"Komfoderm": yokusetshenziswa, incazelo, ukwakheka, analogs kanye nokubuyekeza

Wazini wena mayelana nokulungiselela ezifana "Komfoderm"? Yokusetshenziswa, intengo, ukubuyekezwa, analogs izici jikelele lokhu izidakamizwa aziwa ambalwa. Ngakho-ke, kulesi sihloko, sinqume ukunikeza lonke ulwazi mayelana nemithi.

Ifomu, ukwakheka kanye nencazelo

Ukulungiselela "Komfoderm", yokusetshenziswa elichazwa kamuva, akhiqizwa ngendlela ukhilimu mhlophe futhi iphunga (kungenzeka ngaphandle futhi ube tint ukhilimu).

Izingxenye asebenzayo lokhu ejenti ukuze isicelo nezokusigcoba kukhona atseponat methylprednisolone kanye urea. Futhi namafutha okwelapha izithako asizayo lapho ethulwa njengoba upharafini liquid, propylene glycol, polysorbate 80, carbomer interpolymer (uhlobo A), trometamol, metipparagidroksibenzoata namanzi ahlanzekile.

ayelapha

Uyini izidakamizwa wendawo "Komfoderm" (ukhilimu)? Yokusetshenziswa ibika ukuthi glucocorticosteroid kanye ejenti keratolytic kanyekanye. isenzo sayo kungenxa izici yezingxenye kufakwe ngezithako zawo. Cabanga ngokuningiliziwe impahla yabo.

Methylprednisolone aceponate - lena-non-halogenated zokwenziwa steroid. Ukuze nokusetshenziswa ongaphandle, okwazi abacindezela iguliswa futhi ukuvuvukala isikhumba ukusabela kanye ukusabela okuyizinto ezihlobene ekwandeni ethuthukisiwe. ukuchayeka okunjalo kuholela ekuphikeni ukuncipha eziphawulekayo izimpawu umgomo ukuvuvukala (erythema, edema, cwilisa) futhi emizweni subjective (ukulunywa, ukucasuka ubuhlungu, njll).

Asinakusho ukuthi isicelo yalolu ketshezi at umthamo watusa yemiphumela yayo letindzala emzimbeni womuntu incane.

Ngemva ukusetshenziswa eside futhi okuphindiwe methylprednisolone aceponate ezindaweni isikhumba ezinkulu (40-60%), kanye ukunqunywa yayo ngaphansi kusaladi occlusive ezigulini ningagcini ukushayisana nezindlala adrenal, kuhlanganise amazinga cortisol akazange kwashintsha.

Ingqikithi okukhulunywa uyakwazi ukuhlanganisa uxhumano nomsebenzisi kwezinga glucocorticoid receptor intracellular, okubangela ezihlukahlukene nemiphumela yezinto eziphilayo. Ikakhulukazi, le nqubo kuholela chemical lokungeniswa macrocortin zamagama. Kulesi yokugcina kuvimbela arachidonic acid ukukhululwa kanye kumiswa balamuli ukuvuvukala efana leukotrienes futhi prostaglandins.

Iyiphi indima udlalwa ukulungiselela urea "Komfoderm"? Yokusetshenziswa uthi le ngxenye kunemiphumela hydrating futhi keratolytic. It lubopha amanzi, kanjalo ukuthambisa le corneum stratum ikhuthaza isikhumba.

Ngaphandle isinyathelo keratolytic, urea nomsebenzi ziphephile proteolytic.

kinetics

Ingabe ukhilimu amuncwa umzimba, "Komfoderm"? Yokusetshenziswa ugomela ngokuthi ngemva kwesicelo se-aceponate ithuluzi methylprednisolone hydrolyzes cishe ngokushesha e dermis kanye epidermis.

I asebenzayo iningi kanye metabolite eyinhloko ayinto kuyinto 6alfa-methyl-prednisolone 17-propionate.

I degree of dermal ukumuncwa zomuthi incike esimweni ezibhekwa integument womuntu futhi indlela okwenza ngayo ukusetshenziswa (noma ngaphandle occlusive ngebhandeshi).

ukumuncwa Percutaneous zomuthi kubantu abanegciwane psoriasis futhi atopic dermatitis bungakanani mayelana 2.5%, okuyinto kancane ngaphezu izinga amavolontiya aphilile (mayelana 0.6-1.5%).

Ngemva contact 6alfa-methylprednisolone-17-propionate egazini letindzala usakaze it is conjugated nge glucuronic acid kunalokho ngokushesha, bese inactivated.

Metabolites izindlela babhekwa iqedwe ngokuyinhloko inqamula izinso ngemva kwamahora angu-16. Izithako ezisebenzayo zomuthi kungukuthi cumulate e umzimba. Ngenxa absorbability eliphansi urea uhlelo ngezihloko ezihlukene amathuba ukhilimu yemiphumela letindzala azinakwa.

ubufakazi

Kusukela ngaleso sikhathi esimisiwe 'Komfoderm "(ukhilimu)? Yokusetshenziswa iqukethe uhlu elandelayo izinkomba:

• eczema microbial;
• dermatitis nomzimba (contact);
• neurodermatitis, dermatitis atopic;
• eczema kweqiniso;
• contact dermatitis elula;
• disgidroticheskaya eczema.

Ngamanye amazwi, lo izidakamizwa okukhulunywa kuboniswa ngenxa Izifo ukuvuvukala dermal, soprovozhdayuschihesya keratinization sifo, kanye bembonisa sensitivity high ukuze ukwelashwa nge glucocorticosteroids nezokusigcoba.

Izimo

Izidakamizwa "Komfoderm" yokusetshenziswa esidingeka ukufunda okwazo zonke iziguli, akufanele isetshenziswe:

• Hypersensitivity izakhi ukhilimu;
• sofuba noma izinqubo syphilitic e sebethule nomuthi;
• izifo ezibangelwa amagciwane (kuhlanganise varicella, herpes zoster);
• Rosacea, dermatitis perioral ekusebenziseni amakha namafutha;
• noma yiluphi uhlobo yokugoma;
• abancane.

Nomuthi "Komfoderm" (wamafutha): yokusetshenziswa

Inani yokubika ejenti kuyinto ruble mayelana 480-530. Umuthi isetshenziswa ezindaweni isikhumba ethintekile nge ungqimba elincanyana, kanye ngosuku.

Isikhathi ukwelashwa okuqhubekayo futhi nsuku zonke nale ukhilimu kumele singeqi amasonto 12. Kufanele kuqashelwe ukuthi ukwelapha izilonda zesikhumba kufanele kwenziwe izinsuku 5.

side effects

Wenzenjani ngokwemvelo kungabangela imithi "Komfoderm M2"? Iziyalezo imibiko ukusetshenziswa imiphumela enjalo ezingajwayelekile kakhulu. Ngokuvamile avele ngendlela ukusabela elandelayo wendawo: ukulunywa, erythema, evutha ukuzwa, kumiswa ukuqubuka vesicular.

Kuleso simo, uma nomuthi isetshenziswa amasonto angaphezu kwamane, noma kwezinye izindawo enkulu isikhumba, isiguli singase ukuthuthukisa isikhumba yoma noma telangiectasia futhi avele akneformnye izinguquko, elula amamaki imiphumela letindzala, okuyinto zibangelwa ukumuncwa kwe-ngama-corticosteroid.

izidakamizwa Futhi ngezinye izikhathi kubhekwa kubangela hypertrichosis, folliculitis, depigmentation kwesikhumba, dermatitis perioral, nokungezwani komzimba.

Umthengi ukubuyekezwa kanye analogue "Komfoderma"

kuphela ukhilimu "Advantan" libhekisela analogs yalesi izidakamizwa.

Yini abantu bathini mayelana "Komfoderm" iziguli wamafutha? Ngokusho izimpendulo zabo, i-nomuthi okukhulunywa iyindlela bendawo baphumelela kakhulu. isicelo sayo ikuvumela ukuba balahle izifo ezihlukahlukene isikhumba, kuhlanganise eczema, neurodermatitis, futhi dermatitis. Kwezinye izimo, umuthi isetshenziswa ngisho psoriasis.

I nemibi "Komfoderm" wamafutha zihlanganisa izindleko zalo okusezingeni eliphezulu, kanye nokungakwazi ukusebenzisa izingane.