi imbandakanya phesheya imiphumela lesi sidakamizwa "Avastin" imfundo manual. Izibuyekezo wabo kungabonwa kaningi. Ziyakwazi:

• Ukwanda blood pressure.
• Ukuvela ubuhlungu nokuvuvuka esiswini.
• Umuzwa lobuthakathaka.
• Asthenia.
• ukuhluleka Inhliziyo.
• Neutropenia, leukopenia, ukuntuleka kwegazi emzimbeni.
• Imbangela isicanucanu, ukuhlanza, stomatitis.
• Ukuthuthukiswa anorexia.
• ukopha Rectal.
• Hypoxia.
• ileus.
• Rhinitis, dyspnea.
• Isikhumba iba nombala ezomile futhi ushintsho.
• umbono Ukuphazamiseka.
• Ubuthakathaka bemisipha.
• Ukuthuthukiswa pheshana urinary nezifo.
• It kwandisa izinga lokushisa komzimba.
• Ubuhlungu kokuba kwasendaweni ezahlukene.
• Sepsis - isifo umzimba.
• I-hemoglobin ezingeni kuyehla.

Izixwayiso

Lapho nokwelapha izidakamizwa "Avastin" futhi ekupheleni isicelo sokuba ezinye izinyanga eziyisithupha kunconywa ukusebenzisa inzalo. Sebenzisa zomuthi, kanye ekutholeni umthamo yayo ungenza kuphela uchwepheshe abanolwazi. Umuthi aluhambisani ne isixazululo dextrose.

isicelo

Ukulungiselela "Avastin" sivela kuphela / ukuvuza, ezokuphatha / jet akuvumelekile. Umthamo incike uhlobo lwesifo. Isixazululo "Avastin" kufanele kwenziwe kuphela ngaphansi kwezimo inzalo esiphezulu. Umthamo oyifunayo "Avastin" alulaze-100 ml i-sodium chloride-0.9% isixazululo (iziguli isisindo esikhulu Imininingwane kufanele sifinyelele 200-250 ml).

I ukumnika lokuqala "Avastin" kumele kutsatse emaminithi 90. Sebenzisa umkhiqizo olandela ngamakhemikhali. Uma Kwathi ngemva ekuphathweni wekucala, wesibili isikhathi ukumnika zingenziwa imizuzu 60, futhi okwesithathu - imizuzu engu-30. Uma une-side effects, abathuthukisi akukhuthazwa ukunciphisa umthamo izidakamizwa. Uma udinga ukuba, ke udinga umutsi "Avastin" ngezikhathi ezithile ayeke ngokuphelele.

ukweqisa izidakamizwa

Lapho ukwabela "Avastin" at umthamo esiphezulu (20 mg esisindo / kg, umzimba 2 amaviki isikhawu) kungenzeka ezigulini izimpawu ukweqisa izidakamizwa. Kwezinye iziguli kwakukhona neziqubu migraine ezinzima. Ayikwazanga sibe sibi izimpawu amathuba okuba nemiphumela engemihle.

izimo isitoreji

lokushisa isitoreji umuthi 2-8 degrees Celsius. eshalofini yokuphila - amahora angu-24. "Avastin" Awukwazi ukumisa noma ukunyakaza. Isixazululo ayiqukethe nezivimbelakuvunda, ngakho uma kunjalo, kufanele libhujiswe.

amaphuzu zempikiswano: ukubuyekezwa emihle nemibi mayelana izidakamizwa. Ubani okumelwe ubakholelwe?

Umuthi 'Avastin ", ukubuyekezwa zazo zikhona zombili zibe phozithivu futhi ngokuphelele negative, unyaka ngamunye ezingasho ngokuvamile ebekwe udokotela. Ngokwesayensi kungase kutholakale ngempumelelo emitholampilo ekwelapheni izinhlobo eziningi umdlavuza.

Ukwahlulela ukuphumelela nokwelashwa kweziguli ungathola ulwazi mayelana imithi "Avastin". Izibuyekezo iziguli sihlolisise ku.

Lesi sidakamizwa inenani eliphezulu ngokwanele. Ngokwesilinganiso, uma iqala ngamadijithi ayizinkulungwane 15. Hlikihla. Ngakho-ke, uma iziguli kanye nezifo ezimbi ezibhekene udokotela okwelaphayo zomuthi, masinyane baqala ukucinga ulwazi mayelana izidakamizwa "Avastin" kobufakazi nesineke, ukusebenzisa lolu izidakamizwa, kanye imiyalelo ukusebenzisa kwayo.

Ngokuvamile ungathola ulwazi mayelana okungagunyaziwe ukwelashwa "Avastin" Ezimweni ezinzima kakhulu. Akumelwe sikhohlwe ukuthi akuyena ngaso sonke isikhathi udokotela ekunika imithi, ngokucophelela ahlaziye kahle zonke umehluko wemisindo nemiqondo yamagama elungisa emuthini "Avastin" imfundiso. Izibuyekezo mayelana umphumela omuhle izidakamizwa kula amacala - into ezingavamile. Kuyadingeka ukuba anake impilo yabo, futhi ukukhumbula ukuthi ukwelapha izifo ezibucayi ezifana umdlavuza, kufanele kwenziwe kuphela izisebenzi eziqeqeshiwe.

Esimweni ngasinye, kukhona izizathu eziningi zokuthi 'Avastin "Awukwazi asondele isiguli kanye lula inkambo isifo. Ngakho kudingeka ucabange elibanzi hhayi ukuqondiswa kuphela Izibuyekezo ezingezinhle.

Cabangela ezinye zezihloko okukhulunywa ukubukwa yokuphathwa nale izidakamizwa.

Izibuyekezo mayelana izidakamizwa "Avastin"

Njengoba kuphawulwe ngenhla, ukubuyekezwa kwalo mkhiqizo okwelapha ziyangqubuzana kakhulu. Nokho, iziguli eziningi ukubika ukuthi ukwelapha lesi sifo livela kwenqubekela phambili enkulu. Kwezinye kukhona ukwehla ngobukhulu lwesimila. Kodwa, ngeshwa, alulame ngokugcwele akufanele kulindeleke. "Avastin" kuphela bakwazi ukunweba ukuphila lesiguli kanye ukwenza kube more ntofontofo.

It wachaza eningi amacala okuba nemiphumela engemihle. The njalo kunazo waphawula nokuqinisa ikhanda, igazi umfutho okhuphuka ngokungazelelwe. Imijovo "Avastin" emehlweni ezinye iziguli kuholele umbono ukulahlekelwa kanye ngisho nobumpumputhe.

E-US, kwakukhona umugqa sina phezu ukusetshenziswa "Avastin" ekwelapheni ukonakala macular. Umjovo we izidakamizwa phakathi Vitreous kwaholela isethi ephelele amathuba okuba nemiphumela engemihle. Ngesikhathi esifanayo, iziguli 16 zivakiwe izifo inhlamvu yeso sina. Ezinye athuthukile ubumpumputhe ngokuphelele. Kodwa "Avastin" uqhubeke ukusebenzisa kokubili e-US nase-Europe. ukusetshenziswa okunjalo okusakazekile zomuthi ayikho ubufakazi ongakaphathelani ukuthuthukiswa emthethweni, futhi izindleko ongaphakeme zomuthi liqhathaniswa 'Lucentis "zomthetho, livunyelwe ekwelapheni ukonakala macular.

Umehluko intengo lezi izidakamizwa sikhulu. Nakuba e-US intengo "Avastin" ingu- $ 50, intengo "Lucentis" - 2000 zamadola. Qaphela ukuthi kusukela iphuzu Ngenxa ukubukeka ngenxa yezinkinga side effects, kanye nokuthuthukiswa endophthalmitis "Lucentis" akuyona enhle. Yingakho abantu abaningi basengozini futhi uthenge i "Avastin" olungekho emthethweni.

Ngokusho odokotela abaningi, wonke iphuzu umjovo amasu kusho. Ucwaningo kuyadingeka kule ndawo. Ezinye zazo sezivele zenziwe. Ngakho, uma kuqhathaniswa izenzo bevacizumab futhi ranibizumab (izinto asebenzayo "Avastin" futhi "Lucentis", ngokulandelana). Sekube izifundo ezimbili endaweni, kodwa imiphumela yabo abangu uphikise, ngoba ngesikhathi kuqala Kwatholakala ukuthi iphephile, bevacizumab, kanti eyesibili - ranibizumab.

Kuze kube manje, i-Russia wavimbela izidakamizwa ukusetshenziswa zamehlo. Kodwa usengakwazi ukuthola umthengisi futhi udokotela ozokwenza umjovo. Bamehlo uthanda i "Avastin" engabizi, njengasezulwini yasekhaya imithi-commerce kuyaqhubeka kwanda. Phela, ukuze badonsele ukunaka lesiguli izinketho ashibhile lula kakhulu.

Kulokhu, kufanele kuphawulwe ukuthi iziguli eziningi nge-AMD babe ngcono okukhulu ngemva kokuba isibhamu, "Avastin" esweni. Izibuyekezo we Dynamics zokwelapha omuhle. Ngo nje imijovo ezimbalwa izidakamizwa kwadamba zokuzikhukhumeza amehlo, kwakukhona ngcono acuity ezibukwayo. Ukwelashwa kuba nomphumela omuhle hhayi ngokushesha kodwa ngemva imiphumela emibi zenzeke. Futhi, balindele umphumela ebonakalayo omuhle emva umjovo wokuqala lomuthi kusisize ngalutho.

"Avastin" + nokwelashwa ngamakhemikhali: ukubuyekezwa, ukwelashwa

Ngokungafani Izibuyekezo engqubuzanayo ukusetshenziswa kwezidakamizwa zamehlo, ucwaningo luye lwabonisa ukusebenza kwe "Avastin" lihambisana nokwelashwa ngamakhemikhali ekwelapheni umdlavuza colorectal. Ngo ukusetshenziswa okujwayelekile nokwelashwa ngamakhemikhali zemithi "Avastin" kusiza ukunqinda ikholoni izimila. Ngaphezu kwalokho, imiphumela le yokwelapha ukunyamalala metastases sesibindi esingelapheki kubantu abangamaphesenti 78% eziguli. Ngenxa yalokho, cishe ingxenye eyodwa kwezintathu iziguli zakwazi ukumhlinza, okuyinto ngaphansi simo esihle kungasindisa ukuphila kwabo.

Futhi, ucwaningo lwathola ukuthi "Avastin" is njengoba nomphumela ngoba iziguli esezikhulile njengoba iziguli abasebasha.

Isicelo kanye capecitabine izidakamizwa kwandisa iminyaka yokuphila kwabantu abanomdlavuza colorectal iminyaka emithathu kuya kwemihlanu.

Iphinde kusiza ukunweba ukuphila futhi ukunciphisa ukwakheka metastases e nomdlavuza webele futhi okungezona encane umdlavuza cell wamaphaphu luyinhlanganisela "Avastin" + ngamakhemikhali. Izibuyekezo zale ndlela yokwelapha akhayo. Nokho, isimo kufana: amathuba ukululama ngokugcwele incane.

ngempumelelo emitholampilo

• umdlavuza Colorectal - ne co-therapy "Avastin" nge IFL (irinotecan, fluorouracil, leucovorin) kwelula sokusinda cishe 5 izinyanga. Ukusetshenziswa "Avastin" kanye nokwelashwa ngamakhemikhali kungandisa bempilo esenezinyanga cishe 4.
• Metastatic umdlavuza webele. Infusions "Avastin" 10 mg / kg ngezikhawu amasonto amabili kanye paclitaxel kakhulu amathuba okuba ukumiswa ukuthuthukiswa isifo. Ukuphathwa kanjalo ngezinye izikhathi ithuthukisa nokwelashwa ngamakhemikhali umphumela.
• Non-ezincane umdlavuza cell wamaphaphu. Ukwelashwa "Avastin" kanye nokwelashwa ngamakhemikhali (lapho izidakamizwa-platinum-based) kwandisa amathuba okuphathwa nokusinda ezingozini kanye kwenyusa iminyaka yekuphila.
• Kwezinso cell carcinoma. Sebenzisa "Avastin" kanye interferon-alpha-2a bandisa isikhathi ukusinda njengoba kuqhathaniswa usebenzisa kuphela interferon-alpha-2a.
• Isigaba wesine glioma ebulalayo. Ngemva pre-radiotherapy ukwelashwa "Avastin" ungakwazi bandise nokuphila cishe izinyanga eziyisithupha.

Ngakho, "Avastin" buyisidakamizwa yesimanje for ekwelapheni izimila ahlukahlukene. Effect zomuthi engakaze uphenyo ngokugcwele. Nokho, it is ngokuya ebekwe odokotela ekwelapheni izinhlobo eziningi umdlavuza.

Zifakwe "Avastin" zamehlo, lapho ihlinzeka buphawuleka kakhulu nomphumela omuhle kuleli i- AMD. I umuthi ngempela eqolo, futhi kungabangela eminingi engemihle. impendulo sekukonke ngemva kokusebenzisa "Avastin" akhayo, kodwa futhi kukhona omubi.

Kwezinye iziguli, "Avastin" yalutho, futhi ezinye zibe nemiphumela engemihle. Ngakho-ke, lo muthi kufanele aqoke kuphela kudorhodere, ngokucabangela oyisibopho zonke kungenzeka umuntu impendulo isiguli izingxenye izidakamizwa. Ngaphezu kwalokho, lo ukumnika kufanele kwenziwe ngaphansi kwezimo oyinyumba. Umdlavuza - isifo esiyingozi kakhulu kungaholela ekufeni. Ukusebenzisa izidakamizwa "Avastin" akukuniki isiqinisekiso eliphelele ikhambi, kodwa kungaba ukumisa ukuqhubeka kwesifo nokulondoloza ukuphila kwesiguli. Futhi iziguli yizifo ezibhubhisayo abe inkinga!