ALT. AST egazini

ALT, AST - ngamaphrotheni ekhethekile - ngokunembile, uketshezi eziqukethwe amaseli ezizibandakanyile umzimba amino acid - leso sidakamizwa okuyinto amaprotheni zakhiwa. Indlela u-ALT AST eziqukethwe kuphela kumaseli womuntu. Yinye kuphela isizathu esenza ALT, AST lingene egazini - zilimele noma ukucekelwa phansi amaseli ababehlezi kuyo. Lezi enzyme engatholakali esilinganayo (kuyalingana) kuzo zonke izinhlaka. Ngakho-ke, uma anda amazinga igazi omunye la ma-enzyme, kungase kube uphawu lokungabi sifo isitho esithile. Ngakho, ngokwesibonelo, phakathi yimuphi izifo zesibindi UMTHETHO liphuma ngokwezinga elikhulu ukwedlula UMTHETHO. Ngo-acute isilethikusebenza ALT futhi ngokuphawulekayo kunakunoma AST. umsebenzi AST is kakhulu anda ezinzima umonakalo hepatocyte. Ngokuvamile, umsebenzi AST libhekisela isilinganiso umsebenzi ALT njengoba 1 kuya ku-3 (okubizwa ngokuthi "de Ritis Coefficient"). Mayelana 10 noma izinsuku eziyi-15 ngaphambi ukuqala izimpawu jaundice umsebenzi la ma-enzyme nakho kuyanda. Futhi amasonto ambalwa ngaphambi ukubukeka ukusha kwesibindi kohlobo B liyavela futhi ALT anda AST, okuyinto ifinyelela esiphezulu kuleli viki lesi sifo wesibili noma wesithathu. Futhi ukugeleza evumayo lesi sifo ngosuku lemali 30-40e ALT ubuyela evamile yayo, kuyilapho inani labantu okufanele UMTHETHO - at 25-31. Uma Nokho, kukhuphuke ALT AST liphindwe, lokhu kubonisa ukuthi necrosis isitho onesifo noma okuphindiwe iqhubeka. Kodwa uma lesi sifo uye wathuthela acute nasesikhathini ezingamahlalakhona - ke inani enzyme eziphawulwe ngenhla okunzima egazini akusho wehlise ngokuhamba kwesikhathi ngenkathi asele esitebeleni noma ziyanda.

Lapho ukugeleza isibindi sibe sesomile injalo esicashile, la ma-enzyme ukwanda cishe ningagcini. Nokho, uma isiguli isibindi sibe sesomile ngendlela esebenzayo, ukwanda ALT AST nemithi, kodwa kunalokho ezincane. ukwanda okungaka itholwe iningi labo abagulayo yefomu asebenzayo of isifo sokusha kwesibindi.

Ukuze ulungise ALT usebenzisa ukuhlola ebucayi amaningi kunalawo kuncuma inani AST egazini. Thola umsebenzi la ma-enzyme ukusiza ukuhlolwa igazi. ALT zitholakala ngokuyinhloko kumaseli kwezitho ezifana isibindi, imisipha lwamathambo, inhliziyo, izinso kanye amanyikwe. Uma sekube sanoma yikuphi ukulimala kwe lezi zitho (avame - ngoba isifo), kulesi simo-ALT ku ngegazi elalisesandleni akufanele ukuba izikhonzi zalowo umzimba engumqemane. Imiphumela yaloku kuhlola okungenhla okungafunwa ukwandisa umsebenzi enzyme indima ebalulekile eyadlalwa ukuhlaziywa esifike igazi. ALT, AST, eba igazi, enye indlela ukuchaza kuba cishe kungenakwenzeka. Wenza okuhlukile ungenziwa kuphela ukwenza umchamo.

AST nalo elondolozwe ku myocardium, imisipha yohlaka, isibindi kanye nezicubu sezinzwa. Ngaphansi kuka izinso, amanyikwe kanye namaphaphu. Uma izidumbu oshiwo ngenhla zilimele, kuholela yokuthi ezingeni egazini luyanda AST kanye siphezulu kunokuvamile. Ngakho, kukhuphuke ALT futhi AST - Yilesi isibonakaliso wokuqala ukuthi nanoma yimuphi - noma yiziphi izitho la ma-enzyme atholakala lapho, kwenzeka inkinga.

Norma enzyme kwabesifazane labesilisa akufani. Isilinganiso ALT besilisa akazidluli amayunithi 47 ilitha, futhi abesifazane ALT, AST - kokubili amagugu kumele singeqi amayunithi 31 ilitha ngayinye. Ezinganeni, lezi zibalo ayahluka yobudala kanye ocansini. Ngo abafana, ngesilinganiso AST, ALT phakathi kungaba Amakilasi ambalwa ilitha ephakeme kunaleyo inkomba efanayo ontanga yabo ngalinye.

Akukhona njalo nokwanda kokungabi la ma-enzyme kuwuphawu ukugula. Ngokwesibonelo, u-ALT yanda, AST ngokuvamile kwenzeka labo are yenethiwekhi ephelele ye-hepatitis B antigen Lokhu kubonisa ukuthi esibindini kukhona asymptomatic, kodwa kunalokho izinqubo asebenzayo. Kaningi umama okhathazekile wafunda yayiyini ukuhlaziywa kwegazi - ALT, AST anda ingane. Uma ingane incane futhi ingeqi engu-6 izinyanga - kulesi simo, ezingeni yalezi izinto egazini lakhe angase eqiwe, futhi kuba - hhayi ukuhlukumeza ka kuyinsakavukela.

Uma, njengoba kuboniswa ukuhlolwa igazi, ALT, AST kwabesifazane abakhulelwe akuyona evamile, maningi amathuba okuthi ngenxa yokwanda koshintsho begazi besifazane. Cishe 6 izinyanga yokuqala inqubo sokukhulelwa ALT angawa (nakuba kwezinye izimo liyophuma kule nkathi, okuyilona elisebenzayo futhi ayibonisi ukuthi isifo). Ngaphezu kwalokho, maduze nje ngaphambi kokuzalwa, inani la ma-enzyme, owesifazane angase sibe ngaphezu ngesilinganiso izikhathi ezimbili kuya kwemithathu. Lokhu ngokuvamile kuba ubufakazi obuhle ukuhlolwa igazi. ALT, AST, kukhuphuke ngesikhathi sokukhulelwa, ngokuvamile ungakhulumi yisiphi isifo.