Amakhandlela Bheka "Flex": Umhlahlandlela, ukubuyekezwa, amanani, analogs

"Flex" Amakhandlela iqembu zemithi ama-NSAID (non-steroidal anti-inflammatory ejenti). It has eqeda ukuvuvukala, antipyretic, analgesic kanye antiagregatsionnoe senzo. Kwethulwa amabhlogo izidakamizwa umsebenzi enzayimu (cyclooxygenases 1 no-2) kanye prostaglandin zamagama. Le nqubo ivikela kumiswa balamuli ukuvuvukala futhi kuvimbela ukubonakala leukotrienes.

Amakhandlela Bheka "flex" antibradikininovuyu umsebenzi umbukiso, usimamise lysosomal biomembrane, imbangela okusithiyayo womsebenzi neutrophil ezigulini kwathiwa unesifo "samathambo". Zivimbela platelet wokuhlanganisa. Umthelela analgesic kungenxa kokubili izindlela emaphakathi kanye neuropathy. Odokotela abaningi ngoba ukukhululeka ubuhlungu kanye arthritis ukwelashwa okunqunyiwe "Flex" (amakhandlela). Intengo zomuthi kwenza kube nokwenzeka ukuba sikuzuze izigaba ezahlukene iziguli. Uphenyo nomuthi ezifakazela nokusebenza ngendlela ephakeme nephephile zempilo kuhambisana nezincomo.

Yokusetshenziswa zomuthi oluphakeme elula, kanye nokubuyekeza ukuqinisekisa umphumela sobala zokwelapha. Lokho ingxenye izidakamizwa? Yini izakhiwo ke anazo? Ingabe kukhona eziyingozi side effects? Izimpendulo zale mibuzo athungatha iziguli eziningi.

I amakhemikhali ukwakheka zomuthi

Ukulungiswa kuyinto eyinkimbinkimbi izinto bioactive futhi excipients:

• Ketoprofen (eziyisisekelo kwakwakhe bioactive);
• ngengcina yezinyosi;
• hydrogenated amafutha yemifino;
• colloidal Silicon dioxide;
• sodium ETHYL parahydroxybenzoate;
• sorbitol;
• gelatin;
• amafutha yemifino;
• glycerol;
• soy lecithin;
• titanium dioxide;
• sodium propyl parahydroxybenzoate.

"Flex" amakhandlela analogue

Ngo zokwelapha umkhuba odokotela kunalokho ngenkuthalo usebenzisa analogue of ekwakhiweni elichazwe ngenhla:

• "Artrozilen".
• "Ketonal Duo".
• "Artrum".
• "Bystrumgel".
• "Valusal".
• "Bystrumkaps".
• "Ketonal".
• "Oruvel".
• "Febrofit".
• "Flamaks".
• "Profenid".
• "Ketonal uno".

izinzuzo izidakamizwa

Izinzuzo main zomuthi kuzomele sifake indices ezilandelayo:

• umphumela esiphezulu ezelaphayo;
• bioavailability okusezingeni eliphezulu zomuthi kuqhathaniswa nontanga bayo.

nemibi izidakamizwa

I nemiphumela ethile engathandeki eyinhloko "Flex" kuzomele sifake nalezi zidingo ezilandelayo:

• amanani entengo aphezulu izidakamizwa kuqhathaniswa nontanga;
• akutholakali nsuku zonke (nokunwetshiwe) Ukukhululwa amafomu.

Pharmacokinetics

Bondability izinto bioactive izidakamizwa kanye namaprotheni plasma singamaphesenti angu 99. Amakhandlela Bheka "flex" zinezikhathi bioavailability okusezingeni eliphezulu (90%). okuhlushwa zokwelapha "Flex" egazini inakekelwa amahora 6. Main cleavage umzimba izidakamizwa kwenzeka hepatocytes ngu glyukorirovaniya. Ingxenye-ukuphila cishe amahora amabili. Umuthi akuyona cumulated, isuselwe ikakhulukazi izinso ngokusebenzisa namathumbu.

"Flex" (ikhandlela): yokusetshenziswa, intengo

I nomuthi ngenhla liveza spectrum ebanzi isinyathelo zokwelapha. "Flex" amakhandlela zivame ebekiwe umkhuba emtholampilo ekwelapheni ubuhlungu kanye ukusabela ukuvuvukala zasezindaweni ezihlukahlukene. Ukusetshenziswa imithi Kunconywa pathologies ezilandelayo:

• migraine;
• arthritis psoriatic;
• tenosynovitis;
• colic kwezinso;
• sokuqaqamba kwamalunga gouty;
• bursitis;
• dorsalgia;
• myalgia;
• rheumatoid arthritis;
• abezindaba otitis;
• osteoarthritis kwasendaweni ezahlukene;
• polymyalgia rheumatica;
• ubuhlungu bone;
• sciatica;
• phlebitis;
• ankylosing spondylitis;
• neuralgia;
• thrombophlebitis;
• sciatica;
• adnexitis;
• Pathology ku plexus lumbosacral;
• sciatica;
• algodismenorei;
• nasezinkingeni ezilandela ngemva kokuhlinzwa kwe- senzakalo ukucindezeleka ngenxa yezinhlekelele syndrome ;
• lymphangitis;
• ubuhlungu umdlavuza pathologies.

Thenga izidakamizwa "Flex", intengo zazo luyehluka in the ububanzi ruble 200-300, uma une-kadokotela ngasiphi ekhemisi. Futhi uzinake ukuthi amakhandlela "Flex" e zabesifazane sasivumela ngokuvamile isetshenziswa yabo engabelwe simila wesibeletho. Ngokusho kobufakazi iziguli eziningi, imithi isebenza ngempumelelo. Odokotela abaningi bathi emva kokwelashwa "Fleksenom" izinsuku 10 bese uthola imithi eyengeziwe simila iphele.

Izimo

Uma unquma ukusebenzisa "Flex" (amakhandlela), imfundo manual ikhomba ukuthi lokhu izidakamizwa akufanele isetshenziswe kulezi zimo ezilandelayo:

• ukopha pheshana emathunjini;
• obonakaliswe izinso futhi isibindi ukungasebenzi;
• nokukhulelwa kanye lactation isikhathi;
• hypersensitivity yokungakhokhi steroidal izidakamizwa eqeda ukuvuvukala;
• hemorrhoids;
• "Aspirin" somoya;
• iziyaluyalu kwegazi ekunqandeni ;
• proctitis;
• yobudala engaphansi kwengu-15;
• ukungasebenzi kohlelo hematopoietic (leukopenia, coagulation neziyaluyalu, thrombocytopenia, hemophilia);
• wamathumbu isifo exacerbation.

imiyalelo Special

"Flex" (amakhandlela) Umhlahlandlela ekhombisa kusetshenziswe ngokuqapha in iziguli ukungasebenzi kwezinso, isibindi, ipheshana wokugaya ukudla, isifuba somoya bronchial, ukuba umlutha wotshwala, rhinitis, ngesikhathi ama-polyp ku acinene mucosa, ukuntuleka kwamanzi emzimbeni, urticaria, ukubhema, isifo sokuqina kwesibindi hyperbilirubinemia, izifo igazi sepsis, isifo sikashukela, pathologies umgogodla, abantu asebekhulile. Phakathi ukwelashwa nge nomuthi wathi kudinga ukuqapha ehlelekile umsebenzi so-renal kanye isibindi. Uma "Flex" amakhandlela esimisiwe ngokuhlanganyela anticoagulants (heparin), kwengozi ebangela ukopha. Yiqiniso Long zokwelapha kungenzeka kuphela nemibandela esibhedlela. Phakathi ukwelashwa, gwema ukuthatha izinhlobo zophuzo oludakayo.

isicinganani

Oyinikezwe "Flex" (amakhandlela)? Iziyalezo yokusetshenziswa akusho ukubeka eceleni ukuthuthukiswa amathuba okuba nemiphumela engemihle. Ziyakwazi:

• izinhlungu zekhanda ezinamandla;
• isicanucanu;
• isilungulela;
• isiyezi;
• ukuhlanza;
• ukungakuthandi ukudla;
• ukuqwasha;
• ukopha emathunjini;
• asthenia;
• ukozela;
• conjunctivitis;
• xerophthalmia;
• ukwethuka;
• ukuqunjelwa;
• tinnitus;
• lokukhohlwa;
• angaboni kahle;
• ukusha kwesibindi kohlobo;
• ukulahlekelwa kukuzwa;
• inzululwane;
• peripheral neuropathy;
• gastralgia;
• tachycardia;
• dysuria lezivakashi;
• ngamanzi;
• eczema;
• cystitis;
• syndrome nephrotic;
• urethritis;
• fotodermatit;
• edema laryngeal;
• hematuria;
• erythema;
• ukungasebenzi kwezinso;
• edema syndrome ;
• isikhumba silume;
• komzimba isikhumba;
• anda transaminases (alanine aminotransferase futhi aspartate aminotransferase) egazini serum;
• iphika;
• rhinitis;
• umongozima;
• bronchospasm;
• ukushaqeka anaphylactic.

Ukusetshenziswa suppositories kungase kubangele isifo sohudo, tenesmus Futhi ukushiswa isasasa.

Izimpawu e ukweqisa izidakamizwa

Amakhandlela Bheka "flex" zenzelwe ukusetshenziswa rectal - 1 suppository (100 mg) izikhathi 1-2 ngosuku. esiphezulu umthamo ovumelekile yansuku zonke ketoprofen - 300 mg. Izimpawu ezilandelayo kuyagcinwa uma ukweqisa izidakamizwa:

• ukungasebenzi kwe-isibindi kanye nezinso;
• ukozela;
• isicanucanu;
• ukopha;
• nobuhlungu obukhulu esifundeni epigastric;
• ukuhlanza.

Isebenza kuhle nxa izici ezingenhla babelwe yokwelapha lingaze. Lingekho ikhambi ethize. Njengoba i adsorbent isebenze namalahle, "Sorbeks", "Medetopek" noma "Neointestopan". Dialysis, diuresis ophoqelelwe - ukwelashwa ayizwakali. Yabela ejenti alkalizing ezihambisa ingxenye alimentary izimpawu umsele. glucocorticoids ingasetshenziswa uma kunesidingo. Ngo esingamahlalakhona kwezinso, hemodialysis. Ngo Ukudlikizela ukhombe "Diazepam" benzodiazepanovye noma ezinye izidakamizwa anticonvulsant; e ezinzima hypotension plasma esikhundleni iqondiswa ( "Reopoligljukin", "Poliglyukin", "Enterodez", "Polidez", "Hemodez"). Isiguli kudinga observation njalo izinsuku ezimbalwa, njengoba kukhona ingozi wawubonakalisa kamuva izifo ezithile zesisu (ukopha ulceration).

Ukuxhumana nezinye izidakamizwa

It sithuthukisa isenzo anticoagulants, fibrinolytics, ethanol, ejenti antiplatelet, kunciphisa umphumela vasodilators neuropathy, spironolactone, ukusebenza kahle imithi uricosuric, imithi yezokwelapha kanye isisu hypotensive. Ngenhla ethulwa imithi kungavumelani "Tramadol." Ukusetshenziswa ahlangene we "Flex" nezinye non-steroidal ejenti eqeda ukuvuvukala, ETHYL utshwala, corticosteroids, corticotropin kuphakamisa kumiswa izilonda kanye nokuthuthukiswa ukopha emathunjini. Antacids ukunciphisa nekusebenta ukumuncwa zomuthi. Ezinsukwini ezimbili ngaphambi ukulethwa cwaningo ku okuqukethwe 17-ketosteroids izidakamizwa amankeyane.

"Flex" kwandisa umphumela hypoglycemic insulin nezidakamizwa temlomo hypoglycemic. izidakamizwa Myelotoxic ukwandisa inkulumo izidakamizwa gematotoksichnosti. Inductors microsomal biooxidation esibindini ( "Phenylbutazone", i-ethanol, tricyclic antidepressant, "Phenytoin", "rifampicin" barbiturates) isebenze biosynthesis ka metabolites asebenzayo hydroxylated. isicelo esisodwa "flex" nge "sodium valproate" kuphazamisa platelet wokuhlanganisa.

Izibuyekezo sokulungiselela

Iziguli eziningi unesithakazelo umbuzo yini ngempela amakhandlela "flex". Yokusetshenziswa, izindleko zomuthi, izinkomba kanye contraindications - kuba Yiqiniso, lawo ngamaphuzu ayinhloko esekelwe. Noma kunjalo, kufanele azijwayeze imibono ochwepheshe kanye neziguli kule ndaba. Odokotela abaningi bakholelwa ukuthi analgesic engcono ejenti eqeda ukuvuvukala - "flex" (amakhandlela). Izimpendulo iziguli ezimweni eziningi (80 kuya ku-90%) akhayo, ngenxa ukusebenza kahle eliphezulu zomuthi, ukuqedwa kwezinhlungu okuthembekile omsakazo ezahlukene kanye kwasendaweni, umphumela kanye kalula yokusetshenziswa engapheli. A nomphumela omuhle kungenziwa kuphawulwe kusukela ezinsukwini zokuqala kakhulu yokwemukela. Izibuyekezo ezingezinhle mayelana nokulungiselela ikakhulu ezihlobene ukubukeka side effects kanye nezindleko zayo, kodwa lezi bawo imithi abakwazi akusibekele kahle yaso ephezulu.

Imibandela ukunikezela Pharmacy

I umuthi ngesimo suppositories kanye amaphilisi ezikhishwe ngokuqinile on kadokotela. A nomuthi ngesimo gel kungenziwa akhishwa ngaphandle kadokotela.

izimo isitoreji

Yigcine kude nezingane ezingeni lokushisa akukho ephakeme kuka 25-30 ° C. Elicacisiwe lokushisa ububanzi libhekisela zonke izinhlobo ukukhululwa. Usuku lokuphelelwa yisikhathi ku iphakethe. Imithi akufanele kuthathwe emva kosuku lokuphelelwa yisikhathi!