Umuthi 'Sporagal ": yokusetshenziswa, analogs kanye nokubuyekeza

Indlela ukuthatha lesi sidakamizwa "Sporagal"? Imiyalelo ukusetshenziswa kwezidakamizwa sizobuye kubhekwe. Uyofunda ukuthi kukhona analogue lokhu ukulungiselela, ukuthi kubiza malini, uthini ngaye iziguli, ngayiphi injongo iqondiswa, nokunye. D.

Ifomu, ukubunjwa, emaphaketheni antifungal izidakamizwa

Ukulungiselela "Sporagal" etholakala ifomu capsule. isithako Its main esebenzayo itraconazole. Futhi nomuthi yakhiwa polyethylene glycol 20000, sucrose, futhi hydroxypropyl acrylate copolymer.

Mayelana igobolondo, yakhiwa gelatin, ama-titanium dioxide futhi indigotin.

Ngo iphakheji sithengiswa imithi "Sporagal"? Iziyalezo uyalisebenzisa yini leli thuluzi lishumekwe ebhokisini amakhadibhodi. Iphinde iqukethe kanzima gelatin capsule ngokuluhlaza okwesibhakabhaka (e amabhamuza), okuyinto unayo elimbudumbudu eyindilinga umbala ophuzi.

Pharmacodynamics nomuthi

kanjani "Sporagal" ithebhulethi? Ngokusho imiyalelo, umuthi kuyinto esuselwe triazole. It possesses umsebenzi omkhulu ngokumelene isikhunta.

Lesi sidakamizwa sisiza kancane zamagama begazi ergosterol, ukuhlinzeka umphumela antifungal.

Ochwepheshe bathi itraconazole sivimbela ukukhula nokukhiqizwa lenqwaba zinhlobo isikhunta.

I pharmacokinetics ejenti antifungal

Izidakamizwa "Sporagal", okuyinto analogue uzobe ecacisiwe okwengeziwe, ugxile ngokushesha emgudwini wegazi. Eliphakeme itraconazole kubantu siyenzeka emva 3 amahora. bioavailability Its 55% (esiphezulu is baphawula ngaso amaphilisi reception ngokushesha kulandela ukusetshenziswa ukudla amanoni okunama-kilojoule amaningi).

Itraconazole isakazwa kwezitho ezahlukene nezicubu zomzimba. okuqukethwe emathanjeni, izinso, isibindi, amaphaphu imisipha lwamathambo, isisu, ubende kanye nezikhathi 3 kunaleyo Igazi lawo.

Nomuthi akheka esibindini ukukhulula sebuningini nemikhiqizo. Nokho, gidroksiitrakonazol kuphela has a liphinyiselwe umphumela antifungal.

Cishe 34% we ketshezi esebenzayo ikhishwe emchamweni, futhi mayelana 54% ngokusebenzisa emathunjini.

Ngo abantu nge isibindi umsebenzi kahle nesifo sezinso futhi in iziguli kwamasosha omzimba bioavailability zomuthi zingancishiswa.

izinkomba amaphilisi

Kungani ukhethe "Sporagal"? Ukufundiswa uthi izidakamizwa senzelwe ekwelapheni izifo fungal, eyayibonakala cuphuluza izidakamizwa ukuzwela Amagciwane:

• candidiasis vulvovaginal;
• iziyaluyalu ophthalmological futhi dermatological Lokudabuka fungal (isib keratitis fungal, umbandamu, pityriasis versicolor);
• candidiasis temlomo ;
• onychomycosis, eyayibonakala cuphuluza dermatophytes noma nembiliso;
• mycoses letindzala kuhlanganise cryptococcosis (abantu nge ababuthakathaka izivikeli mzimba ngesikhathi isimiso sezinzwa cryptococcosis nomuthi iqondiswa kuphela ukungabi khona ukwelashwa imiphumela yezinye ejenti antifungal), cryptococcal meningitis, aspergillosis eluhlelweni kanye candidiasis;
• sporotrichosis, paracoccidioidomycosis, blastomycosis, histoplasmosis, nezinye mycoses ezingavamile letindzala.

Izimo ukusetshenziswa amaphilisi

Yiziphi contraindications ukusetshenziswa kwezidakamizwa "Sporagal" (amaphilisi)? Ukufundiswa uthi izidakamizwa akufanele isetshenziswe:

• Hypersensitivity kuya izingxenye aphansi nezamabanga aphakeme zomuthi
• ngokuhlanganyela imithi efana "Eletriptan" blocker HMG-CoA reductase inhibitors (isib, "atorvastatin", "Lovastatin" "simvastatin"), ergot alkaloids, substrates CYP3A4 (isibonelo, "Cisapride", "bepridil," "pimozide" "Dofetilide", "Astemizole" "quinidine" "mizolastine"), "nisoldipine," "Midazolam", "triazolam".

Kufanele kuphawulwe ukuthi ukusetshenziswa kwalesi izidakamizwa is contraindicated kubantu nge ventricular ukungasebenzi kanye senhliziyo, ikakhulukazi uhlamvu congestive.

Izidakamizwa "Sporagal": yokusetshenziswa

Ngokusho imiyalelo, umuthi kumele kuthathwe ngomlomo. Amaphilisi kufanele kudliwe ngokushesha emva kokudla (ukuze kuqinisekiswe ukumuncwa kangcono), iphelele, ngaphandle ukuhlafuna.

Umthamo le imithi incike uhlobo lwesifo ezikhona:

• Dermatological futhi lesion ophthalmologic (isib pityriasis versicolor noma umbandamu) - 200 mg kanye ngosuku isonto lonke.
• izilonda Keratinized kwesikhumba (kwezandla nezinyawo) - 200 mg kabili ngosuku, isonto.
• candidiasis Vulvovaginal - 200 mg kabili ngosuku izinsuku ezintathu.
• Oral candidiasis - mg 100 kanye ngosuku amasonto amabili. In iziguli abane-AIDS noma neutropenia, umthamo linyuke laba ngu-200 mg kanye ngelanga.
• keratitis fungal - 200 mg kanye ngelanga amasonto amathathu.
• Onychomycosis, okuyinto zazibangelwa dermatophytes noma nembiliso, ziphathwa esebenzisa okuphindaphindiwe course. Omunye yokwelapha kuhilela amaphilisi amabili kabili ngosuku, isonto. Ukuze ekwelapheni nail unezilonda iminwe Kwenziwa 2 izifundo lokhu yokwelapha, nezimbadada ezinyaweni zakhe - 3 izifundo. Break phakathi kwalezi zinto zombili kumele kube 3 amaviki. Umthelela kubonakala emva kokuphothulwa Yiqiniso (ngekukhula nail amapuleti).

Ukuthuthwa kwabantu ngenxa yengozi ukulungiselela "Sporagal" nail kanye isikhumba wenziwa isikhathi eside ukwedlula kusukela egazini. Kule ndaba, elilungile imiphumela zokwelapha iziguli siyithola ngemva kwamasonto nje ngemva ezintathu kokuphothulwa yokwelapha izifo futhi cishe ngemva kwezinyanga ezingu-9 ekwelapheni onychomycosis.

Izindlela Yokusebenzisa amaphilisi izilonda letindzala

Njenganoma izilonda letindzala baphathe isicelo? "Sporagal" uqoke ku imithamo ezilandelayo:

• Candidiasis - 100-200 mg kanye nsuku zonke kwaze kwaphela amasonto 5-30.
• Cryptococcosis ngaphandle meningitis - 200 mg ngosuku izinyanga 3-12. Nge double umthamo meningitis.
• Aspergillosis - 200 mg ngosuku izinyanga 3-5.
• Histoplasmosis - 200 mg kabili ngosuku izinyanga eziyisishiyagalombili.
• Chromomycosis - 100-200 mg ngosuku izinyanga eziyisithupha.
• Sporotrichosis - 100 mg ngosuku izinyanga ezintathu.
• Paracoccidioidomycosis - 100 mg nsuku zonke izinyanga eziyisithupha. Ezigulini AIDS, umthamo kungase kukhule.
• Blastomycosis - 100-200 mg kabili ngosuku izinyanga eziyisithupha.

imiphumela emibi yemithi

Zikhona yini imiphumela emibi e seziguli ezithola "Sporagal" izidakamizwa? Izibuyekezo ochwepheshe kubika ukusabela ezilandelayo:

• neutropenia, thrombocytopenia, leukopenia;
• zokuphefumula ipheshana izifo (elingenhla);
• hypertriglyceridemia, hypokalemia, hypocalcemia;
• ikhanda, paresthesia, peripheral neuropathy, hypoesthesia, isiyezi;
• ukugula serum, edema angioneurotic, anaphylactic futhi anaphylactoid komzimba;
• angaboni kahle, diplopia, ukulahlekelwa kukuzwa, tinnitus, angaboni kahle;
• ukumelwa inhliziyo, uhlamvu congestive ikakhulukazi;
• dyspnea, rhinitis, sinusitis, edema yamaphaphu;
• ukuhlanza, dyspepsia, ukusabela hepatotoxic, ubuhlungu besisu, pancreatitis, isicanucanu, dysgeusia, ukuqunjelwa, isifo sokusha kwesibindi, isifo sohudo, ukuvuvukala kwendawo yesikhashana transaminases isibindi;
• ubuhlungu emalungwini nemisipha;
• ukuqubuka, photosensitivity, vasculitis leukocytoclastic, Alopecia, ezinobuthi epidermal necrolysis, pruritus, dermatitis exfoliative, ukuqubuka, acute generalized pustulosis exanthematous, erythema multiforme;
• dysmenorrhea, incontinence urinary, Erectile Dysfunction, pollakiuria;
• imfiva, edema.

izincomo ezithile

Okufanele ukwazi isiguli, ngaphambi kokuthatha lesi sidakamizwa "Sporagal"? Izimpendulo libike ukuthi imfuyo yayo asebenzayo kunomthelela ongemuhle inotropic.

Nakuba kokuthatha lesi imithi zingase ukuthuthukisa congestive inhliziyo ukwehluleka, futhi hepatotoxicity ezinzima.

Lapho encishisiwe asidi izidakamizwa absorbability liwohloka.

Abantu kanyekanye nokusebenzisa antacids kufanele kugcinwe phakathi kwabo nezindlela sokulungiselela isikhawu echazwe-2 amahora.

Izidakamizwa "Sporagal" hhayi lephakanyiselwe iziguli esezikhulile.

Uma unezimpawu ze-neuropathy imithi peripheral ethatha ukukhansela.

Ibele nokukhulelwa

Phakathi nenkathi yokukhulelwa, le imithi kungenzeka iqondiswa kuphela mycoses letindzala, okuyinto banciphisa impilo kamama.

Njengoba for ibele, kule nkathi, "Sporagal" avumelekile, kodwa kuphela ngaphansi izinkomba esiqinile.

Izidakamizwa "Sporagal": analogs futhi intengo

Amathuluzi abalandelayo analogue eyaziwa kakhulu izidakamizwa ngaphansi ukucatshangelwa, "Itrungar", "Sporaksol", "Orungal", "Eszol" futhi "Funit".

Kungakanani buyisidakamizwa "Sporagal"? Intengo yale imithi uyahluka ruble 1100-1200.

Izibuyekezo sokulungiselela

Ngokusho ngempendulo walabo abaphuza umuthi, kungase kuqashelwe ukuthi siyasebenza ngempela kubonakala izinhlobo ezahlukene izifo fungal. kungenziwa behlukene imiyalezo ezingezinhle yilezo bathi leli thuluzi has a izindleko eliphezulu. Nokho, ochwepheshe bathi intengo yaleli izidakamizwa ulungisiswa ngokuphelele kusebenta zayo zokwelapha.

Kepha bokwenza lokhu izidakamizwa, iziguli kaningi ukhombe nezikhathi kuqhathaniswa eside yokwelashwa.