ImpiloImithi

Vitrification zemibungu ngesikhathi iziphathi ngabanye

Kulesi sihloko sizoxoxa umqondo ezifana vitrification zemibungu. UDkt Kuwayama Masashige yasungulwa le ndlela ukuze kriotopah ngisho ngonyaka ngonyaka. Ingane yokuqala kuzalwa ngobisi vitrification imibungu 2003. oocyte sokusinda wezinga landa ngamaphesenti angu-98.

Half of the abesifazane abathola IVF, imibungu ahlale. Kubo labetibambile cryopreservation ivumela iziguli ukuba bonge imali. Phela unfreeze futhi uthumele imibungu kuba lula kakhulu kunokuba afeze ngaphandle kwesibeletho inqubo kokukhulelwa futhi. Kuba yisikhathi futhi lapho umshuwalense uma uma owesifazane engathandi abakhulelwe. Cryopreservation has a inzuzo abahlukene - kuvimbela ukufa zemibungu iphila awasalayo emva olandelwayo.

ontogeny

Ngokuba ukuthuthukiswa subjective umzimba, noma ontogeny, ke sihlehlela emuva kusukela ngesikhathi sokukhulelwa futhi iphela kokufa kwakhe. Lokhu ezinyakazayo kuyinto eqhubekayo ngesikhathi futhi uhlamvu unomphela. Futhi asikwazi yakhe ukuthi amise noma ahoxise ukubambezela ukuthuthukiswa yayo. Kodwa ngokwemvelo zikhona ezehlukile. Lawa izitshalo, ezingenamgogodla ngisho abanye ezilwaneni ezinomgogodla ezinamehlo aphansi ukuthi ashisa ongaphakeme, musa abonise izakhiwo nobuntu eziphilayo.

Kuyini kulala kwasebusika?

Vitrification zemibungu sichaziwe ngezansi. inkathi ngamunye ezolile libizwa basebusika. Ngokwesibonelo, izilwane eziningi eziyosinda okushisa laseSiberia ukufinyelela -90 degrees, kanye amanzi emzimbeni sekuyaphela. Ekuhloleni kwalesi sikhathi ontogenesis ngokwemvelo kukhona umbuzo mayelana nokusetshenziswa okungenzeka okushisa aphansi for the kokuphazamiseka esinqunyiwe kanye esethola ka ukusebenza ephakeme izidalwa yezilwane ezinomgogodla, kuhlanganise nabantu.

cryopreservation

Cryopreservation - kuyindlela ephumelelayo ukumiswa izinqubo yezinto eziphilayo e amaseli ukwenekwa lokushisa ongaphakeme. Lokhu kugcina umsebenzi ukuphila lamaseli ngesikhathi bafudumale. Ngodumo, le ndlela zingaphansi umbungu vitrification. 1 kriotop (esinelebuli krionositel) iqukethe kusuka 1 kuya ku-3 imibungu.

Ngokwesibonelo, lapho wenza inqubo efana IVF, umphumela engcono kubhekwa ihamba ngalo ingaphakathi lesizalo akuyona imibungu engaphezu kwemibili. Asele izinga imibungu kungenziwa cryopreserved ukuze zisetshenziswe esikhathini esizayo. Bangaphinde isicelo kabusha IVF emva kwesikhashana, uma inqubo kuzobonisa yi ezimbi. Nge imigomo enjalo eyenziwa vitrification imibungu on yezinkampani ngabanye.

Kwezinye izimo, ukumisa imigqa yawo wonke imibungu. Kwabesifazane abane- wesibeletho hyperstimulation syndrome ngesikhathi superovulation lokungeniswa wenziwa kakhulu. Ngubani oye Kunconywa okokuqandisa? Iziguli umdlavuza, ikakhulukazi ngaphambi ngekhemikhali inqubo noma ngemisebe. Idatha wabe esethunyelwa imibungu phakathi komgodi lesizalo. Freeze show wonke umuntu ithuba yokukhulelwa ngemva IVF ngasizathu simbe eyehlisiwe. Lokhu kungaba polyp endometrial, enganele ukujiya endometrial ekudluliselweni isikhathi okuhleliwe, ukopha enezinkinga.

izigaba okokuqandisa

Imibungu abangu simisiwe angefani:

  • Iqanda elivundisiwe (zygote);
  • ebhidliza esiteji imibungu;
  • blastocysts.

Okwamanje, kukhona izindlela ezimbili zemibungu umnkantsha.

okokuqandisa kancane

Vitrification zemibungu Kwenziwa ngesikhathi okokuqandisa kancane. Le ndlela kwahlongozwa 70s futhi eyodwa yezindlela lokuqala classical zemibungu umnkantsha. Kusekelwe Ukupholisa kancane ngesilinganiso njalo. Uma eqandisiwe egcinwe ku liquid nitrogen.

Kodwa kufanele kuphawulwe ukuthi ngesikhathi okokuqandisa kancane in isixazululo cryoprotective ice lenyama zinhlayiya akhiwa okuyinto zibulale amaseli we-embryo. Kungabangela ezicekeleké noma ingqikithi izinto eziphilayo azithathe phezu bafudumale. Inombolo zemibungu adluliselwe ngempumelelo ngesikhathi okokuqandisa kancane futhi incibilikiswa, cishe amaphesenti angu-70.

vitrification

Ngemva 2010, waqala ukusebenzisa indlela entsha futhi siphumelele njengezikhonzi cryopreservation - vitrification. Kuqhathaniswa indlela langaphambilini, lokhu kuyindlela eshesha ukumisa izinto eziphilayo azithathe. Ngokuvamile kwenziwe ngemibungu ngemva vitrification PGD (uphethwe zofuzo).

Uma usebenzisa le nqubo isixazululo cryoprotective, lapho imibungu ezibekwe ingeyona ice zinhlayiya ngesikhathi umnkantsha. Ngakho, encishisiwe kokulungisa okungenzeka umbungu. I kuqala le ndlela akuyona nje indlela okokuqandisa, kodwa futhi izinga lokusinda zemibungu ngemva incibilikiswa. Ngokwezibalo, inombolo lokusinda imibungu emva inqubo vitrification akuyona esingaphansi ngamaphesenti angu-95.

Kwenzekani ngemva incibilikiswa?

Ngemva incibilikiswa imibungu musa ihluke imibungu abavamile. Bathatha kanye umile futhi ukhule. Ngu amalahle zonke imibungu ngaphansi hatching ekuzaleni. Ekuqhubeni lo msebenzi ungqimba ebusweni embryo ibizwa ihlukaniswe laser ugongolo zibheke ohlangothini oyifunayo futhi iphephile. Lokhu kusiza umbungu aphume igobolondo futhi kukhulisa kungenzeka ukufakelwa yimpumelelo esibelethweni.

Zeqhwa imibungu ivumela isitoreji isikhathi eside. Le nqubo engabizi, ngoba intengo ukulondolozwa, incibilikiswa kanye ukugxilisa umbungu esibelethweni kuyinto esingaphansi inqubo kwesibeletho fertilization yesibili.

Vitrification kubhekwa njengento inguquko ikhishiwe lapho ikhambi ebandayo ngaphansi ukupholisa ngezansi lokushisa ingilazi inguquko. Ngesikhathi esifanayo luhlala isakhiwo amorphous ingilazi futhi uthola izinga efana ukudla okuqinile crystalline. Ngakho, kokubili ngamangqamuzana aphilayo, ngisho lonke umbungu uguqulwe "ingilazi". isakhiwo Glassy ketshezi etholwe ngaphansi vitrification ngenxa Ukupholisa yayo okusheshayo, isb entropy ketshezi kuyehla esikhathini esifushane isikhathi ngokungadingekile entropy crystal nesakhiwo.

Ngamagama alula, uketshezi ayigongobali uma wawusondela entropy ukuze entropy crystal. Kodwa ukuze vitrified kahle eziphilayo, kubalulekile ukuba sifinyelele izinga lokushisa nokwehla ≈ 108 ° C / imiz., Futhi akunakwenzeka practice, ngoba isicelo ketshezi cryogenic alanele lokhu lokushisa, futhi ayikwazi ukusetshenziswa vitrifitsiruemy isixazululo emqulwini ezincane kuno ivolumu oocyte. Lokhu zonke iphakamisa futhi vitrification zemibungu. Kuyini, manje ucishe ecacile.

Ososayensi bakwazi ukuqinisekisa ukuthi ukwanda ngoLwesithathu ukumisa cryoprotectants ikuvumela ukuba ngokushesha wehlise ijubane okokuqandisa. Ngakho, encwadini kwabantu of 10% propylene glycol nesivinini etilengligolya ancipha kakhulu, engamaphesenti angu-40 ka-kwabantu vitrification kungenzeka ngesilinganiso Ukuphola-10 ° C / imiz, futhi 60% izinga lehla 50 ° C / imiz. Kodwa nokwanda kwabantu cryoprotectants, falling ngoLwesithathu, okwandisa ingozi yazo ongemuhle okokuqandisa biomaterials. Slow okokuqandisa kuphakamisa ekuqongeleleni amanzi chilled ngendlela umzimba begazi futhi isici intracellular. isimo esinjalo kwenzeka ngenxa ezinzima amanzi emzimbeni amaseli nge ukubonakala ice extracellular.

Ngakho, ekwamukelweni izakhiwo Vitreous aphule zamakhemikhali izinqubo zemvelo zokuntula amanzi emzimbeni. Naphezu kweqiniso lokuthi vitrification zemibungu (lokhu okusho ukuthi, uye wachazwa ngokuningiliziwe ngenhla) pretty kanzima uhlelo ngokomzimba, mathiriyeli lo isakhiwo zingatholakala ekuphileni kwethu kwansuku zonke (ingilazi, i-silicon, nokunye).

Vitrification zemibungu: Izibuyekezo

Le ndlela iqoqa okubuyayo kuphela. Inqubo vitrification Kuyinto nokwenzeka. Kodwa-ke has a lot of izici ngezigaba ezahlukene zentuthuko laboratories IVF. Vitrification - akuyona indlela entsha cryopreservation ngamangqamuzana aphilayo. Yena kuyisinyathelo lokugcina okokuqandisa kancane. Namuhla, abesifazane abaningi bayakwazi ukuba babe nomntwana ngoba kwenqubekela-phambili kwezesayensi.

okutholakele

Ngenxa umsebenzi ososayensi abaningi vitrification engenziwa ngaphandle kokusebenzisa amathuluzi okulima abizayo efrijini zahlelwa futhi usebenzisa umshini elula ukuthi uqaphe opharetha. Ngakho, indlela lula futhi umphumela ngcono. Naphezu kwentuthuko enkulu e cryopreservation, ukuqaliswa nokongiwa efanele yezinto eziphilayo ashisa ongaphakeme namuhla akunakwenzeka.

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