Umuthi 'Metozok ": yokusetshenziswa, analogs kanye nokubuyekeza

isifo senhliziyo nemithambo yegazi ukuphazamisa eziningi abantu. Ukuqeda lezi zifo, ukunquma "Metozok". Yokusetshenziswa sinconywa ngaphambi kokusebenzisa lawo amaphilisi kudokotela futhi ungathathi izidakamizwa bebodwa, kungenxa yokuthi wayenezizathu Izimo sina. Imithi kwelekelela izifo angina, ukuhluleka kwenhliziyo okukhulu, tachycardia, migraine nezifo ezifana.

isakhiwo

Ukunikezwa Imvume Yokuthola Umuthi kuyindlela yokuthola "Metozok". Yokusetshenziswa likuchaza ngokuningiliziwe indlela yokwakheka amaphilisi.

A nomuthi nge umthamo 25 mg ehlanganisa 23,83 mg esebenzayo isithako metoprolol tartrate, 50 mg imayelana 47,66 mg isithako esisebenzayo kanye 100 mg - 95,32 mg.

Adjuvants sakhiwa imithi yilezi: hypromellose, ludipress LTSE, povidone, colloidal Silicon dioxide, i-magnesium stearate.

I-Tablet enamathela siqukethe ikhemikhali ngomumo eyenziwe "Opadry II», okuyinto ababethi orange. Kuhlanganisa izingxenye ezifana polyvinyl utshwala, talc, macrogol, ama-titanium dioxide, ophuzi yensimbi oxide Umbala, ezimnyama, futhi indigo.

Tablets ukumela imithi eside esebenza, basuke embozwe emgodleni ukukhanya-oluhlaza. Ingabe isiyingi, convex nhlangothi zombili.

Dragee e inani izingcezu 30 Agcwele amabhodlela epulasitiki kanye izicucu 10 aluminium amabhamuza. Ibhokisi amakhadibhodi iqukethe amabhamuza ezintathu.

Umkhiqizi "Metozoka" iyinkampani Russian JSC "Akrikhin".

isinyathelo kwemithi kanye farmadinamika

Bheka cardioselective beta1-blocker iphilisi "Metozok". Yokusetshenziswa ukuchaza ngokuphelele isenzo kwemithi zomuthi. Umuthi awunalo ulwelwesi eliletha ukuthula izakhiwo kanye nomsebenzi sympathomimetic. antihypertensive libhekene, isenzo antianginal futhi antiarrhythmic.

nengcosana β1-adrenergic receptor siyehla inhliziyo, kwehlisa ukusebenza catecholamine kwakwakhe ikamu ATP, kwehlisa wamanje ngaphakathi ion calcium, wakha chronotropic negative, BATM, dromo- nemiphumela inotropic. Ekuqaleni ukusetshenziswa kwezidakamizwa kwandisa izitsha ukumelana jikelele. Lokhu kungenxa ukukhuthazwa Ukuvinjwa α-adrenoceptor futhi β2-adrenoceptors. Ngemva kwezinsuku ezimbalwa (1-3), uyabuya isiguli yokuqala, kodwa elashwe eside kunciphisa neuropathy ukumelana semithambo.

umthelela Antihypertensive kwenzeka ngokunciphisa isibalo ngomzuzu ukugeleza kwegazi, futhi renin compounds ngokusebenzisa okusithiyayo umsebenzi umsebenzi renin-angiotensin-aldosterone futhi uqondiswe isimiso sezinzwa esiyinhloko, kanye ukuvuselelwa ezifweni we baroreceptors lwaleli yomthambo i-aorta, futhi ekugcineni encishisiwe neuropathy izibalo nozwela. Inciphisa aphakeme wegazi isimo yokuphumula. Ingcindezi ukunciphisa kwenzeka ngesikhathi umzimba ukucindezeleka kwengqondo. I inciphise umfutho wegazi ophakeme ihlala isikhathi esingaphezu kosuku.

impahla Antianginal uveta ukwehla izidingo-mpilo esivimba amanzi okwagcina kunciphisa ukushaya kwenhliziyo kwemisipha ezifweni ithonya innervation nozwela. It kunciphisa inani ekuhlaseleni pectoris angina kanye nokuncipha isikhathi sabo. Bandisa inkonzo bokuphila komuntu. Ngenxa kokwandiswa yokuqedela ingcindezi diastolic e-ventricle engakwesobunxele futhi kuyaqina of the imisipha kokubili ventricles yandisa isidingo oksijini kubantu abaphethwe yisifo senhliziyo.

umphumela Antiarrhythmic kufinyelelwa ukucindezelwa arrhythmogenic ukubonakaliswa ukuthi eshiwo njengoba tachycardia, umfutho ophakeme wegazi nakwezinye izindawo ezifuze lezo. D. Kuvela ukunciphisa okungalindelekile excitation ethunjini futhi itheku isigqi, kanye okusithiyayo we-AV-Umqhubi.

Ephambi kwezinduna tachycardia, supraventricular futhi itheku ezimise uzingela fibrillation atrial, thyrotoxicosis nezinye izifo obusebenzayo kudivayisi inhliziyo incipha ukushaya kwenhliziyo, nakho ezimweni eziningi kuholela ukubuyiselwa itheku isigqi.

Umuthi kuyinto prophylactic kakhulu ngokumelene migraine.

Njengoba lisetshenziswe ngemithamo maphakathi no-zokwelapha, akunamthelela evelele ezithweni nge adrenoceptors β2- futhi akunamthelela izinqubo umzimba emzimbeni carbon. Effect Its kufana umphumela "Propranolol".

Lapho ethola izidakamizwa iminyaka eminingi, ungakwazi kakhulu ukunciphisa inani cholesterol egazini. Lapho ethola ngemithamo nsuku 100 mg yezidakamizwa ithinta kanyekanye zonke subtypes β-adrenoceptor.

"Metozok" (incwadi yeziyalezo iza amaphilisi) kugaywe 95%. Ngokulingene oncibilikayo amafutha. Ehilelekile lokuqala pass umzimba bioavailability 50% ngesikhathi ukusetshenziswa kokuqala imithi 70% - ku izindlela ezilandelayo. Ubuningi esiphezulu into egazini waphawula ngemva kwamahora angu-6-12 emva ukungenisa tablet. Ngo inqubo yokwelapha okuqhubekayo kancane kancane kwandisa bioavailability. Ukudla kwandisa bioavailability 40%.

Active izidakamizwa 10% ixhuma Amaprotheni egazi. Kunalokho matasa ngokushesha ku futhi lingena kusivimbeli gazi ebuchosheni, umzanyana. Ingxenye ethile ke ludlulele ngaphakathi ubisi lwebele.

It is akheka esibindini, kanye metabolites ezimbili eziyinhloko zinezikhathi imisebenzi beta adrenoblokiruyuschey. Umzimba izidakamizwa abathintekayo isozyme CYP2D6.

Ezomhlaba isigamu-ukuphila amahora 3.5-7. Umuthi hhayi kudedelwa umzimba ngesikhathi hemodialysis.

metabolites kobuningi abakhona in iziguli CC 5 ml / imiz., Futhi kulokhu, alo-beta-adrenoceptor Ukuvinjwa umsebenzi ayikhuphuki.

I bioavailability kunyuke ne isifo sokusha isifo sesibindi. Iphinde kunciphise imvume Imininingwane.

"Metozok": izinkomba ukusetshenziswa

Nobufakazi bathi lokhu ukulungiselela aqede tachycardia, ekunciphiseni izinhlungu zenhliziyo kuzole impilo. Izimpawu I-lozenges kuyinto umfutho wegazi ophakeme, ukuhluleka kwenhliziyo futhi ifomu okungamahlalakhona, ise isinxephezelo esiteji. Kulo mBhalo, umuthi Kunconywa ukusebenzisa kanye nezinye izindlela injongo eziyinkimbinkimbi.

Ezinqunyelwe inhliziyo ischemia imithi "Metozok". Izinkomba zenzeka ekuhlaseleni angina (ifomu ezinzile) ekunciphiseni lokufa futhi kunciphisa amathuba kabusha infarction, kulandela ukutheleleka oyingozi.

Umuthi Kunconywa senhliziyo umzimba isigqi, tachycardia supraventricular lapho abakhona, ukunciphisa imvamisa ukusikwa kokubili ventricles ngesikhathi fibrillation atrial futhi ventricular arrhythmia.

Umuthi siyasebenza ezibangela nemisebenzi yokusetshenziswa inhliziyo, okuyinto ahambisana tachycardia ezinzima. It livame ukusetshenziswa migraine zokuvimbela. Iphakanyiswe ukwamukela izidakamizwa "Mezotok" izinkomba. Ingxoxo elandelayo igcizelela ku Izimo.

Izimo ukusetshenziswa

Kunoma ikuphi sinqatshiwe ukuthatha izidakamizwa bebodwa ngaphandle udokotela. Tablets ongabekiwe ukushaqeka cardiogenic kanye AV-ukuvinjelwa II-III zaba namandla kakhulu. Ungayisebenzisi ithuluzi block sinoatrial egula itheku syndrome. Usebenzela ukuvimbela ukusetshenziswa bradycardia (50 u. / Min) isifo senhliziyo ngo decompensated oyingozi futhi ezingalapheki. Contraindicated "Metozok" (umsebenzisi ichaza kabanzi ekusebenziseni zonke izici nomuthi) ngoba hypotension, isilethikusebenza, etholakala esigabeni acute yentuthuko, isifuba somoya ezinzima, feohromotsite, ukuphazamiseka of kwegazi neuropathy. Kakhulu belulekwa ukuba sihlanganise amaphilisi nge mao inhibitor kanye imijovo emthanjeni "Verapamil".

Akubalulekile ukusebenzisa imithi izingane, ogama yobudala kungazange kufinyelele iminyaka eyishumi nesishiyagalombili ubudala, ngesikhathi ibele, abantu ukuntula futhi ukungezwani ne-lactose, kanye malabsorption syndrome, hypersensitivity kuya beta-blocker, kuhlanganise metoprolol ukuba.

Okumele kuqashelwe ebekiwe nomuthi lapho isifo sikashukela, mina degree AV-block futhi Prinzmetal angina. Ukuqapha kufanele ubangele lactic umzimba, isifo somoya bronchial kanye isifo samaphaphu, isibindi uhlelo kwezinso. Cishe asikho ebekiwe ikhambi myasthenia, feohromotsite, i-hyperthyroidism, ukucindezeleka, psoriasis, eziyimbangela yezinkinga ezizuzwa ku nokusakazwa neuropathy, ngesikhathi sokukhulelwa kanye nabantu asebekhulile.

Isiyazanywa kwabesifazane abakhulelwe ithonya izidakamizwa sezenziwe. Kukhona futhi akukho idatha izinga Ukungena zomuthi ku ubisi lwebele. Ngakho-ke, ngesikhathi amaphilisi abantwana lactation ngaphambi kokusebenzisa kuyadingeka ukubonana nodokotela asikisele.

"Metozok": yokusetshenziswa

Uphenyo ezinye iziguli ukubika ukuthi izidakamizwa kungabangela imiphumela engemihle ngesimo ukukhathala. Ngakho-ke kubalulekile ukulandela imithetho futhi wamukele umthamo watusa. Uma udokotela akuyona Ukhethwe iphathwa ngamunye, kufanele uphuze ngendlela yakudala icala iphilisi "Metozok". Yokusetshenziswa uncoma ukusebenzisa izidakamizwa kanye ngosuku ekuseni, kungakhathaliseki ukuthi ukudla. Dragees kungukuthi ezokuhlafunwa wageza phansi ngamanzi amancane. Ukuze ugweme bradycardia, umthamo we imithi liyakhula kancane kancane.

Ephambi kwezinduna angina kanye nomfutho wegazi ophezulu, impatho isiqalisile nge mg ngelanga 50. Uma umphumela awuzange kufinyelelwa, umthamo wansuku zonke senyuselwa 100-200 mg / ngosuku, futhi nomfutho wegazi ophezulu - kwezinye izimo - yokwelapha umphelelisi nomunye umuthi antihypertensive.

Kubantu nesifo senhliziyo ekilasini II ngokuvumelana NYHA ngezigaba, ngaphandle esigabeni acute izinyanga eziyisithupha futhi ngaphandle izinguquko eziphawulekayo ukwelashwa eminyakeni elitjhumi nane izinsuku, uma umthamo kokuqala 25 mg kanye ngelanga. Ngemva kwamasonto amabili, kudingekile uma umthamo wansuku zonke anda ku-50 mg, bese, ngemuva kwamasonto amabili ngaphezulu, - kufike ku 100 mg futhi ngesikhathi esifanayo (izinsuku ezingu-14) senyuselwa mg 200.

Lapho III-IV ezingamahlalakhona congestive ukuhluleka kwenhliziyo, ukuphathwa isiqalisile nge ebangeni 12.5 mg kanye ngosuku kanye kuphela ngemva kwamasonto amabili, inani lakhuphuka lafika ku-25 mg nokunye - kuze umthamo esiphezulu-nsuku zonke mg 200. Nale uphethwe in iziguli ukwanda umthamo zokwelapha kumele kube ngaphansi eduze kweso lwezokwelapha, kusukela isimo zingase zibe zimbi kwezinye iziguli.

Sebenzisa izidakamizwa ngemva zokuvimbela okuphindiwe isilethikusebenza futhi inhliziyo ukwehluleka ku umthamo zokwelapha yansuku zonke mg 100.

Iziguli ezinokuphazamiseka obusebenzayo inhliziyo, lapho kukhona tachycardia, a imithi 50 mg ngosuku. Uma kudingekile, umthamo wansuku zonke anda ukuze mg 200.

Ukuvimbela migraine izidakamizwa Kunconywa ukuphuza ngineminyaka engu-100-200 mg ngosuku.

Musa ulungise umthamo oqabulayo asebekhulile kanye neziguli nokwehluleka kwezinso abaku- hemodialysis.

isifo sesibindi kuthinta nokuqedwa metoprolol emzimbeni, ngakho kulesi simo, ngesikhathi yokwelapha kushintshwe umthamo zokwelapha, kungakhathaliseki isimo lesiguli.

ukweqisa izidakamizwa

Kufanele kube ngokuqapha futhi kuphela ngaphansi oda kadokotela ukuthatha amaphilisi "Metozok". Umhlahlandlela uchaza Izimo lapho yokwamukela izidakamizwa akunakwenzeka. Ochwepheshe bagcizelela ukuthi non-ukuhambisana nemithetho amazinga okukhishwa reception kungenzeka overdosing, okuyinto kuhambisana ventricular extrasystole futhi tachycardia, umuzwa wobukhulu ekhanda, izandla nezinyawo, kanye nokwanda okuphawulekayo blood pressure.

Ukwelashwa Kwenziwa imijovo emthanjeni alpha-blocker ne-beta-blocker futhi.

side effects

Njengoba kushiwo, kwezinye izimo, kuyilapho ngokuthatha izidakamizwa, "Mezotok" bangezwa engemihle. Ngokwe-nesineke, kungase kube ukwenyuka komfutho wegazi, kwenhliziyo, fibrillation ventricular, arrhythmia inhliziyo, futhi bradycardia kardialgiya.

On the ingxenye Central Nervous System isiyezi kungabonakala nasemkhakheni, umuzwa equlekile yokwesatshwa, ukukhathazeka, ubuthongo thuthuva, ikhanda, imisipha amajaqamba, ukundindizela, ukopha palsy, paresthesia.

Ukuze uthole ezinye izifo uhlangothi, nahlulele yi izibuyekezo kodokotela neziguli zabo kukhona izimpawu ezifana isikhumba ugodo, ischemia kwesikhumba endaweni lomjovo, komzimba, necrosis, uqweqwe phezu ijwabu ngemva nokuphathwa imijovo ongama.

Endabeni ka-side effects, uMkhandlu waphakamisa lesi sidakamizwa "Metozok" imfundo manual. Analogs yalesi izidakamizwa kuzokusiza ukhethe udokotela ekwelapheni.

Izixwayiso

Ingabe kubaluleke kakhulu ekumisweni lesi sidakamizwa "Metozok" izinkomba. Analogs zisetshenziselwa zokwelapha lezi zifo akuzona ngakho ezingavamile. ngamapiki yabo onguchwepheshe, ekuhloleni ngokucophelela ngezimo zesiguli, uma kwenzeka ukuthi "Mezotok 'ngasizathu simbe akaphenduli.

Kuyo yonke ukwelashwa kufanele ziqashwe izinkomba of ECG, umfutho wegazi, kwegazi ezandleni nasezinyaweni, kanye okukhipha inhliziyo.

In iziguli nge umfutho wegazi ophakeme emithanjeni kanye congestive ukumelwa inhliziyo, kubalulekile ukuba silondoloze systolic blood pressure at 30-40 mm HG. Art.

Lapho ukwanda wegazi, kulandele izimpawu of tachycardia noma bradycardia, ngezinye izikhathi kunezindlela ukuphazamiseka isigqi inhliziyo. Kulesi simo, ukwelashwa nge "Metozok" (ngesandla esixwayisa imiphumela engemihle) kufanele wayeka. Ukuze ugweme ukwehla yesibili wegazi emva ukuhoxiswa izidakamizwa, umthamo kancane kancane, ikakhulukazi uma kwakukhona isikhathi eside ukumnika, ukuvuza futhi uqhubeke ogulayo uma ngizwa ingcindezi kuyehla kube ukubaluleka 70-80 mm HG. Art.

Ngo abantu abadala inani receptor adrenergic, ikakhulukazi ukungenwa phenylephrine liyancipha. Ngakwelinye ihlangothi, monoamine oxidase inhibitor, okwandisa umphumela ukugxisha ka sympathomimetic, avuse ubuhlungu ekhanda, arrhythmia, ukuhlanza reflex, crisis abanomfutho wegazi ophakeme. Ngenxa yalokhu, iziguli usebenzisa monoamine oxidase inhibitor, izinsuku 2-3 ukunciphisa inani sympathomimetics.

Ngaleso sikhathi, odokotela musa batusa yokwelapha Yiqiniso umsebenzi enobungozi, ogxile ijubane yokusabela - kokubili ngokwengqondo futhi bokuphila.

Ngokucophelela okukhulu kufanele uphuze amaphilisi umuntu ohlushwa isifo sezinso, kanye nabantu asebekhulile. Umuthi akufanele kuthathwe izingane ezingaphansi kweminyaka eyishumi nesishiyagalombili ubudala ngenxa yokuntula ulwazi nemiphumela yayo.

Umuthi ukhululeka Pharmacy ngokuqinile on kadokotela.

Analogs nomuthi

Kuthiwani uma "Metozok" ayingeni ngasizathu simbe? Analogs Ungahlala kungatholakala ekhemisi. Sinenkosi ncamashi ketshezi asebenzayo efanayo futhi ngale ndlela kanjani umzimba. Lezi imithi zihlanganisa:

• "Betalok".
• "Serdol".
• "Egilok C".
• "Vazokardin kuthiye ukukhula."
• "Metoprolol".
• "Korvitol 50".
• "Metokard".
• "Emzok".
• "Atenolol".
• "Lidalok".

Lezi kanye nezinye esikhundleni "Metozok" analogue ziye zasetshenziswa ekwelapheni izifo zenhliziyo ngempumelelo. Zonke izimali zidinga kalula, futhi ngeke kuthathwe bebodwa, ngaphandle udokotela.

nobufakazi

Ukulungiselela "izilinganiso Metozok 'kuyinto ogxile omuhle. Abantu bathi kuba ukhululekile ukuba baphuze (umthamo watusa kuyinto - iphilisi elilodwa ngelanga). Bathi ukuxoxa ke umphumela okunenjongo. Iziguli eziningi bathi ngemva kokuphuza izindlela bayakhohlwa okungikhathazayo enhliziyweni.

Ochwepheshe kulo mkhakha lukazifozonke washo amazwi afanayo okuncoma kakhulu amaphilisi "Metozok". Izibuyekezo lodokotela abonisa ukuthi umuthi ngempumelelo futhi iphephile, ngakho-ke ngokuvamile ebekwe nangodokotela bababhekene nezifo zenhliziyo iziguli zabo. Ochwepheshe bathi phakathi impatho Into esemqoka - ukukhetha Isikali kwesokudla, kungenjalo ungase uzizwe imiphumela emibi ezifana ukukhathala, isicanucanu, ukuhlanza, ukukhishwa yisisu.