Izidakamizwa "Metodzhekt" futhi "Methotrexate" - yini umehluko?

Kulesi sihloko sibheka amalungiselelo "Metodzhekt" futhi "Methotrexate". Uyini umehluko phakathi kwalokhu? On lokhu kamuva.

"Metodzhekt" iyi-ejenti anticancer, okuyinto kunomphumela ophawulekayo immunosuppressive, kuba i-folic acid isitha. Ingabe ukuyeka mitosis yeselula. Umsebenzi wayo oyinhloko futhi uba okusithiyayo of reductase dihydrofolate, iprotheni ayisihluthulelo ekunciphiseni dihydrofolate tetrahydrofolic acid. Izindleko zomuthi - kusuka 700 ruble 1100.

Isenzakalo esidume kunazo zonke Analogue "Metodzhekt" ukulungiselela Austria "Methotrexate Ebewe".

izindleko zawo Kuyinto kule ezahlukene kuka-400 no-1200 ruble.

Ukwakheka "Metodzhekta"

The main isithako zomuthi kuyinto methotrexate disodium. izingxenye engeziwe: chloride sodium, sodium hydroxide, amanzi distilled.

Kuyinto ngempumelelo mayelana zizalela namaseli ekhula ngokushesha. Ikakhulukazi libhekisela EPITHELIAL amaseli bese neoplasms ebulalayo.

Ngezinye isicelo njalo aqoqana kwezicubu. Excreted ngu nezinso Bile. Uma ebucayini izinso umsebenzi, excretion kusuka emzimbeni kubambezela. Kungaphinde ukubambezela futhi ngimpofu kokusebenza kwesibindi.

Ukwakheka "Methotrexate Ebewe"

Njengengxenye izidakamizwa isithako efanayo esebenzayo - methotrexate. It has immunosuppressive, anti-isimila izakhiwo.

It has bioavailability ezinhle excreted ku umchamo kanye nengcosana Bile. It avame ukunqwabelana ezicutshini ngesimo metabolites.

Ngakho, "Metodzhekt" futhi "Methotrexate" - yini umehluko? Ngokwe Ukwakheka kanye nokusebenza cishe ezifanayo.

Kwezinye izimo, ayabelwe "Metodzhekt"?

Izidakamizwa "Metodzhekt 'in Oncology kuyaqabukela esetshenziswa. It is kuboniswe ngoba izifo zesikhumba nezifo emalungeni, njenge:

• Psoriasis, okuyinto kunzima ukuyelapha.
• rheumatoid arthritis.
• sokuqaqamba kwamalunga Juvenile.
• arthritis psoriatic.

immunosuppressive senziwa futhi izakhiwo eqeda ukuvuvukala imithi. Lokhu kuchaza ukusebenza e lezi zifo.

Ukusetshenziswa "Methotrexate" izidakamizwa

Empeleni, "Methotrexate" wabonisa for wokwelapha isifo somdlavuza:

• acute wegazi lymphocytic;
• isifo trophoblastic;
• umdlavuza wesikhumba;
• umdlavuza wesibeletho kanye ngemomozi;
• umdlavuza emphinjeni;
• -squamous cell carcinoma we ikhanda nentamo;
• umdlavuza ukhalo kwezinso futhi ureter;
• futhi sarcomas osteogenic myagkokletochnoy;
• Sarcoma Ewing sika, umdlavuza wamaphaphu, umdlavuza webele;
• lwegciwane cell izimila testis kanye esibelethweni;
• nomdlavuza wesibindi, umdlavuza izinso;
• retinoblastoma, medulloblastoma;
• umdlavuza penile;
• isifo Hodgkin sika.

Ngaphezu kwalokho, kufanele kuphawulwe ukuthi nomuthi sisetshenziswa futhi amafomu ezinzima psoriasis kanye uma ezinzima-rheumatoid arthritis (uma ukwelashwa eyanele kwaba ayizwakali).

Yilowo umehluko. "Metodzhekt" futhi "Methotrexate" asetshenziselwa izifo ezahlukene. Ngakho, "Metodzhekt" - ekwelapheni psoriasis nesifo sokuqaqamba kwamalunga, njengoba "MTX" - in Oncology. Kodwa zingelashwa bese, nokuningi.

Ukukhishwa

"Metodzhekt" - isixazululo kucace ophuzi. Bathengisa kanye imijovo, okuyinto enzelwe ukuthi iqondiswa ngaphansi kwesikhumba, ku imisipha noma emthanjeni.

"Methotrexate" ungaphakathi ampoules kanye amaphilisi.

Njengoba imithi esetshenziswa?

Umthamo zomuthi akhethiwe nge udokotela ukuba khona umuntu ngamunye. Yiqiniso, uma kungekho contraindications. Isetshenziselwa hhayi izikhathi ezingaphezu kwesisodwa ngesonto.

Isiguli kumelwe athathe nokuhlola ngaphambi kokusebenzisa. Kusengaphambili, esikhathini esingangesonto, ukwenza ukuvivinya kwabathinta ngemadlana encane zomuthi, uma umzimba iyaphendula evamile, ukwelapha kungaba kwenziwe.

ukulungiselela kusengaphambili awusebenzi Lapho engemihle. Okokuqala, umthamo ubuncane nomuthi yethulwa, okuyinto 7.5 mg. Khona-ke kancane kancane, ne tolerability ezinhle futhi izinkomba ekhona.

Ngemva kwezinyanga ezimbalwa emva isicelo sokuqala uzophawula umphumela. Inkambo ingahlala isikhathi eside, kuze iminyaka eminingana.

Ukusetshenziswa kwabesifazane abakhulelwe kanye lactating

Lapha umehluko? "Metodzhekt" futhi "Methotrexate" akufanele athathwe phakathi nokukhulelwa kanye lactation.

"Metodzhekt" kuyinto anobuthi ezingenzeka embungwini kungaholela thuthuva sína ukuthuthukiswa futhi kuze kube ngisho nasekufeni kwakhe. Ngo webele ubisi avame ukunqwabelana, ezingasetshenziswa futhi zingayilimaza impilo womntwana.

Uma ukukhulelwa ngesikhatsi ukwelashwa, kungase kube nemiphumela engathandeki ingane. Ngakho-ke kudingeka ukuvimbela inzalo ngokucophelela ngesikhathi yokwelapha.

Siqhathanisa "Metodzhekt" izidakamizwa "Methotrexate Ebewe". Uyini umehluko, kwaba kuyaqondakala. Ingabe uphenyo eminye.

"Metodzhekta" Izimo

Umuthi akufanele isetshenziswe uma kukhona hypersensitivity kuya izingxenye. Futhi akufanele sisetshenziswe uma:

• Alcohol Abuse.
• Isibindi kanye nezinso.
• Hemodyscrasia.
• EBukhoneni ulcer ipheshana yesisu nasesikhathini ngalo ingaphakathi ngomlomo.
• Ukugonywa (ngenxa ukuncishiswa ukuzivikela komzimba, lokugoma kufanele sigcwaliswe reception ngemuva kwezinyanga eziyisithupha kuphela inqanyulwe).
• izifo oyingozi futhi ezingalapheki (kuhlanganise izifo yamuva).
• izifo sokuhlasela kwamasosha omzimba.

isicelo Qaphela kufanele kube uma kukhona:

• I-Herpes.
• Pleural futhi effusions peritoneal.
• Ascites.
• Ukuvuvukala Kwamalunga.
• izifo Obstructive wokugaya ukudla.
• Ukuphelelwa amanzi emzimbeni (siyabhubha amanzi ibhalansi kusho ukwanda ubuthi).
• Asthenia.
• A lokuhlushwa enkulu bilirubin.
• Ukuhlanza nokukhishwa yisisu.
• Ukuqhuba zamakhemikhali ukwelashwa ngemisebe umlando.

"Metodzhekt" zama hhayi ezomisa abadala ngoba kungenzeka ukuthi lokhu kwaphazamisa isibindi kanye nezinso. Ikakhulukazi, ungayisebenzisi "Metodzhekt" futhi "MTX" e UC (izilonda emathunjini).

Kwezinye izimo, kwenqatshelwe ukusebenzisa imithi, "Methotrexate"?

Lapho uzwakalise isibindi womuntu kanye / noma sezinso, leukopenia, thrombocytopenia, nokukhulelwa kanye lactation. Immunodeficiency uthi nazo contraindicated ukusetshenziswa "methotrexate".

Lapho imithi ukwelapha isifo samathambo onaso sibe noma psoriasis, kanye ngenyanga, ukunikeza igazi biochemistry, njengoba ezimweni zaselebhu kubalulekile ukuhlola nezinso isibindi nge imvamisa izikhathi 1-2 ngamunye izinyanga ezimbili.

Lapho psoriasis iphathwa, therapy is kwaqhubeka isicelo sendawo zomuthi.

Uma kwenzeke ukweqisa izidakamizwa, isiguli Kufanele ufake angaphezu kwe-calcium ngamahora amane lokuqala.

Ukuxhumana nezinye izidakamizwa "methotrexate"

"Methotrexate" kwenqatshelwe ukuyisebenzisa nge imithi ezilandelayo:

- izidakamizwa ezingekho steroidal anti-inflammatory;

- penicillin elwa namagciwane okufakwa ekudleni;

- sulfonamides;

- valproic acid;

- colestyramine;

- mercaptopurine;

- neomycin;

- paramomitsinom;

- omeprazole;

- retinoids;

- tetracycline;

- cyclosporine.

Lawa Izimo "Metodzhekt" kwemithi kanye "Methotrexate". Uyini umehluko? Izibuyekezo basikisele ukuba zidluliselwa kanzima ngokulinganayo.

Ukuxhumana "Metodzhekta" nezinye izindlela

reception Kanyekanye "Metodzhekta" nezinye izidakamizwa kuholela noma yokudla yanda, noma nciphisa umphumela zokwelapha. Uma ufuna ukuhlanganisa nganoma iyiphi indlela, kungcono ukwazisa onguchwepheshe.

"Metodzhekt" kuthathwe ngokuqapha nge:

• izidakamizwa Hepatotoxic.
• Izidakamizwa, igazi ezicindezelayo.
• Izidakamizwa ezithinta umnkantsha.
• Utshwala.
• Imithi elwa namagciwane.
• Ama-NSAID futhi salicylates.

uhlu okunqatshelwe kwemithi libanzi. Kumele kukhunjulwe ukuthi ukuxhumana "Metodzhektom" kuzokwenza esindayo kakhulu ubuthi anobuthi komzimba (ukufa is hhayi ngaphandle). Ngezinye izikhathi kungase kuholele izinhlobo zomdlavuza wesikhumba.

itiye Green futhi ikhofi futhi ziyavalwa, kanye iziphuzo kusukela purine alkaloids, theophylline ne-caffeine. Isizathu salokho - kwedivayisi ezimbi nge methotrexate. Kungaba kakhulu alibale ukususwa kwabo.

Kufanele kuqashelwe ukuthi uma ethola ukwelashwa ubonisa Vitamin izakhiwo kanye amalungiselelo equkethe folate, ngoba ukunciphisa izakhiwo anobuthi.

Yikuphi izidakamizwa ukukhetha - "Metodzhekt" futhi "Methotrexate"? Yikuphi okungcono? On lokhu kamuva.

side effects

Imiphumela engemihle ingase ibe khona ehlukile, kodwa ngokuvamile kakhulu kuthinta izinhlaka pheshana emathunjini. Nge imvamisa nobukhali kuphakama, kuncike umthamo kanye izici ngamunye umzimba.

Vela side effects ngokuyinhloko:

• Stomatitis.
• Isicanucanu.
• Ukucindezeleka.
• Isifo sokulahlekelwa yigazi.
• Dermatitis.
• Ubuhlungu bekhanda nesiyezi.
• ukujuluka ngokweqile nomkhuhlane.
• Komzimba futhi ukushaqeka anaphylactic.
• Pericarditis.
• Thromboembolism.
• inyumoniya sesikhala.
• yizifo ezihlukahlukene ezithathelwanayo.

ngezinye izikhathi:

• Ukuhlanza.
• Alopecia.
• Vasculitis.
• Pharyngitis.
• Paresthesia we ephansi nemilenze, iminwe yakhe nezinzwani zakhe.

ezingavamile kakhulu:

• Ngibanjwe nokukhubazeka.
• Visual ukungakhuli.
• esingamahlalakhona yamaphaphu.
• Myalgia.
• Lokhu kwakubangelwa ukukhumuzeka kwamathambo.

Kwangathi ukuthuthukisa pancreatitis, isifo sikashukela, ubuthakathaka, ukungazali, ngisho kungenzeka ukuvela izimila.

Uyini umehluko phakathi Metodzhekt izidakamizwa ' "nethi" Methotrexate "? Lo mbuzo iyathakazelisa eziningi.

Qiniseka ukuthi izivivinyo njalo yalezo ziguli belashwa "Metodzhektom". Ngakho-ke kungavinjelwa ukudakwa. imiphumela ebuhlungu yale esabekayo, mhlawumbe ebulalayo.

Okunqatshelwe ukushayela phakathi ukwelashwa kanye nomsebenzi nge imishini kuyingozi.

Ngokulandelako, cabangela imiphumela emibi izidakamizwa ezifana "Metodzhekt" futhi "MTX". Uyini umehluko phakathi kwalokhu?

Imiphumela emibi "methotrexate"

On the ingxenye isimiso sokugaya ukudla bungene kungenzeka kuwukubonakaliswa stomatitis izilonda emathunjini, sokuzincisha ukudla, gingivitis, pharyngitis, isicanucanu; ezimweni ezingajwayelekile - uhudo, melena, enteritis, pancreatitis, necrosis hepatic, isifo sokuqina kwesibindi yoma amafutha, cystic periportal.

hematopoietic uhlelo angaphendula leukopenia, ukuntuleka kwegazi emzimbeni, thrombocytopenia.

Central nervous system - ukutubeka komzimba, isiyezi; ezimweni ezingajwayelekile - ikhanda, aphasia, ukozela, Ukudlikizela.

uhlelo wokuzala - kuphula umthetho we oogenesis futhi spermatogenesis, oligospermia, ukuphazamiseka kokuya esikhathini, kwehle libido, nokuvusa induku.

uhlelo urinary - hematuria, cystitis, ezinzima kahle umsebenzi kwezinso.

Engaveza ukusabela elandelayo iguliswa: imfiva, ukumelana sehliselwe ukutheleleka; ezimweni ezingajwayelekile - urticaria, ezinobuthi epidermal necrolysis, Stevens-Johnson syndrome.

ukusabela dermatological - ukuqubuka kwesikhumba, ukukhishwa photosensitivity, lesikhumba neziyaluyalu, induna, amathumba.

Lapho yimuphi ukusabela ezingezinhle emuthini kufanele axhumane ngokushesha ne udokotela.

ukweqisa izidakamizwa

Ukweqisa izidakamizwa kuyingozi ohlelweni hematopoietic. Kulezi zimo, umzimba kuyinto hydration. Lokhu kungaba kusheshiswe excretion we ketshezi esebenzayo. Esabelwa futhi ukuthola i-folic acid.

Imibandela kanye nemigomo

Sibheka "Metodzhekt" futhi "Methotrexate". Umehluko uthathe indawo empilweni eshalofini iyatholakala.

I eyomile nemnyama ezingeni lokushisa esingeqile degrees 25, ugcine lezi imithi. Qiniseka ukuhlanza kude nezingane. Ukukhanya kwelanga futhi umswakama basuke contraindicated. Misa kubo engenakwenzeka.

"Metodzhekt" langakufanelekela iminyaka engu-2 kusuka usuku ukwakhiwa, "Methotrexate" - engu-3.

Lezi ezahlukene "Metodzhekt" futhi "Methotrexate". Uyini umehluko okwamanje?

Uma eqhathaniswa "Metodzhektom", ungakhetha ezinye izinga olwehlukanisa "methotrexate". ukungaphathwa kahle imithi kuba kungenzeka, kodwa, ngokubona iziguli, zenzeka kancane njalo. "Methotrexate" liyatholakala amaphilisi, ngoba iziguli eziningi, leli fomu isimo sikuvumela.

Ngakho, siye wachaza ngokuningiliziwe ukusetshenziswa "Metodzhekt" izidakamizwa "Methotrexate". Uyini umehluko, manje sobala.