Triptans ngoba migraine. Triptans: izidakamizwa amanani

Migraine - inkinga iziguli eziningi. Cishe wonke umuntu okungenani kanye nobuhlungu esaphila nakho ekhanda. Njengomthetho, basuke ephelezelwa isiyezi, isicanucanu, ukuhlanza, kanye ndikindiki esibuhlungu kanye ubuthaka emikhawulweni, faneleki futhi phonophobia. Ngemva ukuhlaselwa, iziguli esekhala ukukhathala, ukucobeka futhi ukozela. Ngezinye izikhathi kuba lapho lesi sifo ngakho ugijima, ukuthi ungenziwa kuphela ukusiza isiguli triptans wezakhiwo. Kufanele kuqashelwe ukuthi migraine - isifo abesifazane, njengoba ziyashesha kakhulu zokugula ezinjalo, kunabantu. Cishe 10-18% abantu abadala ukuthi nginesifo migraine.

Inkinga bekhanda obujwayelekile yilowo nalowo

Abantu abaningi-ke kangizidingeli usizo lwezokwelapha abaqeqeshiwe futhi uzama ukubhekana nalesi sifo, uma uthatha analgesics. Akubuzwa, le ndlela yokukhuluma kungasizi, kodwa kuchubekisela embili isifo kuphela. Ukusetshenziswa engalawuliwe analgesics kungabangela ukuthuthukiswa izidakamizwa ngenxa bekhanda ezingamahlalakhona. Ngakho-ke, akumangazi ukuthi kukhona lenqwaba imibuzo mayelana onjani ikhanda amaphilisi - ephumelela kunazo.

Ngokuphelele ukwelapha migraine akunakwenzeka, kodwa ukuthuthukisa izinga lempilo kungenzeka imikhiqizo ekhethekile, okuyinto bamiswa isazi sezinzwa. Kukhona aziwa omningi migraine ukuthi kukhona ngokwanele ngempumelelo kokubili ngesikhathi kuhlaselwa, futhi esikhathini interictal. Ngokulandelayo, sihlolisise izidakamizwa ngoba migraine: uhlu izinsiza kanye acute kuhlasela-free yokwelapha. It is wafakazela ukuthi triptans - izidakamizwa ephumelela kunazo ukuqeda ubuhlungu bekhanda. Nge izidakamizwa prophylactic babelwa amaqembu ezilandelayo:

• β-blocker;
• antidepressant;
• antiemetic;
• amanzi-encibilikayo vitamin B;
• calcium blocker;
• anticonvulsants.

Ukwemukelwa zonke lezi zindlela osekukhulunywe ubalwe njengenye imithi kumele liqoke umuntu oqeqeshiwe.

Kungani ngiphethwe yikhanda?

Ngaphambi baqonde indlela ukwenza triptans ikhanda, intengo zazo kuncike umakhi, kubalulekile ukuqonda inqubo egunjini lokuhlolwa kwezifo. Ikhanda elibuhlungu eba ngenxa ukukhuthazwa receptor we meninges nezitsha palsy. Lapho ukungezwani ngokweqile futhi ugcwele imithambo yegazi, ikakhulukazi imithambo etholakala isimo hypotonic eba sebuhlungwini obunzima, okuyinto luqedwe nje kuphela ngezinto kwemikhiqizo yasekhemisi ekhethekile. Abacwaningi abaningi esasifuna isikhathi eside, amalungiselelo ekwelapheni migraine, baye baphetha ngokuthi triptans - indlela engcono ukuze kuxazululwe le egunjini lokuhlolwa kwezifo.

izakhiwo triptans

Izidakamizwa okuhloswe ngaso ukunciphisa izitsha osuke usuvulekile zobuchopho. Triptans - umuthi ukuthi enza izinto-nucleus futhi la mangqamuzana ezinzwa we emsipheni trigeminal, nakho kunciphisa nozwela embundwini ubuhlungu. Triptans - yesimanje antimigraine izidakamizwa, okuyinto abe selectivity kunalokho okusezingeni eliphezulu kuya yegazi yezingalo Mater Dura (Dura Mater encephali) nezitsha ziqhathaniswa nezinye futhi neuropathy yenhliziyo.

imithi Kwethulwa liphumelele ukunciphisa ubuhlungu ezingeni nucleus umgogodla we emsipheni trigeminal. Ngaphezu wonke triptans ngenhla - izidakamizwa esingagcini nje ukunciphisa izinga lokuhlasela kwesifo isifo ngiwela ogibeni lwezidakamizwa, kodwa futhi uqede ukubonakaliswa ezihambisana basemtholampilo ke (isib, isicanucanu, ukuhlanza, photophobia, futhi umsindo).

Izinzuzo esemqoka triptans

Lezi izindawo kwemithi isivinini okusezingeni eliphezulu lithathwa yi. Ngokwezwi nezwi igama elithi e isigamu sehora zikhona izimpawu imiphumela emihle ye izidakamizwa emzimbeni wesiguli. Umthelela zokwelapha inakekelwa kulo lonke kuhlasela migraine. Iningi leziguli ikhanda akusho ziyabuya.

Kulezi zinsuku, ososayensi baye bafakazela ukuthi ukuthola kokumethemba ukuhlasela kufanele ngokushesha ukuthatha triptans ngoba migraine. Ngasekuqaleni kwakukhona umbono wokuthi ukuhlasela migraine kufanele aphathwe ngezigaba, kuqala reception kwemithi elula.

Izidakamizwa ngoba migraine: uhlu imithi athandwa kakhulu

Eqenjini triptan izidakamizwa kuhlanganisa lokhu okulandelayo:

• 'Zomig'.
• "Amigrenin".
• "Sumatriptan".
• "Imigran".
• "Relpaks".
• "Trimigren".
• "Sumamigren".
• "Rapimed".
• "Almotriptan".
• "Naramig".
• "Naratriptan."
• "Frovatriptan."
• "Zolmitriptan."

Izidakamizwa isiguli ngasinye kungase kube ngokuqinile ngabanye, ngakho ukuze kuqinisekiswe ukusebenza kwale noma eminye imithi, odokotela batusa ukuba uzame nokuyiphuza imishanguzo kuze kuphele ukuhlaselwa ezintathu migraine. Tryptamine iqembu izidakamizwa libhekene bioavailability eziphakeme, okulula kakhulu ukuba akwazi ukunqoba izingqinamba kusivimbeli gazi ebuchosheni, liphumelele ekunciphiseni ukuhlaselwa migraine, ngisho esigabeni ezibuhlungu. Lezi imithi ezifanele ukuba linqume iziguli ngokulinganisela nesifo esinzima zaba namandla kakhulu.

amanothi Isicelo

Kaningi sizwa umbuzo ofanayo: yini amaphilisi ekhanda kungcono? izifundo kokulinganisa baye babonisa ukuthi izindlela eziphumelela kakhulu ukuqeda izimpawu migraine kukhona triptans. Kungcono ukuthatha triptans ngoba migraine uma ithola izimpawu zokuqala kuhlasela. Umkhawulo umphumela analgesic Kuye kwaphawulwa amahora amabili ngemuva kokuthatha imithi. Ngaphambi kokuthatha izidakamizwa, ufunde ngokucophelela iziyalezo futhi athintane nodokotela. Kubalulekile kakhulu ukuvimbela izidakamizwa ukweqisa izidakamizwa. Triptans ngoba migraine is hhayi Kunconywa ukusebenzisa ndawonye zonke ngemithi elwa namagciwane, antifungal, ama-ejenti elwa namagciwane, kanye nemithi yokunciphisa ukucindezeleka.

Ukuze kuzuzwe elamukelekile, iziguli kumele zithobele imihlahlandlela elandelayo ukuthola triptans:

• nge imnene ikhanda ngokulinganisela ukuthatha 1 ithebhulethi (noma umthamo owodwa spray);
• umthamo yesibili esithathwayo ngaphambili kuka 2 chasa;
• emini ungathathi ngemithamo engaphezu kwemibili;
• triptans akunconywa ukuthatha izinsuku ezingaphezu kwezimbili ngesonto.

Phakathi ekwelapheni ekudleni kwakho kufanele ayifakiwe Imikhiqizo tiraminsoderzhaschie:

• cocoa;
• ushokoledi;
• ubhontshisi;
• amaqanda;
• isilimo esidliwayo esinamagatsha anamanzi;
• ezisawolintshi;
• lwezakhamzimba;
• ushizi;
• utamatisi;
• nati;
• izinhlobo zophuzo oludakayo.

Omunye Akufanele udle ukudla abandayo.

Ngezinye nesenzakalo migraine triptane, intengo okuzokwenziwa kuboniswe ngezansi, angasetshenziswa nezinye izidakamizwa, ezifana metoclopramide noma domperidone.

side effects

Lapho ngemva kokudla izidakamizwa ngokweqile, iziguli nazo zinselele ezilandelayo:

• isiyezi;
• ukushaqeka anaphylactic;
• yobunzima;
• isicanucanu;
• imfudumalo;
• infarction we ubende, amathumbu;
• ukuhlanza;
• nomlomo owomile;
• myalgia;
• Ubuhlungu obukhulu besisu,
• ukozela;
• evutha ukuzwa esikhumbeni;
• Angioedema;
• tachycardia;
• isifuba;
• polyuria;
• ukuba buthakathaka kwezicubu;
• kwehle ukunakwa;
• thuthuva sezinzwa;
• uhudo haemorrhagic;
• ukuchama kaningi;
• vasospasm yenhliziyo.

Naphezu kwakho konke lokhu, triptans ngoba migraine - umuthi esheshayo esebenza. Isikali Isihloko kanye nokuvama imithi ingozi nemiphumela engathandeki yalawo maphilisi incane. Ngokuvamile, bonke triptans ikubekezelele umzimba ngendlela evamile. Imiphumela engemihle, uma kwenzeka, wabe esesho omnene futhi uxazulule angesabi ngaphandle kokungenela wezokwelapha. I ethile eyinhloko triptans - lena izindleko zabo. Ngeshwa, akuyona yonke iziguli angakwazi ukukhokhela umuthi onjalo.

Izimo

Triptans ngoba migraine musa batusa ukusebenzisa kulezi zimo ezilandelayo:

• unhlangothi;
• angina angiospastic;
• ukhulelwe;
• ingozi cerebrovascular;
• ngesikhathi ukuncelisa ingane;
• coagulopathy (igazi ekunqandeni);
• usakhula;
• yezifo yisimiso senhliziyo nemithambo yegazi;
• hypersensitivity ukuba izinto bioactive we ekwakhiweni;
• nomfutho wegazi ophezulu engalawuliwe;
• arrhythmia;
• isibindi nezinso isifo;
• isifo sokuqina kwemithambo yegazi.

Ngaphambi enquma triptans ezithile, udokotela ukuba khona kufanele abone engcupheni isifo sokuqina kwemithambo yegazi. Lezi zici zihlanganisa lezi ezilandelayo:

• sikashukela;
• abesifazane post-menopausal;
• ukubhema;
• nomfutho wegazi ophezulu;
• ukukhuluphala;
• ezingeni lelisetulu normal igazi cholesterol;
• yobudala engaphezu kwengu-40 i-amadoda;
• yofuzo ukuba ngemuva kokuhlaselwa yisifo senhliziyo.

Ezinye iziguli abasengozini kufanele zithole umthamo wabo wokuqala tryptamine ngaphansi kokuqondisa onguchwepheshe nangaphansi ECG control.

Isikimu ekwelapheni migraine

Kukhona imigomo ejwayelekile ye yokwelapha izifo ukuthi kuyafaneleka ezimweni eziningi:

• kudingekile ukuba baqale imishanguzo analgesics noma inhlanganisela yawo (kuhlanganise nezidakamizwa nonsteroidal eqeda ukuvuvukala);
• Uma ukusetshenziswa analgesic akukuniki yalokho omuhle ke ngemva 45 amaminithi kufanele uthathe triptan;
• uma triptan bekulokhu ingaphumeleli, kuhlaselwa esilandelayo kumelwe usebenzise elinye izidakamizwa kusukela triptanovoy iqembu;
• nge ikhanda atypical kubalulekile ukusebenzisa non-steroidal izidakamizwa eqeda ukuvuvukala.

Ukusetshenziswa kwamathuluzi esimanje ngoba impatho migraine, wadala ngesisekelo triptans, esiza ukwenza ukuphila kube lula ukuze iziguli eziningi. Ungakhohlwa ukuthi ukuthatha lezi imithi kungenziwa udokotela, futhi kuphela uma uphethwe. Kunezimo lapho triptans nezinye analgesics nonspecific ungayeki elamukelekile futhi alubuqedi ubuhlungu. Kulokhu, odokotela bavame yokwelapha eziyinkimbinkimbi imithi anticonvulsant, ne-beta-blocker. Le mishanguzo zihlanganisa izidakamizwa ezilandelayo:

• "Penbutolol".
• "Nadolol."
• "Betaxolol."
• "Topiramate".
• "Neurontin."
• "Phenobarbital".
• "Timolol".
• "Propranolol".
• "Labetanol".
• "Bellataminal".
• "Metoprolol".
• "Topamax".
• "Acebutolol".

Indlela ukunciphisa izinga lokuhlasela kwesifo ukuhlaselwa?

Ukuze banciphise imvamisa iziguli migraine kufanele ihambisane nemithetho elandelayo:

• udle njalo;
• ukuwakhipha kusuka ukudla yakho yokudla kanye iziphuzo ezibanga ukuhlaselwa (ubhiya, ushokoledi, ushizi, champagne, ezisawolintshi izithelo, newayini elibomvu);
• ukuyeka ukubhema;
• njengoba kungenzeka kwenze ukuba ngaphandle isikhathi eside;
• ugweme ukucindezeleka;
• Ukuzivocavoca (ekahle - ukubhukuda);
• ukugwema uhambo olude ngebhasi, isikebhe, imoto.

Triptans kukhona ikhanda: intengo

Triptans akhiqizwa Isikali ezahlukene izinhlobo: umjovo izixazululo, spray acinene, amaphilisi, suppositories rectal. On izindleko yezidakamizwa ithinta ifomu ukukhululwa, umthamo, inani amaphilisi e iphakheji. Ngenxa yalokho, intengo lezi izidakamizwa siyahlukahluka ezahlukene - ruble 150-1500 iphakethe ngalinye.