KumiswaAmakolishi namanyuvesi

Uyini peptides natriuretic?

Njengoba kwachazwa esikhathini esidlule yamuva, ngaphezu kwalokho okusobala imisebenzi inhliziyo wenza indima endocrine isitho. It kwavusa isithakazelo, hhayi nje phakathi theorists wezokwelapha, kodwa futhi phakathi odokotela. peptides Natriuretic (NUP) kumakwe kuphela myocardium, kodwa futhi eziningi ezinye izitho zangaphakathi, ngaphambili ehlisa endocrine imisebenzi. Ingabe wenza isinqumo collective ukusebenzisa izinkomba ambalwa NFA egazini ngoba isibikezelo pathologies inhliziyo, njengoba le ndlela kwaba okungenani koda futhi kulula ukuze isiguli.

Ukutholakala umsebenzi endocrine wenhliziyo

peptides Natriuretic ziye zatholakala e-Eighties kwekhulu elidlule, lapho ososayensi wayekubonile ukuhlobana ukungezwani kwamakamelo inhliziyo futhi ukushuba uketshezi umchamo. Ukutholakala Ekuqaleni bacabanga kwaba ngumkhuba reflex walinika okusho.

Kamuva, lapho ekutadisheni lo mbuzo zivela pathologists futhi Histology, bathola ukuthi kumaseli ijwabu, ingxenye ATRIUM, kukhona inclusions equkethe amaprotheni molecule ngokwabo. Kuye Ucwaningo wafakazela ukuthi kula Atria amagundane yakha umthelela eqinile isisu. Khona-ke waphumelela ukwenza ukuzihlalela le peptide futhi ukulandelana acid acid izinsalela ezihlanganisa ke.

Ngemva kwesikhathi esithile, biochemists ziye zakhomba iprotheni e yezingxenye ezintathu ezihlukene (i-alpha, beta-gamma), ezahlukene hhayi kuphela isakhiwo sazo sekhemikhali, kodwa futhi ine umphumela-alpha lwaluqinile kunezibopho amanye amabili. Okwamanje zihlukaniswa:

- NUP atrial (uhlobo A);
- NUP cerebral (hlobo B);
- urodilatin (uhlobo C).

Biochemistry peptide natriuretic

Zonke peptides natriuretic zifana ngezindlela isakhiwo futhi kuhluke kuphela ekupheleni ezizivelelayo nitrogen noma ilungiselelo zama-athomu carbon. Namuhla, bonke ukunakwa eligxile bamakhemikhali NUP yohlobo B, njengoba has a ifomu uzinze e-plasma, futhi likuvumela ukuze uthole imiphumela eminingi ulwazi. Atrial NFA udlala indima omunye correctors yamanzi futhi electrolyte ukulingana umzimba. It ikhiqizwa myocardium kuzo zombili evamile futhi ezingalapheki yokumelwa yinhliziyo.

It is wafakazela ukuthi eyandulela kobuchopho NUP siqukethe 108 acid acid izinsalela kuthiwa kuhlelwe umqondo ngu amaseli i-ventricle engakwesobunxele. Lapho otshnurovyvaetsya-molecule kusukela cytoplasm, isenzo enzyme furin kuso, okwenza lokhu amaprotheni injalo okusebenzayo (32 amino acid we 108). NUP ubuchopho likhona igazi imizuzu 40 kuphela, khona-ke ukubola. Ukwandisa izinhlelo zamagama amaprotheni elihlobene ne okhushuliwe ventricular odongeni ukungezwani futhi ischemia inhliziyo.

Excretion UNYP kusukela plasma wenziwa ngezindlela ezimbili eziyinhloko:

- cleavage ka lysosomal enzyme;
- proteolysis.

A indima yokuhola kuhoxiswa nomthelela kokungathathi hlangothi endopeptidase molecule kodwa kokubili izindlela nomthelela ukuqedwa peptides natriuretic.

uhlelo yokwamukela

Zonke imithelela peptides natriuretic kuyenziwa ngenxa ukusebenzisana receptor yabo etholakala ubuchopho, imithambo yegazi, nemisipha, amathambo adipose izicubu. Ilingana ezintathu izinhlobo NFA futhi kukhona izinhlobo ezintathu ezenza - A, B no-C Nokho, ukusatshalaliswa "imisebenzi" boni ngakho:

- uhlobo A receptor uxhumana atrial nobuchopho NUP;
- Uhlobo iyaphendula kuphela urodilatin;
- ama-receptor ungakwazi ukuhlanganisa uxhumano nomsebenzisi zonke izinhlobo ezintathu ama-molecule.

Receptor zihluke nomunye. A no-B izinhlobo zenzelwe ukusebenzisa imiphumela intracellular ka natriuretic peptide receptor kanye nohlobo C ayadingeka biodegradation wamaprotheni molecule. Kukhona kokuqagela ukuthi ukuchayeka cerebral UNYP eyenziwa hhayi nje ngenxa uhlobo A yokwamukela, kodwa futhi nabanye izingxenye abathola ngazo zilalela inani eyindilinga guanosine monophosphate.

Abantu abaningi uhlobo C receptor atholakala izicubu ubuchopho, izindlala adrenal, izinso, nezitsha. Lapho UNYP-molecule sibopha ukuthi yokwamukela ohlobo C, it is amuncwa cell futhi wajinge wanamatsela kanye yokwamukela khulula ebuyiselwa ulwelwesi.

Physiology peptide natriuretic

Brain futhi atrial peptides natriuretic ukuzivocavoca imiphumela yabo ngokusebenzisa uhlelo kwezimpendulo eziyinkimbinkimbi bokuphila. Kodwa zonke luholele umgomo ofanayo - ukunciphisa Layisha enhliziyweni. NUP kuthinta zenhliziyo, endocrine, excretory futhi uqondiswe isimiso sezinzwa esiyinhloko.

Njengoba la mangqamuzana ababuthanda for receptor ezihlukahlukene, gqamisa, imiphumela kohlobo oluthile NFA on uhlelo oluthile, kunzima. Ngaphezu kwalokho, umphumela peptide akuxhomekile nje kuphela esimweni uhlobo yayo, kodwa yokwamukela indawo abathola.

Atrial peptide natriuretic libhekisela peptides vasoactive, isb nomthelela nqgo ubukhulu semithambo. Kodwa ngaphandle ukuthi uyakwazi kukhuthaza ukukhiqizwa kwe-nitrous nitric okuyinto sithuthukisa vasodilation. NUP A no B uhlobo olufanayo nesiqondiso amandla isinyathelo ku zonke izinhlobo izitsha, P-hlobo kakhulu yandisa emithanjeni kuphela.

Okusanda kuye kwasikiselwa ukuthi NFA kufanele waqonda hhayi nje njengomuntu vasodilator, kodwa ngokuyinhloko njengoba isitha of vasoconstrictor. Ngaphezu kwalokho, kunocwaningo ezibonisa ukuthi peptides natriuretic ukuthonya ukusatshalaliswa uketshezi futhi aphume inethiwekhi capillary.

imiphumela kwezinso of peptide natriuretic

Mayelana peptide natriuretic kungashiwo ukuthi kuba diuresis ivuselela. Ngokuyinhloko NUP uhlobo A kwandisa kwezinso ukugeleza kwegazi futhi kwandisa umfutho izitsha glomeruli. Lokhu, kube sekwandisa filtration glomerular. Ngesikhathi esifanayo NUP uhlobo C kwandisa excretion sodium ion, futhi lokhu kuholela ekuphelelweni ukulahlekelwa eminye yamanzi.

Ukuphishekela konke lokhu kwenza yanoma yimuphi ushintsho oluphawulekayo endleleni ingcindezi Uhlelo ningagcini, ngisho noma ezingeni peptide anda izikhathi eziningana. Zonke izazi ziyavuma ukuthi imithelela ukuthi peptides natriuretic kunethonya izinso, zibalulekile ukulungiswa kwamanzi kanye electrolyte ukulinganisela pathologies njalo uhlelo senhliziyo nemithambo yegazi.

Imiphumela phezu CNS

Brain peptide natriuretic njengoba atrial, abakwazi ukungena umgoqo gazi ebuchosheni. Ngakho-ke, kuthinte kwemizwa uhlelo izakhiwo engaphandle kwalo. Kodwa ngenkathi ezinye NFA is ethakwa by ulwelwesi ubuchopho kanye namanye amasayithi yayo.

Imiphumela ephakathi nendawo yendlela esakha peptides natriuretic amanga iqiniso lokuthi baqinise izinguquko neuropathy ekhona. Ngakho, ngokwesibonelo, kanye nokuncipha inhliziyo Layisha umzimba incipha isidingo yayo ngoba amanzi nokumbiwa nosawoti, futhi sishintsha ithoni autonomic nervous system e isiqondiso parasympathetic ingxenye.

nakomaka laboratory

Umqondo ukuthatha natriuretic peptide ukuhlaziywa ngesikhathi iziyaluyalu esimiso senhliziyo nemithambo yegazi ludabuka ezindaweni ekuseni 90-yalolucwaningo kwekhulu elidlule. Ngemva kweminyaka eyishumi, yezincwadi zokuqala nge imiphumela yocwaningo kule ndawo. Kwabikwa ukuthi B-hlobo NPU ulwazi lapho ekuhloleni kobukhulu senhliziyo futhi ukubikezela ukuqhubekela phambili kwesifo.

Amaphrotheni okuqukethwe wamiswa ngo emithambo yegazi lonke igazi, exutshwe EDTA, noma ngokusebenzisa ukuhlaziywa immunochemical. Ngokuvamile UNYP ezingeni kumele singeqi 100 ng / ml. Ngaphezu kwalokho, kungenzeka ukuba kutholakale izinga eyandulela NFA nge indlela electrochemiluminescent. imithi Domestic, hhayi kokuba ezihlukahlukene okunjalo ukusetshenziswa exhumene Assay immunosorbent njengendlela yokuthola jikelele yokunquma inani into e-serum igazi.

Ukunqunywa ukungasebenzi inhliziyo

peptide Natriuretic (kuyinsakavukela - 100 ng / ml) okwamanje umaka ethandwa kakhulu futhi esimanjemanje kakhulu sokunquma inhliziyo imisipha ukungasebenzi. I izifundo lokuqala peptides baxhunywe izinkinga yokuzihlukanisa kwamangqamuzana ngokwemisebenzi yawo ka ezingamahlalakhona ukwehluleka kwegazi futhi ezingalapheki obstructive isifo samaphaphu. Njengoba izimpawu zokwelashwa zazifana, isivivinyo kuyabaveza imbangela izifo ukubikezela ukuthuthukiswa kwaleso sifo.

I zokugula yesibili, okuyinto usebhekene cwaningo nalo mbono, kwaba ischemic isifo senhliziyo. Abalobi izifundo uyavuma ukuthi incazelo NFA ezingeni kusiza ukusungula lokufa kulinganiselwa noma sokuphinda e isiguli. Ngaphezu kwalokho, ashukumisayo ethungatha NFA ileveli umaka ukwelashwa ngempumelelo.

Okwamanje, lizinga NFA kunqunywa in iziguli zenhliziyo, umfutho wegazi ophakeme, stenosis imithambo ezinkulu nezinye izifo kwegazi.

Sebenzisa ukuhlinzwa inhliziyo

Empirically Kwembulwe ukuthi ezingeni atrial peptide natriuretic egazini kungaba kuthathwe kube inkomba yokuthi kobukhulu isimo kanye nokusebenza i-ventricle engakwesobunxele iziguli ngaphambi nangemva kokuhlinzwa inhliziyo.

Lolu cwaningo zalesi simo waqala ngo-1993, kodwa kuphela ufinyelelwe ngezinga elikhulu kowezi-2000. Kwatholakala ukuthi ukwehla elibukhali inani NUP egazini neuropathy, uma ngaphambi level yayo iye ngokuqhubekayo ithuthukiswe, kusikisela ukuthi umsebenzi we myocardium sinciphile ukuhlinzwa kwami kuhambe kahle. Uma ukunciphisa NFA akuzange kwenzeke, neziguli bashonela nge 100% okungenzeka. Ubudlelwano obuphakathi yobudala, ubulili kanye izinga peptide sezihlonziwe, Ngakho-ke, lesi sibalo jikelele zonke izigaba iziguli.

Izibikezelo emva kokuhlinzwa

Ngaphambi kokuba ahlinzwe inhliziyo peptide natriuretic anda. Phela, uma ngabe kwakuhlukile ke isidingo sokwelashwa wayengekho lapho. Izinga eliphezulu iziguli NFA ngaphambi ukwelashwa kuyisici ezingezinhle ukuthi unomthelela kakhulu onalesi sifo ngemva kokuhlinzwa.

Njengobe lelicembu letikhetselwe cwaningo lalilincane, imiphumela abangu elixutshwe. Ngakolunye uhlangothi, sokunquma ezingeni NFA ngaphambi nangemva kokuhlinzwa ivumela odokotela ukuba bakwazi ukubikezela okuyinto edingekayo izidakamizwa futhi ithuluzi ukwesekwa uzobe ukuqedela nokuvulwa inhliziyo imisebenzi yayo. Futhi-ke abanye bakuqaphela ukuthi esengeziwe NUP uhlobo B eyandulela ka fibrillation atrial esikhathini postoperative.

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