Umuthi 'famotidine ": Izibuyekezo lodokotela ekusetshenzisweni

hyperacidity esiswini akugcini nje ukubukeka emizweni ezingemnandi, kodwa ukuthuthukiswa izifo ezibucayi ezifana ukuguguleka kanye nezilonda mucosal. Ngakho-ke, lapho kuqubuka sokusuka ezinjalo kufanele ngokushesha kudokotela uyofuna icebiso, a gastroenterologist.

Inzuzo ekhiqizwa namuhla abaningi izidakamizwa ezahlukene okuyinto zivimbela uketshezi of hydrochloric acid. I okungabizi kakhulu futhi kufinyeleleke izindlela zihlanganisa imithi "famotidine". Uphenyo Odokotela bathi imithi izokwethulwa ngezansi.

ifomu ukukhululwa, emabhokisini incazelo kanye nokusungulwa

Ukulungiselela "ka famotidine" ikhishwa ngesimo pellets ezincane. Ziyakwazi ukuma isiyingi futhi we-lenticular wangakwesokunxele, futhi isikhumba ophuzi noma ensundu.

Isithako asebenzayo lokhu ejenti kuyinto famotidine. Ngaphandle-ke, umkhiqizo iqukethe izingxenye asizayo njengoba magnesium stearate, corn isitashi, microcrystalline cellulose, Silicon dioxide, talc, kanye sodium croscarmellose.

Mayelana igobolondo, ke yakhiwa hypromellose, talc, Macrogol 6000, ama-titanium dioxide (E171) nsundu yensimbi oxide sombala.

Izidakamizwa "famotidine" isithombe sokuthi ubizwa okwethulwa kulesi sihloko ayatholakala ibhamuza amaphakethe, okuyinto equkethwe iphepha amabhokisi.

Yezemithi kwezidakamizwa anti-isilonda

Kuyini izidakamizwa emangalisayo "famotidine"? Izibuyekezo babike ukuthi kuyinto omelene ukuncintisana histamine. Ezinomthelela histamine H2-receptor amangqamuzana parietal, kunciphisa uketshezi of hydrochloric acid, esibangelwa ezishukumisa ahlukahlukene. Iphinde kunciphise ukukhiqiza basal. Lapho lokhu kwenzeka sasihambisana ngokwezinga uketshezi okusithiyayo okubangelwa pepsinogen.

Ukwamukelwa izidakamizwa kokubuyekezwa akaguquki amazinga gastrin egazini. Isikhathi wesenzo phezu isicelo esisodwa umthamo ancike futhi amahora 12-25.

I kinetics kwezidakamizwa

Lapho ukumuncwa lesi sidakamizwa "famotidine"? Izibuyekezo bathi ngemva kokuphathwa ngomlomo izidakamizwa ngokushesha ugxile kusukela pheshana emathunjini. Ngaphezu kwalokho, isiqongo sayo lokuhlushwa kufinyelelwa egazini amahora 1-3.

Ukuxhumana-plasma amaprotheni 17-20%. A umuthi excreted ku ubisi lwebele futhi lingena ngokusebenzisa isithiyo esinomhlapho.

Cishe 30-37% of famotidine is akheka esibindini. okukhipha Its excreted ngokusebenzisa nezinso.

ubufakazi

Yini ebonisa lesi sidakamizwa "famotidine"? Ukusetshenziswa kwalesi ejenti kunomphumela omuhle isimo ipheshana wokugaya ukudla ku:

• gastroduodenitis erosive;
• isilonda kanye nokuvinjelwa Ukuphinda yayo;
• dyspepsia obusebenzayo ;
• lingaze futhi ukucindezeleka isilonda;
• Reflux esophagitis;
• amaningi endocrine adenomatosis;
• Zollinger-Ellison syndrome;
• mastocytosis letindzala;
• nokuvinjelwa lokubuya kwesifo ezophayo esikhathini postoperative;
• Ukuvimbela nenshisekelo of juice esiswini kubantu ababhekene ukuhlinzwa ngaphansi izinzwa jikelele (nge Mendelson Syndrome) ;
• nokuvinjelwa nenshisekelo pneumonitis;
• ne dyspepsia retrosternal noma ubuhlungu epigastric okuyinto zenzeka ebusuku noma ngemva kokudla.

Izimo ukuthola amaphilisi anqanda isilonda

Uma ungawasebenzisi iphilisi "famotidine"? Izibuyekezo sisho futhi ukuthi Izimo yalesi izidakamizwa kukhona uthi elandelayo:

• ibele;
• ukhulelwe;
• engu-eminyakeni emithathu esisindo kufike ku-20 kg;
• hypersensitivity kuya famotidine nezinye blocker ka histamine H2-receptor.

Ngokucophelela okukhulu kuyinto imithi ngoba kwamasosha omzimba, isibindi noma ukungasebenzi kwezinso ezinganeni isifo sokusha encephalopathy isibindi (portosystemic).

kufanele Ngithatha kanjani "famotidine" ithebhulethi?

Izibuyekezo babike ukuthi izidakamizwa esithathwayo ngomlomo, ngaphandle ukuhlafuna.

Abadala nge izilonda of ipheshana wokugaya ukudla bese gastroduodenitis erosive ukhombe 20 mg kabili ngelanga. Uma wayefisa, umthamo wansuku zonke zingandiswa ku-80 noma 160 mg. Lokhu ukwelashwa kufanele kuhlale okungenani amaviki 4-8.

Ephambi kwezinduna dyspepsia, lihlotshaniswa uketshezi anda esiswini, iziguli iphathwa mg izidakamizwa 20 kanye ngosuku.

Ngokuba nokuvimbela isilonda uyahluleka uma elwa nokuphuza ukusetshenziswa kwezidakamizwa 20 mg nsuku zonke ngesikhathi sokulala.

Lapho Zollinger-Ellison syndrome umthamo zomuthi kanye nesikhathi yokwelapha izifundo asethwe ngamunye. Umthamo kokuqala nomuthi lapho kokutshelwa ngokukhubazeka kwengane ngokuvamile 20 mg. Uphuzwe njalo ngemva kwamahora 6. Uma kudingeka, kungase senyukela 160 mg.

Lapho refpyuks esophagitis ukusetshenziswa kwezidakamizwa by 20-40 mg kabili ngosuku eziyisithupha - amasonto nambili.

Izingane ezingaphezulu kweminyaka emithathu imithi isilonda kanye Reflux esophagitis ebekiwe ngesilinganiso 2 mg / kg ngosuku.

side effects

Yini side effects esivela ku izidakamizwa "famotidine"? Izibuyekezo lodokotela ukhombise ukuphendula elandelayo:

• umlomo some, ahlale ekhathele ukuhlanza, isiyezi, ubuhlungu besisu, ukozela, ukuqunjelwa, ukuphazamiseka esesuthi, uvalo umsebenzi okwandisiwe enzyme isibindi, ukuqubuka kwesikhumba, ukukhishwa pancreatitis acute;
• ukudideka, bradycardia, ukuhhema, vasculitis, pyrexia;
• arrhythmia, isikhumba esomile, encishisiwe blood pressure, AV-block;
• Alopecia, leukopenia, induna vulgaris, angaboni kahle, ukuvuvukala antionevrotichesky izinhlungu, ukulunywa, agranulocytosis, bronchospasm;
• ikhanda elibuhlungu, isicanucanu, ukuqwasha, ukukhathazeka, umoya esiswini, ukuqunjelwa, tinnitus, uhudo, ukucindezeleka, isifo sokusha kwesibindi, sengqondo, paresis yokuhlala;
• ukushaqeka anaphylactic, hypoplasia, ekubonakalisweni hypersensitivity;
• thrombocytopenia, amenorrhea, pancytopenia, hyperprolactinemia, aplasia we umnkantsha;
• gynecomastia, ubuthakathaka, imfiva, ubuhlungu emalungeni;
• kwehle libido, ubuhlungu bemisipha, ukwanda urea amazinga egazini.

Izibuyekezo

Ochwepheshe bathi lesi sidakamizwa "famotidine" akulona ephumelela kunazo anti-isilonda ejenti. Naphezu kwakho konke lokhu, uvame kakhulu asetshenziswa ukwelapha izifo emathunjini.

Njengoba for iziguli, bexabana ukuthi ezinsukwini zakuqala ukwelashwa izidakamizwa iziphatha kahle. Ngemva kwalokho, it is inqanyuliwe.